Anticonvulsant prophylaxis and steroid use in adults with metastatic brain tumors: summary of SNO and ASCO endorsement of the Congress of Neurological Surgeons guidelines.

Journal Article (Journal Article)

BACKGROUND: The Congress of Neurological Surgeons (CNS) has developed a series of guidelines on the treatment of adults with metastatic brain tumors, including systemic therapy and supportive care topics. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. METHODS: Two CNS Guidelines were reviewed for developmental rigor by methodologists and an independent multi-disciplinary Expert Panel was formed to review the content and assess agreement with the recommendations. The expert panel voted to endorse the two guidelines and ASCO and SNO independently reviewed and approved the ASCO/SNO guideline endorsement. RESULTS: The ASCO/SNO Expert Panel determined that the recommendations from the CNS anticonvulsants and steroids guidelines, published January 9, 2019, are clear, thorough, and based upon the most relevant scientific evidence. ASCO/SNO endorsed these two CNS guidelines, with minor alterations. CONCLUSIONS: Key recommendations include: prophylactic anti-epileptic drugs were not recommended for routine use; corticosteroids (specifically dexamethasone) were recommended for temporary symptomatic relief in patients with neurologic symptoms and signs related to mass effect from brain metastases.

Full Text

Duke Authors

Cited Authors

  • Chang, SM; Messersmith, H; Ahluwalia, M; Andrews, D; Brastianos, PK; Gaspar, LE; Gatson, NTN; Jordan, JT; Khasraw, M; Lassman, AB; Maues, J; Mrugala, M; Raizer, J; Schiff, D; Stevens, G; Sumrall, A; Van den Bent, M; Vogelbaum, MA

Published Date

  • March 18, 2019

Published In

Volume / Issue

  • 21 / 4

Start / End Page

  • 424 - 427

PubMed ID

  • 30883663

Pubmed Central ID

  • PMC6422436

Electronic International Standard Serial Number (EISSN)

  • 1523-5866

Digital Object Identifier (DOI)

  • 10.1093/neuonc/noz034


  • eng

Conference Location

  • England