NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019.

Journal Article (Journal Article)

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the United States, with less than half of patients living >5 years from diagnosis. A major challenge in treating ovarian cancer is that most patients have advanced disease at initial diagnosis. The best outcomes are observed in patients whose primary treatment includes complete resection of all visible disease plus combination platinum-based chemotherapy. Research efforts are focused on primary neoadjuvant treatments that may improve resectability, as well as systemic therapies providing improved long-term survival. These NCCN Guidelines Insights focus on recent updates to neoadjuvant chemotherapy recommendations, including the addition of hyperthermic intraperitoneal chemotherapy, and the role of PARP inhibitors and bevacizumab as maintenance therapy options in select patients who have completed primary chemotherapy.

Full Text

Duke Authors

Cited Authors

  • Armstrong, DK; Alvarez, RD; Bakkum-Gamez, JN; Barroilhet, L; Behbakht, K; Berchuck, A; Berek, JS; Chen, L-M; Cristea, M; DeRosa, M; ElNaggar, AC; Gershenson, DM; Gray, HJ; Hakam, A; Jain, A; Johnston, C; Leath, CA; Liu, J; Mahdi, H; Matei, D; McHale, M; McLean, K; O'Malley, DM; Penson, RT; Percac-Lima, S; Ratner, E; Remmenga, SW; Sabbatini, P; Werner, TL; Zsiros, E; Burns, JL; Engh, AM

Published Date

  • August 1, 2019

Published In

Volume / Issue

  • 17 / 8

Start / End Page

  • 896 - 909

PubMed ID

  • 31390583

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2019.0039


  • eng

Conference Location

  • United States