Mitochondrial DNA variation in human metabolic rate and energy expenditure.

Journal Article (Journal Article)

The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.

Full Text

Duke Authors

Cited Authors

  • Tranah, GJ; Manini, TM; Lohman, KK; Nalls, MA; Kritchevsky, S; Newman, AB; Harris, TB; Miljkovic, I; Biffi, A; Cummings, SR; Liu, Y

Published Date

  • November 2011

Published In

Volume / Issue

  • 11 / 6

Start / End Page

  • 855 - 861

PubMed ID

  • 21586348

Pubmed Central ID

  • PMC3998521

Electronic International Standard Serial Number (EISSN)

  • 1872-8278

Digital Object Identifier (DOI)

  • 10.1016/j.mito.2011.04.005


  • eng

Conference Location

  • Netherlands