The Alzheimer's Disease Exposome.

Journal Article (Journal Article)


Environmental factors are poorly understood in the etiology of Alzheimer's disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD-risk genetic variants.

Results and discussion

We propose the "AD exposome" to comprehensively assess the modifiable environmental factors relevant to genetic underpinnings of cognitive aging and AD. Analysis of endogenous and exogenous environmental factors requires multi-generational consideration of these interactions over age and time (GxExT). New computational approaches to the multi-level complexities may identify accessible interventions for individual brain aging. International collaborations on diverse populations are needed to identify the most relevant exposures over the life course for GxE interactions.

Full Text

Duke Authors

Cited Authors

  • Finch, CE; Kulminski, AM

Published Date

  • September 2019

Published In

Volume / Issue

  • 15 / 9

Start / End Page

  • 1123 - 1132

PubMed ID

  • 31519494

Pubmed Central ID

  • PMC6788638

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

International Standard Serial Number (ISSN)

  • 1552-5260

Digital Object Identifier (DOI)

  • 10.1016/j.jalz.2019.06.3914


  • eng