Micah Thomas McClain | Scholars@Duke

Micah Thomas McClain
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2020
Member of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014

Contact Information

Duke Box 102359, Durham, NC 27710
Room 161 Hanes House, Trent Drive, Durham, NC 27710
micah.mcclain@duke.edu (919) 613-5636

Background
Education, Training, & Certifications
- Fellowship, Infectious Diseases, Duke University School of Medicine 2006 - 2010
- Residency, General Internal Medicine, Duke University School of Medicine 2004 - 2006
- M.D., University of Oklahoma 2004
- Ph.D., University of Oklahoma 2002
Duke Appointment History
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2016 - 2020
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2010 - 2016
- Instructor Temporary in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010
Recognition
In the News
- SEP 25, 2020 Duke Health News
  
  Duke-Developed Test Identifies Common Viral Infections Before Symptoms Appear
- MAR 16, 2016
  
  New Collaborative Seed Grant Program Gives Eight Awards
Expertise
Subject Headings
Research
Selected Grants
- Sepsis Characterization in Kilimanjaro (R01) awarded by National Institutes of Health 2020 - 2025
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG) awarded by National Institutes of Health 2018 - 2023
- Diagnosis and Outcomes of Pulmonary Invasive Mold Infections in Immunocompromised Children awarded by National Institutes of Health 2018 - 2023
- Duke RDS2 (Respondent-Driven Sampling, Respiratory Disease Surveillance) the SNOWBALL Sampling Study awarded by Centers for Disease Control and Prevention 2020 - 2022
- CIVICS Component C - Option 13A awarded by National Institutes of Health 2019 - 2022
- Prophylaxis and Treatment of COVID19 ¿ Adaptive Platform Trial (PROTECT-APT) awarded by Henry M. Jackson Foundation 2020 - 2022
- COVID Survivors Long Term Follow Up Study--WMD ECHO Detector awarded by Icahn School of Medicine at Mount Sinai 2021 - 2022
- Host Transcriptomic Responses to Non-Invasively Monitor the Inflammatory Response and Rejection Signals of Hepatitis-C Naive Recipients of Hepatitis-C Infected Donor Kidneys awarded by American Society of Transplantation 2020 - 2021
- Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO) awarded by Defense Advanced Research Projects Agency 2019 - 2021
- Adaptive COVID-19 Treatment Trial (ACTT) awarded by Leidos Biomedical Research, Inc. 2020 - 2021
- IPA - Sunil Suchindran awarded by Durham Veterans Affairs Medical Center 2019 - 2021
- IPA- Elizabeth Petzold awarded by Durham Veterans Affairs Medical Center 2019 - 2021
- Human-Based Sensor System for Presymptomatic Biological Exposure Detection awarded by Research Triangle Institute International 2019 - 2021
- Resilience Prediction to RSV Infection awarded by Sanofi US 2018 - 2020
- IPA- Deborah Murray awarded by Durham Veterans Affairs Medical Center 2019 - 2020
- PREdicting contagion using Systems And GEnomic analysis (PRESAGE) awarded by Defense Advanced Research Projects Agency 2017 - 2020
- VTEU Task D Protocol FY.2015.D1B1C1.0032 awarded by National Institutes of Health 2015 - 2020
- Host-derived biomarker signatures to differentiate acute viral, bacterial, and fungal infection awarded by National Institutes of Health 2017 - 2020
- Novel host-based diagnostics of febrile illness in the warfighter awarded by Department of Defense 2016 - 2020
- IPA- Mark Sprenz awarded by Durham Veterans Affairs Medical Center 2019 - 2020
- IPA- Sara Hoffman awarded by Durham Veterans Affairs Medical Center 2019
- Biomarker signatures for diagnosis of acute respiratory syndromes in CF awarded by Cystic Fibrosis Foundation Therapeutics, Inc. 2017 - 2019
- A Double-Blind, Randomized, Placebo-controlled, Phase 1 Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine, HydroVax-001, in Healthy Adults awarded by National Institutes of Health 2014 - 2018
- Center for Statistics and Quantitative Infectious Diseases awarded by Fred Hutchinson Cancer Research Center 2016 - 2017
- Baseline Bio-molecular Models to Predict Infectious Disease Susceptibility awarded by Defense Advanced Research Projects Agency 2015 - 2016
- Center for Statistics and Quantitative Infectious Diseases awarded by Fred Hutchinson Cancer Research Center 2014 - 2016
- Venezuelan Equine Encephalitis Immunology and Vaccine Design awarded by National Institutes of Health 2009 - 2014
External Relationships
- UpToDate
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wang, Liuyang, Thomas J. Balmat, Alejandro L. Antonia, Florica J. Constantine, Ricardo Henao, Thomas W. Burke, Andy Ingham, et al. “An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.” Genome Med 13, no. 1 (May 17, 2021): 83. https://doi.org/10.1186/s13073-021-00904-z.
