Meta-analysis of loci associated with age at natural menopause in African-American women.
Journal Article (Journal Article)
Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.
Full Text
Duke Authors
Cited Authors
- Chen, CTL; Liu, C-T; Chen, GK; Andrews, JS; Arnold, AM; Dreyfus, J; Franceschini, N; Garcia, ME; Kerr, KF; Li, G; Lohman, KK; Musani, SK; Nalls, MA; Raffel, LJ; Smith, J; Ambrosone, CB; Bandera, EV; Bernstein, L; Britton, A; Brzyski, RG; Cappola, A; Carlson, CS; Couper, D; Deming, SL; Goodarzi, MO; Heiss, G; John, EM; Lu, X; Le Marchand, L; Marciante, K; Mcknight, B; Millikan, R; Nock, NL; Olshan, AF; Press, MF; Vaiyda, D; Woods, NF; Taylor, HA; Zhao, W; Zheng, W; Evans, MK; Harris, TB; Henderson, BE; Kardia, SLR; Kooperberg, C; Liu, Y; Mosley, TH; Psaty, B; Wellons, M; Windham, BG; Zonderman, AB; Cupples, LA; Demerath, EW; Haiman, C; Murabito, JM; Rajkovic, A
Published Date
- June 15, 2014
Published In
Volume / Issue
- 23 / 12
Start / End Page
- 3327 - 3342
PubMed ID
- 24493794
Pubmed Central ID
- PMC4030781
Electronic International Standard Serial Number (EISSN)
- 1460-2083
Digital Object Identifier (DOI)
- 10.1093/hmg/ddu041
Language
- eng
Conference Location
- England