Ephraim Tsalik
Adjunct Associate Professor in the Department of Medicine
My research at Duke has focused on understanding the dynamic between host and pathogen so as to discover and develop host-response markers that can diagnose and predict health and disease. This new and evolving approach to diagnosing illness has the potential to significantly impact individual as well as public health considering the rise of antibiotic resistance.
With any potential infectious disease diagnosis, it is difficult, if not impossible, to determine at the time of presentation what the underlying cause of illness is. For example, acute respiratory illness is among the most frequent reasons for patients to seek care. These symptoms, such as cough, sore throat, and fever may be due to a bacterial infection, viral infection, both, or a non-infectious condition such as asthma or allergies. Given the difficulties in making the diagnosis, most patients are inappropriately given antibacterials. However, each of these etiologies (bacteria, virus, or something else entirely) leaves a fingerprint embedded in the host’s response. We are very interested in finding those fingerprints and exploiting them to generate new approaches to understand, diagnose, and manage disease.
These principles also apply to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Just as with acute respiratory illness, it is often difficult to identify whether infection is responsible for a patient’s critical illness. We have embarked on a number of research programs that aim to better identify sepsis; define sepsis subtypes that can be used to guide future clinical research; and to better predict sepsis outcomes. These efforts have focused on many systems biology modalities including transcriptomics, miRNA, metabolomics, and proteomics. Consequently, our Data Science team has utilized these highly complex data to develop new statistical methods, furthering both the clinical and statistical research communities.
These examples are just a small sampling of the breadth of research Dr. Tsalik and his colleagues have conducted.
In April 2022, Dr. Tsalik has joined Danaher Diagnostics as the VP and Chief Scientific Officer for Infectious Disease, where he is applying this experience in biomarkers and diagnostics to shape the future of diagnostics in ID.
Current Appointments & Affiliations
- Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2022
- Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014
Contact Information
- Box 102359 DUMC, Durham, NC 27710
- Room 157 Hanes House Trent Dri, Box 102359, Durham, NC 27710
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e.t@duke.edu
(919) 684-3114
- Background
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Education, Training, & Certifications
- Fellowship in Infectious Diseases, Medicine, Duke University School of Medicine 2008 - 2011
- Residency, Medicine, Duke University School of Medicine 2005 - 2008
- M.D., Columbia University, College of Physicians and Surgeons 2005
- Ph.D., Columbia University, College of Physicians and Surgeons 2003
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Previous Appointments & Affiliations
- Associate Professor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2017 - 2022
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2020 - 2022
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2016 - 2020
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2011 - 2016
- Instructor Temporary in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2011
- Recognition
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In the News
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MAY 5, 2021 Duke Health News -
MAR 16, 2016 -
MAR 16, 2016 Duke Today -
JAN 29, 2016 U.S. News & World Report -
JAN 21, 2016 TIME -
JAN 21, 2016 TIME -
JAN 20, 2016 Duke Today -
JAN 20, 2016 -
JAN 19, 2016 Duke Today -
JAN 19, 2016 -
OCT 20, 2015 Nature -
OCT 20, 2015 Nature -
OCT 11, 2015 -
OCT 11, 2015 Duke Today -
MAY 20, 2015 Duke Today -
MAY 20, 2015
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- Expertise
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Subject Headings
- Acute Disease
- Age Factors
- Aged
- Aged, 80 and over
- Algorithms
- Alleles
- Amino Acid Sequence
- Analysis of Variance
- Animals
- Animals, Genetically Modified
- Anti-Bacterial Agents
- Antiviral Agents
- Area Under Curve
- Autoantigens
- Axons
- Bacteremia
- Bacterial Infections
- Biological Markers
- Blotting, Southern
- C-Reactive Protein
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Calcitonin
- Camping
- Cause of Death
- Cell Differentiation
- Cells, Cultured
- Chemoprevention
- Chemotaxis
- Chromosome Mapping
- Cohort Studies
- Combined Modality Therapy
- Confidence Intervals
- Conflict of Interest
- Cryptococcosis
- Cues
- Culture Media
- DNA Damage
- DNA, Recombinant
- Data Mining
- Disease Models, Animal
- Disease Outbreaks
- Disease Progression
- Disease Susceptibility
- Early Diagnosis
- Emergency Service, Hospital
- Emergency Treatment
- Female
- Follow-Up Studies
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Genes, Reporter
- Genomics
- Graft vs Host Disease
- Green Fluorescent Proteins
- HIV Infections
- Health Care Sector
- Helminth Proteins
- Hematologic Neoplasms
- Hematopoietic Stem Cell Transplantation
- Hemodynamics
- Hepatitis C
- Homeodomain Proteins
- Hospitals, University
- Host-Pathogen Interactions
- Hot Temperature
- Humans
- Hypersensitivity, Immediate
- Immunity, Innate
- Incidental Findings
- Infection
- Infection Control
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Interleukin-6
- Interneurons
- Kaplan-Meier Estimate
- LIM-Homeodomain Proteins
- Lasers
- Length of Stay
- Locomotion
- Logistic Models
- Luminescent Proteins
- Lung Diseases, Fungal
