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Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons.

Publication ,  Journal Article
Chen, O; Donnelly, CR; Ji, R-R
Published in: Curr Opin Neurobiol
June 2020

Inflammation is the body's protective reaction to injury and infection. Pain is a hallmark of inflammation and can be either protective or detrimental during acute or chronic phase. Macrophages play a chief role in the pathogenesis of pain and have bilateral communications with nociceptors, the specialized primary sensory neurons that sense pain. Macrophages 'talk to' nociceptors by releasing pro-inflammatory mediators (e.g. pro-inflammatory cytokines) that induce pain via direct activation of nociceptors. Macrophages also 'listen to' nociceptors, by which nociceptors secrete neuropeptides and chemokines which act on macrophages. Activation of toll-like receptors (TLRs) in nociceptors releases CCL2, activating macrophages and potentiating pathological pain. Emerging evidence also points to a pro-resolution role of macrophages in inflammation and pain. Macrophage GPR37 is activated by neuroprotectin D1, a specialized pro-resolving mediator (SPM) and resolves inflammatory pain via phagocytosis and production of IL-10 that inhibits nociceptors. Macrophage-nociceptor interactions are also mediated by microRNAs and microRNA-containing exosomes in chronic pain. Notably, extracellular microRNAs (e.g. let-7b and miR-711) can directly bind and activate nociceptors. Targeting macrophage-nociceptor interactions will help to control inflammation and pain.

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Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

June 2020

Volume

62

Start / End Page

17 / 25

Location

England

Related Subject Headings

  • Sensory Receptor Cells
  • Pain
  • Nociceptors
  • Neuroimmunomodulation
  • Macrophages
  • Inflammation
  • Humans
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

Citation

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Chen, O., Donnelly, C. R., & Ji, R.-R. (2020). Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Curr Opin Neurobiol, 62, 17–25. https://doi.org/10.1016/j.conb.2019.11.006
Chen, Ouyang, Christopher R. Donnelly, and Ru-Rong Ji. “Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons.Curr Opin Neurobiol 62 (June 2020): 17–25. https://doi.org/10.1016/j.conb.2019.11.006.
Chen O, Donnelly CR, Ji R-R. Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Curr Opin Neurobiol. 2020 Jun;62:17–25.
Chen, Ouyang, et al. “Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons.Curr Opin Neurobiol, vol. 62, June 2020, pp. 17–25. Pubmed, doi:10.1016/j.conb.2019.11.006.
Chen O, Donnelly CR, Ji R-R. Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons. Curr Opin Neurobiol. 2020 Jun;62:17–25.
Journal cover image

Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

June 2020

Volume

62

Start / End Page

17 / 25

Location

England

Related Subject Headings

  • Sensory Receptor Cells
  • Pain
  • Nociceptors
  • Neuroimmunomodulation
  • Macrophages
  • Inflammation
  • Humans
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences