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Micah Thomas McClain

Associate Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Room 161 Hanes House, Trent Drive, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Medicine · 2020 - Present Medicine, Infectious Diseases, Medicine
Member of Duke Center for Applied Genomics and Precision Medicine · 2014 - Present The Precision Medicine Program, Medicine

In the News


Published March 29, 2024
Center for Precision Health Welcomes New Faculty Leaders
Published September 25, 2020
Duke-Developed Test Identifies Common Viral Infections Before Symptoms Appear
Published March 16, 2016
New Collaborative Seed Grant Program Gives Eight Awards

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Recent Publications


Innate immune molecular landscape following controlled human influenza virus infection.

Journal Article Cell Rep · October 28, 2025 Viral infections can induce prolonged changes in innate immunity. Here, we use blood samples from a human influenza H3N2 challenge study (NCT03883113) to perform comprehensive multi-omics analyses. We detect remodeling of immune programs in circulating inn ... Full text Link to item Cite

Pediatric T cell and B cell responses to SARS-CoV-2 infection.

Journal Article JCI Insight · October 22, 2025 BACKGROUNDUnderstanding age-associated differences in acute and memory adaptive immunity to SARS-CoV-2 and how they contribute to more favorable outcomes in children is critically important.METHODSWe evaluated SARS-CoV-2-specific T cell, B cell, and antibo ... Full text Link to item Cite

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons.

Journal Article Animal Model Exp Med · September 14, 2025 BACKGROUND: Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide despite the widespread availability of antibiotics. Novel pneumonia therapies and biomarkers are urgently needed to improve outcomes and advance personalized thera ... Full text Link to item Cite
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Recent Grants


Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis

ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029

Host-Pathogen Dynamics in Leptospirosis - P4

ResearchInvestigator · Awarded by University of California - Los Angeles · 2023 - 2028

Single Dose Texas 2017 (H3N2) Challenge Study

ResearchInvestigator · Awarded by Darwin Biosciences · 2024 - 2027

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Education, Training & Certifications


University of Oklahoma · 2004 M.D.
University of Oklahoma · 2002 Ph.D.