David Stephen Pisetsky | Scholars@Duke

David Stephen Pisetsky
Professor of Medicine

Studies in my laboratory concern the immunological properties of DNA as related to two main topics: 1) the induction of anti-DNA responses in systemic lupus erythematosus; and 2) the stimulation of innate immunity by bacterial DNA. These topics are closely linked since we have established novel disease models in which lupus-like illness can be induced in normal mice by bacterial DNA under conditions in which mammalian DNA is inactive. This model has been useful in elucidating mechanisms of DNA antigen drive in autoimmunity.

To pursue these studies, our laboratory conducts investigations in the following areas: 1) specificity of anti-DNA for epitopes on mammalian and bacterial DNA; 2) molecular analysis of murine mononclonal anti-DNA antibodies; 3) histopathological analyses of DNA-immunized mice; 4) in vitro analysis of proliferation, antibody production and cytokine expression in human and murine immune cells; and 5) analysis of DNA binding to cell surface molecules on B cells, T cells and macrophages. Results of these studies have allowed identification of at least two structural motifs that are immunoactive. We are also exploring the impact of chemical modifications of the DNA backbone.

In addition to work on the immunology of DNA, I am also involved in clinical trials related to new immunomodulatory agents in the treatment of rheumatoid arthritis as well as serological markers of disease activity.

The areas of research for which I am known nationally are anti-DNA antibodies, systemic lupus erythematosus and immunological properties of DNA. I have written textbook chapters and reviews on all these subjects.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 1990
Professor of Immunology, Immunology, Basic Science Departments 1994
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1978
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2014

Contact Information

VA Med Ctr, 508 Fulton St, Durham, NC 27705
VA Med Ctr, 508 Fulton St, Durham, NC 27705
david.pisetsky@duke.edu (919) 286-6835

Background
Education, Training, & Certifications
- Resident, Medicine, Yale University School of Medicine 1974
- Intern, Medicine, Yale University School of Medicine 1973 - 1974
- M.D., Yeshiva University, Albert Einstein College of Medicine 1973
- Ph.D., Yeshiva University, Albert Einstein College of Medicine 1972
Previous Appointments & Affiliations
- Chief, Division of Rheumatology and Immunology, Medicine, Rheumatology and Immunology, Medicine 1996 - 2007
- Assistant Professor of Immunology in the Department of Immunology, Immunology, Basic Science Departments 1993 - 1994
- Assistant Professor of Immunology in the Department of Microbiology and Immunology, Molecular Genetics and Microbiology, Basic Science Departments 1991 - 1992
Recognition
In the News
- FEB 25, 2014 CBS News
  
  Harold Ramis dies: What is autoimmune inflammatory vasculitis?
- FEB 25, 2014 CBS News
  
  Harold Ramis dies: What is autoimmune inflammatory vasculitis?
Research
Selected Grants
- Improving Quality of Life in SLE by Stratified Personalized Health Planning awarded by Department of Defense 2022 - 2026
- Immunogenicity and risk of autoimmune cross-reactivity of COVID-19 mRNA vaccines in SLE - RRF Investigator Award awarded by Rheumatology Research Foundation 2022 - 2025
- Basic Immunology Training Program awarded by National Institutes of Health 2020 - 2025
- Engineering Polymers to Scavenge DAMPs in Arthritis and Lupus awarded by National Institutes of Health 2018 - 2023
- Biomarkers to distinguish between Type 1 and 2 SLE activity awarded by Exagen , Inc. 2020 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Antigenome Signatures as Biomarkers for Subtyping Disease Heterogeneity in Lupus Patients awarded by Department of Defense 2019 - 2022
- VA IPA: Diane Spencer awarded by Durham Veterans Affairs Medical Center 2020 - 2022
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- Metabolomic Analysis of Paired Serum and Skeletal Muscle in Juvenile Inflammatory Myositis Compared to Controls awarded by Cure JM Foundation 2017 - 2019
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Determinants of ANA Expression in Patients with SLE awarded by Lupus Research Institute 2015 - 2017
- Obesity, Biomechanics, and Inflammation in Osteoarthritis awarded by National Institutes of Health 2013 - 2016
- IPA - Diane Spencer awarded by Durham Veterans Affairs Medical Center 2012 - 2014
- IPA - Nancy Stearns awarded by Durham Veterans Affairs Medical Center 2012 - 2014
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- Nucleic Acid Binding Polymers as Anti-Inflammatory Agents awarded by National Institutes of Health 2011 - 2013
- The Role of Sex in Self Antigen Generation in SLE awarded by National Institutes of Health 2009 - 2012
- Microparticles as a Source of Nuclear Antigens in Systemic Lupus Erythematosus awarded by National Institutes of Health 2009 - 2012
- IPA - Julie Lynn Gauley awarded by Veterans Administration Medical Center 2011
- IPA - Julie Gauley awarded by Veterans Administration Medical Center 2009 - 2010
- Nitric Oxide, Oxygen and Mechanical Stress in Cartilage awarded by National Institutes of Health 2004 - 2010
- IPA Charles Reich awarded by Veterans Administration Medical Center 2008 - 2010
- IPA Julie Lynn Gauley awarded by Veterans Administration Medical Center 2008 - 2009
- Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health 2003 - 2009
- IPA - Charles Reich awarded by VAMC 2007 - 2008
- The Immunomodulatory Effects of DNA in SLE awarded by National Institutes of Health 2001 - 2007
- Planning an Early RA Prevention Trial awarded by National Institutes of Health 2005 - 2006
- Strategies for Evaluating and Treating Early Synovitis awarded by National Institutes of Health 2003 - 2006
- Mechanical Stress and Prostaglandins in Cartilage awarded by National Institutes of Health 2001 - 2004
- Same awarded by National Institutes of Health 2000 - 2001
- same awarded by National Institutes of Health 1987 - 2001
- Specialized Center Of Research In Rheumatoid Arthritis awarded by National Institutes of Health 1987 - 1999
- Training Program - Inflammatory And Immunological Diseases awarded by National Institutes of Health 1980 - 1999
- Intravenous Doxycycline For Rheumatoid Arthritis awarded by National Institutes of Health 1994 - 1998
- Specialized Center Of Research In Rheumatoid Arthritis awarded by National Institutes of Health 1987 - 1997
- Identification Of Autoimmune Genes In 1pr Mice awarded by National Institutes of Health 1992 - 1996
- Identification Of 'Autoimmune Genes' In 1pr/1pr Mice awarded by National Institutes of Health 1992 - 1996
- Molecular And Cellular Mechanisms Of Human Inflammatory awarded by National Institutes of Health 1990 - 1992
- Molecular And Cellular Mechanisms Of Human Inflammatory D. awarded by National Institutes of Health 1989 - 1991
- Molecular Mechanisms Of Human Inflammatory Diseases awarded by National Institutes of Health 1988 - 1991
- Molecular Mechanisms Of Human Inflammatory Disease awarded by National Institutes of Health 1987 - 1991
- Molecular And Cellular Mechanisms Of Human Inflammatory Di awarded by National Institutes of Health 1986 - 1991
External Relationships
- BMS Corporation
- Immunovant
- UpToDate, Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wallace, Daniel J., Thomas Dörner, David S. Pisetsky, Jorge Sanchez-Guerrero, Anand C. Patel, Dana Parsons-Rich, Claire Le Bolay, et al. “Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase II, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Trial.” Acr Open Rheumatol 5, no. 1 (January 2023): 38–48. https://doi.org/10.1002/acr2.11511.
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  - Olson, Lyra B., Nicole I. Hunter, Rachel E. Rempel, Haixiang Yu, Diane M. Spencer, Cynthia Z. Sullenger, William S. Greene, et al. “Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity.” Iscience 25, no. 12 (December 22, 2022): 105542. https://doi.org/10.1016/j.isci.2022.105542.
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  - Eudy, A. M., J. L. Rogers, A. Corneli, K. McKenna, M. Maheswaranathan, D. S. Pisetsky, L. G. Criscione-Schreiber, et al. “Intermittent and Persistent Type 2 lupus: patient perspectives on two distinct patterns of Type 2 SLE symptoms.” Lupus Science and Medicine 9, no. 1 (August 1, 2022). https://doi.org/10.1136/lupus-2022-000705.
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  - Pisetsky, David S., and Kevin L. Winthrop. “In the shadow of antibodies: how T cells defend against COVID-19.” Ann Rheum Dis 81, no. 6 (June 2022): 757–59. https://doi.org/10.1136/annrheumdis-2021-221952.
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  - Pisetsky, David S., Angel Garza Reyna, Morgan E. Belina, and Diane M. Spencer. “The Interaction of Anti-DNA Antibodies with DNA: Evidence for Unconventional Binding Mechanisms.” Int J Mol Sci 23, no. 9 (May 7, 2022). https://doi.org/10.3390/ijms23095227.
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  - Dvergsten, Jeffrey A., Ann M. Reed, Lawrence Landerman, David S. Pisetsky, Olga Ilkayeva, and Kim M. Huffman. “Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.” Rheumatology (Oxford) 61, no. 4 (April 11, 2022): 1699–1708. https://doi.org/10.1093/rheumatology/keab520.
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  - Pisetsky, David S. “Are DNA-HLA class II interactions the missing link in SLE?” Nat Rev Rheumatol 17, no. 11 (November 2021): 647–48. https://doi.org/10.1038/s41584-021-00684-1.
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  - Belina, Morgan E., Diane M. Spencer, and David S. Pisetsky. “The Binding Mechanisms of Antibodies to DNA from Healthy Subjects and Patients with Systemic Lupus Erythematosus: The Role of Monogamous Bivalency and Fc Dependence.” Immunohorizons 5, no. 10 (October 8, 2021): 792–801. https://doi.org/10.4049/immunohorizons.2100077.
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  - Pisetsky, David S., Robert Shaffer, Dustin D. Armstrong, and Diane M. Spencer. “The interaction of anti-DNA antibodies with DNA antigen: Evidence for hysteresis for high avidity binding.” Clin Immunol 231 (October 2021): 108848. https://doi.org/10.1016/j.clim.2021.108848.
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  - Pisetsky, David S. “Some disease-modifying osteoarthritis drugs make small improvements in knee and hip osteoarthritis.” Ann Intern Med 174, no. 9 (September 2021): JC104. https://doi.org/10.7326/ACPJ202109210-104.
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  - Spencer, Diane M., Angel Garza Reyna, and David S. Pisetsky. “The Binding of Monoclonal and Polyclonal Anti-Z-DNA Antibodies to DNA of Various Species Origin.” Int J Mol Sci 22, no. 16 (August 19, 2021). https://doi.org/10.3390/ijms22168931.
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  - Pisetsky, David S., Diane M. Spencer, Brad Rovin, and Peter E. Lipsky. “Role of ANA testing in the classification of patients with systemic lupus erythematosus.” Ann Rheum Dis 80, no. 8 (August 2021): e124. https://doi.org/10.1136/annrheumdis-2019-216259.
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  - Pisetsky, David S., Amanda M. Eudy, Megan E. B. Clowse, and Jennifer L. Rogers. “The Categorization of Pain in Systemic Lupus Erythematosus.” Rheum Dis Clin North Am 47, no. 2 (May 2021): 215–28. https://doi.org/10.1016/j.rdc.2020.12.004.
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  - Pisetsky, David S., and Peter E. Lipsky. “Reply to: Diagnostic role of anti-dsDNA antibodies: do not forget autoimmune hepatitis.” Nat Rev Rheumatol 17, no. 4 (April 2021): 245. https://doi.org/10.1038/s41584-021-00574-6.
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  - Rogers, Jennifer L., Amanda M. Eudy, David Pisetsky, Lisa G. Criscione-Schreiber, Kai Sun, Jayanth Doss, and Megan E. B. Clowse. “Using Clinical Characteristics and Patient-Reported Outcome Measures to Categorize Systemic Lupus Erythematosus Subtypes.” Arthritis Care Res (Hoboken) 73, no. 3 (March 2021): 386–93. https://doi.org/10.1002/acr.24135.
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  - Pisetsky, David S. “The role of TASL in the pathogenesis of SLE: X marks the spot.” Ann Rheum Dis 80, no. 1 (January 2021): 6–7. https://doi.org/10.1136/annrheumdis-2020-218643.
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  - Pisetsky, David S., Reinhard Voll, and Edit I. Buzas. “Editorial: The Role of Nuclear Molecules in the Pathogenesis of Autoimmune Disease.” Front Immunol 12 (2021): 737923. https://doi.org/10.3389/fimmu.2021.737923.
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  - Pisetsky, David S. “Immune phenotypes in individuals positive for antinuclear antibodies: The impact of race and ethnicity.” J Allergy Clin Immunol 146, no. 6 (December 2020): 1346–48. https://doi.org/10.1016/j.jaci.2020.09.006.
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  - Toes, René, and David S. Pisetsky. “Response to: "How to communicate in science" by Klareskog et al.” Ann Rheum Dis 79, no. 12 (December 2020): e165. https://doi.org/10.1136/annrheumdis-2019-216045.
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  - Griffith, Darbi M., Dhanya T. Jayaram, Diane M. Spencer, David S. Pisetsky, and Christine K. Payne. “DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona.” Biointerphases 15, no. 5 (October 1, 2020): 051006. https://doi.org/10.1116/6.0000439.
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  - Pisetsky, David S., and Peter E. Lipsky. “New insights into the role of antinuclear antibodies in systemic lupus erythematosus.” Nat Rev Rheumatol 16, no. 10 (October 2020): 565–79. https://doi.org/10.1038/s41584-020-0480-7.
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  - Toes, René, and David S. Pisetsky. “Response to: 'Comment on editorial 'Pathogenic effector functions of ACPA: where do we stand'' by Holmdahl.” Ann Rheum Dis 79, no. 10 (October 2020): e127. https://doi.org/10.1136/annrheumdis-2019-215870.
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  - Woolf, Anthony D., David S. Pisetsky, Scott A. Rodeo, James P. Waddell, Hiroshi Hagino, Gurjit S. Kaeley, Maria Crotty, et al. “Clinical advances - from bench to bedside.” Best Pract Res Clin Rheumatol 34, no. 5 (October 2020): 101598. https://doi.org/10.1016/j.berh.2020.101598.
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  - Pisetsky, David S. “Hopefulness of 'Hope'.” Ann Rheum Dis 79, no. 7 (July 2020): 849–50. https://doi.org/10.1136/annrheumdis-2020-217691.
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  - Pisetsky, D. S. “The value of antinuclear antibody testing and retesting.” The Lancet Rheumatology 2, no. 7 (July 1, 2020): e373–74. https://doi.org/10.1016/S2665-9913(20)30097-7.
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  - Pisetsky, David S. “Evolving story of autoantibodies in systemic lupus erythematosus.” J Autoimmun 110 (June 2020): 102356. https://doi.org/10.1016/j.jaut.2019.102356.
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  - Pisetsky, David S. “The basic and translational science year in review: Confucius in the era of Big Data.” Semin Arthritis Rheum 50, no. 3 (June 2020): 373–79. https://doi.org/10.1016/j.semarthrit.2020.02.010.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to 'Antinuclear antibodies by indirect immunofluorescence and solid phase assays' by Bossuyt et al.” Ann Rheum Dis 79, no. 6 (June 2020): e66. https://doi.org/10.1136/annrheumdis-2019-215479.
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  - Pisetsky, David S., Diane M. Spencer, Fariborz Mobarrez, Enrico Fuzzi, Iva Gunnarsson, and Elisabet Svenungsson. “The binding of SLE autoantibodies to mitochondria.” Clin Immunol 212 (March 2020): 108349. https://doi.org/10.1016/j.clim.2020.108349.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'Can solid-phase assays replace immunofluorescence for ANA screening?' by Bizzaro.” Ann Rheum Dis 79, no. 3 (March 2020): e33. https://doi.org/10.1136/annrheumdis-2018-214829.
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  - Pisetsky, David S. “Of mice, men and microbes: the impact of the microbiome on immune responses.” Ann Rheum Dis 79, no. 2 (February 2020): 167–69. https://doi.org/10.1136/annrheumdis-2020-216936.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'ANA testing in "real life"' by Infantino etal.” Ann Rheum Dis 79, no. 1 (January 2020): e4. https://doi.org/10.1136/annrheumdis-2018-214650.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad Rovin. “Response to: "Antinuclear autoantibodies: discordance among four different assays" by Pacheco et al.” Ann Rheum Dis 79, no. 1 (January 2020): e7. https://doi.org/10.1136/annrheumdis-2018-214766.
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  - Pisetsky, David S., Xavier Bossuyt, and Pier Luigi Meroni. “ANA as an entry criterion for the classification of SLE.” Autoimmun Rev 18, no. 12 (December 2019): 102400. https://doi.org/10.1016/j.autrev.2019.102400.
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  - Weinmann, Sophia C., and David S. Pisetsky. “Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors.” Rheumatology (Oxford) 58, no. Suppl 7 (December 1, 2019): vii59–67. https://doi.org/10.1093/rheumatology/kez308.
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  - Pisetsky, David S., Dana Kathryn Thompson, Joseph Wajdula, Annette Diehl, and Sudhakar Sridharan. “Variability in Antinuclear Antibody Testing to Assess Patient Eligibility for Clinical Trials of Novel Treatments for Systemic Lupus Erythematosus.” Arthritis Rheumatol 71, no. 9 (September 2019): 1534–38. https://doi.org/10.1002/art.40910.
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  - Mobarrez, Fariborz, Enrico Fuzzi, Iva Gunnarsson, Anders Larsson, Susanna Eketjäll, David S. Pisetsky, and Elisabet Svenungsson. “Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes.” J Autoimmun 102 (August 2019): 142–49. https://doi.org/10.1016/j.jaut.2019.05.003.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'Antinuclear antibody as entry criterion for classification of systemic lupus erythematosus: pitfalls and opportunities' by Bossuyt et al.” Ann Rheum Dis 78, no. 8 (August 2019): e77. https://doi.org/10.1136/annrheumdis-2018-213841.
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  - Pisetsky, David S. “Unexpected link between mitochondrial DNA and T cell help in systemic lupus erythematosus.” Ann Rheum Dis 78, no. 6 (June 2019): e59. https://doi.org/10.1136/annrheumdis-2019-215597.
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  - Toes, René, and David S. Pisetsky. “Pathogenic effector functions of ACPA: Where do we stand?” Ann Rheum Dis 78, no. 6 (June 2019): 716–21. https://doi.org/10.1136/annrheumdis-2019-215337.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'Pitfalls of antinuclear antibody detection in systemic lupus erythematosus: the positive experience of a national multi-center study' by Pregnalato et al.” Ann Rheum Dis 78, no. 6 (June 2019): e51. https://doi.org/10.1136/annrheumdis-2018-213582.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'Variation in antinuclear antibody detection by automated indirect immunofluorescence analysis' by van Hoovels et al.” Ann Rheum Dis 78, no. 6 (June 2019): e49. https://doi.org/10.1136/annrheumdis-2018-213558.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'Unending story of the indirect immunofluorescence assay on HEp-2 cells: old problems and new solutions?' by Meroni et al.” Ann Rheum Dis 78, no. 6 (June 2019): e47. https://doi.org/10.1136/annrheumdis-2018-213537.
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  - Pisetsky, David S., Megan E. B. Clowse, Lisa G. Criscione-Schreiber, and Jennifer L. Rogers. “A Novel System to Categorize the Symptoms of Systemic Lupus Erythematosus.” Arthritis Care Res (Hoboken) 71, no. 6 (June 2019): 735–41. https://doi.org/10.1002/acr.23794.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Response to: 'Lack of standardization of ANA and implications for drug development and precision medicine' by Mahler.” Ann Rheum Dis 78, no. 5 (May 2019): e34. https://doi.org/10.1136/annrheumdis-2018-213399.
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  - Pisetsky, David S., and Peter E. Lipsky. “Role of Antinuclear Antibody Determinations in Classification Criteria for Systemic Lupus Erythematosus: Comment on the Article by Leuchten et al.” Arthritis Care Res (Hoboken) 71, no. 5 (May 2019): 696. https://doi.org/10.1002/acr.23559.
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  - Pisetsky, David S. “The central role of nucleic acids in the pathogenesis of systemic lupus erythematosus.” F1000res 8 (2019). https://doi.org/10.12688/f1000research.17959.1.
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  - Mobarrez, Fariborz, Elisabet Svenungsson, and David S. Pisetsky. “Microparticles as autoantigens in systemic lupus erythematosus.” Eur J Clin Invest 48, no. 12 (December 2018): e13010. https://doi.org/10.1111/eci.13010.
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  - Pisetsky, David S. “Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level.” Ann Rheum Dis 77, no. 9 (September 2018): 1249–50. https://doi.org/10.1136/annrheumdis-2018-213783.
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  - Putterman, Chaim, David S. Pisetsky, Michelle Petri, Roberto Caricchio, Alan H. B. Wu, Ignacio Sanz, Jim C. Oates, et al. “The SLE-key test serological signature: new insights into the course of lupus.” Rheumatology (Oxford) 57, no. 9 (September 1, 2018): 1632–40. https://doi.org/10.1093/rheumatology/key149.
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  - Stamm, Tanja Alexandra, Klaus Peter Machold, Daniel Aletaha, Farideh Alasti, Peter Lipsky, David Pisetsky, Robert Landewe, et al. “Induction of sustained remission in early inflammatory arthritis with the combination of infliximab plus methotrexate: the DINORA trial.” Arthritis Res Ther 20, no. 1 (August 9, 2018): 174. https://doi.org/10.1186/s13075-018-1667-z.
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  - Pisetsky, David S. “Effects of immune checkpoint inhibitors on B cells: relationship to immune-related adverse events.” Ann Rheum Dis 77, no. 6 (June 2018): 795–96. https://doi.org/10.1136/annrheumdis-2018-213561.
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  - Pisetsky, David S., Diane M. Spencer, Peter E. Lipsky, and Brad H. Rovin. “Assay variation in the detection of antinuclear antibodies in the sera of patients with established SLE.” Ann Rheum Dis 77, no. 6 (June 2018): 911–13. https://doi.org/10.1136/annrheumdis-2017-212599.
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  - Pisetsky, David S. “How the gut inflames the joints.” Ann Rheum Dis 77, no. 5 (May 2018): 634–35. https://doi.org/10.1136/annrheumdis-2018-212942.
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  - Naqvi, Ibtehaj, Ruwan Gunaratne, Jessica E. McDade, Angelo Moreno, Rachel E. Rempel, Douglas C. Rouse, Silvia Gabriela Herrera, et al. “Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis.” Mol Ther 26, no. 4 (April 4, 2018): 1020–31. https://doi.org/10.1016/j.ymthe.2018.02.018.
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  - Spencer, Diane M., John R. Dye, Claude A. Piantadosi, and David S. Pisetsky. “The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro.” Exp Cell Res 363, no. 2 (February 15, 2018): 151–59. https://doi.org/10.1016/j.yexcr.2017.12.024.
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  - Frank-Bertoncelj, Mojca, David S. Pisetsky, Christoph Kolling, Beat A. Michel, Renate E. Gay, Astrid Jüngel, and Steffen Gay. “TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles.” Front Immunol 9 (2018): 28. https://doi.org/10.3389/fimmu.2018.00028.
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  - Théry, Clotilde, Kenneth W. Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D. Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, et al. “Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.” J Extracell Vesicles 7, no. 1 (2018): 1535750. https://doi.org/10.1080/20013078.2018.1535750.
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  - Pisetsky, David S. “The biological functions of DNA: from the sublime to the slime.” Arthritis Res Ther 19, no. 1 (December 15, 2017): 275. https://doi.org/10.1186/s13075-017-1464-0.
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  - Zerwas, Stephanie, Janne Tidselbak Larsen, Liselotte Petersen, Laura M. Thornton, Michela Quaranta, Susanne Vinkel Koch, David Pisetsky, Preben Bo Mortensen, and Cynthia M. Bulik. “Eating Disorders, Autoimmune, and Autoinflammatory Disease.” Pediatrics 140, no. 6 (December 2017). https://doi.org/10.1542/peds.2016-2089.
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  - Pisetsky, David S. “Antinuclear antibody testing - misunderstood or misbegotten?” Nat Rev Rheumatol 13, no. 8 (August 2017): 495–502. https://doi.org/10.1038/nrrheum.2017.74.
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  - Pisetsky, David S. “EULAR recommendations for disease management: guidance not guidelines.” Ann Rheum Dis 76, no. 6 (June 2017): 935–38. https://doi.org/10.1136/annrheumdis-2016-211005.
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  - Pisetsky, David S., Brad H. Rovin, and Peter E. Lipsky. “New Perspectives in Rheumatology: Biomarkers as Entry Criteria for Clinical Trials of New Therapies for Systemic Lupus Erythematosus: The Example of Antinuclear Antibodies and Anti-DNA.” Arthritis Rheumatol 69, no. 3 (March 2017): 487–93. https://doi.org/10.1002/art.40008.
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  - Pisetsky, D. “The role of microparticles in the pathogenesis of SLE: A new look at an old paradigm.” Lupus Science and Medicine 4, no. 1 (January 1, 2017). https://doi.org/10.1136/lupus-2017-000220.
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  - Shoda, Lisl Km, Christina Battista, Scott Q. Siler, David S. Pisetsky, Paul B. Watkins, and Brett A. Howell. “Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.” Gene Regul Syst Bio 11 (2017): 1177625017696074. https://doi.org/10.1177/1177625017696074.
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  - Borenstein, David G., Afton L. Hassett, and David Pisetsky. “Pain management in rheumatology research, training, and practice.” Clin Exp Rheumatol 35 Suppl 107, no. 5 (2017): 2–7.
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  - Pisetsky, D. S. “Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation.” Adv Protein Chem Struct Biol 106 (2017): 113–37. https://doi.org/10.1016/bs.apcsb.2016.08.003.
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  - Pisetsky, David S. “Advances in the Treatment of Rheumatoid Arthritis: Costs and Challenges.” N C Med J 78, no. 5 (2017): 337–40. https://doi.org/10.18043/ncm.78.5.337.
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  - Mobarrez, Fariborz, Anna Vikerfors, Johanna T. Gustafsson, Iva Gunnarsson, Agneta Zickert, Anders Larsson, David S. Pisetsky, Håkan Wallén, and Elisabet Svenungsson. “Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations.” Sci Rep 6 (October 25, 2016): 36025. https://doi.org/10.1038/srep36025.
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  - Schett, Georg, Paul Emery, Yoshiya Tanaka, Gerd Burmester, David S. Pisetsky, Esperanza Naredo, Bruno Fautrel, and Ronald van Vollenhoven. “Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions.” Ann Rheum Dis 75, no. 8 (August 2016): 1428–37. https://doi.org/10.1136/annrheumdis-2016-209201.
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  - Pisetsky, David S. “The role of mitochondria in immune-mediated disease: the dangers of a split personality.” Arthritis Res Ther 18 (July 16, 2016): 169. https://doi.org/10.1186/s13075-016-1063-5.
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  - Pisetsky, David S. “Modified Framingham Risk Score predicted 10-y CAD better than the original score in patients with lupus.” Ann Intern Med 164, no. 12 (June 21, 2016): JC71. https://doi.org/10.7326/ACPJC-2016-164-12-071.
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  - Magna, Melinda, and David S. Pisetsky. “The Alarmin Properties of DNA and DNA-associated Nuclear Proteins.” Clin Ther 38, no. 5 (May 2016): 1029–41. https://doi.org/10.1016/j.clinthera.2016.02.029.