- Lung Transplantation
- Macrophages
- Male
- Mass Screening
- Metabolomics
- Mice
- Mice, 129 Strain
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, Inbred Strains
- MicroRNAs
- Middle Aged
- Models, Theoretical
- Molecular Diagnostic Techniques
- Molecular Sequence Data
- Motor Neurons
- Multivariate Analysis
- Mutation
- Needs Assessment
- Nervous System
- Neurons
- Neuropeptides
- North Carolina
- Odds Ratio
- Oligonucleotide Array Sequence Analysis
- Oseltamivir
- Patient Discharge
- Plasmids
- Polymerase Chain Reaction
- Predictive Value of Tests
- Prognosis
- Protein Precursors
- Proteomics
- ROC Curve
- Receptors, Biogenic Amine
- Receptors, Dopamine
- Receptors, Serotonin
- Recombinant Fusion Proteins
- Recombinant Proteins
- Registries
- Regulatory Sequences, Nucleic Acid
- Reproducibility of Results
- Research Design
- Respiratory Tract Infections
- Retrospective Studies
- Risk Assessment
- Sensation
- Sepsis
- Sequence Homology, Amino Acid
- Severity of Illness Index
- Sex Factors
- Shock, Septic
- Smell
- Species Specificity
- Staphylococcal Infections
- Staphylococcus aureus
- Statistics, Nonparametric
- Students
- Survival Analysis
- Synapses
- Systemic Inflammatory Response Syndrome
- Time Factors
- Transcription Factors
- Transcriptome
- Transplantation, Homologous
- Treatment Outcome
- United States
- Universities
- Young Adult
- Zanamivir
- Research
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Selected Grants
- Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC) awarded by National Institutes of Health 2023 - 2028
- A randomized controlled trial of a novel, evidence-based algorithm for managing lower respiratory tract infection in a resource-limited setting awarded by National Institutes of Health 2022 - 2027
- Host response-based diagnostics for identifying bacterial versus viral causes of lower respiratory infection in resource-limited settings awarded by National Institutes of Health 2022 - 2024
- AMR Challenge Award 2 awarded by National Institutes of Health 2019 - 2023
- Rapid, point-of-care, host gene expression test for presymptomatic viral infection and to distinguish bacterial from viral illness awarded by Department of Defense 2021 - 2023
- COVID Survivors Long Term Follow Up Study--WMD ECHO Detector awarded by Icahn School of Medicine at Mount Sinai 2021 - 2023
- Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO) awarded by Defense Advanced Research Projects Agency 2019 - 2022
- VTEU Task Area C Option 1 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2017 - 2021
- Adaptive COVID-19 Treatment Trial (ACTT) awarded by Leidos Biomedical Research, Inc. 2020 - 2021
- VTEU Task Area C Option 2-3 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2019 - 2021
- PREdicting contagion using Systems And GEnomic analysis (PRESAGE) awarded by Defense Advanced Research Projects Agency 2017 - 2020
- Novel host-based diagnostics of febrile illness in the warfighter awarded by Department of Defense 2016 - 2020
- VTEU Task Area C Option 2-2 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2018 - 2020
- AMR Challenge Award awarded by National Institutes of Health 2017 - 2019
- VTEU Task Area C Option 2-1 Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2018 - 2019
- Novel Dialysis-Like Therapeutics in Sepsis-induced Shock and Organ Failure awarded by Defense Advanced Research Projects Agency 2015 - 2018
- VTEU Task Area B Protocol 15-0020.B1C1.0040 awarded by National Institutes of Health 2016 - 2017
- Feasibility for Predicting Warfighter Health Using Transcriptional Markers on the MAP Platform awarded by Ibis Biosciences, Inc. 2016
- Validation of the host transcription diagnostic for prediction of incipient respiratory viral infection awarded by Defense Advanced Research Projects Agency 2014 - 2016
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External Relationships
- Biomeme, Inc.
- Publications & Artistic Works
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Selected Publications
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Books
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Ginsburg, G. S., E. L. Tsalik, H. F. Willard, and C. W. Woods. Genomic and precision medicine: Infectious and inflammatory disease, 2019. https://doi.org/10.1016/C2015-0-06902-7.Full Text
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Academic Articles
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Cappuccio, Antonio, Daniel G. Chawla, Xi Chen, Aliza B. Rubenstein, Wan Sze Cheng, Weiguang Mao, Thomas W. Burke, et al. “Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature.” Cell Syst 13, no. 12 (December 21, 2022): 989-1001.e8. https://doi.org/10.1016/j.cels.2022.11.008.Full Text Link to Item
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Ko, Emily R., and Ephraim L. Tsalik. “A New Era in Host Response Biomarkers to Guide Precision Medicine for Infectious Diseases.” J Pediatric Infect Dis Soc 11, no. 11 (December 5, 2022): 477–79. https://doi.org/10.1093/jpids/piac081.Full Text Link to Item
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Fiorino, Cassandra, Yiling Liu, Ricardo Henao, Emily R. Ko, Thomas W. Burke, Geoffrey S. Ginsburg, Micah T. McClain, Christopher W. Woods, and Ephraim L. Tsalik. “Host Gene Expression to Predict Sepsis Progression.” Crit Care Med 50, no. 12 (December 1, 2022): 1748–56. https://doi.org/10.1097/CCM.0000000000005675.Full Text Link to Item
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Giroux, Nicholas S., Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, et al. “Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion.” Sci Rep 12, no. 1 (July 9, 2022): 11714. https://doi.org/10.1038/s41598-022-15668-8.Full Text Open Access Copy Link to Item
