Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., The National Academy of Sciences of Belarus (Republic of Belarus) 1991
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  Previous Appointments & Affiliations

  • Associate Research Professor in the Social Science Research Institute, Social Science Research Institute, University Institutes and Centers 2016 - 2021
• Recognition
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  In the News

  • SEP 24, 2019

    Duke Research Blog

    Alzheimer's Has Many Causes. Research Needs to Be Broader
• Research
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  Selected Grants

  • Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context awarded by National Institutes of Health 2020 - 2025
  • Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases awarded by National Institutes of Health 2020 - 2025
  • Genetics of aging, health and longevity: focus on regulatory mechanisms and functional variants connecting aging and Alzheimer's disease" awarded by National Institutes of Health 2020 - 2024
  • Analysis: The Long Life Family Study awarded by Washington University in St. Louis 2019 - 2024
  • Project 1: The Long Life Family Study awarded by Washington University in St. Louis 2019 - 2024
  • ApoE2 and protective molecular signatures in Alzheimer's disease and aging awarded by National Institutes of Health 2018 - 2023
  • Life Course and Genetic and Non-genetic Factors in Health and Survival awarded by National Institutes of Health 2015 - 2021
  • Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center awarded by National Institutes of Health 2004 - 2019
  • Integrating Population and Basic Science in Cancer Research awarded by National Institutes of Health 2009 - 2015
  • The Future of Major Geriatric Disorders in the US Elderly awarded by National Institutes of Health 2008 - 2013
  • Evaluating New Genetic Effects on Health and Aging from Longitudinal Data awarded by National Institutes of Health 2007 - 2013
  • New Methods of Studying Aging, Health and Longevity: Combining Longitudinal Data awarded by National Institutes of Health 2009 - 2011
  • missing activity
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • He, Liang, Ian Philipp, Stephanie Webster, Jacob V. B. Hjelmborg, and Alexander M. Kulminski. “A robust and fast two-sample test of equal correlations with an application to differential co-expression.” Statistics in Medicine, April 2023. https://doi.org/10.1002/sim.9747.
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    • Nazarian, Alireza, Ian Philipp, Irina Culminskaya, Liang He, and Alexander M. Kulminski. “Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.” Geroscience 45, no. 1 (February 2023): 233–47. https://doi.org/10.1007/s11357-022-00617-0.
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    • Kulminski, Alexander M., Ethan Jain-Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, et al. “APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.” Aging Cell 21, no. 12 (December 2022): e13730. https://doi.org/10.1111/acel.13730.
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    • Kulminski, Alexander M., Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, and Irina Alzheimer’s Disease Neuroimaging Initiative. “Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers.” Aging 14, no. 24 (November 2022): 9782–9804. https://doi.org/10.18632/aging.204384.
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    • Nazarian, Alireza, Yury Loika, Liang He, Irina Culminskaya, and Alexander M. Kulminski. “Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk.” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 18, no. 11 (November 2022): 2067–78. https://doi.org/10.1002/alz.12540.
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    • Nazarian, Alireza, Konstantin G. Arbeev, Arseniy P. Yashkin, and Alexander M. Kulminski. “Genome-wide analysis of genetic predisposition to common polygenic cancers.” Journal of Applied Genetics 63, no. 2 (May 2022): 315–25. https://doi.org/10.1007/s13353-021-00679-4.
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    • He, Liang, Yury Loika, and Alexander M. Kulminski. “Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer's disease-associated genetic variants.” Translational Psychiatry 12, no. 1 (April 2022): 163. https://doi.org/10.1038/s41398-022-01913-1.
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    • Loika, Yury, Fan Feng, Elena Loiko, and Alexander M. Kulminski. “Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids.” Geroscience 44, no. 2 (April 2022): 1141–56. https://doi.org/10.1007/s11357-021-00458-3.
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    • Wojczynski, Mary K., Shiow Jiuan Lin, Paola Sebastiani, Thomas T. Perls, Joseph Lee, Alexander Kulminski, Anne Newman, Joe M. Zmuda, Kaare Christensen, and Michael A. Province. “NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 77, no. 4 (April 2022): 717–27. https://doi.org/10.1093/gerona/glab333.
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    • Kulminski, Alexander M., Elena Loiko, Yury Loika, and Irina Culminskaya. “Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis.” Geroscience 44, no. 1 (February 2022): 265–80. https://doi.org/10.1007/s11357-021-00484-1.
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    • Kulminski, Alexander M., Ian Philipp, Leonardo Shu, and Irina Culminskaya. “Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk.” Neurobiology of Aging 110 (February 2022): 122–31. https://doi.org/10.1016/j.neurobiolaging.2021.09.009.
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    • Nazarian, Alireza, Elena Loiko, Hussein N. Yassine, Caleb E. Finch, and Alexander M. Kulminski. “APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3.” Frontiers in Aging Neuroscience 14 (January 2022): 1023493. https://doi.org/10.3389/fnagi.2022.1023493.
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    • Kulminski, A. M., I. Philipp, L. Shu, and I. Kulminskaya. “The ε4-bearing TOMM40-APOE-APOC1 haplotype but not the ε4 allele confers an exceptionally high risk of Alzheimer's disease.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association 17 (December 1, 2021): e050617. https://doi.org/10.1002/alz.050617.
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    • Kulminski, Alexander M., Ian Philipp, Yury Loika, Liang He, and Irina Culminskaya. “Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men.” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 17, no. 11 (November 2021): 1779–87. https://doi.org/10.1002/alz.12413.
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    • Feitosa, Mary F., Allison L. Kuipers, Mary K. Wojczynski, Lihua Wang, Emma Barinas-Mitchell, Alexander M. Kulminski, Bharat Thyagarajan, et al. “Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments.” Circulation. Genomic and Precision Medicine 14, no. 3 (June 2021): e003201. https://doi.org/10.1161/circgen.120.003201.
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    • He, Liang, Jose Davila-Velderrain, Tomokazu S. Sumida, David A. Hafler, Manolis Kellis, and Alexander M. Kulminski. “NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data.” Communications Biology 4, no. 1 (May 2021): 629. https://doi.org/10.1038/s42003-021-02146-6.
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    • Nazarian, Alireza, and Alexander M. Kulminski. “Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers.” Genes 12, no. 5 (May 2021): 686. https://doi.org/10.3390/genes12050686.
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    • Ukraintseva, Svetlana, Konstantin Arbeev, Matt Duan, Igor Akushevich, Alexander Kulminski, Eric Stallard, and Anatoliy Yashin. “Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.” Mechanisms of Ageing and Development 194 (March 2021): 111418. https://doi.org/10.1016/j.mad.2020.111418.
