Alexander Kulminski | Scholars@Duke

Alexander Kulminski
Associate Research Professor in the Social Science Research Institute

Current Appointments & Affiliations

Associate Research Professor in the Social Science Research Institute, Social Science Research Institute, University Institutes and Centers 2016

Contact Information

2024 W. Main St., Box 90420, Durham, NC 27708-0420
Box 90420, Durham, NC 27708-0408
kulminsk@duke.edu (919) 684-4962

Background
Education, Training, & Certifications
- Ph.D., The National Academy of Sciences of Belarus (Republic of Belarus) 1991
Research
Selected Grants
- ApoE2 and protective molecular signatures in Alzheimer's disease and aging awarded by National Institutes of Health 2018 - 2023
- Life Course and Genetic and Non-genetic Factors in Health and Survival awarded by National Institutes of Health 2015 - 2020
- Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center awarded by National Institutes of Health 2004 - 2019
- Integrating Population and Basic Science in Cancer Research awarded by National Institutes of Health 2009 - 2015
- The Future of Major Geriatric Disorders in the US Elderly awarded by National Institutes of Health 2008 - 2013
- Evaluating New Genetic Effects on Health and Aging from Longitudinal Data awarded by National Institutes of Health 2007 - 2013
- New Methods of Studying Aging, Health and Longevity: Combining Longitudinal Data awarded by National Institutes of Health 2009 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Nazarian, A, Arbeev, KG, Yashkin, AP, and Kulminski, AM. "Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension." Geroscience (May 5, 2019). Full Text
  - Arbeev, KG, Ukraintseva, SV, Bagley, O, Zhbannikov, IY, Cohen, AA, Kulminski, AM, and Yashin, AI. ""Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74, no. 4 (March 2019): 462-468. Full Text
  - Kulminski, AM, Loika, Y, Culminskaya, I, Huang, J, Arbeev, KG, Bagley, O, Feitosa, MF, Zmuda, JM, Christensen, K, Yashin, AI, and Long Life Family Study Research Group, . "Independent associations of TOMM40 and APOE variants with body mass index." Aging Cell 18, no. 1 (February 2019): e12869-null. Full Text
  - Nazarian, A, Yashin, AI, and Kulminski, AM. "Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities." Alzheimer'S Research & Therapy 11, no. 1 (January 12, 2019): 5-null. Full Text
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Bagley, O, Stallard, E, Kulminski, AM, Akushevich, I, Fang, F, Wojczynski, MK, Christensen, K, Newman, AB, Boudreau, RM, Province, MA, Thielke, S, Perls, TT, An, P, Elo, I, and Ukraintseva, SV. "Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 73, no. 11 (October 2018): 1472-1481. Full Text
  - He, L, Culminskaya, I, Loika, Y, Arbeev, KG, Bagley, O, Duan, M, Yashin, AI, and Kulminski, AM. "Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study." Experimental Gerontology 107 (July 2018): 74-86. Full Text
  - Yashin, AI, Fang, F, Kovtun, M, Wu, D, Duan, M, Arbeev, K, Akushevich, I, Kulminski, A, Culminskaya, I, Zhbannikov, I, Yashkin, A, Stallard, E, and Ukraintseva, S. "Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses." Experimental Gerontology 107 (July 2018): 148-160. Full Text
  - Kulminski, AM, Huang, J, Wang, J, He, L, Loika, Y, and Culminskaya, I. "Apolipoprotein E region molecular signatures of Alzheimer's disease." Aging Cell (May 23, 2018): e12779-null. Full Text
  - Kulminski, AM, Huang, J, Loika, Y, Arbeev, KG, Bagley, O, Yashkin, A, Duan, M, and Culminskaya, I. "Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes." Aging 10, no. 3 (March 2018): 492-514. Full Text
