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Mustafa Khasraw

Professor of Neurosurgery
Neurosurgery

Overview


I am a physician-scientist with a background in medical oncology and neuro-oncology, with affiliations to multiple departments, research, and training programs at Duke. 

I lead a Tumor Immunobiology Laboratory where we use various wet and dry lab techniques to understand the interactions between tumors and the immune system. Our goal is to identify vulnerabilities that can be targeted for novel therapies.

I serve as the Deputy Director of the Center for Cancer Immunotherapy at the Duke Cancer Institute where we are tasked to facilitate clinical research and translate promising discoveries made by scientists across various departments and cancer types at Duke, particularly in the field of immune and T cell-based therapies.

My team and our laboratory operate in an environment that enables the transition from bench-side basic scientific discoveries to clinical trials, and back to the bench ensuring the evaluation of new treatments for cancer patients.

Current Appointments & Affiliations


Professor of Neurosurgery · 2020 - Present Neurosurgery, Neurosurgery
Professor in Medicine · 2020 - Present Medicine, Medical Oncology, Medicine
Professor in Integrative Immunobiology · 2023 - Present Integrative Immunobiology, Basic Science Departments
Professor in Pharmacology and Cancer Biology · 2024 - Present Pharmacology & Cancer Biology, Basic Science Departments
Member of the Duke Cancer Institute · 2019 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published May 1, 2025
Michael Bolton Brain Cancer: What Is Glioblastoma, What Are the Symptoms and Can You Prevent It?
Published April 4, 2025
Experimental therapy for brain cancer gives ‘hope’; will be investigated in upcoming trial
Published September 3, 2024
Exclusive: Duke spinout launches in hopes of prevailing with brain cancer bispecific where Amgen, Roche did not

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Recent Publications


A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.

Journal Article Sci Rep · October 23, 2025 Many cancers evade immunosurveillance by downregulating surface major histocompatibility class (MHC)-I. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes MHC-I degradation and is elevated in glioma. Evolocumab is a clinically approved PCSK9 in ... Full text Link to item Cite

Comparing Knowledge and Perceptions of Palliative Care Among Neuro-Oncology Patients, Caregivers, and Providers to a Representative U.S. Sample

Conference American Journal of Hospice and Palliative Medicine · September 1, 2025 Background: Primary brain tumors (PBTs) pose a significant health challenge, affecting patients and their caregivers. While early integration of palliative care (PC) has shown benefits in advanced cancer, its integration for PBT patients, particularly glio ... Full text Cite

A peptide vaccine targeting the CMV antigen pp65 in children and young adults with recurrent high-grade glioma and medulloblastoma: a phase 1 trial.

Journal Article Nat Cancer · September 2025 The human cytomegalovirus (CMV) antigen pp65 is expressed in high-grade glioma (HGG) and medulloblastoma but not in the adjacent brain. This single-arm phase 1 trial ( NCT03299309 ) assessed the safety and immunogenicity of a peptide vaccine (PEP-CMV) targ ... Full text Link to item Cite
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Recent Grants


McCain/Bayh Glioblastoma Consortium

Clinical TrialCo-Project Leader · Awarded by Department of Defense · 2025 - 2029

Glioblastoma Immunotherapy Advancement with Nivolumab and Relatlimab

Clinical TrialPrincipal Investigator · Awarded by Bristol-Myers Squibb Company · 2024 - 2029

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Education, Training & Certifications


Rijksuniversiteit Groningen (The Netherlands) · 2001 M.D.