Meta-analysis of loci associated with age at natural menopause in African-American women.

Journal Article (Journal Article)

Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

Full Text

Duke Authors

Cited Authors

  • Chen, CTL; Liu, C-T; Chen, GK; Andrews, JS; Arnold, AM; Dreyfus, J; Franceschini, N; Garcia, ME; Kerr, KF; Li, G; Lohman, KK; Musani, SK; Nalls, MA; Raffel, LJ; Smith, J; Ambrosone, CB; Bandera, EV; Bernstein, L; Britton, A; Brzyski, RG; Cappola, A; Carlson, CS; Couper, D; Deming, SL; Goodarzi, MO; Heiss, G; John, EM; Lu, X; Le Marchand, L; Marciante, K; Mcknight, B; Millikan, R; Nock, NL; Olshan, AF; Press, MF; Vaiyda, D; Woods, NF; Taylor, HA; Zhao, W; Zheng, W; Evans, MK; Harris, TB; Henderson, BE; Kardia, SLR; Kooperberg, C; Liu, Y; Mosley, TH; Psaty, B; Wellons, M; Windham, BG; Zonderman, AB; Cupples, LA; Demerath, EW; Haiman, C; Murabito, JM; Rajkovic, A

Published Date

  • June 15, 2014

Published In

Volume / Issue

  • 23 / 12

Start / End Page

  • 3327 - 3342

PubMed ID

  • 24493794

Pubmed Central ID

  • PMC4030781

Electronic International Standard Serial Number (EISSN)

  • 1460-2083

Digital Object Identifier (DOI)

  • 10.1093/hmg/ddu041

Language

  • eng

Conference Location

  • England