  - Kulminski, AM, Barochia, AV, Loika, Y, Raghavachari, N, Arbeev, KG, Wojczynski, MK, Thyagarajan, B, Vardarajan, BN, Christensen, K, Yashin, AI, and Levine, SJ. "The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study." Plos One 13, no. 11 (January 2018): e0206873-null. Full Text
  - He, L, Zhbannikov, I, Arbeev, KG, Yashin, AI, and Kulminski, AM. "A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data." Genetic epidemiology 41, no. 7 (November 2017): 620-635. Full Text
  - Kulminski, AM, Kernogitski, Y, Culminskaya, I, Loika, Y, Arbeev, KG, Bagley, O, Duan, M, Arbeeva, L, Ukraintseva, SV, Wu, D, Stallard, E, and Yashin, AI. "Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits." Aging Cell 16, no. 1 (February 2017): 61-72. Full Text Open Access Copy
  - He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in Genetics 8 (January 2017): 226-null. Full Text
  - Moskalev, A, Anisimov, V, Aliper, A, Artemov, A, Asadullah, K, Belsky, D, Baranova, A, de Grey, A, Dixit, VD, Debonneuil, E, Dobrovolskaya, E, Fedichev, P, Fedintsev, A, Fraifeld, V, Franceschi, C, Freer, R, Fülöp, T, Feige, J, Gems, D, Gladyshev, V, Gorbunova, V, Irincheeva, I, Jager, S, Jazwinski, SM, Kaeberlein, M, Kennedy, B, Khaltourina, D, Kovalchuk, I, Kovalchuk, O, Kozin, S, Kulminski, A, Lashmanova, E, Lezhnina, K, Liu, G-H, Longo, V, Mamoshina, P, Maslov, A, Pedro de Magalhaes, J, Mitchell, J, Mitnitski, A, Nikolsky, Y, Ozerov, I, Pasyukova, E, Peregudova, D, Popov, V, Proshkina, E, Putin, E, Rogaev, E, Rogina, B, Schastnaya, J, Seluanov, A, Shaposhnikov, M, Simm, A, Skulachev, V, Skulachev, M, Solovev, I, Spindler, S, Stefanova, N, Suh, Y, Swick, A, Tower, J, Gudkov, AV, Vijg, J, Voronkov, A, West, M, Wagner, W, Yashin, A, Zemskaya, N, Zhumadilov, Z, and Zhavoronkov, A. "A review of the biomedical innovations for healthy longevity." Aging 9, no. 1 (January 2017): 7-25. Full Text
  - Kulminski, AM, He, L, Culminskaya, I, Loika, Y, Kernogitski, Y, Arbeev, KG, Loiko, E, Arbeeva, L, Bagley, O, Duan, M, Yashkin, A, Fang, F, Kovtun, M, Ukraintseva, SV, Wu, D, and Yashin, AI. "Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality." Plos Genetics 12, no. 11 (November 10, 2016): e1006314-null. Full Text
  - Kulminski, AM, Raghavachari, N, Arbeev, KG, Culminskaya, I, Arbeeva, L, Wu, D, Ukraintseva, SV, Christensen, K, and Yashin, AI. "Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study." Biogerontology 17, no. 5-6 (November 2016): 893-905. Full Text Open Access Copy
  - Kulminski, AM, Loika, Y, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Stallard, E, and Yashin, AI. "Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency." Scientific reports 6 (October 14, 2016): 35390-. Full Text Open Access Copy
  - Ukraintseva, S, Yashin, A, Arbeev, K, Kulminski, A, Akushevich, I, Wu, D, Joshi, G, Land, KC, and Stallard, E. "Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants." Biogerontology 17, no. 1 (February 2016): 109-127. (Review) Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Arbeeva, LS, Wu, D, Akushevich, I, Kovtun, M, Yashkin, A, Kulminski, A, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity." Biogerontology 17, no. 1 (February 2016): 89-107. (Review) Full Text Open Access Copy
  - He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in genetics 7 (January 2016): 179-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, L, Kulminski, A, Kulminskaya, I, Akushevich, I, and Ukraintseva, SV. "How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data." North American Actuarial Journal : Naaj 20, no. 3 (January 2016): 201-232. Full Text Open Access Copy
  - Yashin, AI, Zhbannikov, I, Arbeeva, L, Arbeev, KG, Wu, D, Akushevich, I, Yashkin, A, Kovtun, M, Kulminski, AM, Stallard, E, Kulminskaya, I, and Ukraintseva, S. "Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures." Frontiers in Genetics 7 (January 2016): 188-null. Full Text Open Access Copy
  - Kulminski, AM, Arbeev, KG, Culminskaya, I, Ukraintseva, SV, Stallard, E, Province, MA, and Yashin, AI. "Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study." Rejuvenation Research 18, no. 2 (April 2015): 128-135. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Arbeeva, L, Ukraintseva, SV, Stallard, E, Wu, D, and Yashin, AI. "Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies." PLoS ONE 10, no. 8 (January 2015): e0136319-. Full Text Open Access Copy
  - Yashin, AI, Wu, D, Arbeeva, LS, Arbeev, KG, Kulminski, AM, Akushevich, I, Kovtun, M, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "Genetics of aging, health, and survival: dynamic regulation of human longevity related traits." Frontiers in Genetics 6 (January 2015): 122-null. Full Text Open Access Copy
  - Kulminski, A, Culminskaya, I, and Yashin, AI. "Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed." Age (Dordrecht, Netherlands) 36, no. 2 (April 2014): 945-947. (Letter) Full Text Open Access Copy
  - Arbeev, KG, Akushevich, I, Kulminski, AM, Ukraintseva, SV, and Yashin, AI. "Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival." Frontiers in public health 2 (January 2014): 228-. (Review) Full Text Open Access Copy
  - Kulminski, A, Culminskaya, I, and Yashin, AI. "Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed." Age 36, no. 2 (January 1, 2014): 945-947. (Letter) Full Text
  - Kulminski, AM, Arbeev, KG, Culminskaya, I, Arbeeva, L, Ukraintseva, SV, Stallard, E, Christensen, K, Schupf, N, Province, MA, and Yashin, AI. "Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan." Plos Genetics 10, no. 1 (January 1, 2014). Full Text
  - Akushevich, I, Kravchenko, J, Ukraintseva, S, Arbeev, K, Kulminski, A, and Yashin, AI. "Morbidity risks among older adults with pre-existing age-related diseases." Experimental Gerontology 48, no. 12 (December 2013): 1395-1401. Full Text Open Access Copy
  - Kulminski, AM. "Unraveling genetic origin of aging-related traits: evolving concepts." Rejuvenation Research 16, no. 4 (August 2013): 304-312. (Review) Full Text
  - Kulminski, AM, Arbeev, KG, Christensen, K, Stallard, E, Miljkovic, I, Barmada, M, and Yashin, AI. "Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children." J Gerontol A Biol Sci Med Sci 68, no. 7 (July 2013): 760-768. Full Text Open Access Copy Link to Item
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Stallard, E, Arbeeva, L, and Yashin, AI. "The role of lipid-related genes, aging-related processes, and environment in healthspan." Aging Cell 12, no. 2 (April 2013): 237-246. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, and Yashin, AI. "Inter-chromosomal level of genome organization and longevity-related phenotypes in humans." Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 501-518. Full Text Open Access Copy
  - Kulminski, AM, and Culminskaya, I. "Genomics of human health and aging." Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 455-469. Full Text
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Arbeeva, L, and Yashin, AI. "Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations." Rejuvenation research 16, no. 1 (February 2013): 28-34. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Kulminski, A, Akushevich, I, Culminskaya, I, Stallard, E, and Ukraintseva, SV. "How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data." Frontiers in genetics 4 (January 22, 2013): 3-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Kulminski, AM, Akushevich, I, Culminskaya, I, Stallard, E, and Ukraintseva, SV. "How the quality of GWAS of human lifespan and health span can be improved." Frontiers in genetics 4 (January 2013): 125-. Full Text Open Access Copy