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  - Mobarrez, Fariborz, Mirna Abraham-Nordling, Katherina Aguilera-Gatica, Inger Friberg, Aleksandra Antovic, David S. Pisetsky, Gun Jörneskog, and Håkan Wallen. “The expression of microvesicles in the blood of patients with Graves' disease and its relationship to treatment.” Clin Endocrinol (Oxf) 84, no. 5 (May 2016): 729–35. https://doi.org/10.1111/cen.12872.
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  - Stearns, Nancy A., and David S. Pisetsky. “The role of monogamous bivalency and Fc interactions in the binding of anti-DNA antibodies to DNA antigen.” Clin Immunol 166–167 (May 2016): 38–47. https://doi.org/10.1016/j.clim.2016.04.004.
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  - Sokolove, Jeremy, and David Pisetsky. “Bone loss, pain and inflammation: three faces of ACPA in RA pathogenesis.” Ann Rheum Dis 75, no. 4 (April 2016): 637–39. https://doi.org/10.1136/annrheumdis-2015-208308.
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  - Pisetsky, David S. “Anti-DNA antibodies--quintessential biomarkers of SLE.” Nat Rev Rheumatol 12, no. 2 (February 2016): 102–10. https://doi.org/10.1038/nrrheum.2015.151.
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  - Stearns, Nancy A., Shuxia Zhou, Michelle Petri, Steven R. Binder, and David S. Pisetsky. “The Use of Poly-L-Lysine as a Capture Agent to Enhance the Detection of Antinuclear Antibodies by ELISA.” Plos One 11, no. 9 (2016): e0161818. https://doi.org/10.1371/journal.pone.0161818.
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  - Wang, Jian, Hoi-Kei Lon, Shwu-Luan Lee, Gilbert J. Burckart, and David S. Pisetsky. “Oligonucleotide-Based Drug Development: Considerations for Clinical Pharmacology and Immunogenicity.” Ther Innov Regul Sci 49, no. 6 (November 2015): 861–68. https://doi.org/10.1177/2168479015592195.
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  - Magna, M., and D. S. Pisetsky. “The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?” Scand J Immunol 82, no. 3 (September 2015): 218–24. https://doi.org/10.1111/sji.12335.
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  - Pisetsky, David S. “Rheumatoid vasculitis: going, going, but not yet gone.” Arthritis Res Ther 17, no. 1 (May 8, 2015): 116. https://doi.org/10.1186/s13075-015-0635-0.
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  - Mobarrez, Fariborz, Carolina Sjövik, Anne Soop, Lars Hållström, Claes Frostell, David S. Pisetsky, and Håkan Wallén. “CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L.” Platelets 26, no. 5 (2015): 486–90. https://doi.org/10.3109/09537104.2014.932339.
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  - Pisetsky, David S. “The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE.” Autoimmunity 47, no. 8 (December 2014): 487–93. https://doi.org/10.3109/08916934.2014.921811.
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  - Leuchten, Nicolai, Bettina Bauernfeind, Johannes Kuttner, Tanja Stamm, Josef S. Smolen, David S. Pisetsky, and Martin Aringer. “Relevant concepts of functioning for patients with systemic lupus erythematosus identified in a Delphi exercise of experts and a literature review.” Arthritis Care Res (Hoboken) 66, no. 12 (December 2014): 1895–1904. https://doi.org/10.1002/acr.22372.
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  - Grossman, Jennifer M., Megan E. B. Clowse, Peter M. Izmirly, Diane L. Kamen, Alana K. Levine, Meggan Mackey, W Joseph McCune, et al. “Hydroxychloroquine Dosing and Disease Activity in a Large Multi-Racial Lupus Cohort.” Arthritis & Rheumatology 66 (October 1, 2014): S296–97.
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  - Ullal, Anirudh J., Tony N. Marion, and David S. Pisetsky. “The role of antigen specificity in the binding of murine monoclonal anti-DNA antibodies to microparticles from apoptotic cells.” Clin Immunol 154, no. 2 (October 2014): 178–87. https://doi.org/10.1016/j.clim.2014.05.007.
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  - Pisetsky, D. S., S. E. Trace, K. A. Brownley, R. M. Hamer, N. L. Zucker, P. Roux-Lombard, J. -. M. Dayer, and C. M. Bulik. “The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.” Cytokine 69, no. 1 (September 2014): 110–15. https://doi.org/10.1016/j.cyto.2014.05.018.
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  - Spencer, D. M., F. Mobarrez, H. Wallén, and D. S. Pisetsky. “The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro.” Scand J Immunol 80, no. 2 (August 2014): 101–10. https://doi.org/10.1111/sji.12191.
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  - Wang, Xiao, Nancy A. Stearns, Xingfu Li, and David S. Pisetsky. “The effect of polyamines on the binding of anti-DNA antibodies from patients with SLE and normal human subjects.” Clin Immunol 153, no. 1 (July 2014): 94–103. https://doi.org/10.1016/j.clim.2014.04.003.
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  - Spencer, Diane M., Julie Gauley, and David S. Pisetsky. “The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis.” Innate Immun 20, no. 3 (April 2014): 239–48. https://doi.org/10.1177/1753425913492552.
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  - Pisetsky, David S. “The expression of HMGB1 on microparticles released during cell activation and cell death in vitro and in vivo.” Mol Med 20, no. 1 (April 1, 2014): 158–63. https://doi.org/10.2119/molmed.2014.00014.
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  - Magna, Melinda, and David S. Pisetsky. “The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases.” Mol Med 20, no. 1 (March 24, 2014): 138–46. https://doi.org/10.2119/molmed.2013.00164.
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  - Pisetsky, David S. “The translocation of nuclear molecules during inflammation and cell death.” Antioxid Redox Signal 20, no. 7 (March 1, 2014): 1117–25. https://doi.org/10.1089/ars.2012.5143.
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  - Mobarrez, Fariborz, Lukasz Antoniewicz, Jenny A. Bosson, Jeanette Kuhl, David S. Pisetsky, and Magnus Lundbäck. “The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers.” Plos One 9, no. 2 (2014): e90314. https://doi.org/10.1371/journal.pone.0090314.
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  - Pisetsky, D. S. “Gout, tophi and the wonders of NETs.” Arthritis Research &Amp; Therapy 16, no. 5 (January 1, 2014): 431.
  - Pisetsky, David S. “Tumor necrosis factor: is it time to change the name?” Arthritis Res Ther 16, no. 2 (2014): 108. https://doi.org/10.1186/ar4541.
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  - Pisetsky, David S. “Gout, tophi and the wonders of NETs.” Arthritis Res Ther 16, no. 5 (2014): 431. https://doi.org/10.1186/s13075-014-0431-2.
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  - Pisetsky, David S. “Immune activation by histones: plusses and minuses in inflammation.” Eur J Immunol 43, no. 12 (December 2013): 3163–66. https://doi.org/10.1002/eji.201344175.
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  - Kim, Yunjung, Sara E. Trace, James J. Crowley, Kimberly A. Brownley, Robert M. Hamer, David S. Pisetsky, Patrick F. Sullivan, and Cynthia M. Bulik. “Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa.” Psychiatry Res 210, no. 1 (November 30, 2013): 287–93. https://doi.org/10.1016/j.psychres.2013.05.026.
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  - Clowse, Megan E. B., Daniel J. Wallace, Michael Weisman, Andra James, Lisa G. Criscione-Schreiber, and David S. Pisetsky. “Predictors of preterm birth in patients with mild systemic lupus erythematosus.” Ann Rheum Dis 72, no. 9 (September 1, 2013): 1536–39. https://doi.org/10.1136/annrheumdis-2012-202449.
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  - Pisetsky, David S. “The danger of sex and death in Scarf1(-/-) autoimmune mice.” Nat Immunol 14, no. 9 (September 2013): 888–89. https://doi.org/10.1038/ni.2684.
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  - Pisetsky, David S. “The Choosing Wisely initiative: does it have your back?” Arthritis Res Ther 15, no. 4 (August 22, 2013): 117. https://doi.org/10.1186/ar4257.
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  - Dye, J. R., A. J. Ullal, and D. S. Pisetsky. “The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus.” Scand J Immunol 78, no. 2 (August 2013): 140–48. https://doi.org/10.1111/sji.12068.
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  - Soop, A., L. Hållström, C. Frostell, H. Wallén, F. Mobarrez, and D. S. Pisetsky. “Effect of lipopolysaccharide administration on the number, phenotype and content of nuclear molecules in blood microparticles of normal human subjects.” Scand J Immunol 78, no. 2 (August 2013): 205–13. https://doi.org/10.1111/sji.12076.
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  - Beyer, Christian, and David S. Pisetsky. “Modeling nuclear molecule release during in vitro cell death.” Autoimmunity 46, no. 5 (August 2013): 298–301. https://doi.org/10.3109/08916934.2012.750297.
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  - Stolberg-Stolberg, Josef A., Bridgette D. Furman, N William Garrigues, Jaewoo Lee, David S. Pisetsky, Nancy A. Stearns, Louis E. DeFrate, Farshid Guilak, and Steven A. Olson. “Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers.” J Orthop Res 31, no. 8 (August 2013): 1283–92. https://doi.org/10.1002/jor.22348.
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  - Pisetsky, David S. “Standardization of anti-DNA antibody assays.” Immunol Res 56, no. 2–3 (July 2013): 420–24. https://doi.org/10.1007/s12026-013-8415-x.
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  - Pisetsky, David S. “Translation, treatises, and tweets.” Arthritis Care Res (Hoboken) 65, no. 6 (June 2013): 839–42. https://doi.org/10.1002/acr.21974.
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  - Pisetsky, David S. “The butterfly rash of lupus: an example of aposematism?” Arthritis Res Ther 15, no. 1 (February 19, 2013): 106. https://doi.org/10.1186/ar4155.
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  - Pisetsky, David S. “The 2013 ACR meeting: mad macs at the Marina.” Arthritis Res Ther 15, no. 6 (2013): 130. https://doi.org/10.1186/ar4419.
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  - Pisetsky, David S. “The effectors of innate immunity: DAMPs, DAMEs, or DIMEs?” Arthritis Res Ther 15, no. 5 (2013): 123. https://doi.org/10.1186/ar4363.
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  - Ullal, Anirudh J., and David S. Pisetsky. “The role of microparticles in the generation of immune complexes in murine lupus.” Clin Immunol 146, no. 1 (January 2013): 1–9. https://doi.org/10.1016/j.clim.2012.10.004.
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  - Pisetsky, David S., Anirudh J. Ullal, Julie Gauley, and Tony C. Ning. “Microparticles as mediators and biomarkers of rheumatic disease.” Rheumatology (Oxford) 51, no. 10 (October 2012): 1737–46. https://doi.org/10.1093/rheumatology/kes028.
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  - Beyer, Christian, Nancy A. Stearns, Adreas Giessl, Jörg H. W. Distler, Georg Schett, and David S. Pisetsky. “The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death.” Innate Immun 18, no. 5 (October 2012): 727–37. https://doi.org/10.1177/1753425912437981.
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  - Pisetsky, David S. “4th International Forum on Rheumatoid Arthritis: Great times near the Great Wall.” Arthritis Res Ther 14, no. 5 (September 27, 2012): 125. https://doi.org/10.1186/ar4036.
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  - Pisetsky, D. S. “Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification.” Scand J Immunol 76, no. 3 (September 2012): 223–28. https://doi.org/10.1111/j.1365-3083.2012.02728.x.
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  - Harrill, A. H., J. Roach, I. Fier, J. S. Eaddy, C. L. Kurtz, D. J. Antoine, D. M. Spencer, et al. “The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.” Clin Pharmacol Ther 92, no. 2 (August 2012): 214–20. https://doi.org/10.1038/clpt.2012.40.
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  - Pisetsky, David S. “The origin and properties of extracellular DNA: from PAMP to DAMP.” Clin Immunol 144, no. 1 (July 2012): 32–40. https://doi.org/10.1016/j.clim.2012.04.006.
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  - Pisetsky, David S. “The LE cell: crime scene or crime stopper?” Arthritis Res Ther 14, no. 3 (June 26, 2012): 120. https://doi.org/10.1186/ar3878.
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  - Gnatz, Steve M., David S. Pisetsky, and Gunnar B. J. Andersson. “The value in musculoskeletal care: summary and recommendations.” Pm R 4, no. 5 (May 2012): 379–82. https://doi.org/10.1016/j.pmrj.2012.04.004.
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  - Clowse, Megan E. B., Lindsey Harward, Lisa Criscione-Schreiber, David Pisetsky, and Susannah Copland. “Anti-Müllerian hormone: a better marker of ovarian damage from cyclophosphamide.” Arthritis Rheum 64, no. 5 (May 2012): 1305–10. https://doi.org/10.1002/art.34431.
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  - Gnatz, Steve M., David S. Pisetsky, and Gunnar B. J. Andersson. “The value in musculoskeletal care: summary and recommendations.” Semin Arthritis Rheum 41, no. 5 (April 2012): 741–44. https://doi.org/10.1016/j.semarthrit.2012.02.007.
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  - Pisetsky, David S., and Michael M. Ward. “Advances in the treatment of inflammatory arthritis.” Best Pract Res Clin Rheumatol 26, no. 2 (April 2012): 251–61. https://doi.org/10.1016/j.berh.2012.03.001.
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  - Pisetsky, David S. “Microparticles as autoantigens: making immune complexes big.” Arthritis Rheum 64, no. 4 (April 2012): 958–61. https://doi.org/10.1002/art.34377.
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  - Pisetsky, David S. “HMGB1: a smoking gun in lupus nephritis?” Arthritis Res Ther 14, no. 2 (March 14, 2012): 112. https://doi.org/10.1186/ar3754.