    Full Text Link to Item
  - McClain, Micah T., Florica J. Constantine, Bradly P. Nicholson, Marshall Nichols, Thomas W. Burke, Ricardo Henao, Daphne C. Jones, et al. “A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study.” Lancet Infect Dis 21, no. 3 (March 2021): 396–404. https://doi.org/10.1016/S1473-3099(20)30486-2.
    Full Text Open Access Copy Link to Item
  - McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.” Nat Commun 12, no. 1 (February 17, 2021): 1079. https://doi.org/10.1038/s41467-021-21289-y.
    Full Text Open Access Copy Link to Item
  - Tillekeratne, L Gayani, Sunil Suchindran, Emily R. Ko, Elizabeth A. Petzold, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.” Open Forum Infect Dis 7, no. 6 (June 2020): ofaa194. https://doi.org/10.1093/ofid/ofaa194.
    Full Text Open Access Copy Link to Item
  - Steinbrink, Julie M., Aimee K. Zaas, Marisol Betancourt, Jennifer L. Modliszewski, David L. Corcoran, and Micah T. McClain. “A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states.” Transl Res 219 (May 2020): 1–12. https://doi.org/10.1016/j.trsl.2020.02.005.
    Full Text Link to Item
  - McClain, Micah T., and Daniel J. Sexton. “Surveillance for Spotted Fever Group Rickettsial Infections: Problems, Pitfalls, and Potential Solutions.” J Infect Dis 221, no. 8 (March 28, 2020): 1238–40. https://doi.org/10.1093/infdis/jiz317.
    Full Text Link to Item
  - Colón-Emeric, Cathleen, Carl F. Pieper, Kenneth E. Schmader, Richard Sloane, Allison Bloom, Micah McClain, Jay Magaziner, et al. “Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data.” J Gerontol a Biol Sci Med Sci 75, no. 4 (March 9, 2020): 731–38. https://doi.org/10.1093/gerona/glz097.
    Full Text Link to Item
  - Jog, Neelakshi R., Micah T. McClain, Latisha D. Heinlen, Timothy Gross, Rheal Towner, Joel M. Guthridge, Robert C. Axtell, Gabriel Pardo, John B. Harley, and Judith A. James. “Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model.” J Autoimmun 106 (January 2020): 102332. https://doi.org/10.1016/j.jaut.2019.102332.
    Full Text Link to Item
  - Lydon, Emily C., Ricardo Henao, Thomas W. Burke, Mert Aydin, Bradly P. Nicholson, Seth W. Glickman, Vance G. Fowler, et al. “Validation of a host response test to distinguish bacterial and viral respiratory infection.” Ebiomedicine 48 (October 2019): 453–61. https://doi.org/10.1016/j.ebiom.2019.09.040.
    Full Text Open Access Copy Link to Item
  - Bloom, Allison S., Sunil Suchindran, Julie Steinbrink, and Micah T. McClain. “Utility of predictive tools for risk stratification of elderly individuals with all-cause acute respiratory infection.” Infection 47, no. 4 (August 2019): 617–27. https://doi.org/10.1007/s15010-019-01299-1.
