Reprogramming of cellular metabolic pathways by human oncogenic viruses.

Journal Article (Journal Article;Review)

Oncogenic viruses, like all viruses, relies on host metabolism to provide the metabolites and energy needed for virus replication. Many DNA tumor viruses and retroviruses will reprogram metabolism during infection. Additionally, some viral oncogenes may alter metabolism independent of virus replication. Virus infection and cancer development share many similarities regarding metabolic reprogramming as both processes demand increased metabolic activity to produce biomass: cell proliferation in the case of cancer and virion production in the case of infection. This review discusses the parallels in metabolic reprogramming between human oncogenic viruses and oncogenesis.

Full Text

Duke Authors

Cited Authors

  • Purdy, JG; Luftig, MA

Published Date

  • December 2019

Published In

Volume / Issue

  • 39 /

Start / End Page

  • 60 - 69

PubMed ID

  • 31766001

Pubmed Central ID

  • PMC6986357

Electronic International Standard Serial Number (EISSN)

  • 1879-6265

Digital Object Identifier (DOI)

  • 10.1016/j.coviro.2019.11.002


  • eng

Conference Location

  • Netherlands