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  - Pisetsky, David S. “The BRIC-GARN Meeting 2011: of mice and men.” Arthritis Res Ther 14, no. 1 (February 24, 2012): 107. https://doi.org/10.1186/ar3698.
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  - Rutledge, Holly R., Weiwen Jiang, Jun Yang, Laura A. Warg, David A. Schwartz, David S. Pisetsky, and Ivana V. Yang. “Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity.” Innate Immun 18, no. 1 (February 2012): 80–88. https://doi.org/10.1177/1753425910393540.
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  - Harris, Helena Erlandsson, Ulf Andersson, and David S. Pisetsky. “HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.” Nat Rev Rheumatol 8, no. 4 (January 31, 2012): 195–202. https://doi.org/10.1038/nrrheum.2011.222.
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  - Pisetsky, D. S. “Laboratory Testing in the Rheumatic Diseases” 2 (January 1, 2012): 1651–56. https://doi.org/10.1016/B978-1-4377-1604-7.00265-7.
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  - Pisetsky, David S., Jaewoo Lee, Kam W. Leong, and Bruce A. Sullenger. “Nucleic acid-binding polymers as anti-inflammatory agents: reducing the danger of nuclear attack.” Expert Rev Clin Immunol 8, no. 1 (January 2012): 1–3. https://doi.org/10.1586/eci.11.82.
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  - Stearns, Nancy A., Jaewoo Lee, Kam W. Leong, Bruce A. Sullenger, and David S. Pisetsky. “The inhibition of anti-DNA binding to DNA by nucleic acid binding polymers.” Plos One 7, no. 7 (2012): e40862. https://doi.org/10.1371/journal.pone.0040862.
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  - Pisetsky, D. S. “Pus: The Rodney Dangerfield of immunology.” Arthritis Research and Therapy 13, no. 5 (October 26, 2011). https://doi.org/10.1186/ar3477.
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  - Pisetsky, David S., Julie Gauley, and Anirudh J. Ullal. “HMGB1 and microparticles as mediators of the immune response to cell death.” Antioxid Redox Signal 15, no. 8 (October 15, 2011): 2209–19. https://doi.org/10.1089/ars.2010.3865.
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  - Gottlin, Elizabeth B., Rex C. Bentley, Michael J. Campa, David S. Pisetsky, James E. Herndon, and Edward F. Patz. “The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer.” J Thorac Oncol 6, no. 10 (October 2011): 1687–90. https://doi.org/10.1097/JTO.0b013e3182217bec.
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  - Pisetsky, David S., and Diane M. Spencer. “Effects of progesterone and estradiol sex hormones on the release of microparticles by RAW 264.7 macrophages stimulated by Poly(I:C).” Clin Vaccine Immunol 18, no. 9 (September 2011): 1420–26. https://doi.org/10.1128/CVI.05110-11.
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  - Yang, Ivana V., Weiwen Jiang, Holly R. Rutledge, Brad Lackford, Laura A. Warg, Lesly De Arras, Scott Alper, David A. Schwartz, and David S. Pisetsky. “Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands.” Mol Immunol 48, no. 15–16 (September 2011): 1886–95. https://doi.org/10.1016/j.molimm.2011.05.015.
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  - Lee, Jaewoo, Jang Wook Sohn, Ying Zhang, Kam W. Leong, David Pisetsky, and Bruce A. Sullenger. “Nucleic acid-binding polymers as anti-inflammatory agents.” Proc Natl Acad Sci U S A 108, no. 34 (August 23, 2011): 14055–60. https://doi.org/10.1073/pnas.1105777108.
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  - Pisetsky, David S., Amrie C. Grammer, Tony C. Ning, and Peter E. Lipsky. “Are autoantibodies the targets of B-cell-directed therapy?” Nat Rev Rheumatol 7, no. 9 (August 2, 2011): 551–56. https://doi.org/10.1038/nrrheum.2011.108.
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  - Distler, Jörg H. W., Alfiya Akhmetshina, Clara Dees, Astrid Jüngel, Michael Stürzl, Steffen Gay, David S. Pisetsky, Georg Schett, and Oliver Distler. “Induction of apoptosis in circulating angiogenic cells by microparticles.” Arthritis Rheum 63, no. 7 (July 2011): 2067–77. https://doi.org/10.1002/art.30361.
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  - Ullal, Anirudh J., Charles F. Reich, Megan Clowse, Lisa G. Criscione-Schreiber, Martin Tochacek, Marc Monestier, and David S. Pisetsky. “Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus.” J Autoimmun 36, no. 3–4 (May 2011): 173–80. https://doi.org/10.1016/j.jaut.2011.02.001.
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  - Pisetsky, David S. “Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?” Arthritis Res Ther 13, no. 2 (April 21, 2011): 109. https://doi.org/10.1186/ar3282.
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  - Pisetsky, David S. “Platelet microparticles: making blood a bad humor.” J Rheumatol 38, no. 4 (April 2011): 590–92. https://doi.org/10.3899/jrheum.101359.
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  - Pisetsky, David S., Julie Gauley, and Anirudh J. Ullal. “Microparticles as a source of extracellular DNA.” Immunol Res 49, no. 1–3 (April 2011): 227–34. https://doi.org/10.1007/s12026-010-8184-8.
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  - Pisetsky, D. “Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes.” Swiss Med Wkly 141 (2011): w13256. https://doi.org/10.4414/smw.2011.13256.
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  - Pisetsky, David S. “The 2011 ACR meeting: what's new in the Windy City.” Arthritis Res Ther 13, no. 6 (2011): 138. https://doi.org/10.1186/ar3532.
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  - Pisetsky, David S. “Pus: the Rodney Dangerfield of immunology.” Arthritis Res Ther 13, no. 5 (2011): 131. https://doi.org/10.1186/ar3477.
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  - Pisetsky, David S. “The role of HMGB1 in efferocytosis: when the dead go unburied. Focus on "HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin".” Am J Physiol Cell Physiol 299, no. 6 (December 2010): C1253–55. https://doi.org/10.1152/ajpcell.00397.2010.
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  - Pisetsky, David S., and Anirudh J. Ullal. “The blood nucleome in the pathogenesis of SLE.” Autoimmun Rev 10, no. 1 (November 2010): 35–37. https://doi.org/10.1016/j.autrev.2010.07.007.
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  - Pisetsky, David S. “Charlie's List.” Ann Intern Med 153, no. 5 (September 7, 2010): 344. https://doi.org/10.7326/0003-4819-153-5-201009070-00012.
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  - Gauley, Julie, and David S. Pisetsky. “The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands.” J Leukoc Biol 87, no. 6 (June 2010): 1115–23. https://doi.org/10.1189/jlb.0709465.
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  - Pisetsky, David S., and Peter E. Lipsky. “Microparticles as autoadjuvants in the pathogenesis of SLE.” Nat Rev Rheumatol 6, no. 6 (June 2010): 368–72. https://doi.org/10.1038/nrrheum.2010.66.
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  - American College of Rheumatology Pain Management Task Force, Tim D. “Report of the American College of Rheumatology Pain Management Task Force.” Arthritis Care Res (Hoboken) 62, no. 5 (May 2010): 590–99. https://doi.org/10.1002/acr.20005.
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  - Ullal, Anirudh J., and David S. Pisetsky. “The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis.” Apoptosis 15, no. 5 (May 2010): 586–96. https://doi.org/10.1007/s10495-010-0470-3.
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  - Pisetsky, David S. “HMGB1: a dangerous player in lupus pathogenesis.” J Rheumatol 37, no. 4 (April 2010): 689–91. https://doi.org/10.3899/jrheum.091459.
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  - Ullal, Anirudh J., David S. Pisetsky, and Charles F. Reich. “Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems.” Cytometry A 77, no. 3 (March 2010): 294–301. https://doi.org/10.1002/cyto.a.20833.
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  - Grundtman, Cecilia, Joseph Bruton, Takashi Yamada, Therese Ostberg, David S. Pisetsky, Helena Erlandsson Harris, Ulf Andersson, Ingrid E. Lundberg, and Håkan Westerblad. “Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies.” Faseb J 24, no. 2 (February 2010): 570–78. https://doi.org/10.1096/fj.09-144782.
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  - Beyer, Christian, and David S. Pisetsky. “The role of microparticles in the pathogenesis of rheumatic diseases.” Nat Rev Rheumatol 6, no. 1 (January 2010): 21–29. https://doi.org/10.1038/nrrheum.2009.229.
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  - Pisetsky, D. S., and G. McCleane. “Pain in rheumatoid arthritis and osteoarthritis,” December 1, 2009, 170–83. https://doi.org/10.1016/B978-0-323-04019-8.00027-5.
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  - Pisetsky, D. S., and I. A. Vrabie. “Antibodies to DNA: infection or genetics?” Lupus 18, no. 13 (November 2009): 1176–80. https://doi.org/10.1177/0961203309106492.
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  - Su, K. -. Y., and D. S. Pisetsky. “The role of extracellular DNA in autoimmunity in SLE.” Scand J Immunol 70, no. 3 (September 2009): 175–83. https://doi.org/10.1111/j.1365-3083.2009.02300.x.
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  - Pisetsky, David S., and Lars Rönnblom. “Systemic lupus erythematosus: a matter of life and death.” Arthritis Rheum 60, no. 6 (June 2009): 1567–70. https://doi.org/10.1002/art.24531.
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  - Gauley, Julie, and David S. Pisetsky. “The translocation of HMGB1 during cell activation and cell death.” Autoimmunity 42, no. 4 (May 2009): 299–301. https://doi.org/10.1080/08916930902831522.
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  - Ullal, A. J., and D. S. Pisetsky. “Post-Translational Modification of HMGB1 and Its Role in Immune Activation,” April 29, 2009, 165–78. https://doi.org/10.1002/9780470743553.ch10.
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  - Crowley, Steven D., Matthew P. Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A Kathy Pazmino, Carie Facemire, et al. “Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.” J Clin Invest 119, no. 4 (April 2009): 943–53. https://doi.org/10.1172/JCI34862.
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  - Reich, Charles F., and David S. Pisetsky. “The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis.” Exp Cell Res 315, no. 5 (March 10, 2009): 760–68. https://doi.org/10.1016/j.yexcr.2008.12.014.
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  - Pisetsky, David S. “Microparticles as biomarkers in autoimmunity: from dust bin to center stage.” Arthritis Res Ther 11, no. 6 (2009): 135. https://doi.org/10.1186/ar2856.
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  - Pisetsky, D. S. “Systemic lupus erythematosus B. epidemiology, pathology, and pathogenesis,” December 1, 2008, 319–26. https://doi.org/10.1007/978-0-387-68566-3_15.
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  - Pisetsky, David S. “The role of innate immunity in the induction of autoimmunity.” Autoimmun Rev 8, no. 1 (October 2008): 69–72. https://doi.org/10.1016/j.autrev.2008.07.028.
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  - Guiducci, Serena, Jörg H. W. Distler, Astrid Jüngel, Dörte Huscher, Lars C. Huber, Beat A. Michel, Renate E. Gay, et al. “The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis.” Arthritis Rheum 58, no. 9 (September 2008): 2845–53. https://doi.org/10.1002/art.23735.
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  - Gasper-Smith, Nancy, Deanna M. Crossman, John F. Whitesides, Nadia Mensali, Janet S. Ottinger, Steven G. Plonk, M Anthony Moody, et al. “Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design.” J Virol 82, no. 15 (August 2008): 7700–7710. https://doi.org/10.1128/JVI.00605-08.
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  - Jiang, W., and D. S. Pisetsky. “Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus.” Ann Rheum Dis 67, no. 5 (May 2008): 727–28. https://doi.org/10.1136/ard.2007.074484.
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  - Pisetsky, David S. “Rheumatology in the current era: the challenge of success.” Nat Clin Pract Rheumatol 4, no. 4 (April 2008): 165. https://doi.org/10.1038/ncprheum0791.
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  - Jiang, Weiwen, and David S. Pisetsky. “The induction of HMGB1 release from RAW 264.7 cells by transfected DNA.” Mol Immunol 45, no. 7 (April 2008): 2038–44. https://doi.org/10.1016/j.molimm.2007.10.019.
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  - Tran, Trinh T., Pamela Groben, and David S. Pisetsky. “The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis.” Biomarkers 13, no. 2 (March 2008): 184–200. https://doi.org/10.1080/13547500701791719.
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  - Pisetsky, David S. “A landmark study on treatment strategies for rheumatoid arthritis.” Arthritis Rheum 58, no. 2 Suppl (February 2008): S123–25. https://doi.org/10.1002/art.23066.
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  - Ardoin, Stacy P., and David S. Pisetsky. “Developments in the scientific understanding of lupus.” Arthritis Res Ther 10, no. 5 (2008): 218. https://doi.org/10.1186/ar2488.
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  - Pisetsky, David S., Helena Erlandsson-Harris, and Ulf Andersson. “High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease.” Arthritis Res Ther 10, no. 3 (2008): 209. https://doi.org/10.1186/ar2440.
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  - Zetterström, Cecilia K., Weiwen Jiang, Heidi Wähämaa, Therese Ostberg, Ann-Charlotte Aveberger, Hanna Schierbeck, Michael T. Lotze, Ulf Andersson, David S. Pisetsky, and Helena Erlandsson Harris. “Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate.” J Leukoc Biol 83, no. 1 (January 2008): 31–38. https://doi.org/10.1189/jlb.0507323.
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  - Ardoin, Stacy P., and David S. Pisetsky. “The role of cell death in the pathogenesis of autoimmune disease: HMGB1 and microparticles as intercellular mediators of inflammation.” Mod Rheumatol 18, no. 4 (2008): 319–26. https://doi.org/10.1007/s10165-008-0054-z.
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  - Pisetsky, D. S. “Antibodies to DNA,” December 1, 2007, 225–32. https://doi.org/10.1016/B978-0-323-04434-9.50027-0.
