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Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.

Publication ,  Journal Article
Nettleton, JA; Hivert, M-F; Lemaitre, RN; McKeown, NM; Mozaffarian, D; Tanaka, T; Wojczynski, MK; Hruby, A; Djoussé, L; Ngwa, JS; Follis, JL ...
Published in: Am J Epidemiol
January 15, 2013

Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 U.S. and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG (β = -0.004 mmol/L, 95% confidence interval: -0.005, -0.003) and FI (β = -0.008 ln-pmol/L, 95% confidence interval: -0.009, -0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions.

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Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

January 15, 2013

Volume

177

Issue

2

Start / End Page

103 / 115

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Linear Models
  • Insulin
  • Humans
  • Homeostasis
  • Genotype
  • Genome-Wide Association Study
  • Genetic Markers
  • Gene-Environment Interaction
  • Fasting
 

Citation

APA
Chicago
ICMJE
MLA
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Nettleton, J. A., Hivert, M.-F., Lemaitre, R. N., McKeown, N. M., Mozaffarian, D., Tanaka, T., … Franks, P. W. (2013). Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol, 177(2), 103–115. https://doi.org/10.1093/aje/kws297
Nettleton, Jennifer A., Marie-France Hivert, Rozenn N. Lemaitre, Nicola M. McKeown, Dariush Mozaffarian, Toshiko Tanaka, Mary K. Wojczynski, et al. “Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.Am J Epidemiol 177, no. 2 (January 15, 2013): 103–15. https://doi.org/10.1093/aje/kws297.
Nettleton JA, Hivert M-F, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, et al. Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol. 2013 Jan 15;177(2):103–15.
Nettleton, Jennifer A., et al. “Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.Am J Epidemiol, vol. 177, no. 2, Jan. 2013, pp. 103–15. Pubmed, doi:10.1093/aje/kws297.
Nettleton JA, Hivert M-F, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A, Djoussé L, Ngwa JS, Follis JL, Dimitriou M, Ganna A, Houston DK, Kanoni S, Mikkilä V, Manichaikul A, Ntalla I, Renström F, Sonestedt E, van Rooij FJA, Bandinelli S, de Koning L, Ericson U, Hassanali N, Kiefte-de Jong JC, Lohman KK, Raitakari O, Papoutsakis C, Sjogren P, Stirrups K, Ax E, Deloukas P, Groves CJ, Jacques PF, Johansson I, Liu Y, McCarthy MI, North K, Viikari J, Zillikens MC, Dupuis J, Hofman A, Kolovou G, Mukamal K, Prokopenko I, Rolandsson O, Seppälä I, Cupples LA, Hu FB, Kähönen M, Uitterlinden AG, Borecki IB, Ferrucci L, Jacobs DR, Kritchevsky SB, Orho-Melander M, Pankow JS, Lehtimäki T, Witteman JCM, Ingelsson E, Siscovick DS, Dedoussis G, Meigs JB, Franks PW. Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol. 2013 Jan 15;177(2):103–115.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

January 15, 2013

Volume

177

Issue

2

Start / End Page

103 / 115

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Linear Models
  • Insulin
  • Humans
  • Homeostasis
  • Genotype
  • Genome-Wide Association Study
  • Genetic Markers
  • Gene-Environment Interaction
  • Fasting