    Full Text Link to Item
  - Woods, Christopher W., Ana M. Sanchez, Geeta K. Swamy, Micah T. McClain, Lynn Harrington, Debra Freeman, Elizabeth A. Poore, et al. “An observer blinded, randomized, placebo-controlled, phase I dose escalation trial to evaluate the safety and immunogenicity of an inactivated West Nile virus Vaccine, HydroVax-001, in healthy adults.” Vaccine 37, no. 30 (July 9, 2019): 4222–30. https://doi.org/10.1016/j.vaccine.2018.12.026.
    Full Text Link to Item
  - Madan, Anuradha, Shuguang Chen, Phillip Yates, Michael L. Washburn, Grace Roberts, Andrew J. Peat, Yu Tao, et al. “Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza.” Open Forum Infect Dis 6, no. 4 (April 2019): ofz163. https://doi.org/10.1093/ofid/ofz163.
    Full Text Link to Item
  - Lydon, Emily C., Charles Bullard, Mert Aydin, Olga M. Better, Anna Mazur, Bradly P. Nicholson, Emily R. Ko, et al. “A host gene expression approach for identifying triggers of asthma exacerbations.” Plos One 14, no. 4 (2019): e0214871. https://doi.org/10.1371/journal.pone.0214871.
    Full Text Open Access Copy Link to Item
  - Fourati, Slim, Aarthi Talla, Mehrad Mahmoudian, Joshua G. Burkhart, Riku Klén, Ricardo Henao, Thomas Yu, et al. “A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.” Nat Commun 9, no. 1 (October 24, 2018): 4418. https://doi.org/10.1038/s41467-018-06735-8.
    Full Text Open Access Copy Link to Item
  - Poore, Gregory D., Emily R. Ko, Ashlee Valente, Ricardo Henao, Kelsey Sumner, Christopher Hong, Thomas W. Burke, et al. “A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies.” Front Microbiol 9 (2018): 2957. https://doi.org/10.3389/fmicb.2018.02957.
    Full Text Open Access Copy Link to Item
  - Muller, Julius, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, et al. “Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials.” J Transl Med 15, no. 1 (June 8, 2017): 134. https://doi.org/10.1186/s12967-017-1235-3.
    Full Text Link to Item
  - Burke, Thomas W., Ricardo Henao, Erik Soderblom, Ephraim L. Tsalik, J Will Thompson, Micah T. McClain, Marshall Nichols, et al. “Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.” Ebiomedicine 17 (March 2017): 172–81. https://doi.org/10.1016/j.ebiom.2017.02.015.
    Full Text Open Access Copy Link to Item
  - Holcomb, Zachary E., Ephraim L. Tsalik, Christopher W. Woods, and Micah T. McClain. “Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.” J Clin Microbiol 55, no. 2 (February 2017): 360–68. https://doi.org/10.1128/JCM.01057-16.
    Full Text Link to Item
  - Sobel Leonard, Ashley, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, et al. “The effective rate of influenza reassortment is limited during human infection.” Plos Pathog 13, no. 2 (February 2017): e1006203. https://doi.org/10.1371/journal.ppat.1006203.
    Full Text Link to Item
  - Sobel Leonard, Ashley, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, et al. “Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification.” J Virol 90, no. 24 (December 15, 2016): 11247–58. https://doi.org/10.1128/JVI.01657-16.
    Full Text Link to Item
  - Berry, Scott M., Elizabeth A. Petzold, Peter Dull, Nathan M. Thielman, Coleen K. Cunningham, Micah T. McClain, David L. Hoover, James Russell, John McLeod Griffiss, and Christopher W. Woods. “Response.” Clin Trials 13, no. 5 (October 2016): 568–69. https://doi.org/10.1177/1740774516654446.
    Full Text Open Access Copy Link to Item
  - Yang, William E., Sunil Suchindran, Bradly P. Nicholson, Micah T. McClain, Thomas Burke, Geoffrey S. Ginsburg, Clayton D. Harro, et al. “Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.” J Infect Dis 213, no. 9 (May 1, 2016): 1495–1504. https://doi.org/10.1093/infdis/jiv593.
    Full Text Open Access Copy Link to Item
  - McClain, M. T., R. Henao, J. Williams, B. Nicholson, T. Veldman, L. Hudson, E. L. Tsalik, et al. “Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge.” Clin Exp Immunol 183, no. 3 (March 2016): 441–51. https://doi.org/10.1111/cei.12736.