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  - Pisetsky, David S. “Clinician's comment on the management of pain in arthritis.” Health Psychol 26, no. 6 (November 2007): 657–59. https://doi.org/10.1037/0278-6133.26.6.657.
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  - Jüngel, Astrid, Oliver Distler, Ursula Schulze-Horsel, Lars C. Huber, Huy Riem Ha, Beat Simmen, Joachim R. Kalden, David S. Pisetsky, Steffen Gay, and Jörg H. W. Distler. “Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.” Arthritis Rheum 56, no. 11 (November 2007): 3564–74. https://doi.org/10.1002/art.22980.
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  - Pisetsky, David S., and Weiwen Jiang. “Role of Toll-like receptors in HMGB1 release from macrophages.” Ann N Y Acad Sci 1109 (August 2007): 58–65. https://doi.org/10.1196/annals.1398.008.
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  - Pisetsky, David S. “The role of nuclear macromolecules in innate immunity.” Proc Am Thorac Soc 4, no. 3 (July 2007): 258–62. https://doi.org/10.1513/pats.200701-027AW.
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  - Pisetsky, David S. “Autoimmunity: the nuclear arsenal of autoimmunity.” Immunol Cell Biol 85, no. 5 (July 2007): 344–45. https://doi.org/10.1038/sj.icb.7100074.
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  - Pisetsky, David S., and Anna-Marie Fairhurst. “The origin of extracellular DNA during the clearance of dead and dying cells.” Autoimmunity 40, no. 4 (June 2007): 281–84. https://doi.org/10.1080/08916930701358826.
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  - Jiang, Weiwen, Charles W. Bell, and David S. Pisetsky. “The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid.” J Immunol 178, no. 10 (May 15, 2007): 6495–6503. https://doi.org/10.4049/jimmunol.178.10.6495.
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  - Mitchell, Kate L., and David S. Pisetsky. “Early rheumatoid arthritis.” Curr Opin Rheumatol 19, no. 3 (May 2007): 278–83. https://doi.org/10.1097/BOR.0b013e32805e87bf.
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  - Taylor, Holly A., Jeremy Sugarman, David S. Pisetsky, and Joan Bathon. “Formative research in clinical trial development: attitudes of patients with arthritis in enhancing prevention trials.” Ann Rheum Dis 66, no. 4 (April 2007): 542–44. https://doi.org/10.1136/ard.2006.059600.
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  - Huber, Lars C., Astrid Jüngel, Jörg H. W. Distler, Falk Moritz, Renate E. Gay, Beat A. Michel, David S. Pisetsky, Steffen Gay, and Oliver Distler. “The role of membrane lipids in the induction of macrophage apoptosis by microparticles.” Apoptosis 12, no. 2 (February 2007): 363–74. https://doi.org/10.1007/s10495-006-0622-7.
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  - Jiang, Weiwen, and David S. Pisetsky. “Mechanisms of Disease: the role of high-mobility group protein 1 in the pathogenesis of inflammatory arthritis.” Nat Clin Pract Rheumatol 3, no. 1 (January 2007): 52–58. https://doi.org/10.1038/ncprheum0379.
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  - Nair, Smita, David Boczkowski, Martin Fassnacht, David Pisetsky, and Eli Gilboa. “Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity.” Cancer Res 67, no. 1 (January 1, 2007): 371–80. https://doi.org/10.1158/0008-5472.CAN-06-2903.
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  - Ardoin, S. P., J. C. Shanahan, and D. S. Pisetsky. “The role of microparticles in inflammation and thrombosis.” Scand J Immunol 66, no. 2–3 (2007): 159–65. https://doi.org/10.1111/j.1365-3083.2007.01984.x.
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  - Bell, Charles W., Weiwen Jiang, Charles F. Reich, and David S. Pisetsky. “The extracellular release of HMGB1 during apoptotic cell death.” Am J Physiol Cell Physiol 291, no. 6 (December 2006): C1318–25. https://doi.org/10.1152/ajpcell.00616.2005.
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  - Distler, Jörg H. W., Lars C. Huber, Steffen Gay, Oliver Distler, and David S. Pisetsky. “Microparticles as mediators of cellular cross-talk in inflammatory disease.” Autoimmunity 39, no. 8 (December 2006): 683–90. https://doi.org/10.1080/08916930601061538.
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  - Jiang, Weiwen, and David S. Pisetsky. “The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide.” J Immunol 177, no. 5 (September 1, 2006): 3337–43. https://doi.org/10.4049/jimmunol.177.5.3337.
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  - Pisetsky, D. S., and N. Jiang. “The generation of extracellular DNA in SLE: the role of death and sex.” Scand J Immunol 64, no. 3 (September 2006): 200–204. https://doi.org/10.1111/j.1365-3083.2006.01822.x.
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  - Pisetsky, David S. “Fulfilling Koch's postulates of autoimmunity: anti-NR2 antibodies in mice and men.” Arthritis Rheum 54, no. 8 (August 2006): 2349–52. https://doi.org/10.1002/art.22029.
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  - Huber, L. C., S. Gay, O. Distler, and D. S. Pisetsky. “The effect of UVB on lupus skin: new light on the role of apoptosis in the pathogenesis of autoimmunity.” Rheumatology (Oxford) 45, no. 5 (May 2006): 500–501. https://doi.org/10.1093/rheumatology/kel036.
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  - Aringer, M., T. A. Stamm, D. S. Pisetsky, C. H. Yarboro, A. Cieza, J. S. Smolen, and G. Stucki. “ICF core sets: how to specify impairment and function in systemic lupus erythematosus.” Lupus 15, no. 4 (2006): 248–53. https://doi.org/10.1191/0961203306lu2298xx.
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  - Pisetsky, David S. “Rheumatology in 2006: crossroads or crisis?” Bull Nyu Hosp Jt Dis 64, no. 1–2 (2006): 9–11.
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  - Hamilton, Kimberly J., Georg Schett, Charles F. Reich, Josef S. Smolen, and David S. Pisetsky. “The binding of sera of patients with SLE to bacterial and mammalian DNA.” Clin Immunol 118, no. 2–3 (2006): 209–18. https://doi.org/10.1016/j.clim.2005.10.009.
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  - Jiang, Weiwen, Charles F. Reich, and David S. Pisetsky. “In vitro assay of immunostimulatory activities of plasmid vectors.” Methods Mol Med 127 (2006): 55–70. https://doi.org/10.1385/1-59745-168-1:55.
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  - Weinberg, J Brice, Thomas Lang, William E. Wilkinson, David S. Pisetsky, and E William St Clair. “Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures.” Arthritis Res Ther 8, no. 5 (2006): R140. https://doi.org/10.1186/ar2030.
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  - Distler, Jörg H. W., David S. Pisetsky, Lars C. Huber, Joachim R. Kalden, Steffen Gay, and Oliver Distler. “Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases.” Arthritis Rheum 52, no. 11 (November 2005): 3337–48. https://doi.org/10.1002/art.21350.
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  - Fermor, Beverley, J Brice Weinberg, David S. Pisetsky, and Farshid Guilak. “The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage.” Osteoarthritis Cartilage 13, no. 10 (October 2005): 935–41. https://doi.org/10.1016/j.joca.2005.05.001.
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  - Jiang, Weiwen, Jianhua Li, Margot Gallowitsch-Puerta, Kevin J. Tracey, and David S. Pisetsky. “The effects of CpG DNA on HMGB1 release by murine macrophage cell lines.” J Leukoc Biol 78, no. 4 (October 2005): 930–36. https://doi.org/10.1189/jlb.0405208.
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  - Rocha, Paulo N., Troy J. Plumb, Lisa A. Robinson, Robert Spurney, David Pisetsky, Beverly H. Koller, and Thomas M. Coffman. “Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.” Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896–903. https://doi.org/10.1128/CDLI.12.8.896-903.2005.
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  - Distler, J. H. W., L. C. Huber, A. J. Hueber, C. F. Reich, S. Gay, O. Distler, and D. S. Pisetsky. “The release of microparticles by apoptotic cells and their effects on macrophages.” Apoptosis 10, no. 4 (August 2005): 731–41. https://doi.org/10.1007/s10495-005-2941-5.
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  - Choi, Jin-Jung, Charles F. Reich, and David S. Pisetsky. “The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells.” Immunology 115, no. 1 (May 2005): 55–62. https://doi.org/10.1111/j.1365-2567.2005.02130.x.
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  - Docken, William P., and David S. Pisetsky. “Toward optimal health: William P. Docken, M.D. and David S. Pisetsky, M.D., Ph.D. discuss arthritis in women. Interview by Jody R. Godfrey.” J Womens Health (Larchmt) 14, no. 3 (April 2005): 208–13. https://doi.org/10.1089/jwh.2005.14.208.
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  - Jiang, Ning, and David S. Pisetsky. “The effect of inflammation on the generation of plasma DNA from dead and dying cells in the peritoneum.” J Leukoc Biol 77, no. 3 (March 2005): 296–302. https://doi.org/10.1189/jlb.0704411.
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  - Distler, Jörg H. W., Astrid Jüngel, Lars C. Huber, Christian A. Seemayer, Charles F. Reich, Renate E. Gay, Beat A. Michel, et al. “The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.” Proc Natl Acad Sci U S A 102, no. 8 (February 22, 2005): 2892–97. https://doi.org/10.1073/pnas.0409781102.
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  - Rahman, Proton. “Detailing ethnicity and phenotypes is critical for pooling association studies: comment on the article by Huizinga et al.” Arthritis Rheum 52, no. 2 (February 2005): 676. https://doi.org/10.1002/art.20814.
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  - Fermor, Beverley, Devon Jeffcoat, Alfred Hennerbichler, David S. Pisetsky, J Brice Weinberg, and Farshid Guilak. “The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus.” Osteoarthritis Cartilage 12, no. 12 (December 2004): 956–62. https://doi.org/10.1016/j.joca.2004.08.007.
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  - Pisetsky, David S. “The immune response to cell death in SLE.” Autoimmun Rev 3, no. 7–8 (November 2004): 500–504. https://doi.org/10.1016/j.autrev.2004.07.010.
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  - Cook, Donald N., David S. Pisetsky, and David A. Schwartz. “Toll-like receptors in the pathogenesis of human disease.” Nat Immunol 5, no. 10 (October 2004): 975–79. https://doi.org/10.1038/ni1116.
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  - Pisetsky, David S. “DNA as a marker of cell death in systemic lupus erythematosus.” Rheum Dis Clin North Am 30, no. 3 (August 2004): 575–x. https://doi.org/10.1016/j.rdc.2004.04.009.
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  - Huizinga, Tom W. J., David S. Pisetsky, and Robert P. Kimberly. “Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism.” Arthritis Rheum 50, no. 7 (July 2004): 2066–71. https://doi.org/10.1002/art.20360.
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  - Guilak, Farshid, Beverley Fermor, Francis J. Keefe, Virginia B. Kraus, Steven A. Olson, David S. Pisetsky, Lori A. Setton, and J Brice Weinberg. “The role of biomechanics and inflammation in cartilage injury and repair.” Clin Orthop Relat Res, no. 423 (June 2004): 17–26. https://doi.org/10.1097/01.blo.0000131233.83640.91.
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  - Tran, Trinh T., and David S. Pisetsky. “Systemic lupus erythematosus and related diseases.” Autoimmunity 37, no. 4 (June 2004): 301–4. https://doi.org/10.1080/08916930410001708698.
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  - Jiang, Weiwen, Charles F. Reich, Dong You, Ekamber Kandimalla, Sudhir Agrawal, and David S. Pisetsky. “Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis.” Biochem Biophys Res Commun 318, no. 1 (May 21, 2004): 60–66. https://doi.org/10.1016/j.bbrc.2004.04.001.
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  - Jiang, Ning, and David S. Pisetsky. “The effect of dexamethasone on the generation of plasma DNA from dead and dying cells.” Am J Pathol 164, no. 5 (May 2004): 1751–59. https://doi.org/10.1016/S0002-9440(10)63733-9.
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  - Jiang, Weiwen, Charles F. Reich III, and David S. Pisetsky. “Mechanisms of activation of the RAW264.7 macrophage cell line by transfected mammalian DNA.” Cell Immunol 229, no. 1 (May 2004): 31–40. https://doi.org/10.1016/j.cellimm.2004.06.003.
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  - Pisetsky, D. S. “Apoptosis in the rheumatic diseases.” Rheumatic Disease Clinics of North America 30, no. 3 (January 1, 2004). https://doi.org/10.1016/S0889-857X(04)00058-4.
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  - Pisetsky, David S. “OutOfDate.” Pharos Alpha Omega Alpha Honor Med Soc 67, no. 3 (2004): 17–18.
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  - Choi, J. -. J., C. F. Reich, and D. S. Pisetsky. “Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro.” Scand J Immunol 60, no. 1–2 (2004): 159–66. https://doi.org/10.1111/j.0300-9475.2004.01470.x.
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  - Criscione, L. G., and D. S. Pisetsky. “The pathogenesis of systemic lupus erythematosus.” Bulletin on the Rheumatic Diseases 52, no. 6 (December 1, 2003).
  - Tran, Trinh T., Charles F. Reich, Munir Alam, and David S. Pisetsky. “Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant.” Clin Immunol 109, no. 3 (December 2003): 278–87. https://doi.org/10.1016/j.clim.2003.08.012.
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  - Jiang, Ning, Charles F. Reich, and David S. Pisetsky. “Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells.” Blood 102, no. 6 (September 15, 2003): 2243–50. https://doi.org/10.1182/blood-2002-10-3312.
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  - Criscione, Lisa G., and David S. Pisetsky. “B lymphocytes and systemic lupus erythematosus.” Curr Rheumatol Rep 5, no. 4 (August 2003): 264–69. https://doi.org/10.1007/s11926-003-0004-x.
