Ephraim Tsalik
Associate Professor of Medicine
My research is focused on understanding the dynamic between host and pathogen so as to discover and develop host-response markers that can diagnose and predict health and disease. This new and evolving approach to diagnosing illness has the potential to significantly impact individual as well as public health considering the rise of antibiotic resistance.
With any potential infectious disease diagnosis, it is difficult, if not impossible, to determine at the time of presentation what the underlying cause of illness is. For example, acute respiratory illness is among the most frequent reasons for patients to seek care. These symptoms, such as cough, sore throat, and fever may be due to a bacterial infection, viral infection, both, or a non-infectious condition such as asthma or allergies. Given the difficulties in making the diagnosis, most patients are inappropriately given antibacterials. However, each of these etiologies (bacteria, virus, or something else entirely) leaves a fingerprint embedded in the host’s response. We are very interested in finding those fingerprints and exploiting them to generate new approaches to understand, diagnose, and manage disease.
These principles also apply to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Just as with acute respiratory illness, it is often difficult to identify whether infection is responsible for a patient’s critical illness. We have embarked on a number of research programs that aim to better identify sepsis; define sepsis subtypes that can be used to guide future clinical research; and to better predict sepsis outcomes. These efforts have focused on many systems biology modalities including transcriptomics, miRNA, metabolomics, and proteomics. Consequently, our Data Science team has utilized these highly complex data to develop new statistical methods, furthering both the clinical and statistical research communities.
Synergy between multi-disciplinary experts is crucial to tackle the threats posed by infectious diseases and the rise in antimicrobial resistance. We have successfully assembled a team of clinical scientists, data scientists, laboratorians, clinical research coordinators, among many others. Potential collaborators are encouraged to contact us.
These examples are just a small sampling of the breadth of research Dr. Tsalik and his colleagues conduct. Please visit https://precisionmedicine.duke.edu/ for more details.
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2016
- Associate Professor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2017
- Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014
Contact Information
- Box 102359 DUMC, Durham, NC 27710
- Room 157 Hanes House Trent Dri, Box 102359, Durham, NC 27710
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e.t@duke.edu
(919) 684-3114
- Background
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Education, Training, & Certifications
- Fellowship in Infectious Diseases, Medicine, Duke University School of Medicine 2008 - 2011
- Residency, Medicine, Duke University School of Medicine 2005 - 2008
- M.D., Columbia University College of Physicians and Surgeons 2005
- Ph.D., Columbia University College of Physicians and Surgeons 2003
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Duke Appointment History
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2011 - 2016
- Instructor Temporary in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2011
- Recognition
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In the News
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MAR 16, 2016 -
JAN 29, 2016 U.S. News & World Report -
JAN 21, 2016 TIME -
JAN 20, 2016 -
JAN 19, 2016 -
OCT 20, 2015 Nature -
OCT 11, 2015 -
MAY 20, 2015
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- Expertise
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Subject Headings
- Acute Disease
- Age Factors
- Aged
- Aged, 80 and over
- Algorithms
- Alleles
- Amino Acid Sequence
- Analysis of Variance
- Animals
- Animals, Genetically Modified
- Anti-Bacterial Agents
- Antiviral Agents
- Area Under Curve
- Autoantigens
- Axons
- Bacteremia
- Bacterial Infections
- Biological Markers
- Blotting, Southern
- C-Reactive Protein
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Calcitonin
- Camping
- Cause of Death
- Cell Differentiation
- Cells, Cultured
- Chemoprevention
- Chemotaxis
- Chromosome Mapping