    Full Text Link to Item
  - Tsalik, Ephraim L., Yanhong Li, Lori L. Hudson, Vivian H. Chu, Tiffany Himmel, Alex T. Limkakeng, Jason N. Katz, et al. “Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.” Ann Am Thorac Soc 13, no. 3 (March 2016): 401–13. https://doi.org/10.1513/AnnalsATS.201504-205OC.
    Full Text Open Access Copy Link to Item
  - Berry, Scott M., Elizabeth A. Petzold, Peter Dull, Nathan M. Thielman, Coleen K. Cunningham, G Ralph Corey, Micah T. McClain, et al. “A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response.” Clin Trials 13, no. 1 (February 2016): 22–30. https://doi.org/10.1177/1740774515621721.
    Full Text Link to Item
  - Tsalik, Ephraim L., Ricardo Henao, Marshall Nichols, Thomas Burke, Emily R. Ko, Micah T. McClain, Lori L. Hudson, et al. “Host gene expression classifiers diagnose acute respiratory illness etiology.” Sci Transl Med 8, no. 322 (January 20, 2016): 322ra11. https://doi.org/10.1126/scitranslmed.aad6873.
    Full Text Open Access Copy Link to Item
  - McClain, Micah T., Bradly P. Nicholson, Lawrence P. Park, Tzu-Yu Liu, Alfred O. Hero, Ephraim L. Tsalik, Aimee K. Zaas, et al. “A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.” Open Forum Infect Dis 3, no. 1 (January 2016): ofw007. https://doi.org/10.1093/ofid/ofw007.
    Full Text Open Access Copy Link to Item
  - Tsalik, Ephraim L., Micah McClain, and Aimee K. Zaas. “Moving toward prime time: host signatures for diagnosis of respiratory infections.” J Infect Dis 212, no. 2 (July 15, 2015): 173–75. https://doi.org/10.1093/infdis/jiv032.
    Full Text Link to Item
  - Ko, Emily R., William E. Yang, Micah T. McClain, Christopher W. Woods, Geoffrey S. Ginsburg, and Ephraim L. Tsalik. “What was old is new again: using the host response to diagnose infectious disease.” Expert Rev Mol Diagn 15, no. 9 (2015): 1143–58. https://doi.org/10.1586/14737159.2015.1059278.
    Full Text Link to Item
  - Tsalik, Ephraim L., Raymond J. Langley, Darrell L. Dinwiddie, Neil A. Miller, Byunggil Yoo, Jennifer C. van Velkinburgh, Laurie D. Smith, et al. “An integrated transcriptome and expressed variant analysis of sepsis survival and death.” Genome Med 6, no. 11 (2014): 111. https://doi.org/10.1186/s13073-014-0111-5.
    Full Text Open Access Copy Link to Item
  - McClain, Micah T., Lawrence P. Park, Bradly Nicholson, Timothy Veldman, Aimee K. Zaas, Ron Turner, Robert Lambkin-Williams, Anthony S. Gilbert, Geoffrey S. Ginsburg, and Christopher W. Woods. “Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections.” J Clin Virol 58, no. 4 (December 2013): 689–95. https://doi.org/10.1016/j.jcv.2013.09.015.
    Full Text Link to Item
  - Zaas, Aimee K., Thomas Burke, Minhua Chen, Micah McClain, Bradly Nicholson, Timothy Veldman, Ephraim L. Tsalik, et al. “A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.” Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126. https://doi.org/10.1126/scitranslmed.3006280.
    Full Text Link to Item
  - Bagga, Bindiya, Christopher W. Woods, Timothy H. Veldman, Anthony Gilbert, Alex Mann, Ganesh Balaratnam, Robert Lambkin-Williams, et al. “Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals.” Antivir Ther 18, no. 6 (2013): 785–91. https://doi.org/10.3851/IMP2629.