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  - Shin, Sang-Jin, Beverley Fermor, J Brice Weinberg, David S. Pisetsky, and Farshid Guilak. “Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide.” J Appl Physiol (1985) 95, no. 1 (July 2003): 308–13. https://doi.org/10.1152/japplphysiol.00131.2003.
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  - Criscione, Lisa G., Jeremy Sugarman, Linda Sanders, David S. Pisetsky, and E William St Clair. “Informed consent in a clinical trial of a novel treatment for rheumatoid arthritis.” Arthritis Rheum 49, no. 3 (June 15, 2003): 361–67. https://doi.org/10.1002/art.11057.
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  - Björkman, L., C. F. Reich, and D. S. Pisetsky. “The use of fluorometric assays to assess the immune response to DNA in murine systemic lupus erythematosus.” Scand J Immunol 57, no. 6 (June 2003): 525–33. https://doi.org/10.1046/j.1365-3083.2003.01261.x.
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  - Zhu, Fu-Gang, Charles F. Reich, and David S. Pisetsky. “Effect of cytofectins on the immune response of murine macrophages to mammalian DNA.” Immunology 109, no. 2 (June 2003): 255–62. https://doi.org/10.1046/j.1365-2567.2003.01653.x.
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  - Pisetsky, David S., Gene G. Hunder, and Ellen M. Gravallese. “New policy on disclosure of interest for American College of Rheumatology Journals.” Arthritis Rheum 49, no. 2 (April 15, 2003): 149–50. https://doi.org/10.1002/art.10992.
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  - Jiang, Weiwen, and David S. Pisetsky. “Enhancing immunogenicity by CpG DNA.” Curr Opin Mol Ther 5, no. 2 (April 2003): 180–85.
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  - Carlson, Elise, and Naomi Rothfield. “Etanercept-induced lupus-like syndrome in a patient with rheumatoid arthritis.” Arthritis Rheum 48, no. 4 (April 2003): 1165–66. https://doi.org/10.1002/art.11033.
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  - Jawaheer, Damini, Michael F. Seldin, Christopher I. Amos, Wei V. Chen, Russell Shigeta, Carol Etzel, Aarti Damle, et al. “Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families.” Arthritis Rheum 48, no. 4 (April 2003): 906–16. https://doi.org/10.1002/art.10989.
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  - Pisetsky, David S., Gene G. Hunder, and Ellen M. Gravallese. “New policy on disclosure of interest for American College of Rheumatology journals.” Arthritis Rheum 48, no. 4 (April 2003): 873–75. https://doi.org/10.1002/art.10946.
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  - Distler, Oliver, Steffen Gay, Elena Neumann, and Ulf Müller-Ladner. “Minimum information about a microarray experiment: comment on the editorial by Firestein and Pisetsky.” Arthritis Rheum 48, no. 3 (March 2003): 861. https://doi.org/10.1002/art.10756.
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  - Jiang, Ning, Charles F. Reich, Marc Monestier, and David S. Pisetsky. “The expression of plasma nucleosomes in mice undergoing in vivo apoptosis.” Clin Immunol 106, no. 2 (February 2003): 139–47. https://doi.org/10.1016/s1521-6616(02)00027-x.
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  - Zhu, Fu-Gang, Charles F. Reich, and David S. Pisetsky. “Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides.” J Leukoc Biol 72, no. 6 (December 2002): 1154–63.
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  - Fermor, B., J. B. Weinberg, D. S. Pisetsky, M. A. Misukonis, C. Fink, and F. Guilak. “Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.” Osteoarthritis Cartilage 10, no. 10 (October 2002): 792–98. https://doi.org/10.1053/joca.2002.0832.
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  - Pisetsky, David S. “A walk on the beach.” Ann Intern Med 137, no. 5 Part 1 (September 3, 2002): 366–67. https://doi.org/10.7326/0003-4819-137-5_part_1-200209030-00017.
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  - Zhu, Fu-Gang, Charles F. Reich, and David S. Pisetsky. “Inhibition of murine macrophage nitric oxide production by synthetic oligonucleotides.” J Leukoc Biol 71, no. 4 (April 2002): 686–94.
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  - Cernanec, Julie, Farshid Guilak, J Brice Weinberg, David S. Pisetsky, and Beverley Fermor. “Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage.” Arthritis Rheum 46, no. 4 (April 2002): 968–75. https://doi.org/10.1002/art.10213.
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  - Firestein, Gary S., and David S. Pisetsky. “DNA microarrays: boundless technology or bound by technology? Guidelines for studies using microarray technology.” Arthritis Rheum 46, no. 4 (April 2002): 859–61. https://doi.org/10.1002/art.10236.
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  - Pisetsky, David. “A medical education.” Lancet 359, no. 9306 (February 16, 2002): 636. https://doi.org/10.1016/S0140-6736(02)07762-0.
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  - Pisetsky, D. S., and E. W. St Clair. “Progress in the treatment of rheumatoid arthritis.” Jama 286, no. 22 (December 12, 2001): 2787–90. https://doi.org/10.1001/jama.286.22.2787.
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  - Ghosh, D. K., M. A. Misukonis, C. Reich, D. S. Pisetsky, and J. B. Weinberg. “Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.” Infect Immun 69, no. 12 (December 2001): 7703–10. https://doi.org/10.1128/IAI.69.12.7703-7710.2001.
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  - Liang, H., C. F. Reich, D. S. Pisetsky, and P. E. Lipsky. “The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotides.” Scand J Immunol 54, no. 6 (December 2001): 551–63. https://doi.org/10.1046/j.1365-3083.2001.01004.x.
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  - Pisetsky, D. S. “Immune response to DNA in systemic lupus erythematosus.” Isr Med Assoc J 3, no. 11 (November 2001): 850–53.
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  - Zhu, F. G., and D. S. Pisetsky. “Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides.” Infect Immun 69, no. 9 (September 2001): 5546–52. https://doi.org/10.1128/IAI.69.9.5546-5552.2001.
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  - LeGrand, A., B. Fermor, C. Fink, D. S. Pisetsky, J. B. Weinberg, T. P. Vail, and F. Guilak. “Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci.” Arthritis Rheum 44, no. 9 (September 2001): 2078–83. https://doi.org/10.1002/1529-0131(200109)44:9<2078::AID-ART358>3.0.CO;2-J.
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  - Pisetsky, D. S., K. S. Wenk, and C. F. Reich. “The role of cpg sequences in the induction of anti-DNA antibodies.” Clin Immunol 100, no. 2 (August 2001): 157–63. https://doi.org/10.1006/clim.2001.5064.
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  - Fermor, B., B. Haribabu, J. B. Weinberg, D. S. Pisetsky, and F. Guilak. “Mechanical stress and nitric oxide influence leukotriene production in cartilage.” Biochem Biophys Res Commun 285, no. 3 (July 20, 2001): 806–10. https://doi.org/10.1006/bbrc.2001.5237.
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  - Fermor, B., J. B. Weinberg, D. S. Pisetsky, M. A. Misukonis, A. J. Banes, and F. Guilak. “The effects of static and intermittent compression on nitric oxide production in articular cartilage explants.” J Orthop Res 19, no. 4 (July 2001): 729–37. https://doi.org/10.1016/S0736-0266(00)00049-8.
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  - Fink, C., B. Fermor, J. B. Weinberg, D. S. Pisetsky, M. A. Misukonis, and F. Guilak. “The effect of dynamic mechanical compression on nitric oxide production in the meniscus.” Osteoarthritis Cartilage 9, no. 5 (July 2001): 481–87. https://doi.org/10.1053/joca.2001.0415.
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  - Aringer, M., G. Steiner, W. Graninger, and J. Smolen. “Role of tumor necrosis factor alpha and potential benefit of tumor necrosis factor blockade treatment in systemic lupus erythematosus: comment on the editorial by Pisetsky.” Arthritis Rheum 44, no. 7 (July 2001): 1721–22. https://doi.org/10.1002/1529-0131(200107)44:7<1721::AID-ART302>3.0.CO;2-J.
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  - Zhu, F. G., C. F. Reich, and D. S. Pisetsky. “The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.” Immunology 103, no. 2 (June 2001): 226–34. https://doi.org/10.1046/j.1365-2567.2001.01222.x.
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  - St Clair, E. W., W. E. Wilkinson, D. S. Pisetsky, D. J. Sexton, R. Drew, V. B. Kraus, and R. A. Greenwald. “The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial.” Arthritis Rheum 44, no. 5 (May 2001): 1043–47. https://doi.org/10.1002/1529-0131(200105)44:5<1043::AID-ANR183>3.0.CO;2-C.
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  - Jawaheer, D., M. F. Seldin, C. I. Amos, W. V. Chen, R. Shigeta, J. Monteiro, M. Kern, et al. “A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases.” Am J Hum Genet 68, no. 4 (April 2001): 927–36. https://doi.org/10.1086/319518.
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  - Pisetsky, D. S. “The American College of Rheumatology Journals: New directions for Y2K + 1.” Arthritis and Rheumatism 44, no. 1 (February 13, 2001): 1–2. https://doi.org/10.1002/1529-0131(200101)44:1<1::AID-ANR1>3.0.CO;2-2.
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  - Pisetsky, D. S. “Tumor necrosis factor alpha blockers and the induction of anti-DNA autoantibodies.” Arthritis Rheum 43, no. 11 (November 2000): 2381–82. https://doi.org/10.1002/1529-0131(200011)43:11<2381::AID-ANR1>3.0.CO;2-M.
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  - Pisetsky, D. S. “Anti-DNA and autoantibodies.” Curr Opin Rheumatol 12, no. 5 (September 2000): 364–68. https://doi.org/10.1097/00002281-200009000-00002.
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  - Pisetsky, D. S., and C. F. Reich. “Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.” Clin Immunol 96, no. 3 (September 2000): 198–204. https://doi.org/10.1006/clim.2000.4897.
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  - Liang, H., C. F. Reich, D. S. Pisetsky, and P. E. Lipsky. “The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides.” J Immunol 165, no. 3 (August 1, 2000): 1438–45. https://doi.org/10.4049/jimmunol.165.3.1438.
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  - Mannon, R. B., C. Nataraj, and D. S. Pisetsky. “Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.” Cell Immunol 201, no. 1 (April 10, 2000): 14–21. https://doi.org/10.1006/cimm.2000.1635.
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  - Pisetsky, D. S. “Tumor necrosis factor blockers in rheumatoid arthritis.” N Engl J Med 342, no. 11 (March 16, 2000): 810–11. https://doi.org/10.1056/NEJM200003163421110.
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  - Pisetsky, D. S. “The role of bacterial DNA in autoantibody induction.” Curr Top Microbiol Immunol 247 (2000): 143–55. https://doi.org/10.1007/978-3-642-59672-8_10.
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  - Pisetsky, D. S. “Immune responses to DNA in normal and aberrant immunity.” Immunol Res 22, no. 2–3 (2000): 119–26. https://doi.org/10.1385/IR:22:2-3:119.
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  - Pisetsky, D. S. “The antigenic properties of bacterial DNA in normal and aberrant immunity.” Springer Semin Immunopathol 22, no. 1–2 (2000): 153–66. https://doi.org/10.1007/s002810000024.
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  - Pisetsky, D. S. “Mechanisms of immune stimulation by bacterial DNA.” Springer Semin Immunopathol 22, no. 1–2 (2000): 21–33. https://doi.org/10.1007/s002810000021.
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  - Reich, C. F., and D. S. Pisetsky. “In vitro assay of immunostimulatory activities of plasmid vectors.” Methods Mol Med 29 (2000): 173–84. https://doi.org/10.1385/1-59259-688-6:173.
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  - Pisetsky, D. S., and C. F. Reich. “Influence of backbone chemistry on immune activation by synthetic oligonucleotides.” Biochem Pharmacol 58, no. 12 (December 15, 1999): 1981–88. https://doi.org/10.1016/s0006-2952(99)00294-4.
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  - Goeckeritz, B. E., M. Flora, K. Witherspoon, Q. Vos, A. Lees, G. J. Dennis, D. S. Pisetsky, D. M. Klinman, C. M. Snapper, and J. J. Mond. “Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion.” Int Immunol 11, no. 10 (October 1999): 1693–1700. https://doi.org/10.1093/intimm/11.10.1693.
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  - Pisetsky, D. S., and C. F. Reich. “The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors.” J Interferon Cytokine Res 19, no. 10 (October 1999): 1219–26. https://doi.org/10.1089/107999099313163.
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  - Pisetsky, D. S. “A piece of my mind. What we are made of.” Jama 282, no. 12 (September 22, 1999): 1112. https://doi.org/10.1001/jama.282.12.1112-c.
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  - Pisetsky, D., D. Drayton, and Z. Q. Wu. “Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus.” J Rheumatol 26, no. 9 (September 1999): 1934–38.
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  - Goulet, J. L., R. C. Griffiths, P. Ruiz, R. F. Spurney, D. S. Pisetsky, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.” J Immunol 163, no. 1 (July 1, 1999): 359–66.
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  - Pisetsky, D. S., and T. C. Gonzalez. “The influence of DNA size on the binding of antibodies to DNA in the sera of normal human subjects and patients with systemic lupus erythematosus (SLE).” Clin Exp Immunol 116, no. 2 (May 1999): 354–59. https://doi.org/10.1046/j.1365-2249.1999.00875.x.
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  - Pisetsky, D. S., and B. White. “A college for its teachers.” Arthritis Rheum 42, no. 4 (April 1999): 595–98. https://doi.org/10.1002/1529-0131(199904)42:4<595::AID-ANR1>3.0.CO;2-U.
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  - Neujahr, D. C., C. F. Reich, and D. S. Pisetsky. “Immunostimulatory properties of genomic DNA from different bacterial species.” Immunobiology 200, no. 1 (February 1999): 106–19. https://doi.org/10.1016/S0171-2985(99)80036-9.