- Cohort Studies
- Combined Modality Therapy
- Confidence Intervals
- Conflict of Interest
- Cryptococcosis
- Cues
- Culture Media
- DNA Damage
- DNA, Recombinant
- Data Mining
- Disease Models, Animal
- Disease Outbreaks
- Disease Progression
- Disease Susceptibility
- Early Diagnosis
- Emergency Service, Hospital
- Emergency Treatment
- Female
- Follow-Up Studies
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Genes, Reporter
- Genomics
- Graft vs Host Disease
- Green Fluorescent Proteins
- HIV Infections
- Health Care Sector
- Helminth Proteins
- Hematologic Neoplasms
- Hematopoietic Stem Cell Transplantation
- Hemodynamics
- Hepatitis C
- Homeodomain Proteins
- Hospitals, University
- Host-Pathogen Interactions
- Hot Temperature
- Humans
- Hypersensitivity, Immediate
- Immunity, Innate
- Incidental Findings
- Infection
- Infection Control
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Interleukin-6
- Interneurons
- Kaplan-Meier Estimate
- LIM-Homeodomain Proteins
- Lasers
- Length of Stay
- Locomotion
- Logistic Models
- Luminescent Proteins
- Lung Diseases, Fungal
- Lung Transplantation
- Macrophages
- Male
- Mass Screening
- Metabolomics
- Mice
- Mice, 129 Strain
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, Inbred Strains
- MicroRNAs
- Middle Aged
- Models, Theoretical
- Molecular Diagnostic Techniques
- Molecular Sequence Data
- Motor Neurons
- Multivariate Analysis
- Mutation
- Needs Assessment
- Nervous System
- Neurons
- Neuropeptides
- North Carolina
- Odds Ratio
- Oligonucleotide Array Sequence Analysis
- Oseltamivir
- Patient Discharge
- Plasmids
- Polymerase Chain Reaction
- Predictive Value of Tests
- Prognosis
- Protein Precursors
- Proteomics
- ROC Curve
- Receptors, Biogenic Amine
- Receptors, Dopamine
- Receptors, Serotonin
- Recombinant Fusion Proteins
- Recombinant Proteins
- Registries
- Regulatory Sequences, Nucleic Acid
- Reproducibility of Results
- Research Design
- Respiratory Tract Infections
- Retrospective Studies
- Risk Assessment
- Sensation
- Sepsis
- Sequence Homology, Amino Acid
- Severity of Illness Index
- Sex Factors
- Shock, Septic
- Smell
- Species Specificity
- Staphylococcal Infections
- Staphylococcus aureus
- Statistics, Nonparametric
- Students
- Survival Analysis
- Synapses
- Systemic Inflammatory Response Syndrome
- Time Factors
- Transcription Factors
- Transcriptome
- Transplantation, Homologous
- Treatment Outcome
- United States
- Universities
- Young Adult
- Zanamivir
- Research
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Selected Grants
- AMR Challenge Award 2 awarded by National Institutes of Health 2019 - 2021
- Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO) awarded by Defense Advanced Research Projects Agency 2019 - 2021
- Novel host-based diagnostics of febrile illness in the warfighter awarded by Department of Defense 2016 - 2020
- PREdicting contagion using Systems And GEnomic analysis (PRESAGE) awarded by Defense Advanced Research Projects Agency 2017 - 2020
- VTEU Task Area C Option 2-3 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2019 - 2020
- VTEU Task Area C Option 2-2 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2018 - 2020
- VTEU Task Area C Option 1 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2017 - 2020
- AMR Challenge Award awarded by National Institutes of Health 2017 - 2019
- VTEU Task Area C Option 2-1 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2018 - 2019
- Novel Dialysis-Like Therapeutics in Sepsis-induced Shock and Organ Failure awarded by Defense Advanced Research Projects Agency 2015 - 2018
- VTEU Task Area B Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2016 - 2017
- Feasibility for Predicting Warfighter Health Using Transcriptional Markers on the MAP Platform 2016
- Validation of the host transcription diagnostic for prediction of incipient respiratory viral infection awarded by Defense Advanced Research Projects Agency 2014 - 2016
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Industry Relationships
- Predigen, Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Ko, Emily R., Casandra W. Philipson, Thomas W. Burke, Regina Z. Cer, Kimberly A. Bishop-Lilly, Logan J. Voegtly, Ephraim L. Tsalik, Christopher W. Woods, Danielle V. Clark, and Kevin L. Schully. “Direct-from-blood RNA sequencing identifies the cause of post-bronchoscopy fever..” Bmc Infect Dis 19, no. 1 (October 28, 2019). https://doi.org/10.1186/s12879-019-4462-9.Full Text Open Access Copy Link to Item