  - Yashin, AI, Wu, D, Arbeev, KG, Kulminski, AM, Stallard, E, and Ukraintseva, SV. "Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key." Frontiers in Genetics 4 (January 2013): 75-null. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Ukraintseva, SV, Akushevich, I, and Kulminski, A. "Patterns of Aging-Related changes on the way to 100: An Approach to studying aging, mortality, and longevity from longitudinal data." North American Actuarial Journal 16, no. 4 (December 1, 2012): 403-433. Full Text Open Access Copy
  - Kulminski, A. "Have to or may? Re: Expression of concern re: Kulminski AM (2011). Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome. Exp Gerontol. 46, 979-986." Experimental Gerontology 47, no. 6 (June 1, 2012): 481-482. (Letter) Full Text
  - Yashin, AI, Arbeev, KG, Akushevich, I, Kulminski, A, Ukraintseva, SV, Stallard, E, and Land, KC. "Modeling longitudinal data on health aging and life span." Physics of Life Reviews 9, no. 2 (June 1, 2012): 195-197. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Kulminski, A, Ukraintseva, SV, Stallard, E, and Land, KC. "The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span." Physics of life reviews 9, no. 2 (June 2012): 177-188. Full Text Open Access Copy
  - Kulminski, AM. "Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome." Experimental gerontology 46, no. 12 (December 2011): 979-986. Full Text
  - Yashin, AI, Akushevich, I, Arbeev, KG, Kulminski, A, and Ukraintseva, S. "Joint analysis of health histories, physiological state, and survival." Mathematical Population Studies 18, no. 4 (December 1, 2011): 207-233. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, Ukraintseva, SV, Arbeev, KG, Arbeeva, L, Wu, D, Akushevich, I, Land, KC, and Yashin, AI. "Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan." Aging cell 10, no. 3 (June 2011): 533-541. Full Text Open Access Copy
  - Kulminski, AM, Arbeev, KG, Christensen, K, Mayeux, R, Newman, AB, Province, MA, Hadley, EC, Rossi, W, Perls, TT, Elo, IT, and Yashin, AI. "Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits." Mechanisms of ageing and development 132, no. 4 (April 2, 2011): 195-201. Full Text Open Access Copy
  - Arbeev, KG, Ukraintseva, SV, Arbeeva, LS, Akushevich, I, Kulminski, AM, and Yashin, AI. "Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data." Biogerontology 12, no. 2 (April 2011): 157-166. Full Text Open Access Copy
  - Arbeev, KG, Ukraintseva, SV, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, Culminskaya, IV, and Yashin, AI. "Age trajectories of physiological indices in relation to healthy life course." Mechanisms of Ageing and Development 132, no. 3 (March 2011): 93-102. Full Text Open Access Copy
  - Ukraintseva, SV, Arbeev, KG, Akushevich, I, Kulminski, A, Arbeeva, L, Culminskaya, I, Akushevich, L, and Yashin, AI. "Trade-offs between cancer and other diseases: do they exist and influence longevity?." Rejuvenation research 13, no. 4 (August 2010): 387-396. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Ukraintseva, SV, Kulminski, A, Arbeeva, LS, and Culminskaya, I. "Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data." Biogerontology 11, no. 3 (June 2010): 257-265. Full Text
  - Kulminski, AM, Culminskaya, I, Ukraintseva, SV, Arbeev, KG, Land, KC, and Yashin, AI. "Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context." Mechanisms of ageing and development 131, no. 5 (May 2010): 338-345. Full Text Open Access Copy
  - Yashin, A, Akushevich, I, Ukraintseva, S, Akushevich, L, Arbeev, K, and Kulminski, A. "Trends in survival and recovery from stroke: evidence from the National Long-Term Care Survey/Medicare data." Stroke 41, no. 3 (March 2010): 563-565. (Letter) Full Text