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McKittrick, Justine M., Thomas W. Burke, Elizabeth Petzold, Gregory D. Sempowski, Thomas N. Denny, Christopher R. Polage, Ephraim L. Tsalik, and Micah T. McClain. “SARS-CoV-2 reinfection across a spectrum of immunological states.” Health Sci Rep 5, no. 4 (July 2022): e554. https://doi.org/10.1002/hsr2.554.Full Text Open Access Copy Link to Item
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Patel, Robin, Christopher R. Polage, Jennifer Dien Bard, Larissa May, Francesca M. Lee, Valeria Fabre, Mary K. Hayden, et al. “Envisioning Future Urinary Tract Infection Diagnostics.” Clin Infect Dis 74, no. 7 (April 9, 2022): 1284–92. https://doi.org/10.1093/cid/ciab749.Full Text Open Access Copy Link to Item
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Ko, Emily R., Ricardo Henao, Katherine Frankey, Elizabeth A. Petzold, Pamela D. Isner, Anja K. Jaehne, Nakia Allen, et al. “Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection.” Jama Netw Open 5, no. 4 (April 1, 2022): e227299. https://doi.org/10.1001/jamanetworkopen.2022.7299.Full Text Open Access Copy Link to Item
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Bodkin, Nicholas, Melissa Ross, Micah T. McClain, Emily R. Ko, Christopher W. Woods, Geoffrey S. Ginsburg, Ricardo Henao, and Ephraim L. Tsalik. “Systematic comparison of published host gene expression signatures for bacterial/viral discrimination.” Genome Med 14, no. 1 (February 21, 2022): 18. https://doi.org/10.1186/s13073-022-01025-x.Full Text Open Access Copy Link to Item
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Jaffe, Ian S., Anja K. Jaehne, Eugenia Quackenbush, Emily R. Ko, Emanuel P. Rivers, Micah T. McClain, Geoffrey S. Ginsburg, Christopher W. Woods, and Ephraim L. Tsalik. “Comparing the Diagnostic Accuracy of Clinician Judgment to a Novel Host Response Diagnostic for Acute Respiratory Illness.” Open Forum Infect Dis 8, no. 12 (December 2021): ofab564. https://doi.org/10.1093/ofid/ofab564.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Ricardo Henao, Jesse L. Montgomery, Jeff W. Nawrocki, Mert Aydin, Emily C. Lydon, Emily R. Ko, et al. “Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.” Critical Care Medicine 49, no. 10 (October 2021): 1651–63. https://doi.org/10.1097/ccm.0000000000005085.Full Text Open Access Copy
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Grzesiak, Emilia, Brinnae Bent, Micah T. McClain, Christopher W. Woods, Ephraim L. Tsalik, Bradly P. Nicholson, Timothy Veldman, et al. “Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.” Jama Netw Open 4, no. 9 (September 1, 2021): e2128534. https://doi.org/10.1001/jamanetworkopen.2021.28534.Full Text Open Access Copy Link to Item
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Chambers, Henry F., Scott R. Evans, Robin Patel, Heather R. Cross, Anthony D. Harris, Yohei Doi, Helen W. Boucher, et al. “Antibacterial Resistance Leadership Group 2.0: Back to Business.” Clin Infect Dis 73, no. 4 (August 16, 2021): 730–39. https://doi.org/10.1093/cid/ciab141.Full Text Open Access Copy Link to Item
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Mahle, Rachael E., Sunil Suchindran, Ricardo Henao, Julie M. Steinbrink, Thomas W. Burke, Micah T. McClain, Geoffrey S. Ginsburg, Christopher W. Woods, and Ephraim L. Tsalik. “Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts.” Clin Infect Dis 73, no. 4 (August 16, 2021): 605–13. https://doi.org/10.1093/cid/ciab043.Full Text Open Access Copy Link to Item
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Chen, Lingye, Bryan D. Kraft, Victor L. Roggli, Zachary R. Healy, Christopher W. Woods, Ephraim L. Tsalik, Geoffrey S. Ginsburg, et al. “Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia.” Am J Physiol Lung Cell Mol Physiol 321, no. 2 (August 1, 2021): L321–35. https://doi.org/10.1152/ajplung.00337.2020.Full Text Link to Item
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Steinbrink, Julie M., Rachel A. Myers, Kaiyuan Hua, Melissa D. Johnson, Jessica L. Seidelman, Ephraim L. Tsalik, Ricardo Henao, et al. “The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches.” Genome Med 13, no. 1 (July 5, 2021): 108. https://doi.org/10.1186/s13073-021-00924-9.Full Text Open Access Copy Link to Item
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Cawcutt, Kelly A., Robin Patel, Jeff Gerber, Angela M. Caliendo, Sara E. Cosgrove, Elizabeth Dodds Ashley, Piero Garzaro, Melissa Miller, Ebbing Lautenbach, and Ebbing IDSA Research Summit “Leveraging Existing and Novel Diagnostics for Optimizing Outpatient Antibiotic Stewardship in Patients with Respiratory Tract Infections” Group. “Leveraging Existing and Soon-to-Be-Available Novel Diagnostics for Optimizing Outpatient Antibiotic Stewardship in Patients With Respiratory Tract Infections.” Clin Infect Dis 72, no. 12 (June 15, 2021): e1115–21. https://doi.org/10.1093/cid/ciaa1815.Full Text Link to Item
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Yu, Chen, Sejiro Littleton, Nicholas S. Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Yuchen Yang, et al. “Mucosal-associated invariant T cell responses differ by sex in COVID-19.” Med (N Y) 2, no. 6 (June 11, 2021): 755-772.e5. https://doi.org/10.1016/j.medj.2021.04.008.Full Text Open Access Copy Link to Item
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Wang, Liuyang, Thomas J. Balmat, Alejandro L. Antonia, Florica J. Constantine, Ricardo Henao, Thomas W. Burke, Andy Ingham, et al. “An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.” Genome Med 13, no. 1 (May 17, 2021): 83. https://doi.org/10.1186/s13073-021-00904-z.Full Text Link to Item
