Current Appointments & Affiliations
Associate Professor of Medicine
·
2020 - Present
Medicine, Infectious Diseases,
Medicine
Member of Duke Center for Applied Genomics and Precision Medicine
·
2014 - Present
The Precision Medicine Program,
Medicine
Recent Publications
Genetics and environment distinctively shape the human immune cell epigenome.
Journal Article Nat Genet · January 27, 2026 The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-acce ... Full text Link to item CiteMass Spectrometry-Based Quantification of Proteins and Post-Translational Modifications in Dried Blood: Longitudinal Sampling of Patients With Sepsis in Tanzania.
Journal Article Proteomics · December 3, 2025 The proteomic analysis of blood is routine for disease phenotyping and biomarker development. Blood is commonly separated into soluble and cellular fractions. However, this can introduce pre-analytical variability, and analysis of a single component (which ... Full text Link to item CiteInnate immune molecular landscape following controlled human influenza virus infection.
Journal Article Cell Rep · October 28, 2025 Viral infections can induce prolonged changes in innate immunity. Here, we use blood samples from a human influenza H3N2 challenge study (NCT03883113) to perform comprehensive multi-omics analyses. We detect remodeling of immune programs in circulating inn ... Full text Link to item CiteRecent Grants
Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis
ResearchMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Host-Pathogen Dynamics in Leptospirosis - P4
ResearchInvestigator · Awarded by University of California - Los Angeles · 2023 - 2028Validation of RNA biomarkers for infectious and inflammatory diseases diagnosis
ResearchPrincipal Investigator · Awarded by Cepheid · 2025 - 2027View All Grants
Education, Training & Certifications
University of Oklahoma ·
2004
M.D.
University of Oklahoma ·
2002
Ph.D.