In patients with intractable epilepsy, predicting seizures above chance and with clinically acceptable performance has yet to be demonstrated. In this study, an intracranial EEG-based seizure prediction method using measures of similarity with a reference state is proposed.1565 h of continuous intracranial EEG data from 17 patients with mesial temporal lobe epilepsy were investigated. The recordings included 175 seizures. In each patient the data was split into a training set and a testing set. EEG segments were analyzed using continuous wavelet transform. During training, a reference state was defined in the immediate preictal data and used to derive three features quantifying the discrimination between preictal and interictal states. A classifier was then trained in the feature space. Its performance was assessed using testing set and compared with a random predictor for statistical validation.Better than random prediction performance was achieved in 7 patients. The sensitivity was higher than 85%, the warning rate was less than 0.35/h and the proportion of time under warning was less than 30%.Seizures are predicted above chance in 41% of patients using measures of state similarity.Sensitivity and specificity levels are potentially interesting for closed-loop seizure control applications.