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DeMerle, Kimberley M., Derek C. Angus, J Kenneth Baillie, Emily Brant, Carolyn S. Calfee, Joseph Carcillo, Chung-Chou H. Chang, et al. “Sepsis Subclasses: A Framework for Development and Interpretation.” Crit Care Med 49, no. 5 (May 1, 2021): 748–59. https://doi.org/10.1097/CCM.0000000000004842.Full Text Open Access Copy Link to Item
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McClain, Micah T., Florica J. Constantine, Bradly P. Nicholson, Marshall Nichols, Thomas W. Burke, Ricardo Henao, Daphne C. Jones, et al. “A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study.” Lancet Infect Dis 21, no. 3 (March 2021): 396–404. https://doi.org/10.1016/S1473-3099(20)30486-2.Full Text Open Access Copy Link to Item
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McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.” Nat Commun 12, no. 1 (February 17, 2021): 1079. https://doi.org/10.1038/s41467-021-21289-y.Full Text Open Access Copy Link to Item
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Ross, Melissa, Ricardo Henao, Thomas W. Burke, Emily R. Ko, Micah T. McClain, Geoffrey S. Ginsburg, Christopher W. Woods, and Ephraim L. Tsalik. “A comparison of host response strategies to distinguish bacterial and viral infection.” Plos One 16, no. 12 (2021): e0261385. https://doi.org/10.1371/journal.pone.0261385.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Cassandra Fiorino, Ammara Aqeel, Yiling Liu, Ricardo Henao, Emily R. Ko, Thomas W. Burke, et al. “The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.” Front Immunol 12 (2021): 741837. https://doi.org/10.3389/fimmu.2021.741837.Full Text Open Access Copy Link to Item
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Doernberg, Sarah B., Lauren Komarow, Thuy Tien T. Tran, Zoe Sund, Mark W. Pandori, David Jensen, Ephraim L. Tsalik, et al. “Simultaneous Evaluation of Diagnostic Assays for Pharyngeal and Rectal Neisseria gonorrhoeae and Chlamydia trachomatis Using a Master Protocol.” Clin Infect Dis 71, no. 9 (December 3, 2020): 2314–22. https://doi.org/10.1093/cid/ciz1105.Full Text Link to Item
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Liu, Ying, Ephraim L. Tsalik, Yunyun Jiang, Emily R. Ko, Christopher W. Woods, Ricardo Henao, and Scott R. Evans. “Average Weighted Accuracy: Pragmatic Analysis for a Rapid Diagnostics in Categorizing Acute Lung Infections (RADICAL) Study.” Clin Infect Dis 70, no. 12 (June 10, 2020): 2736–42. https://doi.org/10.1093/cid/ciz437.Full Text Open Access Copy Link to Item
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Adamson, Paul C., Mark W. Pandori, Sarah B. Doernberg, Lauren Komarow, Zoe Sund, Thuy Tien T. Tran, David Jensen, et al. “Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs.” J Mol Diagn 22, no. 6 (June 2020): 811–16. https://doi.org/10.1016/j.jmoldx.2020.03.004.Full Text Open Access Copy Link to Item
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Tillekeratne, L Gayani, Sunil Suchindran, Emily R. Ko, Elizabeth A. Petzold, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.” Open Forum Infect Dis 7, no. 6 (June 2020): ofaa194. https://doi.org/10.1093/ofid/ofaa194.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Ayeaye Khine, Abdossamad Talebpour, Alaleh Samiei, Vilcy Parmar, Thomas W. Burke, Micah T. Mcclain, et al. “Rapid, Sample-to-Answer Host Gene Expression Test to Diagnose Viral Infection.” Open Forum Infect Dis 6, no. 11 (November 2019): ofz466. https://doi.org/10.1093/ofid/ofz466.Full Text Open Access Copy Link to Item
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Ko, Emily R., Casandra W. Philipson, Thomas W. Burke, Regina Z. Cer, Kimberly A. Bishop-Lilly, Logan J. Voegtly, Ephraim L. Tsalik, Christopher W. Woods, Danielle V. Clark, and Kevin L. Schully. “Direct-from-blood RNA sequencing identifies the cause of post-bronchoscopy fever.” Bmc Infect Dis 19, no. 1 (October 28, 2019): 905. https://doi.org/10.1186/s12879-019-4462-9.Full Text Open Access Copy Link to Item
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Lydon, Emily C., Ricardo Henao, Thomas W. Burke, Mert Aydin, Bradly P. Nicholson, Seth W. Glickman, Vance G. Fowler, et al. “Validation of a host response test to distinguish bacterial and viral respiratory infection.” Ebiomedicine 48 (October 2019): 453–61. https://doi.org/10.1016/j.ebiom.2019.09.040.Full Text Open Access Copy Link to Item
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Ross, Melissa H., Brittany L. Zick, and Ephraim L. Tsalik. “Host-Based Diagnostics for Acute Respiratory Infections.” Clin Ther 41, no. 10 (October 2019): 1923–38. https://doi.org/10.1016/j.clinthera.2019.06.007.Full Text Open Access Copy Link to Item
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Jaffe, Ian S., Karen Chiswell, and Ephraim L. Tsalik. “A Decade On: Systematic Review of ClinicalTrials.gov Infectious Disease Trials, 2007-2017.” Open Forum Infect Dis 6, no. 6 (June 2019): ofz189. https://doi.org/10.1093/ofid/ofz189.Full Text Open Access Copy Link to Item
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Limkakeng, Alexander T., Ricardo Henao, Deepak Voora, Thomas O’Connell, Michelle Griffin, Ephraim L. Tsalik, Svati Shah, Christopher W. Woods, and Geoffrey S. Ginsburg. “Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.” Plos One 14, no. 2 (2019): e0211762. https://doi.org/10.1371/journal.pone.0211762.Full Text Open Access Copy Link to Item
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Lydon, Emily C., Charles Bullard, Mert Aydin, Olga M. Better, Anna Mazur, Bradly P. Nicholson, Emily R. Ko, et al. “A host gene expression approach for identifying triggers of asthma exacerbations.” Plos One 14, no. 4 (2019): e0214871. https://doi.org/10.1371/journal.pone.0214871.Full Text Open Access Copy Link to Item
