Current Appointments & Affiliations
Associate Professor of Medicine
·
2020 - Present
Medicine, Infectious Diseases,
Medicine
Member of Duke Center for Applied Genomics and Precision Medicine
·
2014 - Present
The Precision Medicine Program,
Medicine
Recent Publications
Genetics and environment distinctively shape the human immune cell epigenome.
Journal Article Nat Genet · February 2026 The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-acce ... Full text Link to item CiteMass Spectrometry-Based Quantification of Proteins and Post-Translational Modifications in Dried Blood: Longitudinal Sampling of Patients With Sepsis in Tanzania.
Journal Article Proteomics · December 3, 2025 The proteomic analysis of blood is routine for disease phenotyping and biomarker development. Blood is commonly separated into soluble and cellular fractions. However, this can introduce pre-analytical variability, and analysis of a single component (which ... Full text Link to item CiteInnate immune molecular landscape following controlled human influenza virus infection.
Journal Article Cell Rep · October 28, 2025 Viral infections can induce prolonged changes in innate immunity. Here, we use blood samples from a human influenza H3N2 challenge study (NCT03883113) to perform comprehensive multi-omics analyses. We detect remodeling of immune programs in circulating inn ... Full text Link to item CiteRecent Grants
Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis
ResearchMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Host-Pathogen Dynamics in Leptospirosis - P4
ResearchInvestigator · Awarded by University of California - Los Angeles · 2023 - 2028Prognostic Biomarkers in Invasive Candidiasis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2028View All Grants
Education
University of Oklahoma ·
2004
M.D.
University of Oklahoma ·
2002
Ph.D.