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Meta-analysis of loci associated with age at natural menopause in African-American women.

Publication ,  Journal Article
Chen, CTL; Liu, C-T; Chen, GK; Andrews, JS; Arnold, AM; Dreyfus, J; Franceschini, N; Garcia, ME; Kerr, KF; Li, G; Lohman, KK; Musani, SK ...
Published in: Hum Mol Genet
June 15, 2014

Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

Duke Scholars

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

June 15, 2014

Volume

23

Issue

12

Start / End Page

3327 / 3342

Location

England

Related Subject Headings

  • White People
  • United States
  • Menopause
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Variation
  • Genetic Loci
  • Female
  • Chromosomes, Human
 

Citation

APA
Chicago
ICMJE
MLA
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Chen, C. T. L., Liu, C.-T., Chen, G. K., Andrews, J. S., Arnold, A. M., Dreyfus, J., … Rajkovic, A. (2014). Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet, 23(12), 3327–3342. https://doi.org/10.1093/hmg/ddu041
Chen, Christina T. L., Ching-Ti Liu, Gary K. Chen, Jeanette S. Andrews, Alice M. Arnold, Jill Dreyfus, Nora Franceschini, et al. “Meta-analysis of loci associated with age at natural menopause in African-American women.Hum Mol Genet 23, no. 12 (June 15, 2014): 3327–42. https://doi.org/10.1093/hmg/ddu041.
Chen CTL, Liu C-T, Chen GK, Andrews JS, Arnold AM, Dreyfus J, et al. Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet. 2014 Jun 15;23(12):3327–42.
Chen, Christina T. L., et al. “Meta-analysis of loci associated with age at natural menopause in African-American women.Hum Mol Genet, vol. 23, no. 12, June 2014, pp. 3327–42. Pubmed, doi:10.1093/hmg/ddu041.
Chen CTL, Liu C-T, Chen GK, Andrews JS, Arnold AM, Dreyfus J, Franceschini N, Garcia ME, Kerr KF, Li G, Lohman KK, Musani SK, Nalls MA, Raffel LJ, Smith J, Ambrosone CB, Bandera EV, Bernstein L, Britton A, Brzyski RG, Cappola A, Carlson CS, Couper D, Deming SL, Goodarzi MO, Heiss G, John EM, Lu X, Le Marchand L, Marciante K, Mcknight B, Millikan R, Nock NL, Olshan AF, Press MF, Vaiyda D, Woods NF, Taylor HA, Zhao W, Zheng W, Evans MK, Harris TB, Henderson BE, Kardia SLR, Kooperberg C, Liu Y, Mosley TH, Psaty B, Wellons M, Windham BG, Zonderman AB, Cupples LA, Demerath EW, Haiman C, Murabito JM, Rajkovic A. Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet. 2014 Jun 15;23(12):3327–3342.
Journal cover image

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

June 15, 2014

Volume

23

Issue

12

Start / End Page

3327 / 3342

Location

England

Related Subject Headings

  • White People
  • United States
  • Menopause
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Variation
  • Genetic Loci
  • Female
  • Chromosomes, Human