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Fourati, Slim, Aarthi Talla, Mehrad Mahmoudian, Joshua G. Burkhart, Riku Klén, Ricardo Henao, Thomas Yu, et al. “A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.” Nat Commun 9, no. 1 (October 24, 2018): 4418. https://doi.org/10.1038/s41467-018-06735-8.Full Text Open Access Copy Link to Item
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Thaden, Joshua T., Karen Chiswell, Ian Jaffe, Stephen P. Bergin, William E. Yang, Andrew Romaine, Jamie Roberts, et al. “Pediatric Antibacterial and Antifungal Trials From 2007 to 2017.” Pediatrics 142, no. 3 (September 2018). https://doi.org/10.1542/peds.2017-1849.Full Text Open Access Copy Link to Item
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Lydon, Emily C., Emily R. Ko, and Ephraim L. Tsalik. “The host response as a tool for infectious disease diagnosis and management.” Expert Rev Mol Diagn 18, no. 8 (August 2018): 723–38. https://doi.org/10.1080/14737159.2018.1493378.Full Text Open Access Copy Link to Item
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Sweeney, Timothy E., Tej D. Azad, Michele Donato, Winston A. Haynes, Thanneer M. Perumal, Ricardo Henao, Jesús F. Bermejo-Martin, et al. “Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.” Crit Care Med 46, no. 6 (June 2018): 915–25. https://doi.org/10.1097/CCM.0000000000003084.Full Text Link to Item
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Sweeney, Timothy E., Thanneer M. Perumal, Ricardo Henao, Marshall Nichols, Judith A. Howrylak, Augustine M. Choi, Jesús F. Bermejo-Martin, et al. “A community approach to mortality prediction in sepsis via gene expression analysis.” Nat Commun 9, no. 1 (February 15, 2018): 694. https://doi.org/10.1038/s41467-018-03078-2.Full Text Link to Item
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Tsalik, Ephraim L., Robert A. Bonomo, and Vance G. Fowler. “New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance.” Annu Rev Med 69 (January 29, 2018): 379–94. https://doi.org/10.1146/annurev-med-052716-030320.Full Text Link to Item
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Duplessis, Christopher, Michael Gregory, Kenneth Frey, Matthew Bell, Luu Truong, Kevin Schully, James Lawler, et al. “Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis.” J Intensive Care 6 (2018): 72. https://doi.org/10.1186/s40560-018-0341-5.Full Text Link to Item
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Poore, Gregory D., Emily R. Ko, Ashlee Valente, Ricardo Henao, Kelsey Sumner, Christopher Hong, Thomas W. Burke, et al. “A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies.” Front Microbiol 9 (2018): 2957. https://doi.org/10.3389/fmicb.2018.02957.Full Text Open Access Copy Link to Item
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Bergin, Stephen P., and Ephraim L. Tsalik. “Procalcitonin: The Right Answer but to Which Question?” Clin Infect Dis 65, no. 2 (July 15, 2017): 191–93. https://doi.org/10.1093/cid/cix323.Full Text Link to Item
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Tsalik, Ephraim L., Elizabeth Petzold, Barry N. Kreiswirth, Robert A. Bonomo, Ritu Banerjee, Ebbing Lautenbach, Scott R. Evans, et al. “Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group.” Clin Infect Dis 64, no. suppl_1 (March 15, 2017): S41–47. https://doi.org/10.1093/cid/ciw831.Full Text Link to Item
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Burke, Thomas W., Ricardo Henao, Erik Soderblom, Ephraim L. Tsalik, J Will Thompson, Micah T. McClain, Marshall Nichols, et al. “Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.” Ebiomedicine 17 (March 2017): 172–81. https://doi.org/10.1016/j.ebiom.2017.02.015.Full Text Open Access Copy Link to Item
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Wang, Liuyang, Emily R. Ko, James J. Gilchrist, Kelly J. Pittman, Anna Rautanen, Matti Pirinen, J Will Thompson, et al. “Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.” Sci Adv 3, no. 3 (March 2017): e1602096. https://doi.org/10.1126/sciadv.1602096.Full Text Open Access Copy Link to Item
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Holcomb, Zachary E., Ephraim L. Tsalik, Christopher W. Woods, and Micah T. McClain. “Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.” Journal of Clinical Microbiology 55, no. 2 (February 2017): 360–68. https://doi.org/10.1128/jcm.01057-16.Full Text
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Patel, Robin, Ephraim L. Tsalik, Elizabeth Petzold, Vance G. Fowler, Jeffrey D. Klausner, Scott Evans, and Scott Antibacterial Resistance Leadership Group (ARLG). “MASTERMIND: Bringing Microbial Diagnostics to the Clinic.” Clin Infect Dis 64, no. 3 (February 1, 2017): 355–60. https://doi.org/10.1093/cid/ciw788.Full Text Open Access Copy Link to Item
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Yan, Qin, Sun Hee Ahn, Felix Mba Medie, Batu K. Sharma-Kuinkel, Lawrence P. Park, William K. Scott, Hitesh Deshmukh, et al. “Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.” Plos One 12, no. 6 (2017): e0179033. https://doi.org/10.1371/journal.pone.0179033.Full Text Link to Item
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Limkakeng, Alexander T., Andrew A. Monte, Christopher Kabrhel, Michael Puskarich, Laura Heitsch, Ephraim L. Tsalik, and Nathan I. Shapiro. “Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?” Acad Emerg Med 23, no. 10 (October 2016): 1097–1106. https://doi.org/10.1111/acem.13027.Full Text Open Access Copy Link to Item
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Yang, William E., Sunil Suchindran, Bradly P. Nicholson, Micah T. McClain, Thomas Burke, Geoffrey S. Ginsburg, Clayton D. Harro, et al. “Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.” J Infect Dis 213, no. 9 (May 1, 2016): 1495–1504. https://doi.org/10.1093/infdis/jiv593.Full Text Open Access Copy Link to Item
