Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension.

Published online

Journal Article

Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from - 23 to + 28% for TBV, - 22 to + 36% for PV and - 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = - 0.03; PV and SBP, r = - 0.12; RBV and SBP, r = - 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

Full Text

Duke Authors

Cited Authors

  • Fudim, M; Blumer, VL; Lopes, RD; Rossignol, P; Feldschuh, M; Miller, WL; Sobotka, PA

Published Date

  • August 28, 2019

Published In

PubMed ID

  • 31463701

Pubmed Central ID

  • 31463701

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-019-09910-4


  • eng

Conference Location

  • United States