  - Yashin, AI, Arbeev, KG, Kulminski, A, Borecki, I, Christensen, K, Barmada, M, Hadley, E, Rossi, W, Lee, JH, Cheng, R, and Elo, IT. ""Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS)." Mechanisms of ageing and development 131, no. 3 (March 2010): 215-222. Full Text
  - Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, Arbeev, KG, Akushevich, I, Land, KC, and Yashin, AI. "Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction." Rejuvenation research 13, no. 1 (February 2010): 13-21. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Arbeeva, L, Kravchenko, J, Il'yasova, D, Kulminski, A, Akushevich, L, Culminskaya, I, Wu, D, and Ukraintseva, SV. "Dynamic determinants of longevity and exceptional health." Current gerontology and geriatrics research (January 2010). Full Text
  - Kulminski, AM, Molleman, F, Culminskaya, IV, Arbeev, KG, Ukraintseva, SV, Carey, JR, and Yashin, AI. "Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens." Experimental gerontology 44, no. 11 (November 2009): 718-726. Full Text
  - Yashin, AI, Ukraintseva, SV, Arbeev, KG, Akushevich, I, Arbeeva, LS, and Kulminski, AM. "Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it change with age?." Mechanisms of Ageing and Development 130, no. 9 (September 2009): 611-618. Full Text
  - Arbeev, KG, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, Ukraintseva, SV, Culminskaya, IV, and Yashin, AI. "Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data." Journal of theoretical biology 258, no. 1 (May 2009): 103-111. Full Text
  - Yashin, AI, Akushevich, I, Arbeev, K, Akushevich, L, Kulminski, A, and Ukraintseva, S. "Studying health histories of cancer: a new model connecting cancer incidence and survival." Mathematical biosciences 218, no. 2 (April 2009): 88-97. Full Text
  - Kulminski, AM, Arbeev, KG, Culminskaya, IV, Ukraintseva, SV, Christensen, K, and Yashin, AI. "Health-related phenotypes and longevity in danish twins." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 64, no. 1 (January 2009): 1-8. Full Text
  - Yashin, AI, Ukraintseva, SV, Akushevich, IV, Arbeev, KG, Kulminski, A, and Akushevich, L. "Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies." Mechanisms of ageing and development 130, no. 1-2 (January 2009): 98-104. Full Text
  - Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, Arbeev, KG, Land, KC, and Yashin, AI. "Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time." Experimental Gerontology 43, no. 12 (December 2008): 1052-1057. Full Text
  - Kulminski, AM, Ukraintseva, SV, Culminskaya, IV, Arbeev, KG, Land, KC, Akushevich, L, and Yashin, AI. "Cumulative deficits and physiological indices as predictors of mortality and long life." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 63, no. 10 (October 2008): 1053-1059. Full Text
  - Kulminski, AM, Arbeev, KG, Ukraintseva, SV, Culminskaya, IV, Land, K, and Yashin, AI. "Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits." Annals of Epidemiology 18, no. 9 (September 2008): 696-701. Full Text
  - Manton, KG, Akushevich, I, and Kulminski, A. "Human mortality at extreme ages: Data from the NLTCS and linked medicare records." Mathematical Population Studies 15, no. 3 (July 1, 2008): 137-159. Full Text
  - Kulminski, A, Ukraintseva, SV, Arbeev, KG, Manton, KG, Oshima, J, Martin, GM, and Yashin, AI. "Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample." Age and Ageing 37, no. 3 (May 2008): 288-293. Full Text
  - Kulminski, AM, Ukraintseva, SV, Kulminskaya, IV, Arbeev, KG, Land, K, and Yashin, AI. "Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study." Journal of the American Geriatrics Society 56, no. 5 (May 2008): 898-903. Full Text
  - Yashin, AI, Arbeev, KG, Kulminski, A, Akushevich, I, Akushevich, L, and Ukraintseva, SV. "What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare data." Mechanisms of Ageing and Development 129, no. 4 (April 2008): 191-200. Full Text
  - Kulminski, AM, Ukraintseva, SV, Arbeev, KG, Manton, KG, Oshima, J, Martin, GM, Il'yasova, D, and Yashin, AI. "Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men." Journal of the American Geriatrics Society 56, no. 3 (March 2008): 478-483. Full Text
  - Kulminski, AM, Kulminskaya, IV, Ukraintseva, SV, Land, K, and Yashin, AI. "An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey." Rejuvenation Research 11, no. 1 (February 2008): 251-257. Full Text
  - Yashin, AI, Arbeev, KG, Akushevich, I, Kulminski, A, Akushevich, L, and Ukraintseva, SV. "Model of hidden heterogeneity in longitudinal data." Theoretical Population Biology 73, no. 1 (February 2008): 1-10. Full Text
  - Kulminski, AM, Arbeev, KG, Kulminskaya, IV, Ukraintseva, SV, Land, K, Akushevich, I, and Yashin, AI. "Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals." Journal of the American Geriatrics Society 56, no. 1 (January 2008): 105-110. Full Text
  - Kulminski, A, Ukraintseva, SV, Akushevich, I, Arbeev, KG, Land, K, and Yashin, AI. "Accelerated accumulation of health deficits as a characteristic of aging." Experimental Gerontology 42, no. 10 (October 2007): 963-970. Full Text
  - Kulminski, AM, Ukraintseva, SV, and Yashin, AI. "The apolipoprotein E epsilon2 allele and aging-associated health deterioration in older males." Journal of the American Geriatrics Society 55, no. 9 (September 2007): 1479-1480. (Letter) Full Text
  - Yashin, AI, Arbeev, KG, Akushevich, I, Kulminski, A, Akushevich, L, and Ukraintseva, SV. "Stochastic model for analysis of longitudinal data on aging and mortality." Mathematical Biosciences 208, no. 2 (August 2007): 538-551. Full Text
  - Kulminski, AM, Ukraintseva, SV, Akushevich, IV, Arbeev, KG, and Yashin, AI. "Cumulative index of health deficiencies as a characteristic of long life." Journal of the American Geriatrics Society 55, no. 6 (June 2007): 935-940. Full Text
  - Yashin, AI, Arbeev, KG, Kulminski, A, Akushevich, I, Akushevich, L, and Ukraintseva, SV. "Health decline, aging and mortality: how are they related?." Biogerontology 8, no. 3 (June 2007): 291-302. Full Text
  - Kulminski, A, Yashin, A, Arbeev, K, Akushevich, I, Ukraintseva, S, Land, K, and Manton, K. "Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey." Mechanisms of Ageing and Development 128, no. 3 (March 2007): 250-258. Full Text
  - Yashin, AI, Arbeev, KG, Kulminski, A, Akushevich, I, Akushevich, L, and Ukraintseva, SV. "Cumulative index of elderly disorders and its dynamic contribution to mortality and longevity." Rejuvenation Research 10, no. 1 (March 2007): 75-86. Full Text
  - Yashin, AI, Akushevich, IV, Arbeev, KG, Akushevich, L, Ukraintseva, SV, and Kulminski, A. "Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study." Age (Dordrecht, Netherlands) 28, no. 4 (December 2006): 363-374. Full Text
  - Akushevich, I, Manton, KG, Kulminski, A, Kovtun, M, Kravchenko, J, and Yashin, A. "Population models for the health effects of ionizing radiation." Radiatsionnaia biologiia, radioecologiia 46, no. 6 (November 2006): 663-674. (Review)
  - Kulminski, A, Yashin, A, Ukraintseva, S, Akushevich, I, Arbeev, K, Land, K, and Manton, K. "Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data." Mechanisms of Ageing and Development 127, no. 11 (November 2006): 840-848. Full Text
  - Manton, KG, Kulminski, A, Akushevich, I, and Kravchenko, J. "Modeling the effects of biologically incorporated radionuclides and chronic low-dose ionizing radiation exposure on both cancer and chronic non-cancer diseases." Radiatsionnaia biologiia, radioecologiia 46, no. 6 (November 2006): 675-686.
  - Akushevich, I, Kulminski, A, and Manton, KG. "Life tables with covariates: Dynamic model for nonlinear analysis of longitudinal data." Mathematical Population Studies 12, no. 2 (April 1, 2005): 51-80. Full Text
  - Kulminski, A, Manton, K, Akushevich, I, and Yashin, A. "The effect of the organisms' body size and energy reserves in models for population dynamics." Journal of Biological Systems 12, no. 4 (December 1, 2004): 419-437. Full Text
  - Manton, KG, Volovik, S, and Kulminski, A. "ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation." Current Alzheimer Research 1, no. 4 (November 2004): 277-293. (Review) Full Text
  - Manton, KG, Akushevich, I, and Kulminski, A. "Demographic analysis and modeling of human populations exposed to ionizing radiation." Frontiers in Bioscience : a Journal and Virtual Library 9 (September 2004): 2144-2152. Full Text
  - Kulminski, A, Akushevich, I, and Manton, K. "Modeling nonlinear effects in longitudinal survival data: implications for the physiological dynamics of biological systems." Frontiers in bioscience : a journal and virtual library 9 (January 2004): 481-493. (Review) Full Text
  - Doherty, A, Kernogitski, Y, Kulminski, AM, and Pedro de Magalhães, J. "Identification of polymorphisms in cancer patients that differentially affect survival with age (Published online)." Aging . Full Text
- Book Sections
  - Yashin, AI, Akushevich, I, Arbeev, K, Kulminski, A, and Ukraintseva, S. "Methodological aspects of studying human aging, health, and mortality." In Applied Demography and Public Health, 337-355. January 1, 2013. Full Text
- Conference Papers
  - "GENETIC PREDISPOSITION TO AGE-RELATED PHENOTYPES IN THE LIGHT OF EVOLUTION." : Oxford University Press (OUP), November 2016. Full Text
  - "PLEIOTROPIC META-ANALYSIS IDENTIFIES SHARED GENETIC CONNECTIONS BETWEEN DISTINCT AGE-RELATED TRAITS." : Oxford University Press (OUP), November 2016. Full Text
  - "GENES WITH PLEIOTROPIC EFFECTS ON AGING-RELATED TRAITS IN HUMANS." : Oxford University Press (OUP), November 2016. Full Text
  - "A NOVEL ALLELIC VARIANT IN A 2Q22 REGION CONFERS RISKS OF MAJOR HUMAN DISEASES AND MORTALITY." : Oxford University Press (OUP), November 2016. Full Text
  - Arbeev, KG, Arbeeva, LS, Zhbannikov, IY, Bagley, O, Akushevich, I, Kovtun, M, Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, and Yashin, AI. "High-Resolution Analyses of Effects of Polygenic Risk Scores on Time-to-Event Outcomes in Longitudinal Studies." November 2016. Link to Item
  - Loika, Y, Kernogitski, Y, Culminskaya, I, He, L, Huang, J, Loiko, E, and Kulminski, A. "Extensive Pleiotropy with Age-Related Disease Traits: The Candidate Gene Association Resource." November 2016. Link to Item
  - Yashin, AI, Arbeev, KG, Arbeeva, LS, Wu, D, Akushevich, I, Kulminski, A, Kovtun, M, Zhbannikov, I, and Ukraintseva, SV. "Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity." March 11, 2016. Full Text Open Access Copy
  - "GENETIC HETEROGENEITY AND ITS ROLE IN GWAS OF HUMAN AGING AND LONGEVITY." : Oxford University Press (OUP), November 2015. Full Text
  - "BIODEMOGRAPHIC APPROACHES TO ANALYSES OF POLYGENETIC EFFECTS ON MORTALITY AND AGING." : Oxford University Press (OUP), November 2015. Full Text
  - "PLEIOTROPIC EFFECTS OF GENES ON AGE-RELATED PHENOTYPES: INSIGHTS FROM GERONTOLOGICAL APPROACHES." : Oxford University Press (OUP), November 2015. Full Text
  - "PLEIOTROPIC EFFECTS OF GENES ON PHENOTYPES OF AGING, COMPLEX DISEASE AND LONGEVITY." : Oxford University Press (OUP), November 2015. Full Text
  - "THE ROLE OF BIODEMOGRAPHIC FACTORS IN GENETICS OF AGE-RELATED PHENOTYPES." : Oxford University Press (OUP), November 2015. Full Text
  - Arbeev, KG, Arbeeva, LS, Bagley, O, Duan, H, Akushevich, I, Kulminski, AM, Kovtun, M, Culminskaya, IV, Wu, D, Ukraintseva, SV, and Yashin, AI. "On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies." November 2015. Link to Item