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McClain, M. T., R. Henao, J. Williams, B. Nicholson, T. Veldman, L. Hudson, E. L. Tsalik, et al. “Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge.” Clin Exp Immunol 183, no. 3 (March 2016): 441–51. https://doi.org/10.1111/cei.12736.Full Text Link to Item
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Tsalik, Ephraim L., Yanhong Li, Lori L. Hudson, Vivian H. Chu, Tiffany Himmel, Alex T. Limkakeng, Jason N. Katz, et al. “Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.” Ann Am Thorac Soc 13, no. 3 (March 2016): 401–13. https://doi.org/10.1513/AnnalsATS.201504-205OC.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Ricardo Henao, Marshall Nichols, Thomas Burke, Emily R. Ko, Micah T. McClain, Lori L. Hudson, et al. “Host gene expression classifiers diagnose acute respiratory illness etiology.” Sci Transl Med 8, no. 322 (January 20, 2016): 322ra11. https://doi.org/10.1126/scitranslmed.aad6873.Full Text Open Access Copy Link to Item
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McClain, Micah T., Bradly P. Nicholson, Lawrence P. Park, Tzu-Yu Liu, Alfred O. Hero, Ephraim L. Tsalik, Aimee K. Zaas, et al. “A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.” Open Forum Infect Dis 3, no. 1 (January 2016): ofw007. https://doi.org/10.1093/ofid/ofw007.Full Text Open Access Copy Link to Item
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Ruopp, Marcus, Karen Chiswell, Joshua T. Thaden, Kunal Merchant, and Ephraim L. Tsalik. “Respiratory Tract Infection Clinical Trials from 2007 to 2012. A Systematic Review of ClinicalTrials.gov.” Ann Am Thorac Soc 12, no. 12 (December 2015): 1852–63. https://doi.org/10.1513/AnnalsATS.201505-291OC.Full Text Link to Item
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Tsalik, Ephraim L., Laurel K. Willig, Brandon J. Rice, Jennifer C. van Velkinburgh, Robert P. Mohney, Jonathan E. McDunn, Darrell L. Dinwiddie, et al. “Renal systems biology of patients with systemic inflammatory response syndrome.” Kidney Int 88, no. 4 (October 2015): 804–14. https://doi.org/10.1038/ki.2015.150.Full Text Open Access Copy Link to Item
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Tsalik, Ephraim L., Micah McClain, and Aimee K. Zaas. “Moving toward prime time: host signatures for diagnosis of respiratory infections.” J Infect Dis 212, no. 2 (July 15, 2015): 173–75. https://doi.org/10.1093/infdis/jiv032.Full Text Link to Item
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Tsalik, E. L. “Beauty is only skin deep.” Science Translational Medicine 7, no. 282 (April 8, 2015). https://doi.org/10.1126/scitranslmed.aab0846.Full Text
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Tsalik, E. L. “Seq and the city.” Science Translational Medicine 7, no. 276 (February 25, 2015). https://doi.org/10.1126/scitranslmed.aaa5547.Full Text
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Tsalik, E. L. “Fear as a cardiovascular risk factor.” Science Translational Medicine 7, no. 270 (January 1, 2015). https://doi.org/10.1126/scitranslmed.aaa6252.Full Text
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Yang, W. E., C. W. Woods, and E. L. Tsalik. “Host-based diagnostics for detection and prognosis of infectious diseases” 42 (January 1, 2015): 465–500. https://doi.org/10.1016/bs.mim.2015.06.001.Full Text
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Yuan, X., R. Henao, E. L. Tsalik, R. J. Langley, and L. Carin. “Non-Gaussian discriminative factor models via the max-margin rank-likelihood.” 32nd International Conference on Machine Learning, Icml 2015 2 (January 1, 2015): 1254–63.Open Access Copy
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Ko, Emily R., William E. Yang, Micah T. McClain, Christopher W. Woods, Geoffrey S. Ginsburg, and Ephraim L. Tsalik. “What was old is new again: using the host response to diagnose infectious disease.” Expert Rev Mol Diagn 15, no. 9 (2015): 1143–58. https://doi.org/10.1586/14737159.2015.1059278.Full Text Link to Item
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Tsalik, E. L. “Crowdsourcing disease prognosis.” Science Translational Medicine 6, no. 264 (November 26, 2014). https://doi.org/10.1126/scitranslmed.aaa2069.Full Text
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Tsalik, E. L. “Sequence-specific antibiotics.” Science Translational Medicine 6, no. 259 (October 22, 2014): 259ec183. https://doi.org/10.1126/scitranslmed.aaa0896.Full Text
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Zaas, Aimee K., Bronwen H. Garner, Ephraim L. Tsalik, Thomas Burke, Christopher W. Woods, and Geoffrey S. Ginsburg. “The current epidemiology and clinical decisions surrounding acute respiratory infections.” Trends Mol Med 20, no. 10 (October 2014): 579–88. https://doi.org/10.1016/j.molmed.2014.08.001.Full Text Link to Item
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Tsalik, E. L. “The microbial origins of obesity.” Science Translational Medicine 6, no. 252 (September 3, 2014). https://doi.org/10.1126/scitranslmed.3010265.Full Text
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Langley, Raymond J., Jennifer L. Tipper, Shannon Bruse, Rebecca M. Baron, Ephraim L. Tsalik, James Huntley, Angela J. Rogers, et al. “Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.” Am J Respir Crit Care Med 190, no. 4 (August 15, 2014): 445–55. https://doi.org/10.1164/rccm.201404-0624OC.Full Text Link to Item
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Tsalik, E. L. “Cardiovascular genetics: All systems point to TREML4.” Science Translational Medicine 6, no. 246 (July 23, 2014). https://doi.org/10.1126/scitranslmed.3009814.Full Text
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Tsalik, E. L. “Antimicrobial drug resistance in all four corners of the earth.” Science Translational Medicine 6, no. 240 (June 11, 2014). https://doi.org/10.1126/scitranslmed.3009591.Full Text
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Yan, Qin, Batu K. Sharma-Kuinkel, Hitesh Deshmukh, Ephraim L. Tsalik, Derek D. Cyr, Joseph Lucas, Christopher W. Woods, et al. “Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.” Plos Pathog 10, no. 6 (June 2014): e1004149. https://doi.org/10.1371/journal.ppat.1004149.Full Text Open Access Copy Link to Item
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Tsalik, E. L. “The sum of one's parts? What our microbiomes say about us.” Science Translational Medicine 6, no. 234 (April 30, 2014). https://doi.org/10.1126/scitranslmed.3009260.Full Text
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Goswami, Neela D., Ephraim L. Tsalik, Susanna Naggie, William C. Miller, John R. Horton, Christopher D. Pfeiffer, and Charles B. Hicks. “A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.” Trials 15 (January 22, 2014): 31. https://doi.org/10.1186/1745-6215-15-31.Full Text Link to Item
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Langley, R. J., E. L. Tsalik, R. P. Mohney, K. S. Harrod, C. B. Cairns, E. Rivers, C. W. Woods, and S. F. Kingsmore. “Integrative Analysis Of The Metabolome, Proteome, And Transcriptome In Systemic Inflammatory Response Syndrome.” American Journal of Respiratory and Critical Care Medicine 189 (January 1, 2014).Link to Item
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Tsalik, Ephraim L., Raymond J. Langley, Darrell L. Dinwiddie, Neil A. Miller, Byunggil Yoo, Jennifer C. van Velkinburgh, Laurie D. Smith, et al. “An integrated transcriptome and expressed variant analysis of sepsis survival and death.” Genome Med 6, no. 11 (2014): 111. https://doi.org/10.1186/s13073-014-0111-5.Full Text Open Access Copy Link to Item
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Xiao, Bin, Yu Wang, Wei Li, Megan Baker, Jian Guo, Kelly Corbet, Ephraim L. Tsalik, et al. “Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.” Blood 122, no. 19 (November 7, 2013): 3365–75. https://doi.org/10.1182/blood-2013-06-510586.Full Text Link to Item
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Zaas, Aimee K., Thomas Burke, Minhua Chen, Micah McClain, Bradly Nicholson, Timothy Veldman, Ephraim L. Tsalik, et al. “A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.” Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126. https://doi.org/10.1126/scitranslmed.3006280.Full Text Link to Item
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Langley, Raymond J., Ephraim L. Tsalik, Jennifer C. van Velkinburgh, Seth W. Glickman, Brandon J. Rice, Chunping Wang, Bo Chen, et al. “An integrated clinico-metabolomic model improves prediction of death in sepsis.” Sci Transl Med 5, no. 195 (July 24, 2013): 195ra95. https://doi.org/10.1126/scitranslmed.3005893.Full Text Link to Item
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Ahn, Sun Hee, Ephraim L. Tsalik, Derek D. Cyr, Yurong Zhang, Jennifer C. van Velkinburgh, Raymond J. Langley, Seth W. Glickman, et al. “Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.” Plos One 8, no. 1 (2013): e48979. https://doi.org/10.1371/journal.pone.0048979.Full Text Open Access Copy Link to Item
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Goswami, Neela D., Christopher D. Pfeiffer, John R. Horton, Karen Chiswell, Asba Tasneem, and Ephraim L. Tsalik. “The state of infectious diseases clinical trials: a systematic review of ClinicalTrials.gov.” Plos One 8, no. 10 (2013): e77086. https://doi.org/10.1371/journal.pone.0077086.Full Text Link to Item
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Tsalik, Ephraim L., L Brett Jaggers, Seth W. Glickman, Raymond J. Langley, Jennifer C. van Velkinburgh, Lawrence P. Park, Vance G. Fowler, Charles B. Cairns, Stephen F. Kingsmore, and Christopher W. Woods. “Discriminative value of inflammatory biomarkers for suspected sepsis.” J Emerg Med 43, no. 1 (July 2012): 97–106. https://doi.org/10.1016/j.jemermed.2011.05.072.Full Text Link to Item
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Tsalik, Ephraim L., Coleen K. Cunningham, Hannah M. Cunningham, Maria G. Lopez-Marti, Devdutta G. Sangvai, William K. Purdy, Deverick J. Anderson, et al. “An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer camp.” J Am Coll Health 59, no. 5 (2011): 419–26. https://doi.org/10.1080/07448481.2010.534215.Full Text Link to Item
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Tsalik, Ephraim L., and Lauren Brett Jaggers. “Life-threatening asymptomatic incidentaloma: a case report of idiopathic CD4 lymphocytopenia and opportunistic infections.” Am J Med Sci 340, no. 2 (August 2010): 158–59. https://doi.org/10.1097/MAJ.0b013e3181e5f118.Full Text Link to Item
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Glickman, Seth W., Charles B. Cairns, Ronny M. Otero, Christopher W. Woods, Ephraim L. Tsalik, Raymond J. Langley, Jennifer C. van Velkinburgh, et al. “Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis.” Acad Emerg Med 17, no. 4 (April 2010): 383–90. https://doi.org/10.1111/j.1553-2712.2010.00664.x.Full Text Link to Item
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Tsalik, Ephraim L., Edward F. Hendershot, Devdutta G. Sangvai, Hannah M. Cunningham, Coleen K. Cunningham, Maria G. Lopez-Marti, William K. Purdy, Christopher W. Woods, and L Brett Caram. “Clinical presentation and response to treatment of novel influenza A H1N1 in a university-based summer camp population.” J Clin Virol 47, no. 3 (March 2010): 286–88. https://doi.org/10.1016/j.jcv.2009.12.012.Full Text Link to Item
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Tsalik, Ephraim L., Daphne Jones, Bradly Nicholson, Lynette Waring, Oliver Liesenfeld, Lawrence P. Park, Seth W. Glickman, et al. “Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis.” J Clin Microbiol 48, no. 1 (January 2010): 26–33. https://doi.org/10.1128/JCM.01447-09.Full Text Link to Item
