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Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).

Publication ,  Journal Article
An, P; Miljkovic, I; Thyagarajan, B; Kraja, AT; Daw, EW; Pankow, JS; Selvin, E; Kao, WHL; Maruthur, NM; Nalls, MA; Liu, Y; Harris, TB ...
Published in: Metabolism
April 2014

OBJECTIVE: Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. It is also associated with premature aging and increased mortality. To uncover novel loci for HbA1c that are associated with healthy aging, we conducted a genome-wide association study (GWAS) using non-diabetic participants in the Long Life Family Study (LLFS), a study with familial clustering of exceptional longevity in the US and Denmark. METHODS: A total of 4088 non-diabetic subjects from the LLFS were used for GWAS discoveries, and a total of 8231 non-diabetic subjects from the Atherosclerosis Risk in Communities Study (ARIC, in the MAGIC Consortium) and the Health, Aging, and Body Composition Study (HABC) were used for GWAS replications. HbA1c was adjusted for age, sex, centers, 20 principal components, without and with BMI. A linear mixed effects model was used for association testing. RESULTS: Two known loci at GCK rs730497 (or rs2908282) and HK1 rs17476364 were confirmed (p<5e-8). Of 25 suggestive (5e-8

Duke Scholars

Published In

Metabolism

DOI

EISSN

1532-8600

Publication Date

April 2014

Volume

63

Issue

4

Start / End Page

461 / 468

Location

United States

Related Subject Headings

  • United States
  • Phenotype
  • Middle Aged
  • Male
  • Longevity
  • Humans
  • Glycated Hemoglobin
  • Genotype
  • Genome-Wide Association Study
  • Female
 

Citation

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An, P., Miljkovic, I., Thyagarajan, B., Kraja, A. T., Daw, E. W., Pankow, J. S., … Province, M. A. (2014). Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). Metabolism, 63(4), 461–468. https://doi.org/10.1016/j.metabol.2013.11.018
An, Ping, Iva Miljkovic, Bharat Thyagarajan, Aldi T. Kraja, E Warwick Daw, James S. Pankow, Elizabeth Selvin, et al. “Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).Metabolism 63, no. 4 (April 2014): 461–68. https://doi.org/10.1016/j.metabol.2013.11.018.
An, Ping, et al. “Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).Metabolism, vol. 63, no. 4, Apr. 2014, pp. 461–68. Pubmed, doi:10.1016/j.metabol.2013.11.018.
An P, Miljkovic I, Thyagarajan B, Kraja AT, Daw EW, Pankow JS, Selvin E, Kao WHL, Maruthur NM, Nalls MA, Liu Y, Harris TB, Lee JH, Borecki IB, Christensen K, Eckfeldt JH, Mayeux R, Perls TT, Newman AB, Province MA. Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). Metabolism. 2014 Apr;63(4):461–468.
Journal cover image

Published In

Metabolism

DOI

EISSN

1532-8600

Publication Date

April 2014

Volume

63

Issue

4

Start / End Page

461 / 468

Location

United States

Related Subject Headings

  • United States
  • Phenotype
  • Middle Aged
  • Male
  • Longevity
  • Humans
  • Glycated Hemoglobin
  • Genotype
  • Genome-Wide Association Study
  • Female