Micah Thomas McClain | Scholars@Duke

Micah Thomas McClain
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2016

Contact Information

Duke Box 102359, Durham, NC 27710
Room 161 Hanes House, Trent Drive, Durham, NC 27710
micah.mcclain@duke.edu (919) 613-5636

Background
Education, Training, & Certifications
- Fellowship, Infectious Diseases, Duke University School of Medicine 2006 - 2010
- Residency, General Internal Medicine, Duke University School of Medicine 2004 - 2006
- M.D., University of Oklahoma 2004
- Ph.D., University of Oklahoma 2002
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2010 - 2016
- Instructor Temporary in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010
Recognition
In the News
- MAR 16, 2016
  
  New Collaborative Seed Grant Program Gives Eight Awards
Expertise
Subject Headings
Research
Selected Grants
- Transplant Infectious Diseases Interdisciplinary Research Training Grant awarded by National Institutes of Health 2018 - 2023
- Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections awarded by National Institutes of Health 2018 - 2023
- VTEU Task D Protocol FY.2015.D1B1C1.0032 awarded by National Institutes of Health 2015 - 2020
- Resilience Prediction to RSV Infection awarded by Sanofi US 2018 - 2019
- Novel host-based diagnostics of febrile illness in the warfighter awarded by Department of Defense 2016 - 2019
- Biomarker signatures for diagnosis of acute respiratory syndromes in CF awarded by Cystic Fibrosis Foundation Therapeutics, Inc. 2017 - 2019
- Host-derived biomarker signatures to differentiate acute viral, bacterial, and fungal infection awarded by National Institutes of Health 2017 - 2019
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative awarded by National Institutes of Health 2017 - 2019
- PREdicting contagion using Systems And GEnomic analysis (PRESAGE) awarded by Defense Advanced Research Projects Agency 2017 - 2019
- VTEU Task Area C: Protocal implementation for protocal # 13-0020 awarded by National Institutes of Health 2014 - 2018
- Center for Statistics and Quantitative Infectious Diseases awarded by Fred Hutchinson Cancer Research Center 2016 - 2017
- Baseline Bio-molecular Models to Predict Infectious Disease Susceptibility awarded by Defense Advanced Research Projects Agency 2015 - 2016
- Center for Statistics and Quantitative Infectious Diseases awarded by Fred Hutchinson Cancer Research Center 2014 - 2016
- Venezuelan Equine Encephalitis Immunology and Vaccine Design awarded by National Institutes of Health 2009 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bloom, AS, Suchindran, S, Steinbrink, J, and McClain, MT. "Utility of predictive tools for risk stratification of elderly individuals with all-cause acute respiratory infection." Infection (March 30, 2019). Full Text
  - Woods, CW, Sanchez, AM, Swamy, GK, McClain, MT, Harrington, L, Freeman, D, Poore, EA, Slifka, DK, Poer DeRaad, DE, Amanna, IJ, Slifka, MK, Cai, S, Shahamatdar, V, Wierzbicki, MR, Amegashie, C, and Walter, EB. "An observer blinded, randomized, placebo-controlled, phase I dose escalation trial to evaluate the safety and immunogenicity of an inactivated West Nile virus Vaccine, HydroVax-001, in healthy adults." Vaccine (January 18, 2019). Full Text
  - Fourati, S, Talla, A, Mahmoudian, M, Burkhart, JG, Klén, R, Henao, R, Yu, T, Aydın, Z, Yeung, KY, Ahsen, ME, Almugbel, R, Jahandideh, S, Liang, X, Nordling, TEM, Shiga, M, Stanescu, A, Vogel, R, Respiratory Viral DREAM Challenge Consortium, , Pandey, G, Chiu, C, McClain, MT, Woods, CW, Ginsburg, GS, Elo, LL, Tsalik, EL, Mangravite, LM, and Sieberts, SK. "A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection." Nature Communications 9, no. 1 (October 24, 2018): 4418-null. Full Text
  - Poore, GD, Ko, ER, Valente, A, Henao, R, Sumner, K, Hong, C, Burke, TW, Nichols, M, McClain, MT, Huang, ES, Ginsburg, GS, Woods, CW, and Tsalik, EL. "A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies." Frontiers in Microbiology 9 (January 2018): 2957-null. Full Text
  - Muller, J, Parizotto, E, Antrobus, R, Francis, J, Bunce, C, Stranks, A, Nichols, M, McClain, M, Hill, AVS, Ramasamy, A, and Gilbert, SC. "Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials." Journal of translational medicine 15, no. 1 (June 8, 2017): 134-. Full Text
  - Burke, TW, Henao, R, Soderblom, E, Tsalik, EL, Thompson, JW, McClain, MT, Nichols, M, Nicholson, BP, Veldman, T, Lucas, JE, Moseley, MA, Turner, RB, Lambkin-Williams, R, Hero, AO, Woods, CW, and Ginsburg, GS. "Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection." Ebiomedicine 17 (March 2017): 172-181. Full Text
  - Sobel Leonard, A, McClain, MT, Smith, GJD, Wentworth, DE, Halpin, RA, Lin, X, Ransier, A, Stockwell, TB, Das, SR, Gilbert, AS, Lambkin-Williams, R, Ginsburg, GS, Woods, CW, Koelle, K, and Illingworth, CJR. "The effective rate of influenza reassortment is limited during human infection." Plos Pathogens 13, no. 2 (February 7, 2017): e1006203-null. Full Text
  - Holcomb, ZE, Tsalik, EL, Woods, CW, and McClain, MT. "Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases." Journal of Clinical Microbiology 55, no. 2 (February 2017): 360-368. (Review) Full Text
  - Sobel Leonard, A, McClain, MT, Smith, GJD, Wentworth, DE, Halpin, RA, Lin, X, Ransier, A, Stockwell, TB, Das, SR, Gilbert, AS, Lambkin-Williams, R, Ginsburg, GS, Woods, CW, and Koelle, K. "Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification." Journal of Virology 90, no. 24 (December 2016): 11247-11258. Full Text
  - Berry, SM, Petzold, EA, Dull, P, Thielman, NM, Cunningham, CK, McClain, MT, Hoover, DL, Russell, J, Griffiss, JM, and Woods, CW. "Response." Clinical Trials (London, England) 13, no. 5 (October 2016): 568-569. Full Text Open Access Copy
  - Yang, WE, Suchindran, S, Nicholson, BP, McClain, MT, Burke, T, Ginsburg, GS, Harro, CD, Chakraborty, S, Sack, DA, Woods, CW, and Tsalik, EL. "Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans." The Journal of Infectious Diseases 213, no. 9 (May 2016): 1495-1504. Full Text Open Access Copy
  - McClain, MT, Henao, R, Williams, J, Nicholson, B, Veldman, T, Hudson, L, Tsalik, EL, Lambkin-Williams, R, Gilbert, A, Mann, A, Ginsburg, GS, and Woods, CW. "Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge." Clinical and Experimental Immunology 183, no. 3 (March 2016): 441-451. Full Text
  - Tsalik, EL, Li, Y, Hudson, LL, Chu, VH, Himmel, T, Limkakeng, AT, Katz, JN, Glickman, SW, McClain, MT, Welty-Wolf, KE, Fowler, VG, Ginsburg, GS, Woods, CW, and Reed, SD. "Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients." Annals of the American Thoracic Society 13, no. 3 (March 2016): 401-413. Full Text Open Access Copy
  - Berry, SM, Petzold, EA, Dull, P, Thielman, NM, Cunningham, CK, Corey, GR, McClain, MT, Hoover, DL, Russell, J, Griffiss, JM, and Woods, CW. "A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response." Clinical Trials (London, England) 13, no. 1 (February 2016): 22-30. Full Text
  - McClain, MT, Nicholson, BP, Park, LP, Liu, T-Y, Hero, AO, Tsalik, EL, Zaas, AK, Veldman, T, Hudson, LL, Lambkin-Williams, R, Gilbert, A, Burke, T, Nichols, M, Ginsburg, GS, and Woods, CW. "A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses." Open Forum Infectious Diseases 3, no. 1 (January 19, 2016): ofw007-null. Full Text Open Access Copy
  - Tsalik, EL, Henao, R, Nichols, M, Burke, T, Ko, ER, McClain, MT, Hudson, LL, Mazur, A, Freeman, DH, Veldman, T, Langley, RJ, Quackenbush, EB, Glickman, SW, Cairns, CB, Jaehne, AK, Rivers, EP, Otero, RM, Zaas, AK, Kingsmore, SF, Lucas, J, Fowler, VG, Carin, L, Ginsburg, GS, and Woods, CW. "Host gene expression classifiers diagnose acute respiratory illness etiology." Science Translational Medicine 8, no. 322 (January 2016): 322ra11-null. Full Text Open Access Copy
  - Tsalik, EL, McClain, M, and Zaas, AK. "Moving toward prime time: host signatures for diagnosis of respiratory infections." The Journal of infectious diseases 212, no. 2 (July 2015): 173-175. Full Text
  - Ko, ER, Yang, WE, McClain, MT, Woods, CW, Ginsburg, GS, and Tsalik, EL. "What was old is new again: using the host response to diagnose infectious disease." Expert Review of Molecular Diagnostics 15, no. 9 (January 2015): 1143-1158. (Review) Full Text