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Lydon, Emily C., Ricardo Henao, Thomas W. Burke, Mert Aydin, Bradly P. Nicholson, Seth W. Glickman, Vance G. Fowler, et al. “Validation of a host response test to distinguish bacterial and viral respiratory infection..” Ebiomedicine 48 (October 2019): 453–61. https://doi.org/10.1016/j.ebiom.2019.09.040.Full Text Open Access Copy Link to Item
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Ross, Melissa H., Brittany L. Zick, and Ephraim L. Tsalik. “Host-Based Diagnostics for Acute Respiratory Infections..” Clin Ther 41, no. 10 (October 2019): 1923–38. https://doi.org/10.1016/j.clinthera.2019.06.007.Full Text Link to Item
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Limkakeng, Alexander T., Ricardo Henao, Deepak Voora, Thomas O’Connell, Michelle Griffin, Ephraim L. Tsalik, Svati Shah, Christopher W. Woods, and Geoffrey S. Ginsburg. “Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing..” Plos One 14, no. 2 (2019). https://doi.org/10.1371/journal.pone.0211762.Full Text Link to Item
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Lydon, Emily C., Charles Bullard, Mert Aydin, Olga M. Better, Anna Mazur, Bradly P. Nicholson, Emily R. Ko, et al. “A host gene expression approach for identifying triggers of asthma exacerbations..” Plos One 14, no. 4 (2019). https://doi.org/10.1371/journal.pone.0214871.Full Text Open Access Copy Link to Item
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Fourati, Slim, Aarthi Talla, Mehrad Mahmoudian, Joshua G. Burkhart, Riku Klén, Ricardo Henao, Thomas Yu, et al. “A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection..” Nat Commun 9, no. 1 (October 24, 2018). https://doi.org/10.1038/s41467-018-06735-8.Full Text Link to Item
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Thaden, Joshua T., Karen Chiswell, Ian Jaffe, Stephen P. Bergin, William E. Yang, Andrew Romaine, Jamie Roberts, et al. “Pediatric Antibacterial and Antifungal Trials From 2007 to 2017..” Pediatrics 142, no. 3 (September 2018). https://doi.org/10.1542/peds.2017-1849.Full Text Link to Item
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Lydon, Emily C., Emily R. Ko, and Ephraim L. Tsalik. “The host response as a tool for infectious disease diagnosis and management..” Expert Rev Mol Diagn 18, no. 8 (August 2018): 723–38. https://doi.org/10.1080/14737159.2018.1493378.Full Text Link to Item
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Sweeney, Timothy E., Tej D. Azad, Michele Donato, Winston A. Haynes, Thanneer M. Perumal, Ricardo Henao, Jesús F. Bermejo-Martin, et al. “Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters..” Crit Care Med 46, no. 6 (June 2018): 915–25. https://doi.org/10.1097/CCM.0000000000003084.Full Text Link to Item
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Sweeney, Timothy E., Thanneer M. Perumal, Ricardo Henao, Marshall Nichols, Judith A. Howrylak, Augustine M. Choi, Jesús F. Bermejo-Martin, et al. “A community approach to mortality prediction in sepsis via gene expression analysis..” Nat Commun 9, no. 1 (February 15, 2018). https://doi.org/10.1038/s41467-018-03078-2.Full Text Link to Item
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Tsalik, Ephraim L., Robert A. Bonomo, and Vance G. Fowler. “New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance..” Annu Rev Med 69 (January 29, 2018): 379–94. https://doi.org/10.1146/annurev-med-052716-030320.Full Text Link to Item
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Duplessis, Christopher, Michael Gregory, Kenneth Frey, Matthew Bell, Luu Truong, Kevin Schully, James Lawler, et al. “Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis..” J Intensive Care 6 (2018). https://doi.org/10.1186/s40560-018-0341-5.Full Text Link to Item
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Poore, Gregory D., Emily R. Ko, Ashlee Valente, Ricardo Henao, Kelsey Sumner, Christopher Hong, Thomas W. Burke, et al. “A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies..” Front Microbiol 9 (2018). https://doi.org/10.3389/fmicb.2018.02957.Full Text Link to Item
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Bergin, Stephen P., and Ephraim L. Tsalik. “Procalcitonin: The Right Answer but to Which Question?.” Clin Infect Dis 65, no. 2 (July 15, 2017): 191–93. https://doi.org/10.1093/cid/cix323.Full Text Link to Item