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Tsalik, E. L., D. Jones, B. Nicholson, L. B. Caram, O. Liesenfeld, V. G. Fowler, S. W. Glickman, et al. “DETECTION OF BACTERIAL AND FUNGAL PATHOGENS ASSOCIATED WITH SEPSIS IN PATIENTS PRESENTING TO THE EMERGENCY ROOM.” Intensive Care Medicine 35 (September 1, 2009): 196–196.Link to Item
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Tsalik, Ephraim L., and Christopher W. Woods. “Sepsis redefined: the search for surrogate markers.” Int J Antimicrob Agents 34 Suppl 4 (2009): S16–20. https://doi.org/10.1016/S0924-8579(09)70560-6.Full Text Link to Item
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Tsalik, Ephraim L. “DNA-based immunotherapy to treat atopic disease.” Ann Allergy Asthma Immunol 95, no. 5 (November 2005): 403–10. https://doi.org/10.1016/S1081-1206(10)61163-5.Full Text Link to Item
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Tsalik, Ephraim L., Timothy Niacaris, Adam S. Wenick, Kelvin Pau, Leon Avery, and Oliver Hobert. “LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.” Dev Biol 263, no. 1 (November 1, 2003): 81–102. https://doi.org/10.1016/s0012-1606(03)00447-0.Full Text Link to Item
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Tsalik, Ephraim L., and Oliver Hobert. “Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans.” J Neurobiol 56, no. 2 (August 2003): 178–97. https://doi.org/10.1002/neu.10245.Full Text Link to Item
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Altun-Gultekin, Z., Y. Andachi, E. L. Tsalik, D. Pilgrim, Y. Kohara, and O. Hobert. “A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.” Development 128, no. 11 (June 2001): 1951–69. https://doi.org/10.1242/dev.128.11.1951.Full Text Link to Item
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Tsalik, E. L., and M. R. Gartenberg. “Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damage.” Yeast 14, no. 9 (June 30, 1998): 847–52. https://doi.org/10.1002/(SICI)1097-0061(19980630)14:9<847::AID-YEA285>3.0.CO;2-9.Full Text Link to Item
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Book Sections
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Woods, C. W., and E. L. Tsalik. “Overview: Genomic and precision medicine for infectious and inflammatory disease.” In Genomic and Precision Medicine: Infectious and Inflammatory Disease, 1–7, 2019. https://doi.org/10.1016/B978-0-12-801496-7.00001-0.Full Text
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Conference Papers
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Blair, Paul W., George Oduro, Chris Oppong, Stephen Okello, Charmagne Beckett, Andrew Letizia, Anne Fox, et al. “THE PERFORMANCE OF QSOFA IN PATIENTS WITH SUSPECTED SEPSIS IN CAMBODIA, GHANA, UGANDA, AND THE UNITED STATES.” In Shock, 53:91–91, 2020.Link to Item
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Brandsma, Joost, Will J. Thompson, Deborah A. Striegel, Paul W. Blair, Josh Chenoweth, Subramaniam Krishnan, Kevin Schully, et al. “METABOLOMICS BIOMARKER DISCOVERY IN SEPSIS PATIENTS FROM AUSTERE ENVIRONMENTS.” In Shock, 53:74–74, 2020.Link to Item
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Robertshaw, M., E. L. Tsalik, V. Chu, A. Limkakeng, J. Katz, S. Glickman, M. McClain, E. Welty-Wolf, and C. Woods. “Serum Procalcitonin Trends in Hospital-Acquired Infections: A Prospective Multi-Center Observational Cohort.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.Link to Item
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Clowse, Megan, Jennifer Rogers, Amanda Eudy, Lisa Criscione-Schreiber, Jayanth Doss, Rebecca Sadun, Kai Sun, et al. “Biologic Differences Between Type 1 and 2 Lupus.” In Arthritis & Rheumatology, Vol. 71. WILEY, 2019.Link to Item
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Brandsma, Joost, Kevin Schully, Deborah Striegel, Josh G. Chenoweth, Anissa Elayadi, Subramaniam Krishnan, Dennis Faix, et al. “MOLECULAR PROFILING OF SEPSIS PATIENTS FROM AUSTERE ENVIRONMENTS USING TOPOLOGICAL DATA ANALYSIS.” In American Journal of Tropical Medicine and Hygiene, 101:147–147. AMER SOC TROP MED & HYGIENE, 2019.Link to Item
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Tillekeratne, L Gayani, Sunil Suchindran, Emily R. Ko, Elizabeth A. Petzold, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “HOST GENES ARE DIFFERENTIALLY EXPRESSED IN DENGUE COMPARED TO INFLUENZA INFECTIONS.” In American Journal of Tropical Medicine and Hygiene, 101:263–263. AMER SOC TROP MED & HYGIENE, 2019.Link to Item
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Dela Cruz, Charles S., Richard G. Wunderink, David C. Christiani, Stephania A. Cormier, Kristina Crothers, Claire M. Doerschuk, Scott E. Evans, et al. “Future Research Directions in Pneumonia. NHLBI Working Group Report.” In Am J Respir Crit Care Med, 198:256–63, 2018. https://doi.org/10.1164/rccm.201801-0139WS.Full Text Link to Item
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Tillekeratne, L., Sunil Suchindran, Emily Ko, Elizabeth Petzold, Champica Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “A GENE EXPRESSION SIGNATURE ACCURATELY IDENTIFIES VIRAL ACUTE RESPIRATORY INFECTIONS IN A SRI LANKAN POPULATION.” In American Journal of Tropical Medicine and Hygiene, 99:641–42. AMER SOC TROP MED & HYGIENE, 2018.Link to Item
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Langley, R. J., T. E. Sweeney, T. Perumal, R. Henao, H. R. Wong, B. Tang, P. Khatri, E. Tsalik, and L. Mangravite. “Federated Gene Expression Analysis Of Mortality Prediction In Sepsis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.Link to Item
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