A stepwise approach to implementing pharmacogenetic testing in the primary care setting.

Journal Article (Journal Article)

Pharmacogenetic testing can help identify primary care patients at increased risk for medication toxicity, poor response or treatment failure and inform drug therapy. While testing availability is increasing, providers are unprepared to routinely use pharmacogenetic testing for clinical decision-making. Practice-based resources are needed to overcome implementation barriers for pharmacogenetic testing in primary care.The NHGRI's IGNITE I Network (Implementing GeNomics In pracTicE; www.ignite-genomics.org) explored practice models, challenges and implementation barriers for clinical pharmacogenomics. Based on these experiences, we present a stepwise approach pharmacogenetic testing in primary care: patient identification; pharmacogenetic test ordering; interpretation and application of test results, and patient education. We present clinical factors to consider, test-ordering processes and resources, and provide guidance to apply test results and counsel patients. Practice-based resources such as this stepwise approach to clinical decision-making are important resources to equip primary care providers to use pharmacogenetic testing.

Full Text

Duke Authors

Cited Authors

  • Weitzel, KW; Duong, BQ; Arwood, MJ; Owusu-Obeng, A; Abul-Husn, NS; Bernhardt, BA; Decker, B; Denny, JC; Dietrich, E; Gums, J; Madden, EB; Pollin, TI; Wu, RR; Haga, SB; Horowitz, CR

Published Date

  • October 2019

Published In

Volume / Issue

  • 20 / 15

Start / End Page

  • 1103 - 1112

PubMed ID

  • 31588877

Pubmed Central ID

  • PMC6854439

Electronic International Standard Serial Number (EISSN)

  • 1744-8042

Digital Object Identifier (DOI)

  • 10.2217/pgs-2019-0053


  • eng

Conference Location

  • England