  - Kulminski, AM, Loika, Y, Culminskaya, I, Arbeev, KG, and Yashin, AI. "Unfolding heterogeneity of complex traits has strong potential for advancing GWAS." November 2015. Link to Item
  - Arbeev, KG, Ukraintseva, SV, Kulminski, AM, Arbeeva, LS, Akushevich, I, Culminskaya, IV, Wu, D, and Yashin, AI. "Relationship Between the APOE Polymorphism and Risks of Cancer and Alzheimer's Disease: Application of the Genetic Stochastic Process Model." November 2012. Link to Item
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Arbeeva, L, and Yashin, AI. "The Role of Genes and Life Course in Late Life Diseases." Annual Meeting of the International-Genetic-Epidemiology-Society (IGES). Stevenson, WA. October 18, 2012 - October 20, 2012.: WILEY-BLACKWELL, November 1, 2012. Link to Item
  - Kulminski, AM, Culminskaya, I, and Yashin, AI. "Developmental Processes can Drive Inter-chromosomal Linkage Disequilibrium." November 2012. Link to Item
  - Arbeev, KG, Kulminski, A, Ukraintseva, SV, Arbeeva, LS, Akushevich, I, Culminskaya, IV, Wu, D, and Yashin, AI. "Trade-Off In The Effects Of The APOE Polymorphism On The Ages At Onset Of CVD And Cancer: Insights From The Genetic Stochastic Process Model." February 2012. Link to Item
  - Kulminski, A, Culminskaya, I, Ukraintseva, S, Arbeev, K, and Yashin, A. "Complex Modalities Of Gene Action On Phenotypes With Post Reproductive Manifestation: The Case Of Genetic Trade-Off." February 2012. Link to Item
  - Kulminski, A, and Culminskaya, I. "Heritable Late Life Phenotypes and Inter-Chromosomal Linkage Disequilibrium in the Human Genome." February 2012. Link to Item
  - Kulminski, A. "AGING-RELATED PHENOTYPES AND INTER-CHROMOSOMAL LINKAGE DISEQUILIBRIUM IN THE HUMAN GENOME." November 2011. Link to Item
  - Arbeev, KG, Ukraintseva, SV, Arbeeva, LS, Akushevich, I, Kulminski, AM, Wu, D, and Yashin, AI. "Evaluation of Effects of Genetic polymorphisms and Age Trajectories of Physiological Indices on survival." December 2010. Link to Item
  - Arbeev, KG, Ukraintseva, SV, Arbeeva, LS, Kulminski, AM, Akushevich, I, and Yashin, AI. "Evaluation of Genotype-specific Age Patterns of Hazard Rates Using Joint Analysis of Genetic and Non-genetic Subsamples of Longitudinal Data." December 2009. Link to Item
  - Kulminski, A, Ukraintseva, S, Arbeev, K, Culminskaya, I, and Yashin, A. "Polymorphisms in the Angiotensin-Converting Enzyme (ACE) Gene as Determinants of Cardiovascular Diseases Risks and Short Life in Framingham Heart Study." December 2009. Link to Item
  - Kulminski, A, Ukraintseva, S, Culminskaya, I, Arbeev, K, Akushevich, I, and Yashin, A. "The Role of Polymorphisms in the ACE and ADRB2 Genes in Incidence of Myocardial Infarction in Framingham Heart Study Participants." December 2009. Link to Item
  - Arbeev, KG, Yashin, AI, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, and Ukraintseva, SV. "Stochastic Model for Joint Analysis of Genetic and Non-Genetic Data from Longitudinal Studies of Aging, Health and Longevity." November 2008. Link to Item
  - Yashin, AI, Culminskaya, IV, Arbeev, KG, Ukraintseva, SV, Akushevich, I, and Kulminski, A. "Effects of ACE D/I Polymorphism and 11 SNPs Heterozygosity in the Same Gene on Health Risks in Framingham Study." 17th Annual Meeting of the International-Genetic-Epidemiology-Society. St Louis, MO. September 14, 2008 - September 16, 2008.: WILEY, November 1, 2008. Link to Item
  - Yashin, AI, Ukraintseva, SV, Arbeev, KG, Culminskaya, IV, Akushevich, I, and Kulminski, A. "Interacting Effect of ACE D/I Polymorphism and Smoking on Health Risks in Framingham Study." 17th Annual Meeting of the International-Genetic-Epidemiology-Society. St Louis, MO. September 14, 2008 - September 16, 2008.: WILEY, November 1, 2008. Link to Item
  - Mitnitski, A, Rockwood, K, Kulminski, A, Yashin, A, Gavrilov, L, and Martin, G. "SYSTEM BIOLOGY OF AGING: QUANTITATIVE ASPECTS AND A MODELING PERSPECTIVE." October 2008. Link to Item

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