Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.

Journal Article (Journal Article)

Semen is the vehicle for virion dissemination in the female reproductive tract (FRT) in male-to-female HIV transmission. Recent data suggests that higher frequency semen exposure is associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, we use a non-human primate (NHP) model to show that repeated vaginal exposure to semen significantly reduces subsequent infection by repeated low-dose vaginal SIVmac251 challenge. Repeated semen exposures result in lower CCR5 expression in circulating CD4+ T-cells, as well as higher expression of Mx1 (in correlation with IFNε expression) and FoxP3 in the cervicovaginal mucosa, and increased infiltration of CD4+ T-cells. Establishing in vivo evidence of competing effects of semen on transmission impacts our basic understanding of what factors may determine HIV infectivity in humans. Our results clearly indicate that repeated semen exposure can profoundly modulate the FRT microenvironment, paradoxically promoting host resistance against HIV acquisition.

Full Text

Duke Authors

Cited Authors

  • Abdulhaqq, SA; Martinez, M; Kang, G; Rodriguez, IV; Nichols, SM; Beaumont, D; Joseph, J; Azzoni, L; Yin, X; Wise, M; Weiner, D; Liu, Q; Foulkes, A; Münch, J; Kirchhoff, F; Coutifaris, C; Tomaras, GD; Sariol, C; Marx, PA; Li, Q; Kraiselburd, EN; Montaner, LJ

Published Date

  • August 21, 2019

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 3753 -

PubMed ID

  • 31434895

Pubmed Central ID

  • PMC6704120

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-019-11814-5

Language

  • eng

Conference Location

  • England