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    • He, Liang, Yury Loika, Yongjin Park, Yongjin Genotype Tissue Expression (GTEx) consortium, David A. Bennett, Manolis Kellis, Alexander M. Kulminski, and Alexander M. Alzheimer’s Disease Neuroimaging Initiative. “Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.” Translational Psychiatry 11, no. 1 (February 2021): 146. https://doi.org/10.1038/s41398-021-01263-4.
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    • Ukraintseva, Svetlana, Matt Duan, Konstantin Arbeev, Deqing Wu, Olivia Bagley, Arseniy P. Yashkin, Galina Gorbunova, Igor Akushevich, Alexander Kulminski, and Anatoliy Yashin. “Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.” Frontiers in Cell and Developmental Biology 9 (January 2021): 692020. https://doi.org/10.3389/fcell.2021.692020.
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    • Loika, Yury, Irina Irincheeva, Irina Culminskaya, Alireza Nazarian, and Alexander M. Kulminski. “Polygenic risk scores: pleiotropy and the effect of environment.” Geroscience 42, no. 6 (December 2020): 1635–47. https://doi.org/10.1007/s11357-020-00203-2.
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    • Kulminski, Alexander M., Yury Loika, Alireza Nazarian, and Irina Culminskaya. “Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 10 (September 2020): 1811–19. https://doi.org/10.1093/gerona/glz225.
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    • He, Liang, and Alexander M. Kulminski. “Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models.” Genetics 215, no. 1 (May 2020): 41–58. https://doi.org/10.1534/genetics.119.302940.
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    • Nazarian, Alireza, Anatoliy I. Yashin, and Alexander M. Kulminski. “Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer's Disease.” Journal of Clinical Medicine 9, no. 5 (May 2020): E1489. https://doi.org/10.3390/jcm9051489.
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    • Arbeev, Konstantin G., Olivia Bagley, Svetlana V. Ukraintseva, Deqing Wu, Hongzhe Duan, Alexander M. Kulminski, Eric Stallard, et al. “Genetics of physiological dysregulation: findings from the long life family study using joint models.” Aging 12, no. 7 (April 2020): 5920–47. https://doi.org/10.18632/aging.102987.
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    • Kulminski, Alexander M., Leonardo Shu, Yury Loika, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, and Irina Culminskaya. “APOE region molecular signatures of Alzheimer's disease across races/ethnicities.” Neurobiology of Aging 87 (March 2020): 141.e1-141.e8. https://doi.org/10.1016/j.neurobiolaging.2019.11.007.
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    • Nazarian, Alireza, Konstantin G. Arbeev, and Alexander M. Kulminski. “The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees.” Journal of Applied Genetics 61, no. 1 (February 2020): 75–86. https://doi.org/10.1007/s13353-019-00526-7.
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    • Arbeev, Konstantin G., Olivia Bagley, Svetlana V. Ukraintseva, Hongzhe Duan, Alexander M. Kulminski, Eric Stallard, Deqing Wu, et al. “Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.” Frontiers in Public Health 8 (January 2020): 56. https://doi.org/10.3389/fpubh.2020.00056.
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    • Kulminski, Alexander M., Ian Philipp, Yury Loika, Liang He, and Irina Culminskaya. “Haplotype architecture of the Alzheimer's risk in the APOE region via co-skewness.” Alzheimer’S & Dementia (Amsterdam, Netherlands) 12, no. 1 (January 2020): e12129. https://doi.org/10.1002/dad2.12129.
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    • Kulminski, Alexander M., Leonardo Shu, Yury Loika, Liang He, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, and Irina Culminskaya. “Genetic and regulatory architecture of Alzheimer's disease in the APOE region.” Alzheimer’S & Dementia (Amsterdam, Netherlands) 12, no. 1 (January 2020): e12008. https://doi.org/10.1002/dad2.12008.
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    • Kulminski, Alexander M., Chansuk Kang, Stanislav A. Kolpakov, Yury Loika, Alireza Nazarian, Anatoliy I. Yashin, Eric Stallard, and Irina Culminskaya. “Polygenic risk score for disability and insights into disability-related molecular mechanisms.” Geroscience 41, no. 6 (December 2019): 881–93. https://doi.org/10.1007/s11357-019-00125-8.
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    • Kuipers, Allison L., Mary K. Wojczynski, Emma Barinas-Mitchell, Ryan L. Minster, Lihua Wang, Mary F. Feitosa, Alexander Kulminski, et al. “Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families.” Atherosclerosis 291 (December 2019): 19–26. https://doi.org/10.1016/j.atherosclerosis.2019.10.008.
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    • Finch, Caleb E., and Alexander M. Kulminski. “The Alzheimer's Disease Exposome.” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 15, no. 9 (September 2019): 1123–32. https://doi.org/10.1016/j.jalz.2019.06.3914.
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    • Nazarian, Alireza, Konstantin G. Arbeev, Arseniy P. Yashkin, and Alexander M. Kulminski. “Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.” Geroscience 41, no. 2 (April 2019): 137–54. https://doi.org/10.1007/s11357-019-00071-5.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Olivia Bagley, Ilya Y. Zhbannikov, Alan A. Cohen, Alexander M. Kulminski, and Anatoliy I. Yashin. “"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74, no. 4 (March 2019): 462–68. https://doi.org/10.1093/gerona/gly136.
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    • Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Mary F. Feitosa, et al. “Independent associations of TOMM40 and APOE variants with body mass index.” Aging Cell 18, no. 1 (February 2019): e12869. https://doi.org/10.1111/acel.12869.
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    • Kulminski, Alexander M., Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, and Irina Culminskaya. “Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms.” Frontiers in Genetics 10 (January 2019): 433. https://doi.org/10.3389/fgene.2019.00433.
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    • Nazarian, Alireza, Anatoliy I. Yashin, and Alexander M. Kulminski. “Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.” Alzheimer’S Research & Therapy 11, no. 1 (January 2019): 5. https://doi.org/10.1186/s13195-018-0458-8.
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    • Nazarian, Alireza, and Alexander M. Kulminski. “Evaluation of the Genetic Variance of Alzheimer's Disease Explained by the Disease-Associated Chromosomal Regions.” Journal of Alzheimer’S Disease : Jad 70, no. 3 (January 2019): 907–15. https://doi.org/10.3233/jad-190168.
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    • Wolters, Frank J., Qiong Yang, Mary L. Biggs, Johanna Jakobsdottir, Shuo Li, Daniel S. Evans, Joshua C. Bis, et al. “The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE).” Plos One 14, no. 7 (January 2019): e0219668. https://doi.org/10.1371/journal.pone.0219668.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Olivia Bagley, Eric Stallard, Alexander M. Kulminski, et al. “Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 73, no. 11 (October 2018): 1472–81. https://doi.org/10.1093/gerona/gly057.
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    • Kulminski, Alexander M., Jian Huang, Jiayi Wang, Liang He, Yury Loika, and Irina Culminskaya. “Apolipoprotein E region molecular signatures of Alzheimer's disease.” Aging Cell 17, no. 4 (August 2018): e12779. https://doi.org/10.1111/acel.12779.
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    • He, Liang, Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, Anatoliy I. Yashin, and Alexander M. Kulminski. “Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.” Experimental Gerontology 107 (July 2018): 74–86. https://doi.org/10.1016/j.exger.2017.09.019.
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    • Yashin, Anatoliy I., Fang Fang, Mikhail Kovtun, Deqing Wu, Matt Duan, Konstantin Arbeev, Igor Akushevich, et al. “Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.” Experimental Gerontology 107 (July 2018): 148–60. https://doi.org/10.1016/j.exger.2017.10.020.
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    • Kulminski, Alexander M., Jian Huang, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Arseniy Yashkin, Matt Duan, and Irina Culminskaya. “Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.” Aging 10, no. 3 (March 2018): 492–514. https://doi.org/10.18632/aging.101407.
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    • Arbeeva, Liubov S., Heidi A. Hanson, Konstantin G. Arbeev, Alexander M. Kulminski, Eric Stallard, Svetlana V. Ukraintseva, Deqing Wu, et al. “How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database.” Frontiers in Public Health 6 (January 2018): 277. https://doi.org/10.3389/fpubh.2018.00277.
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    • Kulminski, Alexander M., Amisha V. Barochia, Yury Loika, Nalini Raghavachari, Konstantin G. Arbeev, Mary K. Wojczynski, Bharat Thyagarajan, et al. “The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study.” Plos One 13, no. 11 (January 2018): e0206873. https://doi.org/10.1371/journal.pone.0206873.
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    • He, Liang, Ilya Zhbannikov, Konstantin G. Arbeev, Anatoliy I. Yashin, and Alexander M. Kulminski. “A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.” Genetic Epidemiology 41, no. 7 (November 2017): 620–35. https://doi.org/10.1002/gepi.22058.
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    • Doherty, Aoife, Yelena Kernogitski, Alexander M. Kulminski, and João Pedro de Magalhães. “Identification of polymorphisms in cancer patients that differentially affect survival with age.” Aging 9, no. 10 (October 2017): 2117–36. https://doi.org/10.18632/aging.101305.
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    • Kulminski, Alexander M., Yelena Kernogitski, Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, et al. “Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.” Aging Cell 16, no. 1 (February 2017): 61–72. https://doi.org/10.1111/acel.12526.
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    • Moskalev, Alexey, Vladimir Anisimov, Aleksander Aliper, Artem Artemov, Khusru Asadullah, Daniel Belsky, Ancha Baranova, et al. “A review of the biomedical innovations for healthy longevity.” Aging 9, no. 1 (January 2017): 7–25. https://doi.org/10.18632/aging.101163.
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    • He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 8 (January 2017): 226. https://doi.org/10.3389/fgene.2017.00226.
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    • Kulminski, Alexander M., Nalini Raghavachari, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Deqing Wu, Svetlana V. Ukraintseva, Kaare Christensen, and Anatoliy I. Yashin. “Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.” Biogerontology 17, no. 5–6 (November 2016): 893–905. https://doi.org/10.1007/s10522-016-9659-3.
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    • Kulminski, Alexander M., Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G. Arbeev, Elena Loiko, et al. “Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.” Plos Genetics 12, no. 11 (November 2016): e1006314. https://doi.org/10.1371/journal.pgen.1006314.
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    • Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Eric Stallard, and Anatoliy I. Yashin. “Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.” Scientific Reports 6 (October 2016): 35390. https://doi.org/10.1038/srep35390.
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    • Ukraintseva, Svetlana, Anatoliy Yashin, Konstantin Arbeev, Alexander Kulminski, Igor Akushevich, Deqing Wu, Gaurang Joshi, Kenneth C. Land, and Eric Stallard. “Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.” Biogerontology 17, no. 1 (February 2016): 109–27. https://doi.org/10.1007/s10522-015-9600-1.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Liubov S. Arbeeva, Deqing Wu, Igor Akushevich, Mikhail Kovtun, Arseniy Yashkin, et al. “How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.” Biogerontology 17, no. 1 (February 2016): 89–107. https://doi.org/10.1007/s10522-015-9594-8.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov Arbeeva, Alexander Kulminski, Irina Kulminskaya, Igor Akushevich, and Svetlana V. Ukraintseva. “How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.” North American Actuarial Journal : Naaj 20, no. 3 (January 2016): 201–32. https://doi.org/10.1080/10920277.2016.1178588.
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    • Arbeev, Konstantin G., Alan A. Cohen, Liubov S. Arbeeva, Emmanuel Milot, Eric Stallard, Alexander M. Kulminski, Igor Akushevich, Svetlana V. Ukraintseva, Kaare Christensen, and Anatoliy I. Yashin. “Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.” Frontiers in Public Health 4 (January 2016): 3. https://doi.org/10.3389/fpubh.2016.00003.
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    • He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 7 (January 2016): 179. https://doi.org/10.3389/fgene.2016.00179.
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    • Yashin, Anatoliy I., Ilya Zhbannikov, Liubov Arbeeva, Konstantin G. Arbeev, Deqing Wu, Igor Akushevich, Arseniy Yashkin, et al. “Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.” Frontiers in Genetics 7 (January 2016): 188. https://doi.org/10.3389/fgene.2016.00188.
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    • Kulminski, Alexander M., Konstantin G. Arbeev, Irina Culminskaya, Svetlana V. Ukraintseva, Eric Stallard, Michael A. Province, and Anatoli I. Yashin. “Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.” Rejuvenation Research 18, no. 2 (April 2015): 128–35. https://doi.org/10.1089/rej.2014.1616.
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    • Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Deqing Wu, and Anatoliy I. Yashin. “Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.” Plos One 10, no. 8 (January 2015): e0136319. https://doi.org/10.1371/journal.pone.0136319.
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    • Yashin, Anatoliy I., Deqing Wu, Liubov S. Arbeeva, Konstantin G. Arbeev, Alexander M. Kulminski, Igor Akushevich, Mikhail Kovtun, et al. “Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.” Frontiers in Genetics 6 (January 2015): 122. https://doi.org/10.3389/fgene.2015.00122.
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    • Kulminski, Alexander, Irina Culminskaya, and Anatoli I. Yashin. “Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed.” Age (Dordrecht, Netherlands) 36, no. 2 (April 2014): 945–47. https://doi.org/10.1007/s11357-013-9602-3.
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    • Arbeev, Konstantin G., Igor Akushevich, Alexander M. Kulminski, Svetlana V. Ukraintseva, and Anatoliy I. Yashin. “Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.” Frontiers in Public Health 2 (January 2014): 228. https://doi.org/10.3389/fpubh.2014.00228.
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    • Kulminski, A. M., K. G. Arbeev, I. Culminskaya, L. Arbeeva, S. V. Ukraintseva, E. Stallard, K. Christensen, N. Schupf, M. A. Province, and A. I. Yashin. “Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan.” Plos Genetics 10, no. 1 (January 1, 2014). https://doi.org/10.1371/journal.pgen.1004141.
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    • Akushevich, Igor, Julia Kravchenko, Svetlana Ukraintseva, Konstantin Arbeev, Alexander Kulminski, and Anatoliy I. Yashin. “Morbidity risks among older adults with pre-existing age-related diseases.” Exp Gerontol 48, no. 12 (December 2013): 1395–1401. https://doi.org/10.1016/j.exger.2013.09.005.
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    • Kulminski, Alexander M. “Unraveling genetic origin of aging-related traits: evolving concepts.” Rejuvenation Research 16, no. 4 (August 2013): 304–12. https://doi.org/10.1089/rej.2013.1441.
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    • Kulminski, Alexander M., Konstantin G. Arbeev, Kaare Christensen, Eric Stallard, Iva Miljkovic, Michael Barmada, and Anatoliy I. Yashin. “Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.” J Gerontol a Biol Sci Med Sci 68, no. 7 (July 2013): 760–68. https://doi.org/10.1093/gerona/gls243.
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    • Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Eric Stallard, Liubov Arbeeva, and Anatoli I. Yashin. “The role of lipid-related genes, aging-related processes, and environment in healthspan.” Aging Cell 12, no. 2 (April 2013): 237–46. https://doi.org/10.1111/acel.12046.
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    • Kulminski, Alexander M., Irina Culminskaya, and Anatoli I. Yashin. “Inter-chromosomal level of genome organization and longevity-related phenotypes in humans.” Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 501–18. https://doi.org/10.1007/s11357-011-9374-6.
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    • Kulminski, Alexander M., and Irina Culminskaya. “Genomics of human health and aging.” Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 455–69. https://doi.org/10.1007/s11357-011-9362-x.
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    • Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Liubov Arbeeva, and Anatoli I. Yashin. “Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.” Rejuvenation Research 16, no. 1 (February 2013): 28–34. https://doi.org/10.1089/rej.2012.1362.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, Alexander M. Kulminski, Eric Stallard, and Svetlana V. Ukraintseva. “Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key.” Frontiers in Genetics 4 (January 2013): 75. https://doi.org/10.3389/fgene.2013.00075.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander M. Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How the quality of GWAS of human lifespan and health span can be improved.” Frontiers in Genetics 4 (January 2013): 125. https://doi.org/10.3389/fgene.2013.00125.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.” Frontiers in Genetics 4 (January 2013): 3. https://doi.org/10.3389/fgene.2013.00003.
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    • Yashin, A. I., K. G. Arbeev, S. V. Ukraintseva, I. Akushevich, and A. Kulminski. “Patterns of Aging-Related changes on the way to 100: An Approach to studying aging, mortality, and longevity from longitudinal data.” North American Actuarial Journal 16, no. 4 (December 1, 2012): 403–33. https://doi.org/10.1080/10920277.2012.10597640.
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    • Yashin, A. I., K. G. Arbeev, I. Akushevich, A. Kulminski, S. V. Ukraintseva, E. Stallard, and K. C. Land. “Modeling longitudinal data on health aging and life span.” Physics of Life Reviews 9, no. 2 (June 1, 2012): 195–97. https://doi.org/10.1016/j.plrev.2012.05.018.
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    • Yashin, A. I., K. G. Arbeev, I. Akushevich, A. Kulminski, S. V. Ukraintseva, E. Stallard, and K. C. Land. “The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span.” Physics of Life Reviews 9, no. 2 (June 2012): 177–88. https://doi.org/10.1016/j.plrev.2012.05.002.
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    • Kulminski, A. “Have to or may? Re: Expression of concern re: Kulminski AM (2011). Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome. Exp Gerontol. 46, 979-986.” Experimental Gerontology 47, no. 6 (June 1, 2012): 481–82. https://doi.org/10.1016/j.exger.2012.03.009.
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    • Yashin, A. I., I. Akushevich, K. G. Arbeev, A. Kulminski, and S. Ukraintseva. “Joint analysis of health histories, physiological state, and survival.” Mathematical Population Studies 18, no. 4 (December 1, 2011): 207–33. https://doi.org/10.1080/08898480.2011.614486.
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    • Kulminski, Alexander M. “Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome.” Experimental Gerontology 46, no. 12 (December 2011): 979–86. https://doi.org/10.1016/j.exger.2011.08.010.
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    • Kulminski, Alexander M., Irina Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Liubov Arbeeva, Deqing Wu, Igor Akushevich, Kenneth C. Land, and Anatoli I. Yashin. “Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.” Aging Cell 10, no. 3 (June 2011): 533–41. https://doi.org/10.1111/j.1474-9726.2011.00689.x.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Liubov S. Arbeeva, Igor Akushevich, Alexander M. Kulminski, and Anatoliy I. Yashin. “Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data.” Biogerontology 12, no. 2 (April 2011): 157–66. https://doi.org/10.1007/s10522-010-9316-1.
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    • Kulminski, Alexander M., Konstantin G. Arbeev, Kaare Christensen, Richard Mayeux, Anne B. Newman, Michael A. Province, Evan C. Hadley, et al. “Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits.” Mechanisms of Ageing and Development 132, no. 4 (April 2011): 195–201. https://doi.org/10.1016/j.mad.2011.03.006.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Igor Akushevich, Alexander M. Kulminski, Liubov S. Arbeeva, Lucy Akushevich, Irina V. Culminskaya, and Anatoliy I. Yashin. “Age trajectories of physiological indices in relation to healthy life course.” Mechanisms of Ageing and Development 132, no. 3 (March 2011): 93–102. https://doi.org/10.1016/j.mad.2011.01.001.
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    • Ukraintseva, Svetlana V., Konstantin G. Arbeev, Igor Akushevich, Alexander Kulminski, Liubov Arbeeva, Irina Culminskaya, Lucy Akushevich, and Anatoli I. Yashin. “Trade-offs between cancer and other diseases: do they exist and influence longevity?” Rejuvenation Research 13, no. 4 (August 2010): 387–96. https://doi.org/10.1089/rej.2009.0941.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Svetlana V. Ukraintseva, Alexander Kulminski, Liubov S. Arbeeva, and Irina Culminskaya. “Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data.” Biogerontology 11, no. 3 (June 2010): 257–65. https://doi.org/10.1007/s10522-009-9243-1.
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    • Kulminski, Alexander M., Irina Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth C. Land, and Anatoli I. Yashin. “Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.” Mechanisms of Ageing and Development 131, no. 5 (May 2010): 338–45. https://doi.org/10.1016/j.mad.2010.04.001.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Alexander Kulminski, Ingrid Borecki, Kaare Christensen, Michael Barmada, Evan Hadley, et al. “"Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS).” Mechanisms of Ageing and Development 131, no. 3 (March 2010): 215–22. https://doi.org/10.1016/j.mad.2010.02.001.
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    • Yashin, Anatoli, Igor Akushevich, Svetlana Ukraintseva, Lucy Akushevich, Konstantin Arbeev, and Alexander Kulminski. “Trends in survival and recovery from stroke: evidence from the National Long-Term Care Survey/Medicare data.” Stroke 41, no. 3 (March 2010): 563–65. https://doi.org/10.1161/strokeaha.109.572339.
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    • Kulminski, Alexander M., Irina V. Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Igor Akushevich, Kenneth C. Land, and Anatoli I. Yashin. “Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction.” Rejuvenation Research 13, no. 1 (February 2010): 13–21. https://doi.org/10.1089/rej.2009.0905.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Liubov Arbeeva, Julia Kravchenko, Dora Il’yasova, Alexander Kulminski, et al. “Dynamic determinants of longevity and exceptional health.” Curr Gerontol Geriatr Res 2010 (2010). https://doi.org/10.1155/2010/381637.
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    • Kulminski, Alexander M., Freerk Molleman, Irina V. Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, James R. Carey, and Anatoli I. Yashin. “Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.” Experimental Gerontology 44, no. 11 (November 2009): 718–26. https://doi.org/10.1016/j.exger.2009.08.007.
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    • Yashin, Anatoli I., Svetlana V. Ukraintseva, Konstantin G. Arbeev, Igor Akushevich, Liubov S. Arbeeva, and Alexander M. Kulminski. “Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it change with age?” Mechanisms of Ageing and Development 130, no. 9 (September 2009): 611–18. https://doi.org/10.1016/j.mad.2009.07.004.
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    • Arbeev, Konstantin G., Igor Akushevich, Alexander M. Kulminski, Liubov S. Arbeeva, Lucy Akushevich, Svetlana V. Ukraintseva, Irina V. Culminskaya, and Anatoli I. Yashin. “Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data.” Journal of Theoretical Biology 258, no. 1 (May 2009): 103–11. https://doi.org/10.1016/j.jtbi.2009.01.023.
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    • Yashin, Anatoli I., Igor Akushevich, Konstantin Arbeev, Lucy Akushevich, Alexander Kulminski, and Svetlana Ukraintseva. “Studying health histories of cancer: a new model connecting cancer incidence and survival.” Mathematical Biosciences 218, no. 2 (April 2009): 88–97. https://doi.org/10.1016/j.mbs.2008.12.007.
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    • Kulminski, Alexander M., Konstantin G. Arbeev, Irina V. Culminskaya, Svetlana V. Ukraintseva, Kaare Christensen, and Anatoli I. Yashin. “Health-related phenotypes and longevity in danish twins.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 64, no. 1 (January 2009): 1–8. https://doi.org/10.1093/gerona/gln051.
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    • Yashin, Anatoli I., Svetlana V. Ukraintseva, Igor V. Akushevich, Konstantin G. Arbeev, Alexander Kulminski, and Lucy Akushevich. “Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.” Mechanisms of Ageing and Development 130, no. 1–2 (January 2009): 98–104. https://doi.org/10.1016/j.mad.2008.03.006.
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    • Kulminski, Alexander M., Irina V. Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth C. Land, and Anatoli I. Yashin. “Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time.” Experimental Gerontology 43, no. 12 (December 2008): 1052–57. https://doi.org/10.1016/j.exger.2008.09.007.
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    • Kulminski, Alexander M., Svetlana V. Ukraintseva, Irina V. Culminskaya, Konstantin G. Arbeev, Kenneth C. Land, Lucy Akushevich, and Anatoli I. Yashin. “Cumulative deficits and physiological indices as predictors of mortality and long life.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 63, no. 10 (October 2008): 1053–59. https://doi.org/10.1093/gerona/63.10.1053.
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    • Kulminski, Alexander M., Konstantin G. Arbeev, Svetlana V. Ukraintseva, Irina V. Culminskaya, Kenneth Land, and Anatoli I. Yashin. “Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits.” Annals of Epidemiology 18, no. 9 (September 2008): 696–701. https://doi.org/10.1016/j.annepidem.2008.06.005.
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    • Manton, K. G., I. Akushevich, and A. Kulminski. “Human mortality at extreme ages: Data from the NLTCS and linked medicare records.” Mathematical Population Studies 15, no. 3 (July 1, 2008): 137–59. https://doi.org/10.1080/08898480802221665.
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    • Kulminski, Alexander M., Svetlana V. Ukraintseva, Irina V. Kulminskaya, Konstantin G. Arbeev, Kenneth Land, and Anatoli I. Yashin. “Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study.” Journal of the American Geriatrics Society 56, no. 5 (May 2008): 898–903. https://doi.org/10.1111/j.1532-5415.2008.01656.x.
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    • Kulminski, Alexander, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth G. Manton, Junko Oshima, George M. Martin, and Anatoli I. Yashin. “Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample.” Age and Ageing 37, no. 3 (May 2008): 288–93. https://doi.org/10.1093/ageing/afn003.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Alexander Kulminski, Igor Akushevich, Lucy Akushevich, and Svetlana V. Ukraintseva. “What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare data.” Mechanisms of Ageing and Development 129, no. 4 (April 2008): 191–200. https://doi.org/10.1016/j.mad.2007.12.005.
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    • Kulminski, Alexander M., Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth G. Manton, Junko Oshima, George M. Martin, Dora Il’yasova, and Anatoli I. Yashin. “Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men.” J Am Geriatr Soc 56, no. 3 (March 2008): 478–83. https://doi.org/10.1111/j.1532-5415.2007.01574.x.
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    • Kulminski, Alexander M., Irina V. Kulminskaya, Svetlana V. Ukraintseva, Kenneth Land, and Anatoli I. Yashin. “An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey.” Rejuvenation Research 11, no. 1 (February 2008): 251–57. https://doi.org/10.1089/rej.2007.0611.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Alexander Kulminski, Lucy Akushevich, and Svetlana V. Ukraintseva. “Model of hidden heterogeneity in longitudinal data.” Theoretical Population Biology 73, no. 1 (February 2008): 1–10. https://doi.org/10.1016/j.tpb.2007.09.001.
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    • Kulminski, Alexander M., Konstantin G. Arbeev, Irina V. Kulminskaya, Svetlana V. Ukraintseva, Kenneth Land, Igor Akushevich, and Anatoli I. Yashin. “Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals.” Journal of the American Geriatrics Society 56, no. 1 (January 2008): 105–10. https://doi.org/10.1111/j.1532-5415.2007.01494.x.
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    • Kulminski, Alexander, Svetlana V. Ukraintseva, Igor Akushevich, Konstantin G. Arbeev, Kenneth Land, and Anatoli I. Yashin. “Accelerated accumulation of health deficits as a characteristic of aging.” Experimental Gerontology 42, no. 10 (October 2007): 963–70. https://doi.org/10.1016/j.exger.2007.05.009.
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    • Kulminski, Alexander M., Svetlana V. Ukraintseva, and Anatoli I. Yashin. “The apolipoprotein E epsilon2 allele and aging-associated health deterioration in older males.” Journal of the American Geriatrics Society 55, no. 9 (September 2007): 1479–80. https://doi.org/10.1111/j.1532-5415.2007.01311.x.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Aliaksandr Kulminski, Lucy Akushevich, and Svetlana V. Ukraintseva. “Stochastic model for analysis of longitudinal data on aging and mortality.” Mathematical Biosciences 208, no. 2 (August 2007): 538–51. https://doi.org/10.1016/j.mbs.2006.11.006.
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    • Kulminski, Alexander M., Svetlana V. Ukraintseva, Igor V. Akushevich, Konstantin G. Arbeev, and Anatoli I. Yashin. “Cumulative index of health deficiencies as a characteristic of long life.” Journal of the American Geriatrics Society 55, no. 6 (June 2007): 935–40. https://doi.org/10.1111/j.1532-5415.2007.01155.x.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Aliaksandr Kulminski, Igor Akushevich, Lucy Akushevich, and Svetlana V. Ukraintseva. “Health decline, aging and mortality: how are they related?” Biogerontology 8, no. 3 (June 2007): 291–302. https://doi.org/10.1007/s10522-006-9073-3.
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    • Kulminski, A., A. Yashin, K. Arbeev, I. Akushevich, S. Ukraintseva, K. Land, and K. Manton. “Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey.” Mechanisms of Ageing and Development 128, no. 3 (March 2007): 250–58. https://doi.org/10.1016/j.mad.2006.12.004.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Alexander Kulminski, Igor Akushevich, Lucy Akushevich, and Svetlana V. Ukraintseva. “Cumulative index of elderly disorders and its dynamic contribution to mortality and longevity.” Rejuvenation Research 10, no. 1 (March 2007): 75–86. https://doi.org/10.1089/rej.2006.0500.
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    • Yashin, Anatoli I., Igor V. Akushevich, Konstantin G. Arbeev, Lucy Akushevich, Svetlana V. Ukraintseva, and Aliaksandr Kulminski. “Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study.” Age (Dordrecht, Netherlands) 28, no. 4 (December 2006): 363–74. https://doi.org/10.1007/s11357-006-9023-7.
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    • Kulminski, Alexander, Anatoli Yashin, Svetlana Ukraintseva, Igor Akushevich, Konstantin Arbeev, Kenneth Land, and Kenneth Manton. “Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data.” Mechanisms of Ageing and Development 127, no. 11 (November 2006): 840–48. https://doi.org/10.1016/j.mad.2006.08.005.
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    • Akushevich, I., K. G. Manton, A. Kulminski, M. Kovtun, J. Kravchenko, and A. Yashin. “Population models for the health effects of ionizing radiation.” Radiats Biol Radioecol 46, no. 6 (2006): 663–74.
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    • Manton, K. G., A. Kulminski, I. Akushevich, and J. Kravchenko. “Modeling the effects of biologically incorporated radionuclides and chronic low-dose ionizing radiation exposure on both cancer and chronic non-cancer diseases.” Radiats Biol Radioecol 46, no. 6 (2006): 675–86.
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    • Akushevich, I., A. Kulminski, and K. G. Manton. “Life tables with covariates: Dynamic model for nonlinear analysis of longitudinal data.” Mathematical Population Studies 12, no. 2 (April 1, 2005): 51–80. https://doi.org/10.1080/08898480590932296.
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    • Kulminski, A., K. Manton, I. Akushevich, and A. Yashin. “The effect of the organisms' body size and energy reserves in models for population dynamics.” Journal of Biological Systems 12, no. 4 (December 1, 2004): 419–37. https://doi.org/10.1142/S0218339004001336.
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    • Manton, Kenneth G., Serge Volovik, and Alexander Kulminski. “ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation.” Current Alzheimer Research 1, no. 4 (November 2004): 277–93. https://doi.org/10.2174/1567205043332036.
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    • Manton, K. G., I. Akushevich, and A. Kulminski. “Demographic analysis and modeling of human populations exposed to ionizing radiation.” Frontiers in Bioscience : A Journal and Virtual Library 9 (September 2004): 2144–52. https://doi.org/10.2741/1374.
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    • Kulminski, A., I. Akushevich, and K. Manton. “Modeling nonlinear effects in longitudinal survival data: implications for the physiological dynamics of biological systems.” Frontiers in Bioscience : A Journal and Virtual Library 9 (January 2004): 481–93. https://doi.org/10.2741/1221.
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  • Book Sections

    • Arbeev, K. G., I. Akushevich, A. M. Kulminski, K. C. Land, and A. I. Yashin. “Approaches to Statistical Analysis of Longitudinal Data on Aging, Health, and Longevity: Biodemographic Perspectives.” In Springer Series on Demographic Methods and Population Analysis, 40:241–61, 2016. https://doi.org/10.1007/978-94-017-7587-8_11.
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    • Kulminski, A. M., A. I. Yashin, I. Culminskaya, K. C. Land, and S. V. Ukraintseva. “Conclusions Regarding Empirical Patterns of Aging, Health, and Longevity.” In Springer Series on Demographic Methods and Population Analysis, 40:231–37, 2016. https://doi.org/10.1007/978-94-017-7587-8_10.
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    • Kulminski, A. M., A. I. Yashin, I. Culminskaya, K. C. Land, and S. V. Ukraintseva. “The Complex Role of Genes in Diseases and Traits in Late Life: An Example of the Apolipoprotein E Polymorphism.” In Springer Series on Demographic Methods and Population Analysis, 40:211–30, 2016. https://doi.org/10.1007/978-94-017-7587-8_9.
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    • Kulminski, A. M., A. I. Yashin, K. G. Arbeev, S. V. Ukraintseva, I. Akushevich, K. C. Land, and E. Stallard. “Continuing the Search for Determinants of Healthy Life Span and Longevity.” In Springer Series on Demographic Methods and Population Analysis, 40:453–63, 2016. https://doi.org/10.1007/978-94-017-7587-8_20.
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    • Kulminski, A. M., I. Akushevich, K. C. Land, and A. I. Yashin. “Conclusions Regarding Statistical Modeling of Aging, Health, and Longevity.” In Springer Series on Demographic Methods and Population Analysis, 40:445–50, 2016. https://doi.org/10.1007/978-94-017-7587-8_19.
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    • Kulminski, A. M., K. C. Land, and A. I. Yashin. “Indices of Cumulative Deficits.” In Springer Series on Demographic Methods and Population Analysis, 40:163–86, 2016. https://doi.org/10.1007/978-94-017-7587-8_7.
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    • Ukraintseva, S. V., K. G. Arbeev, I. Akushevich, A. M. Kulminski, E. Stallard, and A. I. Yashin. “Factors That May Increase Vulnerability to Cancer and Longevity in Modern Human Populations.” In Springer Series on Demographic Methods and Population Analysis, 40:113–41, 2016. https://doi.org/10.1007/978-94-017-7587-8_5.
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    • Yashin, A. I., I. Akushevich, K. G. Arbeev, A. M. Kulminski, and S. V. Ukraintseva. “Integrative Mortality Models for the Study of Aging, Health, and Longevity: Benefits of Combining Data.” In Springer Series on Demographic Methods and Population Analysis, 40:331–52, 2016. https://doi.org/10.1007/978-94-017-7587-8_16.
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    • Yashin, A. I., I. Akushevich, K. G. Arbeev, A. M. Kulminski, and S. V. Ukraintseva. “Integrative Mortality Models with Parameters That Have Biological Interpretations.” In Springer Series on Demographic Methods and Population Analysis, 40:321–30, 2016. https://doi.org/10.1007/978-94-017-7587-8_15.
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    • Yashin, A. I., K. G. Arbeev, L. S. Arbeeva, I. Akushevich, S. V. Ukraintseva, A. M. Kulminski, E. Stallard, and K. C. Land. “Stochastic Process Models of Mortality and Aging.” In Springer Series on Demographic Methods and Population Analysis, 40:263–84, 2016. https://doi.org/10.1007/978-94-017-7587-8_12.
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    • Yashin, A. I., K. G. Arbeev, S. V. Ukraintseva, L. S. Arbeeva, I. Akushevich, J. Kravchenko, A. M. Kulminski, I. Culminskaya, D. Wu, and K. C. Land. “Dynamic Characteristics of Aging-Related Changes as Predictors of Longevity and Healthy Lifespan.” In Springer Series on Demographic Methods and Population Analysis, 40:187–210, 2016. https://doi.org/10.1007/978-94-017-7587-8_8.
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    • Yashin, A. I., L. S. Arbeeva, K. G. Arbeev, I. Akushevich, A. M. Kulminski, E. Stallard, and S. V. Ukraintseva. “Age Trajectories of Physiological Indices: Which Factors Influence Them?” In Springer Series on Demographic Methods and Population Analysis, 40:21–45, 2016. https://doi.org/10.1007/978-94-017-7587-8_2.
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    • Yashin, A. I., S. V. Ukraintseva, I. Akushevich, A. M. Kulminski, K. G. Arbeev, and E. Stallard. “Evidence for Dependence Among Diseases.” In Springer Series on Demographic Methods and Population Analysis, 40:95–111, 2016. https://doi.org/10.1007/978-94-017-7587-8_4.
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    • Yashin, A. I., I. Akushevich, K. Arbeev, A. Kulminski, and S. Ukraintseva. “Methodological aspects of studying human aging, health, and mortality.” In Applied Demography and Public Health, 337–55, 2013. https://doi.org/10.1007/978-94-007-6140-7_19.
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  • Conference Papers

    • Arbeev, Konstantin G., Liubov S. Arbeeva, Ilya Y. Zhbannikov, Olivia Bagley, Igor Akushevich, Mikhail Kovtun, Alexander M. Kulminski, Irina V. Culminskaya, Svetlana V. Ukraintseva, and Anatoliy I. Yashin. “High-Resolution Analyses of Effects of Polygenic Risk Scores on Time-to-Event Outcomes in Longitudinal Studies.” In Genetic Epidemiology, 40:622–622. WILEY-BLACKWELL, 2016.
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    • Loika, Y., Y. Kernogitski, I. Culminskaya, L. He, J. Huang, E. Loiko, and A. Kulminski. “Extensive Pleiotropy with Age-Related Disease Traits: The Candidate Gene Association Resource.” In Gerontologist, Vol. 56. OXFORD UNIV PRESS INC, 2016.
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    • “GENETIC PREDISPOSITION TO AGE-RELATED PHENOTYPES IN THE LIGHT OF EVOLUTION.” In The Gerontologist, 56:49–49. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.204.
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    • “PLEIOTROPIC META-ANALYSIS IDENTIFIES SHARED GENETIC CONNECTIONS BETWEEN DISTINCT AGE-RELATED TRAITS.” In The Gerontologist, 56:251–251. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.1006.
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    • “GENES WITH PLEIOTROPIC EFFECTS ON AGING-RELATED TRAITS IN HUMANS.” In The Gerontologist, 56:266–266. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.1074.
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    • “A NOVEL ALLELIC VARIANT IN A 2Q22 REGION CONFERS RISKS OF MAJOR HUMAN DISEASES AND MORTALITY.” In The Gerontologist, 56:266–266. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.1072.
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    • Yashin, A. I., K. G. Arbeev, L. S. Arbeeva, D. Wu, I. Akushevich, A. Kulminski, M. Kovtun, I. Zhbannikov, and S. V. Ukraintseva. “Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity.” In Proceedings  2nd International Symposium on Stochastic Models in Reliability Engineering, Life Science, and Operations Management, Smrlo 2016, 403–9, 2016. https://doi.org/10.1109/SMRLO.2016.70.
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    • Arbeev, Konstantin G., Liubov S. Arbeeva, Olivia Bagley, Hongzhe Duan, Igor Akushevich, Alexander M. Kulminski, Mikhail Kovtun, et al. “On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies.” In Genetic Epidemiology, 39:530–530. WILEY-BLACKWELL, 2015.