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  - Rice, J. R., and D. S. Pisetsky. “Pain in the rheumatic diseases. Practical aspects of diagnosis and treatment.” Rheum Dis Clin North Am 25, no. 1 (February 1999): 15–30. https://doi.org/10.1016/s0889-857x(05)70053-3.
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  - Knudsen, N. S. “Doing everything.” Ann Intern Med 130, no. 2 (January 19, 1999): 165–66. https://doi.org/10.7326/0003-4819-130-2-199901190-00026.
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  - Pisetsky, D. S., and L. A. Bradley. “Preface.” Rheumatic Disease Clinics of North America 25, no. 1 (January 1, 1999). https://doi.org/10.1016/S0889-857X(05)70050-8.
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  - Pisetsky, D. S. “The influence of base sequence on the immunostimulatory properties of DNA.” Immunol Res 19, no. 1 (1999): 35–46. https://doi.org/10.1007/BF02786475.
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  - Pisetsky, D. S., and C. F. Reich. “The binding of anti-DNA antibodies to phosphorothioate oligonucleotides in a solid phase immunoassay.” Mol Immunol 35, no. 18 (December 1998): 1161–70. https://doi.org/10.1016/s0161-5890(98)00108-4.
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  - Pisetsky, D. “New treatments for rheumatoid arthritis.” Health News 4, no. 14 (November 20, 1998): 3.
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  - Pisetsky, D. S., and C. F. Reich. “The influence of base sequence on the immunological properties of defined oligonucleotides.” Immunopharmacology 40, no. 3 (November 1998): 199–208. https://doi.org/10.1016/s0162-3109(98)00044-7.
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  - Gilkeson, G. S., J. Conover, M. Halpern, D. S. Pisetsky, A. Feagin, and D. M. Klinman. “Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice.” J Immunol 161, no. 8 (October 15, 1998): 3890–95.
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  - Wloch, M. K., S. Pasquini, H. C. Ertl, and D. S. Pisetsky. “The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.” Hum Gene Ther 9, no. 10 (July 1, 1998): 1439–47. https://doi.org/10.1089/hum.1998.9.10-1439.
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  - Pisetsky, D. S. “Doing everything.” Ann Intern Med 128, no. 10 (May 15, 1998): 869–70. https://doi.org/10.7326/0003-4819-128-10-199805150-00013.
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  - Pisetsky, D. S. “Anti-DNA antibodies in systemic lupus erythematosus: a case of mistaken identity?” J Rheumatol 25, no. 2 (February 1998): 195–97.
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  - Pisetsky, D. S. “Antibody responses to DNA in normal immunity and aberrant immunity.” Clin Diagn Lab Immunol 5, no. 1 (January 1998): 1–6. https://doi.org/10.1128/CDLI.5.1.1-6.1998.
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  - Pisetsky, D. S. “Immune recognition of DNA in SLE.” Clin Immunol Immunopathol 86, no. 1 (January 1998): 1–2. https://doi.org/10.1006/clin.1997.4464.
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  - Pisetsky, D. S. “The influence of susceptibility factors on the immune response to DNA.” Environ Toxicol Pharmacol 4, no. 3–4 (December 1997): 295–98. https://doi.org/10.1016/s1382-6689(97)10026-6.
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  - Pisetsky, D. S. “Till death do us part.” J Gen Intern Med 12, no. 11 (November 1997): 705–6. https://doi.org/10.1046/j.1525-1497.1997.07144.x.
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  - Gilkeson, G. S., J. S. Mudgett, M. F. Seldin, P. Ruiz, A. A. Alexander, M. A. Misukonis, D. S. Pisetsky, and J. B. Weinberg. “Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.” J Exp Med 186, no. 3 (August 4, 1997): 365–73. https://doi.org/10.1084/jem.186.3.365.
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  - Pisetsky, D. S. “Immunostimulatory DNA: a clear and present danger?” Nat Med 3, no. 8 (August 1997): 829–31. https://doi.org/10.1038/nm0897-829.
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  - Wu, Z. Q., D. Drayton, and D. S. Pisetsky. “Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE).” Clin Exp Immunol 109, no. 1 (July 1997): 27–31. https://doi.org/10.1046/j.1365-2249.1997.4301328.x.
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  - Pisetsky, D. S., and D. M. Drayton. “Deficient expression of antibodies specific for bacterial DNA by patients with systemic lupus erythematosus.” Proc Assoc Am Physicians 109, no. 3 (May 1997): 237–44.
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  - Wloch, M. K., A. L. Alexander, A. M. Pippen, D. S. Pisetsky, and G. S. Gilkeson. “Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA.” J Immunol 158, no. 9 (May 1, 1997): 4500–4506.
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  - Pisetsky, D. S. “DNA and the immune system.” Ann Intern Med 126, no. 2 (January 15, 1997): 169–71. https://doi.org/10.7326/0003-4819-126-2-199701150-00015.
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  - Pisetsky, D. S. “Specificity and immunochemical properties of antibodies to bacterial DNA.” Methods 11, no. 1 (January 1997): 55–61. https://doi.org/10.1006/meth.1996.0387.
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  - Pisetsky, D. S., G. Gilkeson, and E. W. St Clair. “Systemic lupus erythematosus. Diagnosis and treatment.” Med Clin North Am 81, no. 1 (January 1997): 113–28. https://doi.org/10.1016/s0025-7125(05)70507-1.
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  - Liang, H., Y. Nishioka, C. Reich, D. Pisetsky, and P. E. Lipsky. “Human b cell activation induced by specific oligodeoxynucleotides.” Faseb Journal 10, no. 6 (December 1, 1996).
  - Sato, S., N. Ono, D. A. Steeber, D. S. Pisetsky, and T. F. Tedder. “CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity.” J Immunol 157, no. 10 (November 15, 1996): 4371–78.
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  - Merkel, P. A., M. A. Dooley, D. V. Dawson, D. S. Pisetsky, and R. P. Polisson. “Interleukin-2 receptor levels in sera of patients with rheumatoid arthritis treated with sulfasalazine, parenteral gold, or placebo.” J Rheumatol 23, no. 11 (November 1996): 1856–61.
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  - Pisetsky, D. S. “Immune activation by bacterial DNA: a new genetic code.” Immunity 5, no. 4 (October 1996): 303–10. https://doi.org/10.1016/s1074-7613(00)80256-3.
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  - Liang, H., Y. Nishioka, C. F. Reich, D. S. Pisetsky, and P. E. Lipsky. “Activation of human B cells by phosphorothioate oligodeoxynucleotides.” J Clin Invest 98, no. 5 (September 1, 1996): 1119–29. https://doi.org/10.1172/JCI118894.
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  - St Clair, E. W., W. E. Wilkinson, T. Lang, L. Sanders, M. A. Misukonis, G. S. Gilkeson, D. S. Pisetsky, D. I. Granger, and J. B. Weinberg. “Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients.” J Exp Med 184, no. 3 (September 1, 1996): 1173–78. https://doi.org/10.1084/jem.184.3.1173.
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  - Wloch, M. K., A. L. Alexander, A. M. Pippen, D. S. Pisetsky, and G. S. Gilkeson. “Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis.” Eur J Immunol 26, no. 9 (September 1996): 2225–33. https://doi.org/10.1002/eji.1830260939.
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  - Pisetsky, D. S. “Final act.” Arthritis Care Res 9, no. 4 (August 1996): 248–50. https://doi.org/10.1002/art.1790090403.
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  - Twombly, R. “Fact or fiction?” Ann Intern Med 124, no. 11 (June 1, 1996): 1016–17. https://doi.org/10.7326/0003-4819-124-11-199606010-00019.
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  - Gilkeson, G. S., P. Ruiz, A. M. Pippen, A. L. Alexander, J. B. Lefkowith, and D. S. Pisetsky. “Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA.” J Exp Med 183, no. 4 (April 1, 1996): 1389–97. https://doi.org/10.1084/jem.183.4.1389.
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  - Polisson, R. P., G. S. Gilkeson, E. H. Pyun, D. S. Pisetsky, E. A. Smith, and L. S. Simon. “A multicenter trial of recombinant human interferon gamma in patients with systemic sclerosis: effects on cutaneous fibrosis and interleukin 2 receptor levels.” J Rheumatol 23, no. 4 (April 1996): 654–58.
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  - Pisetsky, D. S. “A piece of my mind. Moments of love.” Jama 275, no. 6 (February 14, 1996): 433–34. https://doi.org/10.1001/jama.275.6.433.
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  - Pisetsky, D. S. “Restoring our health.” Arthritis Care Res 9, no. 1 (February 1996): 9–12. https://doi.org/10.1002/art.1790090104.
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  - Pisetsky, D. S. “The breakthrough.” Ann Intern Med 124, no. 3 (February 1, 1996): 345–47. https://doi.org/10.7326/0003-4819-124-3-199602010-00013.
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  - Pisetsky, D. S. “The immunologic properties of DNA.” J Immunol 156, no. 2 (January 15, 1996): 421–23.
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  - Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. “Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha.” Cell Immunol 167, no. 1 (January 10, 1996): 72–78. https://doi.org/10.1006/cimm.1996.0009.
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  - Pisetsky, D. S. “American Dream.” Journal of Medical Humanities 17, no. 3 (January 1, 1996): 203–11. https://doi.org/10.1007/BF02276617.
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  - Pisetsky, D. S. “Consultation at twilight.” N C Med J 56, no. 12 (December 1995): 608–10.
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  - Pisetsky, D. S., C. Reich, S. D. Crowley, and M. D. Halpern. “Immunological properties of bacterial DNA.” Ann N Y Acad Sci 772 (November 27, 1995): 152–63. https://doi.org/10.1111/j.1749-6632.1995.tb44740.x.
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  - Barrera, P. “Letters to the Editor.” Clinical Immunology and Immunopathology 76, no. 1 (July 1, 1995): 102–4. https://doi.org/10.1006/clin.1995.1094.
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  - Gilkeson, G. S., K. Bernstein, A. M. Pippen, S. H. Clarke, T. Marion, D. S. Pisetsky, P. Ruiz, and J. B. Lefkowith. “The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.” Clin Immunol Immunopathol 76, no. 1 Pt 1 (July 1995): 59–67. https://doi.org/10.1006/clin.1995.1088.
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  - Fan, P. Y., P. Ruiz, D. S. Pisetsky, and R. F. Spurney. “The effects of short-term treatment with the prostaglandin E1 (PGE1) analog misoprostol on inflammatory mediator production in murine lupus nephritis.” Clin Immunol Immunopathol 75, no. 2 (May 1995): 125–30. https://doi.org/10.1006/clin.1995.1061.
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  - Gilkeson, G. S., A. M. Pippen, and D. S. Pisetsky. “Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.” J Clin Invest 95, no. 3 (March 1995): 1398–1402. https://doi.org/10.1172/JCI117793.
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  - Halpern, M. D., and D. S. Pisetsky. “In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers.” Immunopharmacology 29, no. 1 (February 1995): 47–52. https://doi.org/10.1016/0162-3109(95)00043-s.
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  - Pisetsky, D. S. “Immunologic consequences of nucleic acid therapy.” Antisense Res Dev 5, no. 3 (1995): 219–25. https://doi.org/10.1089/ard.1995.5.219.
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  - Shan, H., M. J. Shlomchik, A. Marshak-Rothstein, D. S. Pisetsky, S. Litwin, and M. G. Weigert. “The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.” J Immunol 153, no. 11 (December 1, 1994): 5104–20.
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  - Ward, M. M., E. Pyun, and D. S. Pisetsky. “Serial measurement of serum interleukin-2 receptor levels in patients with rheumatoid arthritis: limited evidence for a role of T cell activation in clinical exacerbations.” Clin Immunol Immunopathol 73, no. 3 (December 1994): 296–304. https://doi.org/10.1006/clin.1994.1202.
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  - Spurney, R. F., P. Ruiz, C. R. Albrightson, D. S. Pisetsky, and T. M. Coffman. “Fish oil feeding modulates leukotriene production in murine lupus nephritis.” Prostaglandins 48, no. 5 (November 1994): 331–48. https://doi.org/10.1016/0090-6980(94)90032-9.
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  - Bunyard, M. P., and D. S. Pisetsky. “Characterization of antibodies to bacterial double-stranded DNA in the sera of normal human subjects.” Int Arch Allergy Immunol 105, no. 2 (October 1994): 122–27. https://doi.org/10.1159/000236813.
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  - Pisetsky, D. S., and C. F. Reich. “The influence of DNA size on the binding of anti-DNA antibodies in the solid and fluid phase.” Clin Immunol Immunopathol 72, no. 3 (September 1994): 350–56. https://doi.org/10.1006/clin.1994.1152.
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  - Bloom, D. D., E. W. St Clair, D. S. Pisetsky, and S. H. Clarke. “The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage.” Eur J Immunol 24, no. 6 (June 1994): 1332–38. https://doi.org/10.1002/eji.1830240614.
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  - Weinberg, J. B., D. L. Granger, D. S. Pisetsky, M. F. Seldin, M. A. Misukonis, S. N. Mason, A. M. Pippen, P. Ruiz, E. R. Wood, and G. S. Gilkeson. “The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.” J Exp Med 179, no. 2 (February 1, 1994): 651–60. https://doi.org/10.1084/jem.179.2.651.
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  - Pisetsky, D. S. “Antinuclear antibodies.” Immunology and Allergy Clinics of North America 14, no. 2 (January 1, 1994): 371–85.
  - Pisetsky, D. S., and C. F. Reich. “Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus.” Life Sci 54, no. 2 (1994): 101–7. https://doi.org/10.1016/0024-3205(94)00780-2.
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  - Polisson, R. P., M. A. Dooley, D. V. Dawson, and D. S. Pisetsky. “Interleukin-2 receptor levels in the sera of rheumatoid arthritis patients treated with methotrexate.” Arthritis Rheum 37, no. 1 (January 1994): 50–56. https://doi.org/10.1002/art.1780370108.