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Tsalik, Ephraim L., Elizabeth Petzold, Barry N. Kreiswirth, Robert A. Bonomo, Ritu Banerjee, Ebbing Lautenbach, Scott R. Evans, et al. “Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group..” Clin Infect Dis 64, no. suppl_1 (March 15, 2017): S41–47. https://doi.org/10.1093/cid/ciw831.Full Text Link to Item
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Burke, Thomas W., Ricardo Henao, Erik Soderblom, Ephraim L. Tsalik, J Will Thompson, Micah T. McClain, Marshall Nichols, et al. “Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection..” Ebiomedicine 17 (March 2017): 172–81. https://doi.org/10.1016/j.ebiom.2017.02.015.Full Text Link to Item
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Wang, Liuyang, Emily R. Ko, James J. Gilchrist, Kelly J. Pittman, Anna Rautanen, Matti Pirinen, J Will Thompson, et al. “Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis..” Sci Adv 3, no. 3 (March 2017). https://doi.org/10.1126/sciadv.1602096.Full Text Open Access Copy Link to Item
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Holcomb, Zachary E., Ephraim L. Tsalik, Christopher W. Woods, and Micah T. McClain. “Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases..” J Clin Microbiol 55, no. 2 (February 2017): 360–68. https://doi.org/10.1128/JCM.01057-16.Full Text Link to Item
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Patel, Robin, Ephraim L. Tsalik, Elizabeth Petzold, Vance G. Fowler, Jeffrey D. Klausner, Scott Evans, and Scott Antibacterial Resistance Leadership Group (ARLG). “MASTERMIND: Bringing Microbial Diagnostics to the Clinic..” Clin Infect Dis 64, no. 3 (February 1, 2017): 355–60. https://doi.org/10.1093/cid/ciw788.Full Text Open Access Copy Link to Item
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Yan, Qin, Sun Hee Ahn, Felix Mba Medie, Batu K. Sharma-Kuinkel, Lawrence P. Park, William K. Scott, Hitesh Deshmukh, et al. “Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans..” Plos One 12, no. 6 (2017). https://doi.org/10.1371/journal.pone.0179033.Full Text Link to Item
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Limkakeng, Alexander T., Andrew A. Monte, Christopher Kabrhel, Michael Puskarich, Laura Heitsch, Ephraim L. Tsalik, and Nathan I. Shapiro. “Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?.” Acad Emerg Med 23, no. 10 (October 2016): 1097–1106. https://doi.org/10.1111/acem.13027.Full Text Open Access Copy Link to Item
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Yang, William E., Sunil Suchindran, Bradly P. Nicholson, Micah T. McClain, Thomas Burke, Geoffrey S. Ginsburg, Clayton D. Harro, et al. “Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans..” J Infect Dis 213, no. 9 (May 1, 2016): 1495–1504. https://doi.org/10.1093/infdis/jiv593.Full Text Open Access Copy Link to Item
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McClain, M. T., R. Henao, J. Williams, B. Nicholson, T. Veldman, L. Hudson, E. L. Tsalik, et al. “Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge..” Clin Exp Immunol 183, no. 3 (March 2016): 441–51. https://doi.org/10.1111/cei.12736.Full Text Link to Item
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Tsalik, Ephraim L., Yanhong Li, Lori L. Hudson, Vivian H. Chu, Tiffany Himmel, Alex T. Limkakeng, Jason N. Katz, et al. “Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients..” Ann Am Thorac Soc 13, no. 3 (March 2016): 401–13. https://doi.org/10.1513/AnnalsATS.201504-205OC.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Ricardo Henao, Marshall Nichols, Thomas Burke, Emily R. Ko, Micah T. McClain, Lori L. Hudson, et al. “Host gene expression classifiers diagnose acute respiratory illness etiology..” Sci Transl Med 8, no. 322 (January 20, 2016). https://doi.org/10.1126/scitranslmed.aad6873.Full Text Open Access Copy Link to Item
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McClain, Micah T., Bradly P. Nicholson, Lawrence P. Park, Tzu-Yu Liu, Alfred O. Hero, Ephraim L. Tsalik, Aimee K. Zaas, et al. “A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses..” Open Forum Infect Dis 3, no. 1 (January 2016). https://doi.org/10.1093/ofid/ofw007.Full Text Open Access Copy Link to Item
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Ruopp, Marcus, Karen Chiswell, Joshua T. Thaden, Kunal Merchant, and Ephraim L. Tsalik. “Respiratory Tract Infection Clinical Trials from 2007 to 2012. A Systematic Review of ClinicalTrials.gov..” Ann Am Thorac Soc 12, no. 12 (December 2015): 1852–63. https://doi.org/10.1513/AnnalsATS.201505-291OC.Full Text Link to Item
