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Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates.

Publication ,  Journal Article
Chapman, AK; Aucott, SW; Gilmore, MM; Advani, S; Clarke, W; Milstone, AM
Published in: J Perinatol
October 2013

OBJECTIVE: To assess chlorhexidine absorption and skin tolerability in premature infants, following skin antisepsis with 2% aqueous chlorhexidine gluconate (CHG) prior to peripherally inserted central catheter (PICC) placement. STUDY DESIGN: Neonates less than 32 weeks gestation had skin cleansed with CHG prior to PICC placement. CHG concentrations were measured on serial blood samples. Skin integrity was evaluated for 2 weeks after CHG exposure. RESULT: Twenty infants were enrolled; median gestational age was 28 2/7 weeks (range 24 3/7 to 31 4/7). Ten infants had detectable serum chlorhexidine concentrations (range 1.6 to 206 ng ml(-1)). Seven of these infants had their highest serum concentration 2 to 3 days following exposure. No CHG-related skin irritation occurred in any infant. CONCLUSION: CHG was detected in the blood of preterm infants receiving CHG skin antisepsis for PICC insertion. Highest serum concentrations occurred 2 to 3 days after exposure. Further investigation is needed to determine the clinical relevance of CHG absorption in preterm infants.

Duke Scholars

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

October 2013

Volume

33

Issue

10

Start / End Page

768 / 771

Location

United States

Related Subject Headings

  • Tandem Mass Spectrometry
  • Skin Absorption
  • Pilot Projects
  • Pediatrics
  • Male
  • Infant, Premature
  • Infant, Newborn
  • Infant Care
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chapman, A. K., Aucott, S. W., Gilmore, M. M., Advani, S., Clarke, W., & Milstone, A. M. (2013). Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. J Perinatol, 33(10), 768–771. https://doi.org/10.1038/jp.2013.61
Chapman, A. K., S. W. Aucott, M. M. Gilmore, S. Advani, W. Clarke, and A. M. Milstone. “Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates.J Perinatol 33, no. 10 (October 2013): 768–71. https://doi.org/10.1038/jp.2013.61.
Chapman AK, Aucott SW, Gilmore MM, Advani S, Clarke W, Milstone AM. Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. J Perinatol. 2013 Oct;33(10):768–71.
Chapman, A. K., et al. “Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates.J Perinatol, vol. 33, no. 10, Oct. 2013, pp. 768–71. Pubmed, doi:10.1038/jp.2013.61.
Chapman AK, Aucott SW, Gilmore MM, Advani S, Clarke W, Milstone AM. Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. J Perinatol. 2013 Oct;33(10):768–771.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

October 2013

Volume

33

Issue

10

Start / End Page

768 / 771

Location

United States

Related Subject Headings

  • Tandem Mass Spectrometry
  • Skin Absorption
  • Pilot Projects
  • Pediatrics
  • Male
  • Infant, Premature
  • Infant, Newborn
  • Infant Care
  • Humans
  • Female