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Angiotensin II and aldosterone in retinal vasculopathy and inflammation.

Publication ,  Journal Article
Wilkinson-Berka, JL; Suphapimol, V; Jerome, JR; Deliyanti, D; Allingham, MJ
Published in: Exp Eye Res
October 2019

Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone system (RAAS) and have a central role in hypertension as well as cardiovascular and renal disease. The localization of RAAS components within the retina has led to studies investigating the roles of angiotensin II, aldosterone and the counter regulatory arm of the pathway in vision-threatening retinopathies. This review will provide a brief overview of RAAS components as well as the vascular pathology that develops in the retinal diseases, retinopathy of prematurity, diabetic retinopathy and neovascular age-related macular degeneration. The review will discuss pre-clinical and clinical evidence that modulation of the RAAS alters the development of vasculopathy and inflammation in the aforementioned retinopathies, as well as the emerging role of aldosterone and the mineralocorticoid receptor in central serous chorioretinopathy.

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Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

October 2019

Volume

187

Start / End Page

107766

Location

England

Related Subject Headings

  • Wet Macular Degeneration
  • Retinopathy of Prematurity
  • Retinitis
  • Retinal Vessels
  • Renin-Angiotensin System
  • Receptor, Angiotensin, Type 1
  • Ophthalmology & Optometry
  • Humans
  • Diabetic Retinopathy
  • Angiotensin-Converting Enzyme Inhibitors
 

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Wilkinson-Berka, J. L., Suphapimol, V., Jerome, J. R., Deliyanti, D., & Allingham, M. J. (2019). Angiotensin II and aldosterone in retinal vasculopathy and inflammation. Exp Eye Res, 187, 107766. https://doi.org/10.1016/j.exer.2019.107766
Wilkinson-Berka, Jennifer L., Varaporn Suphapimol, Jack R. Jerome, Devy Deliyanti, and Michael J. Allingham. “Angiotensin II and aldosterone in retinal vasculopathy and inflammation.Exp Eye Res 187 (October 2019): 107766. https://doi.org/10.1016/j.exer.2019.107766.
Wilkinson-Berka JL, Suphapimol V, Jerome JR, Deliyanti D, Allingham MJ. Angiotensin II and aldosterone in retinal vasculopathy and inflammation. Exp Eye Res. 2019 Oct;187:107766.
Wilkinson-Berka, Jennifer L., et al. “Angiotensin II and aldosterone in retinal vasculopathy and inflammation.Exp Eye Res, vol. 187, Oct. 2019, p. 107766. Pubmed, doi:10.1016/j.exer.2019.107766.
Wilkinson-Berka JL, Suphapimol V, Jerome JR, Deliyanti D, Allingham MJ. Angiotensin II and aldosterone in retinal vasculopathy and inflammation. Exp Eye Res. 2019 Oct;187:107766.
Journal cover image

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

October 2019

Volume

187

Start / End Page

107766

Location

England

Related Subject Headings

  • Wet Macular Degeneration
  • Retinopathy of Prematurity
  • Retinitis
  • Retinal Vessels
  • Renin-Angiotensin System
  • Receptor, Angiotensin, Type 1
  • Ophthalmology & Optometry
  • Humans
  • Diabetic Retinopathy
  • Angiotensin-Converting Enzyme Inhibitors