Axonal Odorant Receptors Mediate Axon Targeting.

Journal Article (Journal Article)

In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and at the axon terminal. The mechanism of activation and function of the odorant receptor at the axon terminal is, however, still unknown. Here, we identify phosphatidylethanolamine-binding protein 1 as a putative ligand that activates the odorant receptor at the axon terminal and affects the turning behavior of sensory axons. Genetic ablation of phosphatidylethanolamine-binding protein 1 in mice results in a strongly disturbed olfactory sensory map. Our data suggest that the odorant receptor at the axon terminal of olfactory neurons acts as an axon guidance cue that responds to molecules originating in the olfactory bulb. The dual function of the odorant receptor links specificity of odor perception and axon targeting.

Full Text

Duke Authors

Cited Authors

  • Zamparo, I; Francia, S; Franchi, SA; Redolfi, N; Costanzi, E; Kerstens, A; Fukutani, Y; Battistutta, R; Polverino de Laureto, P; Munck, S; De Strooper, B; Matsunami, H; Lodovichi, C

Published Date

  • December 24, 2019

Published In

Volume / Issue

  • 29 / 13

Start / End Page

  • 4334 - 4348.e7

PubMed ID

  • 31875544

Pubmed Central ID

  • PMC6941231

Electronic International Standard Serial Number (EISSN)

  • 2211-1247

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2019.11.099

Language

  • eng

Conference Location

  • United States