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Tsalik, Ephraim L., Laurel K. Willig, Brandon J. Rice, Jennifer C. van Velkinburgh, Robert P. Mohney, Jonathan E. McDunn, Darrell L. Dinwiddie, et al. “Renal systems biology of patients with systemic inflammatory response syndrome..” Kidney Int 88, no. 4 (October 2015): 804–14. https://doi.org/10.1038/ki.2015.150.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Micah McClain, and Aimee K. Zaas. “Moving toward prime time: host signatures for diagnosis of respiratory infections..” J Infect Dis 212, no. 2 (July 15, 2015): 173–75. https://doi.org/10.1093/infdis/jiv032.Full Text Link to Item
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Ko, Emily R., William E. Yang, Micah T. McClain, Christopher W. Woods, Geoffrey S. Ginsburg, and Ephraim L. Tsalik. “What was old is new again: using the host response to diagnose infectious disease..” Expert Rev Mol Diagn 15, no. 9 (2015): 1143–58. https://doi.org/10.1586/14737159.2015.1059278.Full Text Link to Item
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Tsalik, E. L. “Fear as a cardiovascular risk factor.” Science Translational Medicine 7, no. 270 (January 1, 2015). https://doi.org/10.1126/scitranslmed.aaa6252.Full Text
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Tsalik, E. L. “Seq and the city.” Science Translational Medicine 7, no. 276 (January 1, 2015). https://doi.org/10.1126/scitranslmed.aaa5547.Full Text
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Tsalik, E. L. “Beauty is only skin deep.” Science Translational Medicine 7, no. 282 (January 1, 2015). https://doi.org/10.1126/scitranslmed.aab0846.Full Text
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Yang, W. E., C. W. Woods, and E. L. Tsalik. “Host-based diagnostics for detection and prognosis of infectious diseases” 42 (January 1, 2015): 465–500. https://doi.org/10.1016/bs.mim.2015.06.001.Full Text
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Yuan, X., R. Henao, E. L. Tsalik, R. J. Langley, and L. Carin. “Non-Gaussian discriminative factor models via the max-margin rank-likelihood.” 32nd International Conference on Machine Learning, Icml 2015 2 (January 1, 2015): 1254–63.Open Access Copy
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Zaas, Aimee K., Bronwen H. Garner, Ephraim L. Tsalik, Thomas Burke, Christopher W. Woods, and Geoffrey S. Ginsburg. “The current epidemiology and clinical decisions surrounding acute respiratory infections..” Trends Mol Med 20, no. 10 (October 2014): 579–88. https://doi.org/10.1016/j.molmed.2014.08.001.Full Text Link to Item
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Langley, Raymond J., Jennifer L. Tipper, Shannon Bruse, Rebecca M. Baron, Ephraim L. Tsalik, James Huntley, Angela J. Rogers, et al. “Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes..” Am J Respir Crit Care Med 190, no. 4 (August 15, 2014): 445–55. https://doi.org/10.1164/rccm.201404-0624OC.Full Text Link to Item
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Tsalik, E. L. “Cardiovascular genetics: All systems point to TREML4.” Science Translational Medicine 6, no. 246 (July 23, 2014). https://doi.org/10.1126/scitranslmed.3009814.Full Text
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Tsalik, E. L. “Antimicrobial drug resistance in all four corners of the earth.” Science Translational Medicine 6, no. 240 (June 11, 2014). https://doi.org/10.1126/scitranslmed.3009591.Full Text
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Yan, Qin, Batu K. Sharma-Kuinkel, Hitesh Deshmukh, Ephraim L. Tsalik, Derek D. Cyr, Joseph Lucas, Christopher W. Woods, et al. “Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis..” Plos Pathog 10, no. 6 (June 2014). https://doi.org/10.1371/journal.ppat.1004149.Full Text Open Access Copy Link to Item
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Tsalik, E. L. “The sum of one's parts? What our microbiomes say about us.” Science Translational Medicine 6, no. 234 (April 30, 2014). https://doi.org/10.1126/scitranslmed.3009260.Full Text
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Goswami, Neela D., Ephraim L. Tsalik, Susanna Naggie, William C. Miller, John R. Horton, Christopher D. Pfeiffer, and Charles B. Hicks. “A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design..” Trials 15 (January 22, 2014). https://doi.org/10.1186/1745-6215-15-31.Full Text Link to Item
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Langley, R. J., E. L. Tsalik, R. P. Mohney, K. S. Harrod, C. B. Cairns, E. Rivers, C. W. Woods, and S. F. Kingsmore. “Integrative Analysis Of The Metabolome, Proteome, And Transcriptome In Systemic Inflammatory Response Syndrome.” American Journal of Respiratory and Critical Care Medicine 189 (January 1, 2014).Link to Item
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Tsalik, E. L. “The microbial origins of obesity.” Science Translational Medicine 6, no. 252 (January 1, 2014). https://doi.org/10.1126/scitranslmed.3010265.Full Text
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Tsalik, E. L. “Sequence-specific antibiotics.” Science Translational Medicine 6, no. 259 (January 1, 2014). https://doi.org/10.1126/scitranslmed.aaa0896.Full Text
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Tsalik, E. L. “Crowdsourcing disease prognosis.” Science Translational Medicine 6, no. 264 (January 1, 2014). https://doi.org/10.1126/scitranslmed.aaa2069.Full Text
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Tsalik, Ephraim L., Raymond J. Langley, Darrell L. Dinwiddie, Neil A. Miller, Byunggil Yoo, Jennifer C. van Velkinburgh, Laurie D. Smith, et al. “An integrated transcriptome and expressed variant analysis of sepsis survival and death..” Genome Med 6, no. 11 (2014). https://doi.org/10.1186/s13073-014-0111-5.Full Text Open Access Copy Link to Item
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Xiao, Bin, Yu Wang, Wei Li, Megan Baker, Jian Guo, Kelly Corbet, Ephraim L. Tsalik, et al. “Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease..” Blood 122, no. 19 (November 7, 2013): 3365–75. https://doi.org/10.1182/blood-2013-06-510586.Full Text Link to Item
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Zaas, Aimee K., Thomas Burke, Minhua Chen, Micah McClain, Bradly Nicholson, Timothy Veldman, Ephraim L. Tsalik, et al. “A host-based RT-PCR gene expression signature to identify acute respiratory viral infection..” Sci Transl Med 5, no. 203 (September 18, 2013). https://doi.org/10.1126/scitranslmed.3006280.Full Text Link to Item
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Langley, Raymond J., Ephraim L. Tsalik, Jennifer C. van Velkinburgh, Seth W. Glickman, Brandon J. Rice, Chunping Wang, Bo Chen, et al. “An integrated clinico-metabolomic model improves prediction of death in sepsis..” Sci Transl Med 5, no. 195 (July 24, 2013). https://doi.org/10.1126/scitranslmed.3005893.Full Text Link to Item
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Ahn, Sun Hee, Ephraim L. Tsalik, Derek D. Cyr, Yurong Zhang, Jennifer C. van Velkinburgh, Raymond J. Langley, Seth W. Glickman, et al. “Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans..” Plos One 8, no. 1 (2013). https://doi.org/10.1371/journal.pone.0048979.Full Text Open Access Copy Link to Item
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Goswami, Neela D., Christopher D. Pfeiffer, John R. Horton, Karen Chiswell, Asba Tasneem, and Ephraim L. Tsalik. “The state of infectious diseases clinical trials: a systematic review of ClinicalTrials.gov..” Plos One 8, no. 10 (2013). https://doi.org/10.1371/journal.pone.0077086.Full Text Link to Item
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Tsalik, Ephraim L., L Brett Jaggers, Seth W. Glickman, Raymond J. Langley, Jennifer C. van Velkinburgh, Lawrence P. Park, Vance G. Fowler, Charles B. Cairns, Stephen F. Kingsmore, and Christopher W. Woods. “Discriminative value of inflammatory biomarkers for suspected sepsis..” J Emerg Med 43, no. 1 (July 2012): 97–106. https://doi.org/10.1016/j.jemermed.2011.05.072.Full Text Link to Item
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Tsalik, Ephraim L., Coleen K. Cunningham, Hannah M. Cunningham, Maria G. Lopez-Marti, Devdutta G. Sangvai, William K. Purdy, Deverick J. Anderson, et al. “An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer camp..” J Am Coll Health 59, no. 5 (2011): 419–26. https://doi.org/10.1080/07448481.2010.534215.Full Text Link to Item
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Tsalik, Ephraim L., and Lauren Brett Jaggers. “Life-threatening asymptomatic incidentaloma: a case report of idiopathic CD4 lymphocytopenia and opportunistic infections..” Am J Med Sci 340, no. 2 (August 2010): 158–59. https://doi.org/10.1097/MAJ.0b013e3181e5f118.Full Text Link to Item
