Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

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Journal Article

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Full Text

Duke Authors

Cited Authors

  • Soler Artigas, M; Loth, DW; Wain, LV; Gharib, SA; Obeidat, M; Tang, W; Zhai, G; Zhao, JH; Smith, AV; Huffman, JE; Albrecht, E; Jackson, CM; Evans, DM; Cadby, G; Fornage, M; Manichaikul, A; Lopez, LM; Johnson, T; Aldrich, MC; Aspelund, T; Barroso, I; Campbell, H; Cassano, PA; Couper, DJ; Eiriksdottir, G; Franceschini, N; Garcia, M; Gieger, C; Gislason, GK; Grkovic, I; Hammond, CJ; Hancock, DB; Harris, TB; Ramasamy, A; Heckbert, SR; Heliövaara, M; Homuth, G; Hysi, PG; James, AL; Jankovic, S; Joubert, BR; Karrasch, S; Klopp, N; Koch, B; Kritchevsky, SB; Launer, LJ; Liu, Y; Loehr, LR; Lohman, K; Loos, RJF; Lumley, T; Al Balushi, KA; Ang, WQ; Barr, RG; Beilby, J; Blakey, JD; Boban, M; Boraska, V; Brisman, J; Britton, JR; Brusselle, GG; Cooper, C; Curjuric, I; Dahgam, S; Deary, IJ; Ebrahim, S; Eijgelsheim, M; Francks, C; Gaysina, D; Granell, R; Gu, X; Hankinson, JL; Hardy, R; Harris, SE; Henderson, J; Henry, A; Hingorani, AD; Hofman, A; Holt, PG; Hui, J; Hunter, ML; Imboden, M; Jameson, KA; Kerr, SM; Kolcic, I; Kronenberg, F; Liu, JZ; Marchini, J; McKeever, T; Morris, AD; Olin, A-C; Porteous, DJ; Postma, DS; Rich, SS; Ring, SM; Rivadeneira, F; Rochat, T; Sayer, AA; Sayers, I; Sly, PD; Smith, GD; Sood, A; Starr, JM; Uitterlinden, AG; Vonk, JM; Wannamethee, SG; Whincup, PH; Wijmenga, C; Williams, OD; Wong, A; Mangino, M; Marciante, KD; McArdle, WL; Meibohm, B; Morrison, AC; North, KE; Omenaas, E; Palmer, LJ; Pietiläinen, KH; Pin, I; Pola Sbreve Ek, O; Pouta, A; Psaty, BM; Hartikainen, A-L; Rantanen, T; Ripatti, S; Rotter, JI; Rudan, I; Rudnicka, AR; Schulz, H; Shin, S-Y; Spector, TD; Surakka, I; Vitart, V; Völzke, H; Wareham, NJ; Warrington, NM; Wichmann, H-E; Wild, SH; Wilk, JB; Wjst, M; Wright, AF; Zgaga, L; Zemunik, T; Pennell, CE; Nyberg, F; Kuh, D; Holloway, JW; Boezen, HM; Lawlor, DA; Morris, RW; Probst-Hensch, N; International Lung Cancer Consortium, ; GIANT consortium, ; Kaprio, J; Wilson, JF; Hayward, C; Kähönen, M; Heinrich, J; Musk, AW; Jarvis, DL; Gläser, S; Järvelin, M-R; Ch Stricker, BH; Elliott, P; O'Connor, GT; Strachan, DP; London, SJ; Hall, IP; Gudnason, V; Tobin, MD

Published Date

  • September 25, 2011

Published In

Volume / Issue

  • 43 / 11

Start / End Page

  • 1082 - 1090

PubMed ID

  • 21946350

Pubmed Central ID

  • 21946350

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.941

Language

  • eng

Conference Location

  • United States