Host-Based Diagnostics for Acute Respiratory Infections.

Journal Article (Journal Article;Review)

PURPOSE: The inappropriate use of antimicrobials, especially in acute respiratory infections (ARIs), is largely driven by difficulty distinguishing bacterial, viral, and noninfectious etiologies of illness. A new frontier in infectious disease diagnostics looks to the host response for disease classification. This article examines how host response-based diagnostics for ARIs are being used in clinical practice, as well as new developments in the research pipeline. METHODS: A limited search was conducted of the relevant literature, with emphasis placed on literature published in the last 5 years (2014-2019). FINDINGS: Advances are being made in all areas of host response-based diagnostics for ARIs. Specifically, there has been significant progress made in single protein biomarkers, as well as in various "omics" fields (including proteomics, metabolomics, and transcriptomics) and wearable technologies. There are many potential applications of a host response-based approach; a few key examples include the ability to discriminate bacterial and viral disease, presymptomatic diagnosis of infection, and pathogen-specific host response diagnostics, including modeling disease progression. IMPLICATIONS: As biomarker measurement technologies continue to improve, host response-based diagnostics will increasingly be translated to clinically available platforms that can generate a holistic characterization of an individual's health. This knowledge, in the hands of both patient and provider, can improve care for the individual patient and help fight rising rates of antibiotic resistance.

Full Text

Duke Authors

Cited Authors

  • Ross, MH; Zick, BL; Tsalik, EL

Published Date

  • October 2019

Published In

Volume / Issue

  • 41 / 10

Start / End Page

  • 1923 - 1938

PubMed ID

  • 31353133

Electronic International Standard Serial Number (EISSN)

  • 1879-114X

Digital Object Identifier (DOI)

  • 10.1016/j.clinthera.2019.06.007


  • eng

Conference Location

  • United States