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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Publication ,  Journal Article
Soler Artigas, M; Loth, DW; Wain, LV; Gharib, SA; Obeidat, M; Tang, W; Zhai, G; Zhao, JH; Smith, AV; Huffman, JE; Albrecht, E; Jackson, CM ...
Published in: Nat Genet
September 25, 2011

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

September 25, 2011

Volume

43

Issue

11

Start / End Page

1082 / 1090

Location

United States

Related Subject Headings

  • White People
  • Respiratory Function Tests
  • Pulmonary Disease, Chronic Obstructive
  • Humans
  • Genome-Wide Association Study
  • Developmental Biology
  • Child
  • 3105 Genetics
  • 3102 Bioinformatics and computational biology
  • 3001 Agricultural biotechnology
 

Citation

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Soler Artigas, M., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., … Tobin, M. D. (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet, 43(11), 1082–1090. https://doi.org/10.1038/ng.941
Soler Artigas, María, Daan W. Loth, Louise V. Wain, Sina A. Gharib, Ma’en Obeidat, Wenbo Tang, Guangju Zhai, et al. “Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nat Genet 43, no. 11 (September 25, 2011): 1082–90. https://doi.org/10.1038/ng.941.
Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011 Sep 25;43(11):1082–90.
Soler Artigas, María, et al. “Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nat Genet, vol. 43, no. 11, Sept. 2011, pp. 1082–90. Pubmed, doi:10.1038/ng.941.
Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJF, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin A-C, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen A-L, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin S-Y, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann H-E, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, International Lung Cancer Consortium, GIANT consortium, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin M-R, Ch Stricker BH, Elliott P, O’Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011 Sep 25;43(11):1082–1090.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

September 25, 2011

Volume

43

Issue

11

Start / End Page

1082 / 1090

Location

United States

Related Subject Headings

  • White People
  • Respiratory Function Tests
  • Pulmonary Disease, Chronic Obstructive
  • Humans
  • Genome-Wide Association Study
  • Developmental Biology
  • Child
  • 3105 Genetics
  • 3102 Bioinformatics and computational biology
  • 3001 Agricultural biotechnology