Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors: ASCO and SNO Endorsement of the Congress of Neurological Surgeons Guidelines.

Journal Article (Journal Article)

PURPOSE: The Congress of Neurological Surgeons (CNS) has developed a series of guidelines for the treatment of adults with metastatic brain tumors, including systemic therapy and supportive care topics. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. METHODS: Two CNS guidelines were reviewed for developmental rigor by methodologists, and an independent multidisciplinary Expert Panel was formed to review the content and assess agreement with the recommendations. The Expert Panel voted to endorse the two guidelines, and ASCO and Society for Neuro-Oncology (SNO) independently reviewed and approved the ASCO/SNO guideline endorsement. RESULTS: The ASCO/SNO Expert Panel determined that the recommendations from the CNS anticonvulsants and steroids guidelines, published January 9, 2019, are clear, thorough, and based on the most relevant scientific evidence. ASCO/SNO endorsed these two CNS guidelines with minor alterations. RECOMMENDATIONS: Key recommendations include the following: prophylactic antiepileptic drugs were not recommended for routine use; and corticosteroids, specifically dexamethasone, were recommended for temporary symptomatic relief in patients with neurologic symptoms and signs related to mass effect from brain metastases. Additional information is available at .

Full Text

Duke Authors

Cited Authors

  • Chang, SM; Messersmith, H; Ahluwalia, M; Andrews, D; Brastianos, PK; Gaspar, LE; Gatson, NTN; Jordan, JT; Khasraw, M; Lassman, AB; Maues, J; Mrugala, M; Raizer, J; Schiff, D; Stevens, G; Sumrall, A; van den Bent, M; Vogelbaum, MA

Published Date

  • May 1, 2019

Published In

Volume / Issue

  • 37 / 13

Start / End Page

  • 1130 - 1135

PubMed ID

  • 30883246

Pubmed Central ID

  • PMC7098828

Electronic International Standard Serial Number (EISSN)

  • 1527-7755

Digital Object Identifier (DOI)

  • 10.1200/JCO.18.02085


  • eng

Conference Location

  • United States