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Glickman, Seth W., Charles B. Cairns, Ronny M. Otero, Christopher W. Woods, Ephraim L. Tsalik, Raymond J. Langley, Jennifer C. van Velkinburgh, et al. “Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis..” Acad Emerg Med 17, no. 4 (April 2010): 383–90. https://doi.org/10.1111/j.1553-2712.2010.00664.x.Full Text Link to Item
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Tsalik, Ephraim L., Edward F. Hendershot, Devdutta G. Sangvai, Hannah M. Cunningham, Coleen K. Cunningham, Maria G. Lopez-Marti, William K. Purdy, Christopher W. Woods, and L Brett Caram. “Clinical presentation and response to treatment of novel influenza A H1N1 in a university-based summer camp population..” J Clin Virol 47, no. 3 (March 2010): 286–88. https://doi.org/10.1016/j.jcv.2009.12.012.Full Text Link to Item
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Tsalik, Ephraim L., Daphne Jones, Bradly Nicholson, Lynette Waring, Oliver Liesenfeld, Lawrence P. Park, Seth W. Glickman, et al. “Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis..” J Clin Microbiol 48, no. 1 (January 2010): 26–33. https://doi.org/10.1128/JCM.01447-09.Full Text Link to Item
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Tsalik, E. L., D. Jones, B. Nicholson, L. B. Caram, O. Liesenfeld, V. G. Fowler, S. W. Glickman, et al. “DETECTION OF BACTERIAL AND FUNGAL PATHOGENS ASSOCIATED WITH SEPSIS IN PATIENTS PRESENTING TO THE EMERGENCY ROOM.” Intensive Care Medicine 35 (September 1, 2009): 196–196.Link to Item
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Tsalik, Ephraim L., and Christopher W. Woods. “Sepsis redefined: the search for surrogate markers..” Int J Antimicrob Agents 34 Suppl 4 (2009): S16–20. https://doi.org/10.1016/S0924-8579(09)70560-6.Full Text Link to Item
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Tsalik, Ephraim L. “DNA-based immunotherapy to treat atopic disease..” Ann Allergy Asthma Immunol 95, no. 5 (November 2005): 403–10. https://doi.org/10.1016/S1081-1206(10)61163-5.Full Text Link to Item
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Tsalik, Ephraim L., Timothy Niacaris, Adam S. Wenick, Kelvin Pau, Leon Avery, and Oliver Hobert. “LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system..” Dev Biol 263, no. 1 (November 1, 2003): 81–102. https://doi.org/10.1016/s0012-1606(03)00447-0.Full Text Link to Item
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Tsalik, Ephraim L., and Oliver Hobert. “Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans..” J Neurobiol 56, no. 2 (August 2003): 178–97. https://doi.org/10.1002/neu.10245.Full Text Link to Item
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Altun-Gultekin, Z., Y. Andachi, E. L. Tsalik, D. Pilgrim, Y. Kohara, and O. Hobert. “A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans..” Development 128, no. 11 (June 2001): 1951–69.Link to Item
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Tsalik, E. L., and M. R. Gartenberg. “Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damage..” Yeast 14, no. 9 (June 30, 1998): 847–52. https://doi.org/10.1002/(SICI)1097-0061(19980630)14:9<847::AID-YEA285>3.0.CO;2-9.Full Text Link to Item
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Conference Papers
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Dela Cruz, Charles S., Richard G. Wunderink, David C. Christiani, Stephania A. Cormier, Kristina Crothers, Claire M. Doerschuk, Scott E. Evans, et al. “Future Research Directions in Pneumonia. NHLBI Working Group Report..” In Am J Respir Crit Care Med, 198:256–63, 2018. https://doi.org/10.1164/rccm.201801-0139WS.Full Text Link to Item
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Tillekeratne, L., Sunil Suchindran, Emily Ko, Elizabeth Petzold, Champica Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “A GENE EXPRESSION SIGNATURE ACCURATELY IDENTIFIES VIRAL ACUTE RESPIRATORY INFECTIONS IN A SRI LANKAN POPULATION.” In American Journal of Tropical Medicine and Hygiene, 99:641–42. AMER SOC TROP MED & HYGIENE, 2018.Link to Item
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Langley, R. J., T. E. Sweeney, T. Perumal, R. Henao, H. R. Wong, B. Tang, P. Khatri, E. Tsalik, and L. Mangravite. “Federated Gene Expression Analysis Of Mortality Prediction In Sepsis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.Link to Item
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