Fluorinated copolymer nanoparticles for multimodal imaging applications

Journal Article (Journal Article)

Nanomaterials have emerged as valuable tools in biomedical imaging techniques. Here, the synthesis and characterization of a novel fluorinated nanoparticle with potential applications as an MRI contrast agent is reported. Particles were synthesized using a free radical polymer-ízation technique. Secondary ion mass spectrometry analysis showed that the particles' surface contained fluorinated groups and nitrogen-containing groups. Solid-state NMR spectroscopy suggested the presence of two distinct fluorine resonances, which conforms to the structure of the fluorinated monomer. Ongoing studies aim to evaluate the performance of the nanoparticles as MRI contrast agents both in vitro and in vivo. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA,.

Full Text

Duke Authors

Cited Authors

  • Bailey, MM; Mahoney, CM; Dempah, KE; Davis, JM; Becker, ML; Khondee, S; Munson, EJ; Berkland, C

Published Date

  • January 4, 2010

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 87 - 92

Electronic International Standard Serial Number (EISSN)

  • 1521-3927

International Standard Serial Number (ISSN)

  • 1022-1336

Digital Object Identifier (DOI)

  • 10.1002/marc.200900505

Citation Source

  • Scopus