Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model.

Published

Journal Article

Multiple sclerosis (MS) is an autoimmune demyelinating disease with progressive neurodegeneration and complex etiology likely involving genetic and environmental factors. MS has been associated with Epstein Barr virus (EBV) infection, with patients often showing enhanced responses to EBV antigens. To determine whether abnormal EBV nuclear antigen-1 (EBNA-1) humoral immunity can serve as an initiator of autoimmune responses in MS, we investigated the fine specificities of the humoral immune response against EBNA-1 in MS patients using solid phase epitope mapping. Antibodies from MS patients recognized an EBNA-1 epitope spanning amino acids 411-426, previously unknown to be recognized specifically by untreated MS patients. Antibodies against this epitope cross-reacted to myelin basic protein (MBP). Furthermore, animals immunized with this EBNA-1 polypeptide mounted a response against MBP and developed signs of experimental autoimmune encephalitis (EAE). These data support a link between MS and EBV through antibodies that cross-react between EBV proteins and the MBP autoantigen.

Full Text

Duke Authors

Cited Authors

  • Jog, NR; McClain, MT; Heinlen, LD; Gross, T; Towner, R; Guthridge, JM; Axtell, RC; Pardo, G; Harley, JB; James, JA

Published Date

  • January 2020

Published In

Volume / Issue

  • 106 /

Start / End Page

  • 102332 -

PubMed ID

  • 31515129

Pubmed Central ID

  • 31515129

Electronic International Standard Serial Number (EISSN)

  • 1095-9157

Digital Object Identifier (DOI)

  • 10.1016/j.jaut.2019.102332

Language

  • eng

Conference Location

  • England