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Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.

Publication ,  Journal Article
Abdulhaqq, SA; Martinez, M; Kang, G; Rodriguez, IV; Nichols, SM; Beaumont, D; Joseph, J; Azzoni, L; Yin, X; Wise, M; Weiner, D; Liu, Q; Li, Q ...
Published in: Nat Commun
August 21, 2019

Semen is the vehicle for virion dissemination in the female reproductive tract (FRT) in male-to-female HIV transmission. Recent data suggests that higher frequency semen exposure is associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, we use a non-human primate (NHP) model to show that repeated vaginal exposure to semen significantly reduces subsequent infection by repeated low-dose vaginal SIVmac251 challenge. Repeated semen exposures result in lower CCR5 expression in circulating CD4+ T-cells, as well as higher expression of Mx1 (in correlation with IFNε expression) and FoxP3 in the cervicovaginal mucosa, and increased infiltration of CD4+ T-cells. Establishing in vivo evidence of competing effects of semen on transmission impacts our basic understanding of what factors may determine HIV infectivity in humans. Our results clearly indicate that repeated semen exposure can profoundly modulate the FRT microenvironment, paradoxically promoting host resistance against HIV acquisition.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 21, 2019

Volume

10

Issue

1

Start / End Page

3753

Location

England

Related Subject Headings

  • Vagina
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Semen
  • Receptors, CCR5
  • Myxovirus Resistance Proteins
  • Mucous Membrane
  • Macaca mulatta
  • Humans
 

Citation

APA
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Abdulhaqq, S. A., Martinez, M., Kang, G., Rodriguez, I. V., Nichols, S. M., Beaumont, D., … Montaner, L. J. (2019). Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun, 10(1), 3753. https://doi.org/10.1038/s41467-019-11814-5
Abdulhaqq, Shaheed A., Melween Martinez, Guobin Kang, Idia V. Rodriguez, Stephanie M. Nichols, David Beaumont, Jocelin Joseph, et al. “Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.Nat Commun 10, no. 1 (August 21, 2019): 3753. https://doi.org/10.1038/s41467-019-11814-5.
Abdulhaqq SA, Martinez M, Kang G, Rodriguez IV, Nichols SM, Beaumont D, et al. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun. 2019 Aug 21;10(1):3753.
Abdulhaqq, Shaheed A., et al. “Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.Nat Commun, vol. 10, no. 1, Aug. 2019, p. 3753. Pubmed, doi:10.1038/s41467-019-11814-5.
Abdulhaqq SA, Martinez M, Kang G, Rodriguez IV, Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras GD, Sariol C, Marx PA, Li Q, Kraiselburd EN, Montaner LJ. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun. 2019 Aug 21;10(1):3753.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 21, 2019

Volume

10

Issue

1

Start / End Page

3753

Location

England

Related Subject Headings

  • Vagina
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Semen
  • Receptors, CCR5
  • Myxovirus Resistance Proteins
  • Mucous Membrane
  • Macaca mulatta
  • Humans