    Full Text Link to Item
  - Woods, Christopher W., Micah T. McClain, Minhua Chen, Aimee K. Zaas, Bradly P. Nicholson, Jay Varkey, Timothy Veldman, et al. “A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.” Plos One 8, no. 1 (2013): e52198. https://doi.org/10.1371/journal.pone.0052198.
    Full Text Open Access Copy Link to Item
  - Huang, Yongsheng, Aimee K. Zaas, Arvind Rao, Nicolas Dobigeon, Peter J. Woolf, Timothy Veldman, N Christine Øien, et al. “Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.” Plos Genet 7, no. 8 (August 2011): e1002234. https://doi.org/10.1371/journal.pgen.1002234.
    Full Text Open Access Copy Link to Item
  - Moody, M Anthony, Ruijun Zhang, Emmanuel B. Walter, Christopher W. Woods, Geoffrey S. Ginsburg, Micah T. McClain, Thomas N. Denny, et al. “H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.” Plos One 6, no. 10 (2011): e25797. https://doi.org/10.1371/journal.pone.0025797.
    Full Text Open Access Copy Link to Item
  - Heinlen, Latisha D., Lauren L. Ritterhouse, Micah T. McClain, Michael P. Keith, Barbara R. Neas, John B. Harley, and Judith A. James. “Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides.” J Mol Med (Berl) 88, no. 7 (July 2010): 719–27. https://doi.org/10.1007/s00109-010-0618-1.
    Full Text Link to Item
  - Heinlen, Latisha D., Micah T. McClain, Lauren L. Ritterhouse, Benjamin F. Bruner, Colin C. Edgerton, Michael P. Keith, Judith A. James, and John B. Harley. “60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.” Plos One 5, no. 3 (March 10, 2010): e9599. https://doi.org/10.1371/journal.pone.0009599.
    Full Text Link to Item
  - Heinlen, Latisha D., Micah T. McClain, Joan Merrill, Yasmin W. Akbarali, Colin C. Edgerton, John B. Harley, and Judith A. James. “Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms.” Arthritis Rheum 56, no. 7 (July 2007): 2344–51. https://doi.org/10.1002/art.22665.
    Full Text Link to Item
  - James, J. A., X. R. Kim-Howard, B. F. Bruner, M. K. Jonsson, M. T. McClain, M. R. Arbuckle, C. Walker, G. J. Dennis, J. T. Merrill, and J. B. Harley. “Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus.” Lupus 16, no. 6 (2007): 401–9. https://doi.org/10.1177/0961203307078579.
    Full Text Link to Item
  - McClain, Micah T., Brian D. Poole, Benjamin F. Bruner, Kenneth M. Kaufman, John B. Harley, and Judith A. James. “An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus.” Arthritis Rheum 54, no. 1 (January 2006): 360–68. https://doi.org/10.1002/art.21682.
    Full Text Link to Item
  - Scofield, R Hal, Biji T. Kurien, Samantha Ganick, Micah T. McClain, Quentin Pye, Judith A. James, Rebecca I. Schneider, Robert H. Broyles, Michael Bachmann, and Kenneth Hensley. “Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading.” Free Radic Biol Med 38, no. 6 (March 15, 2005): 719–28. https://doi.org/10.1016/j.freeradbiomed.2004.11.001.
    Full Text Link to Item
  - McClain, Micah T., Latisha D. Heinlen, Gregory J. Dennis, Jon Roebuck, John B. Harley, and Judith A. James. “Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry.” Nat Med 11, no. 1 (January 2005): 85–89. https://doi.org/10.1038/nm1167.
    Full Text Link to Item
  - McClain, Micah T., Melissa R. Arbuckle, Latisha D. Heinlen, Gregory J. Dennis, Jon Roebuck, Mark V. Rubertone, John B. Harley, and Judith A. James. “The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus.” Arthritis Rheum 50, no. 4 (April 2004): 1226–32. https://doi.org/10.1002/art.20120.
    Full Text Link to Item
  - McClain, Micah T., Carol S. Lutz, Kenneth M. Kaufman, Ofer Z. Faig, Timothy F. Gross, and Judith A. James. “Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.” Proc Natl Acad Sci U S A 101, no. 10 (March 9, 2004): 3551–56. https://doi.org/10.1073/pnas.0306267101.