  - Tsalik, EL, Langley, RJ, Dinwiddie, DL, Miller, NA, Yoo, B, van Velkinburgh, JC, Smith, LD, Thiffault, I, Jaehne, AK, Valente, AM, Henao, R, Yuan, X, Glickman, SW, Rice, BJ, McClain, MT, Carin, L, Corey, GR, Ginsburg, GS, Cairns, CB, Otero, RM, Fowler, VG, Rivers, EP, Woods, CW, and Kingsmore, SF. "An integrated transcriptome and expressed variant analysis of sepsis survival and death." Genome Medicine 6, no. 11 (January 2014): 111-null. Full Text Open Access Copy
  - McClain, MT, Park, LP, Nicholson, B, Veldman, T, Zaas, AK, Turner, R, Lambkin-Williams, R, Gilbert, AS, Ginsburg, GS, and Woods, CW. "Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections." Journal of Clinical Virology 58, no. 4 (December 1, 2013): 689-695. Full Text
  - McClain, MT, Park, LP, Nicholson, B, Veldman, T, Zaas, AK, Turner, R, Lambkin-Williams, R, Gilbert, AS, Ginsburg, GS, and Woods, CW. "Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology 58, no. 4 (December 2013): 689-695. Full Text
  - Zaas, AK, Burke, T, Chen, M, McClain, M, Nicholson, B, Veldman, T, Tsalik, EL, Fowler, V, Rivers, EP, Otero, R, Kingsmore, SF, Voora, D, Lucas, J, Hero, AO, Carin, L, Woods, CW, and Ginsburg, GS. "A host-based RT-PCR gene expression signature to identify acute respiratory viral infection." Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126-null. Full Text Link to Item
  - Woods, CW, McClain, MT, Chen, M, Zaas, AK, Nicholson, BP, Varkey, J, Veldman, T, Kingsmore, SF, Huang, Y, Lambkin-Williams, R, Gilbert, AG, Hero, AO, Ramsburg, E, Glickman, S, Lucas, JE, Carin, L, and Ginsburg, GS. "A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2." Plos One 8, no. 1 (January 9, 2013): e52198-null. Full Text Open Access Copy
  - Bagga, B, Woods, CW, Veldman, TH, Gilbert, A, Mann, A, Balaratnam, G, Lambkin-Williams, R, Oxford, JS, McClain, MT, Wilkinson, T, Nicholson, BP, Ginsburg, GS, and Devincenzo, JP. "Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals." Antiviral Therapy 18, no. 6 (January 2013): 785-791. Full Text
  - Huang, Y, Zaas, AK, Rao, A, Dobigeon, N, Woolf, PJ, Veldman, T, Øien, NC, McClain, MT, Varkey, JB, Nicholson, B, Carin, L, Kingsmore, S, Woods, CW, Ginsburg, GS, and Hero, AO. "Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection." Plos Genetics 7, no. 8 (August 25, 2011): e1002234-null. Full Text Open Access Copy
  - Moody, MA, Zhang, R, Walter, EB, Woods, CW, Ginsburg, GS, McClain, MT, Denny, TN, Chen, X, Munshaw, S, Marshall, DJ, Whitesides, JF, Drinker, MS, Amos, JD, Gurley, TC, Eudailey, JA, Foulger, A, DeRosa, KR, Parks, R, Meyerhoff, RR, Yu, J-S, Kozink, DM, Barefoot, BE, Ramsburg, EA, Khurana, S, Golding, H, Vandergrift, NA, Alam, SM, Tomaras, GD, Kepler, TB, Kelsoe, G, Liao, H-X, and Haynes, BF. "H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination." Plos One 6, no. 10 (2011): e25797-null. Full Text Link to Item
  - Heinlen, LD, McClain, MT, Ritterhouse, LL, Bruner, BF, Edgerton, CC, Keith, MP, James, JA, and Harley, JB. "60 kD Ro and nRNP A frequently initiate human lupus autoimmunity." PLoS ONE 5, no. 3 (2010). Full Text
  - Heinlen, LD, Ritterhouse, LL, McClain, MT, Keith, MP, Neas, BR, Harley, JB, and James, JA. "Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides." Journal of Molecular Medicine 88, no. 7 (2010): 719-727. Full Text
  - Heinlen, LD, McClain, MT, Merrill, J, Akbarali, YW, Edgerton, CC, Harley, JB, and James, JA. "Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms." Arthritis and Rheumatism 56, no. 7 (2007): 2344-2351. Full Text
  - James, JA, Kim-Howard, XR, Bruner, BF, Jonsson, MK, McClain, MT, Arbuckle, MR, Walker, C, Dennis, GJ, Merrill, JT, and Harley, JB. "Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus." Lupus 16, no. 6 (January 2007): 401-409. Full Text
  - McClain, MT, Poole, BD, Bruner, BF, Kaufman, KM, Harley, JB, and James, JA. "An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus." Arthritis and Rheumatism 54, no. 1 (2006): 360-368. Full Text
  - McClain, MT, Heinlen, LD, Dennis, GJ, Roebuck, J, Harley, JB, and James, JA. "Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry." Nature Medicine 11, no. 1 (January 2005): 85-89. Full Text
  - Scofield, RH, Kurien, BT, Ganick, S, McClain, MT, Pye, Q, James, JA, Schneider, RI, Broyles, RH, Bachmann, M, and Hensley, K. "Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading." Free Radical Biology and Medicine 38, no. 6 (2005): 719-728. Full Text
  - Kelleher, P, James, JA, McClain, MT, Arbuckle, MR, and Harley, JB. "Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus [3] (multiple letters)." New England Journal of Medicine 350, no. 3 (2004): 305--. Full Text
  - McClain, MT, Arbuckle, MR, Heinlen, LD, Dennis, GJ, Roebuck, J, Rubertone, MV, Harley, JB, and James, JA. "The Prevalence, Onset, and Clinical Significance of Antiphospholipid Antibodies Prior to Diagnosis of Systemic Lupus Erythematosus." Arthritis and Rheumatism 50, no. 4 (2004): 1226-1232. Full Text
  - McClain, MT, Lutz, CS, Kaufman, KM, Faig, OZ, Gross, TF, and James, JA. "Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response." Proceedings of the National Academy of Sciences of the United States of America 101, no. 10 (2004): 3551-3556. Full Text
  - Arbuckle, MR, McClain, MT, Rubertone, MV, Scofield, RH, Dennis, GJ, James, JA, and Harley, JB. "Development of autoantibodies before the clinical onset of systemic lupus erythematosus." The New England Journal of Medicine 349, no. 16 (October 2003): 1526-1533. Full Text
  - Arbuckle, MR, James, JA, Dennis, GJ, Rubertone, MV, McClain, MT, Kim, XR, and Harley, JB. "Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus." Lupus 12, no. 2 (2003): 99-106. Full Text
  - Heinlen, LD, McClain, MT, Kim, X, Del-Rio, AIQ, James, JA, Harley, JB, and Scofield, RH. "Anti-Ro and anti-nRNP response in unaffected family members of SLE patients [2]." Lupus 12, no. 4 (2003): 335-337. Full Text
  - McClain, MT, Rapp, EC, Harley, JB, and James, JA. "Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1." Journal of Medical Virology 70, no. 2 (2003): 253-257. Full Text
  - Lutz, CS, McClain, MT, Harley, JB, and James, JA. "Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA." Journal of Molecular Recognition 15, no. 3 (2002): 163-170. Full Text
  - McClain, MT, Ramsland, PA, Kaufman, KM, and James, JA. "Anti-Sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens." Journal of Immunology 168, no. 4 (2002): 2054-2062.
  - Mcclain, MT, Scofield, RH, Kurien, BT, Gross, TF, and James, JA. "Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE." Scandinavian Journal of Immunology 56, no. 4 (2002): 399-407. Full Text
  - Kaufman, KM, Kirby, MY, McClain, MT, Harley, JB, and James, JA. "Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B′." Biochemical and Biophysical Research Communications 285, no. 5 (2001): 1206-1212. Full Text
  - McClain, MT, Harley, JB, and James, JA. "The role of Epstein-Barr virus in systemic lupus erythematosus." Front Biosci 6 (2001): E137-E147.
  - James, JA, McClain, MT, Koelsch, G, Williams, DG, and Harley, JB. "Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies." Journal of Autoimmunity 12, no. 1 (1999): 43-49. Full Text
  - McClain, MT, Kaufman, KM, Koelsch, G, Harley, JB, and James, JA. "Identification and analysis of peptide determinants of murine monoclonal anti-Sm B/B' autoantibodies." Faseb Journal 12, no. 5 (March 20, 1998).
  - Davis, AL, McClain, MT, Gross, TF, Harley, JB, and James, JA. "Immunization with 60kD Ro leads to a diversified immune response to several lupus autoantigens." FASEB Journal 12, no. 4 (1998): A610-.
  - James, JA, Gross, TF, Davis, AL, McClain, MT, and Harley, JB. "Immunization with a common epitope of nRNP a induces lupus autoimmunity." FASEB Journal 12, no. 4 (1998): A606-.
Teaching & Mentoring
Recent Courses
- MEDICINE 231C: Introduction to Infectious Diseases 2019
- MEDICINE 440C: Clinical Infectious Diseases 2019

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Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Recent Courses