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Anterior gland focal cryoablation: proof-of-concept primary prostate cancer treatment in select men with localized anterior cancers detected by multi-parametric magnetic resonance imaging.

Publication ,  Journal Article
Sze, C; Tsivian, E; Tay, KJ; Schulman, AA; Davis, LG; Gupta, RT; Polascik, TJ
Published in: BMC Urol
December 5, 2019

BACKGROUND: Due to their location away from the nerve bundles, anterior prostate cancers (APC) represent a rational target for image-guided cryoablation. This report describes the feasibility and short-term outcomes of anterior focal cryosurgery. METHODS: A retrospective review between 2012 and 2016 of patients with clinically localized APC treated with anterior gland cryoablation was performed. Descriptive statistics were used to report: age, PSA, prostate volume, prostate cancer grade group (PGG), median time to follow-up, and changes in functional status measured with the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function (IIEF-5) score. RESULTS: A total of 17 patients underwent anterior focal cryoablation with a median follow-up of 15 months. Median age and PSA at diagnosis were 67 years and 8.7 ng/mL. Pre-operative PGG1 was identified in 12 (71%) men and PGG2 in 5 (29%) men. Median (IQR) lesion volume was 2 mL(0.86, 3.1). Preoperative median IIEF-5 and IPSS scores were 19.5 and 5, and decreased to 19 and 4, post-operatively. All patients remained continent with no change in sexual function. All post-procedure targeted biopsies of the treated cancers were negative. CONCLUSION: Our pilot study demonstrates the feasibility of treating APCs with image-guided targeted focal cryoablation as a good balance between short-term oncologic control and near complete preservation of genitourinary function. Further follow-up is necessary to examine the potential benefits long-term.

Duke Scholars

Published In

BMC Urol

DOI

EISSN

1471-2490

Publication Date

December 5, 2019

Volume

19

Issue

1

Start / End Page

127

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Tumor Burden
  • Treatment Outcome
  • Retrospective Studies
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Proof of Concept Study
  • Pilot Projects
  • Penile Erection
 

Citation

APA
Chicago
ICMJE
MLA
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Sze, C., Tsivian, E., Tay, K. J., Schulman, A. A., Davis, L. G., Gupta, R. T., & Polascik, T. J. (2019). Anterior gland focal cryoablation: proof-of-concept primary prostate cancer treatment in select men with localized anterior cancers detected by multi-parametric magnetic resonance imaging. BMC Urol, 19(1), 127. https://doi.org/10.1186/s12894-019-0562-5
Sze, Christina, Efrat Tsivian, Kae Jack Tay, Ariel A. Schulman, Leah G. Davis, Rajan T. Gupta, and Thomas J. Polascik. “Anterior gland focal cryoablation: proof-of-concept primary prostate cancer treatment in select men with localized anterior cancers detected by multi-parametric magnetic resonance imaging.BMC Urol 19, no. 1 (December 5, 2019): 127. https://doi.org/10.1186/s12894-019-0562-5.
Journal cover image

Published In

BMC Urol

DOI

EISSN

1471-2490

Publication Date

December 5, 2019

Volume

19

Issue

1

Start / End Page

127

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Tumor Burden
  • Treatment Outcome
  • Retrospective Studies
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Proof of Concept Study
  • Pilot Projects
  • Penile Erection