Recent advances in the use of imaging in psychiatry: functional magnetic resonance imaging of large-scale brain networks in late-life depression.

Journal Article (Journal Article;Review)

Advances in neuroimaging have identified neural systems that contribute to clinical symptoms that occur across various psychiatric disorders. This transdiagnostic approach to understanding psychiatric illnesses may serve as a precise guide to identifying disease mechanisms and informing successful treatments. While this work is ongoing across multiple psychiatric disorders, in this article we emphasize recent findings pertaining to major depression in the elderly, or late-life depression (LLD), a common and debilitating neuropsychiatric illness. We discuss how neural functioning of three networks is linked to symptom presentation, illness course, and cognitive decline in LLD. These networks are (1) an executive control network responsible for complex cognitive processing, (2) a default mode network normally deactivated during cognitive demanding when individuals are at rest, and a (3) salience network relevant to attending to internal and external emotional and physiological sensations. We discuss how dysfunction in multiple networks contributes to common behavioral syndromes, and we present an overview of the cognitive control, default mode, and salience networks observed in LLD.

Full Text

Duke Authors

Cited Authors

  • Manning, K; Wang, L; Steffens, D

Published Date

  • 2019

Published In

Volume / Issue

  • 8 /

PubMed ID

  • 31448089

Pubmed Central ID

  • PMC6685449

Electronic International Standard Serial Number (EISSN)

  • 2046-1402

Digital Object Identifier (DOI)

  • 10.12688/f1000research.17399.1


  • eng

Conference Location

  • England