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Neuroendocrine neoplasms of the GI tract: the role of cytotoxic chemotherapy.

Publication ,  Journal Article
Khasraw, M; Yap, SY; Ananda, S
Published in: Expert Rev Anticancer Ther
April 2013

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of neoplasms derived from peptide- and amine-secreting cells of the neuroendocrine system. NENs commonly arise in the GI tract but can arise in most organs of the body. NENs in different organs share many common pathologic features. Although the incidence of NENs is not high, the prevalence is not low because many patients may live relatively long periods without major symptoms from the disease. While many of these tumors lead an indolent clinical course, they constitute a therapeutic challenge when they progress, metastasize and become symptomatic. Treatment requires a multidisciplinary approach including cytotoxic chemotherapy. Almost all clinical trials investigating cytotoxic chemotherapy in NENs are small single-arm studies and guidelines are derived from expert opinion and from extrapolating results from small cell lung cancer studies. This article briefly reviews NENs before focusing on reviewing data on the role of cytotoxic chemotherapy studies in NENs.

Duke Scholars

Published In

Expert Rev Anticancer Ther

DOI

EISSN

1744-8328

Publication Date

April 2013

Volume

13

Issue

4

Start / End Page

451 / 459

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neuroendocrine Tumors
  • Humans
  • Gastrointestinal Neoplasms
  • Cytotoxins
  • Apoptosis
  • Antineoplastic Agents
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Khasraw, M., Yap, S. Y., & Ananda, S. (2013). Neuroendocrine neoplasms of the GI tract: the role of cytotoxic chemotherapy. Expert Rev Anticancer Ther, 13(4), 451–459. https://doi.org/10.1586/era.13.22
Khasraw, Mustafa, Saw Yee Yap, and Sumitra Ananda. “Neuroendocrine neoplasms of the GI tract: the role of cytotoxic chemotherapy.Expert Rev Anticancer Ther 13, no. 4 (April 2013): 451–59. https://doi.org/10.1586/era.13.22.
Khasraw M, Yap SY, Ananda S. Neuroendocrine neoplasms of the GI tract: the role of cytotoxic chemotherapy. Expert Rev Anticancer Ther. 2013 Apr;13(4):451–9.
Khasraw, Mustafa, et al. “Neuroendocrine neoplasms of the GI tract: the role of cytotoxic chemotherapy.Expert Rev Anticancer Ther, vol. 13, no. 4, Apr. 2013, pp. 451–59. Pubmed, doi:10.1586/era.13.22.
Khasraw M, Yap SY, Ananda S. Neuroendocrine neoplasms of the GI tract: the role of cytotoxic chemotherapy. Expert Rev Anticancer Ther. 2013 Apr;13(4):451–459.
Journal cover image

Published In

Expert Rev Anticancer Ther

DOI

EISSN

1744-8328

Publication Date

April 2013

Volume

13

Issue

4

Start / End Page

451 / 459

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neuroendocrine Tumors
  • Humans
  • Gastrointestinal Neoplasms
  • Cytotoxins
  • Apoptosis
  • Antineoplastic Agents
  • Animals
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis