Current Appointments & Affiliations
Research Professor in the Social Science Research Institute
·
2021 - Present
Social Science Research Institute,
University Institutes and Centers
Recent Publications
Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci.
Journal Article GeroScience · June 2025 Genetics is the second strongest risk factor for Alzheimer's disease (AD) after age. More than 70 loci have been implicated in AD susceptibility so far, and the genetic architecture of AD entails both additive and nonadditive contributions from these loci. ... Full text CiteMethods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study.
Journal Article Aging · May 2025 Studying the relationships between longitudinal changes in omics variables and event risks requires specific methodologies for joint analyses of longitudinal and time-to-event outcomes. We applied two such approaches (joint models [JM], stochastic process ... Full text CiteAssociation of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · February 2025 IntroductionTOMM40 and APOC1 variants can modulate the APOE-ε4-related Alzheimer's disease (AD) risk by up to fourfold. We aim to investigate whether the genetic modulation of ε4-related AD risk is reflected in brain morphology.MethodsWe ... Full text CiteRecent Grants
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2020 - 2026Project 1: The Long Life Family Study
ResearchSenior Research Scientist · Awarded by Washington University in St. Louis · 2019 - 2026Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases
ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2020 - 2026View All Grants
Education, Training & Certifications
The National Academy of Sciences of Belarus (Republic of Belarus) ·
1991
Ph.D.