The Effect of Tobacco Smoking on Adverse Events Following Adult Complex Deformity Surgery: Analysis of 270 Patients From the Prospective, Multicenter Scoli-RISK-1 Study.


Journal Article

STUDY DESIGN: Post-hoc analysis of a prospective, multicenter cohort study. OBJECTIVE: To analyze the impact of smoking on rates of postoperative adverse events (AEs) in patients undergoing high-risk adult spine deformity surgery. SUMMARY OF BACKGROUND DATA: Smoking is a known predictor of medical complications after adult deformity surgery, but the effect on complications, implant failure and other AEs has not been adequately described in prospective studies. METHODS: Twenty-six patients with a history of current smoking were identified out of the 272 patients enrolled in the SCOLI-RISK-1 study who underwent complex adult spinal deformity surgery at 15 centers, with 2-year follow-up. The outcomes and incidence of AEs in these patients were compared to the nonsmoking cohort (n = 244) using univariate analysis, with additional multivariate regression to adjust for the effect of patient demographics, complexity of surgery, and other confounders. RESULTS: The number of levels and complexity of surgery in both cohorts were comparable. In the univariate analysis, the rates of implant failure were almost double (odds ratio 2.28 [0.75-6.18]) in smoking group (n = 7; 26.9%)) that observed in the nonsmoking group (n = 34; 13.9%), but this was not statistically significant (P = 0.088). Surgery-related excessive bleeding (>4 L) was significantly higher in the smoking group (n = 5 vs. n = 9; 19.2% vs. 3.7%; OR 6.22[1.48 - 22.75]; P = 0.006). Wound infection rates and respiratory complications were similar in both groups. In the multivariate analysis, the smoking group demonstrated a higher incidence of any surgery-related AEs over 2 years (n = 13 vs. n = 95; 50.0% vs. 38.9%; OR 2.12 [0.88-5.09]) (P = 0.094). CONCLUSION: In this secondary analysis of patients from the SCOLI-RISK-1 study, a history of smoking significantly increased the risk of excessive intraoperative bleeding and nonsignificantly increased the rate of implant failure or surgery-related AEs over 2 years. The authors therefore advocate a smoking cessation program in patients undergoing complex adult spine deformity surgery. LEVEL OF EVIDENCE: 2.

Full Text

Duke Authors

Cited Authors

  • Wilson, JRF; Jiang, F; Badhiwala, JH; Shaffrey, CI; Carreon, LY; Cheung, KMC; Dahl, BT; Ames, CP; Boachie-Adjei, O; Dekutoski, MB; Lewis, SJ; Matsuyama, Y; Mehdian, H; Pellisé, F; Qiu, Y; Schwab, FJ; Lenke, LG; Fehlings, MG

Published Date

  • January 1, 2020

Published In

Volume / Issue

  • 45 / 1

Start / End Page

  • 32 - 37

PubMed ID

  • 31415459

Pubmed Central ID

  • 31415459

Electronic International Standard Serial Number (EISSN)

  • 1528-1159

Digital Object Identifier (DOI)

  • 10.1097/BRS.0000000000003200


  • eng

Conference Location

  • United States