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Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes.

Publication ,  Journal Article
Rogers, JL; Eudy, AM; Pisetsky, D; Criscione-Schreiber, LG; Sun, K; Doss, J; Clowse, MEB
Published in: Arthritis Care Res (Hoboken)
March 2021

OBJECTIVE: The type 1 and type 2 systemic lupus erythematosus (SLE) categorization system was recently proposed to validate the patients' perspective of disease and to capture a more comprehensive spectrum of symptoms. The objective of this study was to characterize the clinical manifestations of SLE subtypes and to determine the correlation between the patient- and physician-reported measures used in the model. METHODS: This was a cross-sectional study of patients with SLE in a university clinic. Patients completed the Systemic Lupus Activity Questionnaire (SLAQ) and 2011 American College of Rheumatology fibromyalgia (FM) criteria. Active SLE was defined as Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score ≥6, clinical SLEDAI score ≥4, or active lupus nephritis. We identified 4 groups: type 1 SLE (active SLE without FM), type 2 SLE (inactive SLE with FM), mixed SLE (active SLE with FM), and minimal SLE (inactive SLE without FM). RESULTS: In this cohort of 212 patients (92% female, mean age 45 years), 30% had type 1 SLE, 8% had type 2 SLE, 13% had mixed SLE, and 49% had minimal SLE. Regardless of SLE disease activity, patients with FM (21%), reported higher SLAQ scores, patient global assessment scores, and self-reported lupus flare that resulted in discordance between patient- and physician-reported measures. CONCLUSION: Fatigue, widespread pain, sleep dysfunction, and mood disorders are common symptoms in SLE. Identifying these symptoms as type 2 SLE may be a method to improve patient communication and understanding. The level of type 2 SLE impacts patients' perception of disease and self-reported symptoms. The SLAQ may need to be reinterpreted based on the FM severity scale.

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Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

March 2021

Volume

73

Issue

3

Start / End Page

386 / 393

Location

United States

Related Subject Headings

  • Symptom Flare Up
  • Symptom Assessment
  • Severity of Illness Index
  • Self Report
  • Prevalence
  • Pilot Projects
  • Physicians
  • Patient Reported Outcome Measures
  • North Carolina
  • Middle Aged
 

Citation

APA
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Rogers, J. L., Eudy, A. M., Pisetsky, D., Criscione-Schreiber, L. G., Sun, K., Doss, J., & Clowse, M. E. B. (2021). Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes. Arthritis Care Res (Hoboken), 73(3), 386–393. https://doi.org/10.1002/acr.24135
Rogers, Jennifer L., Amanda M. Eudy, David Pisetsky, Lisa G. Criscione-Schreiber, Kai Sun, Jayanth Doss, and Megan E. B. Clowse. “Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes.Arthritis Care Res (Hoboken) 73, no. 3 (March 2021): 386–93. https://doi.org/10.1002/acr.24135.
Rogers JL, Eudy AM, Pisetsky D, Criscione-Schreiber LG, Sun K, Doss J, et al. Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes. Arthritis Care Res (Hoboken). 2021 Mar;73(3):386–93.
Rogers, Jennifer L., et al. “Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes.Arthritis Care Res (Hoboken), vol. 73, no. 3, Mar. 2021, pp. 386–93. Pubmed, doi:10.1002/acr.24135.
Rogers JL, Eudy AM, Pisetsky D, Criscione-Schreiber LG, Sun K, Doss J, Clowse MEB. Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes. Arthritis Care Res (Hoboken). 2021 Mar;73(3):386–393.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

March 2021

Volume

73

Issue

3

Start / End Page

386 / 393

Location

United States

Related Subject Headings

  • Symptom Flare Up
  • Symptom Assessment
  • Severity of Illness Index
  • Self Report
  • Prevalence
  • Pilot Projects
  • Physicians
  • Patient Reported Outcome Measures
  • North Carolina
  • Middle Aged