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    • Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Konstantin G. Arbeev, and Anatoliy I. Yashin. “Unfolding heterogeneity of complex traits has strong potential for advancing GWAS.” In Genetic Epidemiology, 39:562–562. WILEY-BLACKWELL, 2015.
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    • “GENETIC HETEROGENEITY AND ITS ROLE IN GWAS OF HUMAN AGING AND LONGEVITY.” In The Gerontologist, 55:859–859. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv490.04.
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    • “BIODEMOGRAPHIC APPROACHES TO ANALYSES OF POLYGENETIC EFFECTS ON MORTALITY AND AGING.” In The Gerontologist, 55:200–200. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv554.16.
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    • “PLEIOTROPIC EFFECTS OF GENES ON AGE-RELATED PHENOTYPES: INSIGHTS FROM GERONTOLOGICAL APPROACHES.” In The Gerontologist, 55:460–61. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv195.07.
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    • “PLEIOTROPIC EFFECTS OF GENES ON PHENOTYPES OF AGING, COMPLEX DISEASE AND LONGEVITY.” In The Gerontologist, 55:459–459. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv195.02.
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    • “THE ROLE OF BIODEMOGRAPHIC FACTORS IN GENETICS OF AGE-RELATED PHENOTYPES.” In The Gerontologist, 55:460–460. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv195.06.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Alexander M. Kulminski, Liubov S. Arbeeva, Igor Akushevich, Irina V. Culminskaya, Deqing Wu, and Anatoliy I. Yashin. “Relationship Between the APOE Polymorphism and Risks of Cancer and Alzheimer's Disease: Application of the Genetic Stochastic Process Model.” In Genetic Epidemiology, 36:747–747. WILEY-BLACKWELL, 2012.
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    • Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Liubov Arbeeva, and Anatoli I. Yashin. “The Role of Genes and Life Course in Late Life Diseases.” In Genetic Epidemiology, 36:743–44. WILEY-BLACKWELL, 2012.
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    • Kulminski, Alexander M., Irina Culminskaya, and Anatoli I. Yashin. “Developmental Processes can Drive Inter-chromosomal Linkage Disequilibrium.” In Genetic Epidemiology, 36:725–26. WILEY-BLACKWELL, 2012.
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    • Arbeev, Konstantin G., AlexanderM Kulminski, Svetlana V. Ukraintseva, Liubov S. Arbeeva, Igor Akushevich, Irina V. Culminskaya, Deqing Wu, and Anatoliy I. Yashin. “Trade-Off In The Effects Of The APOE Polymorphism On The Ages At Onset Of CVD And Cancer: Insights From The Genetic Stochastic Process Model.” In Genetic Epidemiology, 36:157–157. WILEY-BLACKWELL, 2012.
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    • Kulminski, Alexander, Irina Culminskaya, Svetlana Ukraintseva, Konstantin Arbeev, and Anatoli Yashin. “Complex Modalities Of Gene Action On Phenotypes With Post Reproductive Manifestation: The Case Of Genetic Trade-Off.” In Genetic Epidemiology, 36:162–162. WILEY-BLACKWELL, 2012.
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    • Kulminski, Alexander, and Irina Culminskaya. “Heritable Late Life Phenotypes and Inter-Chromosomal Linkage Disequilibrium in the Human Genome.” In Genetic Epidemiology, 36:162–63. WILEY-BLACKWELL, 2012.
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    • Kulminski, A. “AGING-RELATED PHENOTYPES AND INTER-CHROMOSOMAL LINKAGE DISEQUILIBRIUM IN THE HUMAN GENOME.” In Gerontologist, 51:123–123. OXFORD UNIV PRESS INC, 2011.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Liubov S. Arbeeva, Igor Akushevich, Alexander M. Kulminski, Deqing Wu, and Anatoliy I. Yashin. “Evaluation of Effects of Genetic polymorphisms and Age Trajectories of Physiological Indices on survival.” In Genetic Epidemiology, 34:965–66. WILEY-BLACKWELL, 2010.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Liubov S. Arbeeva, Alexander M. Kulminski, Igor Akushevich, and Anatoli I. Yashin. “Evaluation of Genotype-specific Age Patterns of Hazard Rates Using Joint Analysis of Genetic and Non-genetic Subsamples of Longitudinal Data.” In Genetic Epidemiology, 33:822–822. WILEY-LISS, 2009.
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    • Kulminski, Alexander, Svetlana Ukraintseva, Irina Culminskaya, Konstantin Arbeev, Igor Akushevich, and Anatoli Yashin. “The Role of Polymorphisms in the ACE and ADRB2 Genes in Incidence of Myocardial Infarction in Framingham Heart Study Participants.” In Genetic Epidemiology, 33:824–824. WILEY-LISS, 2009.
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    • Kulminski, Alexander, Svetlana Ukraintseva, Konstantin Arbeev, Irina Culminskaya, and Anatoli Yashin. “Polymorphisms in the Angiotensin-Converting Enzyme (ACE) Gene as Determinants of Cardiovascular Diseases Risks and Short Life in Framingham Heart Study.” In Genetic Epidemiology, 33:822–822. WILEY-LISS, 2009.
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    • Arbeev, K. G., A. I. Yashin, I. Akushevich, A. M. Kulminski, L. S. Arbeeva, L. Akushevich, and S. V. Ukraintseva. “Stochastic Model for Joint Analysis of Genetic and Non-Genetic Data from Longitudinal Studies of Aging, Health and Longevity.” In Genetic Epidemiology, 32:678–678. WILEY-LISS, 2008.
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    • Yashin, A. I., I. V. Culminskaya, K. G. Arbeev, S. V. Ukraintseva, I. Akushevich, and A. Kulminski. “Effects of ACE D/I Polymorphism and 11 SNPs Heterozygosity in the Same Gene on Health Risks in Framingham Study.” In Genetic Epidemiology, 32:722–722. WILEY, 2008.
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    • Yashin, A. I., S. V. Ukraintseva, K. G. Arbeev, I. V. Culminskaya, I. Akushevich, and A. Kulminski. “Interacting Effect of ACE D/I Polymorphism and Smoking on Health Risks in Framingham Study.” In Genetic Epidemiology, 32:722–23. WILEY, 2008.
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    • Mitnitski, A., K. Rockwood, A. Kulminski, A. Yashin, L. Gavrilov, and G. Martin. “SYSTEM BIOLOGY OF AGING: QUANTITATIVE ASPECTS AND A MODELING PERSPECTIVE.” In Gerontologist, 48:160–61. OXFORD UNIV PRESS INC, 2008.
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