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Common variants in Mendelian kidney disease genes and their association with renal function.

Publication ,  Journal Article
Parsa, A; Fuchsberger, C; Köttgen, A; O'Seaghdha, CM; Pattaro, C; de Andrade, M; Chasman, DI; Teumer, A; Endlich, K; Olden, M; Chen, M-H ...
Published in: J Am Soc Nephrol
December 2013

Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidney function in the general population. Using the Online Mendelian Inheritance in Man database, we identified 731 unique disease entries related to specific renal search terms and confirmed a kidney phenotype in 218 of these entries, corresponding to mutations in 258 genes. We interrogated common SNPs (minor allele frequency >5%) within these genes for association with the estimated GFR in 74,354 European-ancestry participants from the CKDGen Consortium. However, the top four candidate SNPs (rs6433115 at LRP2, rs1050700 at TSC1, rs249942 at PALB2, and rs9827843 at ROBO2) did not achieve significance in a stage 2 meta-analysis performed in 56,246 additional independent individuals, indicating that these common SNPs are not associated with estimated GFR. The effect of less common or rare variants in these genes on kidney function in the general population and disease-specific cohorts requires further research.

Duke Scholars

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

December 2013

Volume

24

Issue

12

Start / End Page

2105 / 2117

Location

United States

Related Subject Headings

  • White People
  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Mendelian Randomization Analysis
  • Kidney
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
 

Citation

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Parsa, A., Fuchsberger, C., Köttgen, A., O’Seaghdha, C. M., Pattaro, C., de Andrade, M., … Böger, C. A. (2013). Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol, 24(12), 2105–2117. https://doi.org/10.1681/ASN.2012100983
Parsa, Afshin, Christian Fuchsberger, Anna Köttgen, Conall M. O’Seaghdha, Cristian Pattaro, Mariza de Andrade, Daniel I. Chasman, et al. “Common variants in Mendelian kidney disease genes and their association with renal function.J Am Soc Nephrol 24, no. 12 (December 2013): 2105–17. https://doi.org/10.1681/ASN.2012100983.
Parsa A, Fuchsberger C, Köttgen A, O’Seaghdha CM, Pattaro C, de Andrade M, et al. Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol. 2013 Dec;24(12):2105–17.
Parsa, Afshin, et al. “Common variants in Mendelian kidney disease genes and their association with renal function.J Am Soc Nephrol, vol. 24, no. 12, Dec. 2013, pp. 2105–17. Pubmed, doi:10.1681/ASN.2012100983.
Parsa A, Fuchsberger C, Köttgen A, O’Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen M-H, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A, Rao M, Smith AV, O’Connell JR, Struchalin M, Tanaka T, Li G, Hwang S-J, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra BA, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Döring A, Wichmann H-E, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Colhoun H, Doney A, Robino A, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun G-A, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, van Duijn CM, Borecki I, Kardia SLR, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Bochud M, Heid IM, Siscovick DS, Fox CS, Kao WL, Böger CA. Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol. 2013 Dec;24(12):2105–2117.

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

December 2013

Volume

24

Issue

12

Start / End Page

2105 / 2117

Location

United States

Related Subject Headings

  • White People
  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Mendelian Randomization Analysis
  • Kidney
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation