The Alzheimer's Disease Exposome.
Environmental factors are poorly understood in the etiology of Alzheimer's disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD-risk genetic variants.We propose the "AD exposome" to comprehensively assess the modifiable environmental factors relevant to genetic underpinnings of cognitive aging and AD. Analysis of endogenous and exogenous environmental factors requires multi-generational consideration of these interactions over age and time (GxExT). New computational approaches to the multi-level complexities may identify accessible interventions for individual brain aging. International collaborations on diverse populations are needed to identify the most relevant exposures over the life course for GxE interactions.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Humans
- Geriatrics
- Gene-Environment Interaction
- Exposome
- Alzheimer Disease
- Aging
- 5202 Biological psychology
- 3209 Neurosciences
- 3202 Clinical sciences
- 1109 Neurosciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Humans
- Geriatrics
- Gene-Environment Interaction
- Exposome
- Alzheimer Disease
- Aging
- 5202 Biological psychology
- 3209 Neurosciences
- 3202 Clinical sciences
- 1109 Neurosciences