    Full Text Link to Item
  - Kelleher, Peter. “Autoantibodies before the clinical onset of systemic lupus erythematosus.” N Engl J Med 350, no. 3 (January 15, 2004): 305. https://doi.org/10.1056/NEJM200401153500320.
    Full Text Link to Item
  - Arbuckle, Melissa R., Micah T. McClain, Mark V. Rubertone, R Hal Scofield, Gregory J. Dennis, Judith A. James, and John B. Harley. “Development of autoantibodies before the clinical onset of systemic lupus erythematosus.” N Engl J Med 349, no. 16 (October 16, 2003): 1526–33. https://doi.org/10.1056/NEJMoa021933.
    Full Text Link to Item
  - McClain, Micah T., Erin C. Rapp, John B. Harley, and Judith A. James. “Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1.” J Med Virol 70, no. 2 (June 2003): 253–57. https://doi.org/10.1002/jmv.10385.
    Full Text Link to Item
  - Arbuckle, M. R., J. A. James, G. J. Dennis, M. V. Rubertone, M. T. McClain, X. R. Kim, and J. B. Harley. “Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus.” Lupus 12, no. 2 (2003): 99–106. https://doi.org/10.1191/0961203303lu334oa.
    Full Text Link to Item
  - Heinlen, Latisha D., Micah T. McClain, Xana Kim, Del-Rio Ana I. Quintero, Judith A. James, John B. Harley, and R Hal Scofield. “Anti-Ro and anti-nRNP response in unaffected family members of SLE patients.” Lupus 12, no. 4 (2003): 335–37. https://doi.org/10.1191/0961203303lu377xx.
    Full Text Link to Item
  - McClain, M. T., R. H. Scofield, B. T. Kurien, T. F. Gross, and J. A. James. “Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE.” Scand J Immunol 56, no. 4 (October 2002): 399–407. https://doi.org/10.1046/j.1365-3083.2002.01141.x.
    Full Text Link to Item
  - Lutz, Carol S., Micah T. McClain, John B. Harley, and Judith A. James. “Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA.” J Mol Recognit 15, no. 3 (May 2002): 163–70. https://doi.org/10.1002/jmr.569.
    Full Text Link to Item
  - McClain, Micah T., Paul A. Ramsland, Kenneth M. Kaufman, and Judith A. James. “Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens.” J Immunol 168, no. 4 (February 15, 2002): 2054–62. https://doi.org/10.4049/jimmunol.168.4.2054.
    Full Text Link to Item
  - McClain, M. T., J. B. Harley, and J. A. James. “The role of Epstein-Barr virus in systemic lupus erythematosus.” Front Biosci 6 (October 1, 2001): E137–47. https://doi.org/10.2741/mcclain.
    Full Text Link to Item
  - Kaufman, K. M., M. Y. Kirby, M. T. McClain, J. B. Harley, and J. A. James. “Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'.” Biochem Biophys Res Commun 285, no. 5 (August 3, 2001): 1206–12. https://doi.org/10.1006/bbrc.2001.5302.
    Full Text Link to Item
  - James, J. A., M. T. McClain, G. Koelsch, D. G. Williams, and J. B. Harley. “Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies.” J Autoimmun 12, no. 1 (February 1999): 43–49. https://doi.org/10.1006/jaut.1998.0252.
    Full Text Link to Item
  - McClain, M. T., K. M. Kaufman, G. Koelsch, J. B. Harley, and J. A. James. “Identification and analysis of peptide determinants of murine monoclonal anti-Sm B/B' autoantibodies.” Faseb Journal 12, no. 5 (March 20, 1998).
  - Davis, A. L., M. T. McClain, T. F. Gross, J. B. Harley, and J. A. James. “Immunization with 60kD Ro leads to a diversified immune response to several lupus autoantigens.” Faseb Journal 12, no. 4 (1998): A610.
  - James, J. A., T. F. Gross, A. L. Davis, M. T. McClain, and J. B. Harley. “Immunization with a common epitope of nRNP a induces lupus autoimmunity.” Faseb Journal 12, no. 4 (1998): A606.
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Recent Courses