Autism, Psychosis, or Both? Unraveling Complex Patient Presentations


Journal Article (Review)

© 2019 Elsevier Inc. Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders co-occur at elevated rates. Although these conditions are diagnostically distinct, they share multiple clinical features and genetic risk factors. This article describes the epidemiologic features and clinical manifestations of psychosis in individuals with ASDs, while also discussing shared genetic risk factors and affected brain regions. Components of a diagnostic assessment, including a thorough developmental, behavioral, medical, and psychiatric history, will be reviewed. The authors highlight the manifestations of catatonia in this population and note the shared features between catatonia and ASDs. Finally, treatment approaches and areas for future study are suggested.

Full Text

Duke Authors

Cited Authors

  • Chandrasekhar, T; Copeland, JN; Spanos, M; Sikich, L

Published Date

  • January 1, 2019

Published In

Electronic International Standard Serial Number (EISSN)

  • 1558-0490

International Standard Serial Number (ISSN)

  • 1056-4993

Digital Object Identifier (DOI)

  • 10.1016/j.chc.2019.08.003

Citation Source

  • Scopus