Michael John Allingham | Scholars@Duke

Michael John Allingham
Assistant Professor of Ophthalmology

Michael Allingham, MD PhD is a retina fellowship-trained clinician scientist with expertise in the diagnosis and treatment of medical conditions affecting the retina. Trained in the interpretation of retinal vascular imaging techniques, including video fluorescein angiography (FA) and indocyanine green (ICG) angiography, he specializes in the use of these imaging studies to guide injection and laser-based treatment of disease. His research focuses on using a mouse model of retinal edema to elucidate the role of Müller cell dysfunction in diseases such as diabetic macular edema and retinal vein occlusion. He also studies the use of computer aided image analysis in predicting response to specific treatment modalities in patients with diabetic macular edema. Dr. Allingham’s ultimate goal is to develop new therapies for macular edema and to better utilize ocular image analysis techniques to guide individualized treatment of his patients.

Dr. Allingham attended Duke University where he earned a B.S. in Chemistry with Distinction. He next pursued his M.D./Ph.D. at the nearby University of North Carolina. He earned his Ph.D. in Cell and Developmental Biology in the lab of Keith Burridge, Ph.D., an internationally recognized expert in cell adhesion. As a graduate student, Dr. Allingham studied the role of leukocyte-endothelial adhesive interactions in the endothelial regulation of leukocyte diapedesis. Upon completing his M.D./Ph.D., he returned to Duke for his internship, residency in ophthalmology and fellowship in medical retina before accepting a faculty position in the Duke Eye Center Department of Ophthalmology.

Current Appointments & Affiliations

Assistant Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2014

Contact Information

2351 Erwin Road, Box 3802, Durham, NC 27710
Box 3802 Med Ctr, Durham, NC 27710
mike.allingham@duke.edu (919) 684-3316

Background
Education, Training, & Certifications
- Ophthalmology Residency, Ophthalmology, Duke University School of Medicine 2010 - 2013
- Preliminary Internship, Medicine, Duke University School of Medicine 2009 - 2010
- B.S., Duke University 2009
- M.D., University of North Carolina, Chapel Hill, School of Medicine 2009
- Ph.D., University of North Carolina - Chapel Hill 2007
Duke Appointment History
- Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2013 - 2014
Research
Selected Grants
- Muller glial dysfunction in retinal edema awarded by National Institutes of Health 2016 - 2020
- Computer Aided Classification of Diabetic Macular Edema awarded by National Institutes of Health 2012 - 2018
- NEI Mentored Clinical Scientist Development Program Award (K12) awarded by National Institutes of Health 2004 - 2016
External Relationships
- Clearside Biomedical
- Eclipse Life Sciences
- Eclipse Life Sciences
- Eyedea Bio
- Eyedea Bio
- Eyedesis Biosciences
- Pulsar Life Sciences
- Pulsar Life Sciences
- Stealth Biotherapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mettu, Priyatham S., Michael J. Allingham, and Scott W. Cousins. “Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities.” Prog Retin Eye Res, October 3, 2020, 100906. https://doi.org/10.1016/j.preteyeres.2020.100906.
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  - Allingham, Michael J., Priyatham S. Mettu, and Scott W. Cousins. “Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.” Exp Eye Res 188 (November 2019): 107788. https://doi.org/10.1016/j.exer.2019.107788.
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  - Wilkinson-Berka, Jennifer L., Varaporn Suphapimol, Jack R. Jerome, Devy Deliyanti, and Michael J. Allingham. “Angiotensin II and aldosterone in retinal vasculopathy and inflammation.” Exp Eye Res 187 (October 2019): 107766. https://doi.org/10.1016/j.exer.2019.107766.
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  - Allingham, Michael J., Nomingerel Tserentsoodol, Peter Saloupis, Priyatham S. Mettu, and Scott W. Cousins. “Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice.” Invest Ophthalmol Vis Sci 59, no. 8 (July 2, 2018): 3355–65. https://doi.org/10.1167/iovs.17-23073.
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  - Allingham, Michael J., Dibyendu Mukherjee, Erin B. Lally, Hossein Rabbani, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “A Quantitative Approach to Predict Differential Effects of Anti-VEGF Treatment on Diffuse and Focal Leakage in Patients with Diabetic Macular Edema: A Pilot Study.” Transl Vis Sci Technol 6, no. 2 (March 2017): 7. https://doi.org/10.1167/tvst.6.2.7.
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  - Polans, James, David Cunefare, Eli Cole, Brenton Keller, Priyatham S. Mettu, Scott W. Cousins, Michael J. Allingham, Joseph A. Izatt, and Sina Farsiu. “Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients.” Opt Lett 42, no. 1 (January 1, 2017): 17–20. https://doi.org/10.1364/OL.42.000017.
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  - Zhang, Wenlan, Peter Nicholas, Stefanie Gail Schuman, Michael John Allingham, Ambar Faridi, Tushar Suthar, Scott William Cousins, and Sasapin Grace Prakalapakorn. “Screening for Diabetic Retinopathy Using a Portable, Noncontact, Nonmydriatic Handheld Retinal Camera.” Journal of Diabetes Science and Technology 11, no. 1 (January 2017): 128–34. https://doi.org/10.1177/1932296816658902.
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  - Smith, R Theodore, Sina Farsiu, and Michael Allingham. “Understanding RPE Lipofuscin.” Invest Ophthalmol Vis Sci 57, no. 15 (December 1, 2016): 6766. https://doi.org/10.1167/iovs.16-21081.
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  - Allingham, Michael J. “Bilateral Proliferative Retinopathy Associated With Hoyeraal-Hreidarsson Syndrome, a Severe Form of Dyskeratosis Congenita.” Ophthalmic Surg Lasers Imaging Retina 47, no. 4 (April 1, 2016): 366–68. https://doi.org/10.3928/23258160-20160324-11.
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  - Allingham, Michael J., Qing Nie, Eleonora M. Lad, Daniel J. Izatt, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration.” Invest Ophthalmol Vis Sci 57, no. 4 (April 1, 2016): 2283–89. https://doi.org/10.1167/iovs.15-19008.
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  - Estrada, Rolando, Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, Carlo Tomasi, and Sina Farsiu. “Retinal Artery-Vein Classification via Topology Estimation.” Ieee Trans Med Imaging 34, no. 12 (December 2015): 2518–34. https://doi.org/10.1109/TMI.2015.2443117.
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  - Chiu, Stephanie J., Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, Joseph A. Izatt, and Sina Farsiu. “Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema.” Biomed Opt Express 6, no. 4 (April 1, 2015): 1172–94. https://doi.org/10.1364/BOE.6.001172.
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  - Rabbani, Hossein, Michael J. Allingham, Priyatham S. Mettu, Scott W. Cousins, and Sina Farsiu. “Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema.” Invest Ophthalmol Vis Sci 56, no. 3 (January 29, 2015): 1482–92. https://doi.org/10.1167/iovs.14-15457.
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  - Allingham, Michael J., Michelle T. Cabrera, Rachelle V. O’Connell, Ramiro S. Maldonado, Du Tran-Viet, Cynthia A. Toth, Sharon F. Freedman, and Mays A. El-Dairi. “Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography.” J Aapos 17, no. 5 (October 2013): 501–6. https://doi.org/10.1016/j.jaapos.2013.06.014.
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  - Cabrera, Michelle T., Rachelle V. O’Connell, Cynthia A. Toth, Ramiro S. Maldonado, Du Tran-Viet, Michael J. Allingham, Stephanie J. Chiu, et al. “Macular findings in healthy full-term Hispanic newborns observed by hand-held spectral-domain optical coherence tomography.” Ophthalmic Surg Lasers Imaging Retina 44, no. 5 (September 2013): 448–54. https://doi.org/10.3928/23258160-20130801-01.
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  - Aghajanian, A., E. S. Wittchen, M. J. Allingham, T. A. Garrett, and K. Burridge. “Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.” J Thromb Haemost 6, no. 9 (September 2008): 1453–60. https://doi.org/10.1111/j.1538-7836.2008.03087.x.
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  - Buul, Jaap D. van, Michael J. Allingham, Thomas Samson, Julia Meller, Etienne Boulter, Rafael García-Mata, and Keith Burridge. “RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.” J Cell Biol 178, no. 7 (September 24, 2007): 1279–93. https://doi.org/10.1083/jcb.200612053.
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  - Allingham, Michael J., Jaap D. van Buul, and Keith Burridge. “ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.” J Immunol 179, no. 6 (September 15, 2007): 4053–64. https://doi.org/10.4049/jimmunol.179.6.4053.
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  - Silinski, P., M. J. Allingham, and M. C. Fitzgerald. “Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).” Biochemistry 40, no. 14 (April 10, 2001): 4493–4502. https://doi.org/10.1021/bi002752b.
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Education, Training, & Certifications

Duke Appointment History

Selected Grants

External Relationships

Selected Publications

Academic Articles