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  - Pisetsky, D. S. “DNA vaccination. A clue to memory?” Hum Immunol 38, no. 4 (December 1993): 241–42. https://doi.org/10.1016/0198-8859(93)90550-k.
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  - Dooley, M. A., J. J. Cush, P. E. Lipsky, D. V. Dawson, and D. S. Pisetsky. “The effects of nonsteroidal antiinflammatory drug therapy in early rheumatoid arthritis on serum levels of soluble interleukin 2 receptor, CD4, and CD8.” J Rheumatol 20, no. 11 (November 1993): 1857–62.
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  - Pisetsky, D. S., and C. Reich. “Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides.” Mol Biol Rep 18, no. 3 (October 1993): 217–21. https://doi.org/10.1007/BF01674433.
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  - Pisetsky, D. S. “Autoantibodies and their significance.” Curr Opin Rheumatol 5, no. 5 (September 1993): 549–56. https://doi.org/10.1097/00002281-199305050-00002.
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  - Gilkeson, G. S., P. Ruiz, D. Howell, J. B. Lefkowith, and D. S. Pisetsky. “Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA.” Clin Immunol Immunopathol 68, no. 3 (September 1993): 283–92. https://doi.org/10.1006/clin.1993.1129.
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  - Gilkeson, G. S., D. D. Bloom, D. S. Pisetsky, and S. H. Clarke. “Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.” J Immunol 151, no. 3 (August 1, 1993): 1353–64.
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  - Palmer, S. M., G. S. Gilkeson, and D. S. Pisetsky. “Effect of sex on the induction of anti-DNA antibodies in normal mice immunized with bacterial DNA.” Lupus 2, no. 4 (August 1993): 251–55. https://doi.org/10.1177/096120339300200408.
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  - Wang, J., C. H. Chou, J. Blankson, M. Satoh, M. W. Knuth, R. A. Eisenberg, D. S. Pisetsky, and W. H. Reeves. “Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.” Mol Biol Rep 18, no. 1 (June 1993): 15–28. https://doi.org/10.1007/BF01006891.
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  - Messina, J. P., G. S. Gilkeson, and D. S. Pisetsky. “The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens.” Cell Immunol 147, no. 1 (March 1993): 148–57. https://doi.org/10.1006/cimm.1993.1055.
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  - Bloom, D. D., J. L. Davignon, M. W. Retter, M. J. Shlomchik, D. S. Pisetsky, P. L. Cohen, R. A. Eisenberg, and S. H. Clarke. “V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.” J Immunol 150, no. 4 (February 15, 1993): 1591–1610.
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  - Pyun, E. H., D. S. Pisetsky, and G. S. Gilkeson. “The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.” J Autoimmun 6, no. 1 (February 1993): 11–26. https://doi.org/10.1006/jaut.1993.1002.
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  - Spurney, R. F., J. J. Onorato, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Characterization of glomerular thromboxane receptors in murine lupus nephritis.” J Pharmacol Exp Ther 264, no. 2 (February 1993): 584–90.
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  - Watson, M. L., J. K. Rao, G. S. Gilkeson, P. Ruiz, E. M. Eicher, D. S. Pisetsky, A. Matsuzawa, J. M. Rochelle, and M. F. Seldin. “Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.” J Exp Med 176, no. 6 (December 1, 1992): 1645–56. https://doi.org/10.1084/jem.176.6.1645.
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  - Pisetsky, D. S. “Autoantibodies and their idiotypes.” Curr Opin Rheumatol 4, no. 5 (October 1992): 635–43.
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  - Gilkeson, G. S., R. Spurney, T. M. Coffman, R. Kurlander, P. Ruiz, and D. S. Pisetsky. “Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.” Clin Immunol Immunopathol 64, no. 2 (August 1992): 166–72. https://doi.org/10.1016/0090-1229(92)90195-t.
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  - Pincus, S. H., R. Cole, and D. S. Pisetsky. “A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice.” Mol Immunol 29, no. 6 (June 1992): 801–6. https://doi.org/10.1016/0161-5890(92)90190-9.
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  - Pisetsky, D. S. “Anti-DNA antibodies in systemic lupus erythematosus.” Rheum Dis Clin North Am 18, no. 2 (May 1992): 437–54.
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  - Spurney, R. F., P. Y. Fan, P. Ruiz, F. Sanfilippo, D. S. Pisetsky, and T. M. Coffman. “Thromboxane receptor blockade reduces renal injury in murine lupus nephritis.” Kidney Int 41, no. 4 (April 1992): 973–82. https://doi.org/10.1038/ki.1992.149.
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  - Pisetsky, D. S. “Mechanisms of anti-DNA antibody expression in normal and aberrant immunity.” Concepts Immunopathol 8 (1992): 71–84.
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  - Robertson, C. R., G. S. Gilkeson, M. M. Ward, and D. S. Pisetsky. “Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus.” Clin Immunol Immunopathol 62, no. 1 Pt 1 (January 1992): 25–32. https://doi.org/10.1016/0090-1229(92)90019-k.
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  - Robertson, C. R., and D. S. Pisetsky. “Immunochemical properties of anti-DNA antibodies in the sera of patients with Escherichia coli bacteremia.” Int Arch Allergy Immunol 98, no. 4 (1992): 311–16. https://doi.org/10.1159/000236204.
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  - Robertson, C. R., and D. S. Pisetsky. “Specificity analysis of antibodies to single-stranded micrococcal DNA in the sera of normal human subjects and patients with systemic lupus erythematosus.” Clin Exp Rheumatol 10, no. 6 (1992): 589–94.
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  - Vernino, L. A., D. S. Pisetsky, and P. E. Lipsky. “Analysis of the expression of CD5 by human B cells and correlation with functional activity.” Cell Immunol 139, no. 1 (January 1992): 185–97. https://doi.org/10.1016/0008-8749(92)90111-2.
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  - Pisetsky, D. S. “Systemic lupus erythematosus.” Curr Opin Immunol 3, no. 6 (December 1991): 917–23. https://doi.org/10.1016/s0952-7915(05)80014-7.
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  - Pisetsky, D. S. “Autoantibodies and their idiotypes.” Curr Opin Rheumatol 3, no. 5 (October 1991): 731–37. https://doi.org/10.1097/00002281-199110000-00003.
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  - Messina, J. P., G. S. Gilkeson, and D. S. Pisetsky. “Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.” J Immunol 147, no. 6 (September 15, 1991): 1759–64.
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  - Ward, M. M., D. S. Pisetsky, and R. P. Hall. “Soluble interleukin-2 receptor levels in patients with dermatitis herpetiformis.” J Invest Dermatol 97, no. 3 (September 1991): 568–72. https://doi.org/10.1111/1523-1747.ep12481904.
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  - Gilkeson, G. S., P. Ruiz, A. J. Pritchard, and D. S. Pisetsky. “Genetic control of inflammatory arthritis and glomerulonephritis in congenic lpr mice and their F1 hybrids.” J Autoimmun 4, no. 4 (August 1991): 595–606. https://doi.org/10.1016/0896-8411(91)90179-g.
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  - Spurney, R. F., R. J. Bernstein, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Physiologic role for enhanced renal thromboxane production in murine lupus nephritis.” Prostaglandins 42, no. 1 (July 1991): 15–28. https://doi.org/10.1016/0090-6980(91)90090-3.
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  - Pisetsky, D. S., B. F. Haynes, P. E. Lipsky, A. H. Kang, and A. E. Postlethwaite. “The specialized centers of research in rheumatoid arthritis. Recent progress and prospects for future advances.” Hum Immunol 31, no. 2 (June 1991): 148–51. https://doi.org/10.1016/0198-8859(91)90019-6.
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  - Gilkeson, G. S., A. J. Pritchard, and D. S. Pisetsky. “Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.” Clin Immunol Immunopathol 59, no. 2 (May 1991): 288–300. https://doi.org/10.1016/0090-1229(91)90025-6.
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  - Ward, M. M., D. V. Dawson, and D. S. Pisetsky. “Serum immunoglobulin levels in systemic lupus erythematosus: the effects of age, sex, race and disease duration.” J Rheumatol 18, no. 4 (April 1991): 540–44.
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  - St Clair, E. W., D. Kenan, J. A. Burch, J. D. Keene, and D. S. Pisetsky. “Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity.” J Immunol 146, no. 6 (March 15, 1991): 1885–92.
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  - Ward, M. M., M. A. Dooley, V. D. Christenson, and D. S. Pisetsky. “The relationship between soluble interleukin 2 receptor levels and antidouble stranded DNA antibody levels in patients with systemic lupus erythematosus.” J Rheumatol 18, no. 2 (February 1991): 235–40.
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  - Spurney, R. F., P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.” Kidney Int 39, no. 1 (January 1991): 95–102. https://doi.org/10.1038/ki.1991.12.
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  - Pisetsky, D. S., B. S. Darwin, and C. F. Reich. “IgG binding of monoclonal anti-nuclear antibodies from MRL-lpr/lpr mice.” Immunology 71, no. 4 (December 1990): 586–91.
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  - Ward, M. M., and D. S. Pisetsky. “Heavy and light chain utilization in autoantibodies of elderly patients with systemic lupus erythematosus.” Clin Immunol Immunopathol 57, no. 2 (November 1990): 280–96. https://doi.org/10.1016/0090-1229(90)90042-o.
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  - Ward, M. M., R. P. Hall, and D. S. Pisetsky. “Serum interleukin-2 receptor responses to immunization.” Clin Immunol Immunopathol 57, no. 1 (October 1990): 120–24. https://doi.org/10.1016/0090-1229(90)90027-n.
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  - Wu, D. P., G. S. Gilkeson, J. Armitage, C. F. Reich, and D. S. Pisetsky. “Selective recognition of DNA antigenic determinants by murine monoclonal anti-DNA antibodies.” Clin Exp Immunol 82, no. 1 (October 1990): 33–37.
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  - Gilkeson, G. S., A. J. Pritchard, and D. S. Pisetsky. “Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA.” Eur J Immunol 20, no. 8 (August 1990): 1789–94. https://doi.org/10.1002/eji.1830200825.
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  - St Clair, E. W., D. Kenan, J. A. Burch, J. D. Keene, and D. S. Pisetsky. “The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen.” J Immunol 144, no. 10 (May 15, 1990): 3868–76.
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  - Ward, M. M., D. V. Dawson, D. W. Kredich, and D. S. Pisetsky. “Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus.” Clin Immunol Immunopathol 55, no. 2 (May 1990): 273–84. https://doi.org/10.1016/0090-1229(90)90103-w.
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  - Currie, M. S., M. Vala, D. S. Pisetsky, C. S. Greenberg, J. Crawford, and H. J. Cohen. “Correlation between erythrocyte CR1 reduction and other blood proteinase markers in patients with malignant and inflammatory disorders.” Blood 75, no. 8 (April 15, 1990): 1699–1704.
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  - Pisetsky, D. S., D. F. Jelinek, L. M. McAnally, C. F. Reich, and P. E. Lipsky. “In vitro autoantibody production by normal adult and cord blood B cells.” J Clin Invest 85, no. 3 (March 1990): 899–903. https://doi.org/10.1172/JCI114517.
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  - Pisetsky, D. S., J. P. Grudier, and G. S. Gilkeson. “A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus.” Arthritis Rheum 33, no. 2 (February 1990): 153–59. https://doi.org/10.1002/art.1780330202.
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  - St Clair, E. W., C. C. Query, R. Bentley, J. D. Keene, R. P. Polisson, N. B. Allen, D. S. Caldwell, J. R. Rice, C. Cox, and D. S. Pisetsky. “Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.” Clin Immunol Immunopathol 54, no. 2 (February 1990): 266–80. https://doi.org/10.1016/0090-1229(90)90088-8.
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  - St Clair, E. W., J. A. Burch, M. M. Ward, J. D. Keene, and D. S. Pisetsky. “Temporal correlation of antibody responses to different epitopes of the human La autoantigen.” J Clin Invest 85, no. 2 (February 1990): 515–21. https://doi.org/10.1172/JCI114467.
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  - Eisenberg, R. A., D. S. Pisetsky, S. Y. Craven, J. P. Grudier, M. A. O’Donnell, and P. L. Cohen. “Regulation of the anti-Sm autoantibody response in systemic lupus erythematosus mice by monoclonal anti-Sm antibodies.” J Clin Invest 85, no. 1 (January 1990): 86–92. https://doi.org/10.1172/JCI114437.
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  - Shlomchik, M., M. Mascelli, H. Shan, M. Z. Radic, D. Pisetsky, A. Marshak-Rothstein, and M. Weigert. “Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.” J Exp Med 171, no. 1 (January 1, 1990): 265–92. https://doi.org/10.1084/jem.171.1.265.
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  - Pisetsky, D. S., and J. P. Grudier. “Polyspecific binding of Escherichia coli beta-galactosidase by murine antibodies to DNA.” J Immunol 143, no. 11 (December 1, 1989): 3609–13.
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  - Gilkeson, G. S., P. Ruiz, J. P. Grudier, R. J. Kurlander, and D. S. Pisetsky. “Genetic control of inflammatory arthritis in congenic lpr mice.” Clin Immunol Immunopathol 53, no. 3 (December 1989): 460–74. https://doi.org/10.1016/0090-1229(89)90008-1.
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  - Shergy, W. J., D. W. Kredich, and D. S. Pisetsky. “Patterns of autoantibody expression in pediatric and adult systemic lupus erythematosus.” J Rheumatol 16, no. 10 (October 1989): 1329–34.
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  - St Clair, E. W., N. Talal, H. M. Moutsopoulos, A. Ballester, L. Zerva, J. D. Keene, and D. S. Pisetsky. “Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.” J Autoimmun 2, no. 4 (August 1989): 335–44. https://doi.org/10.1016/0896-8411(89)90161-3.
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  - Gilkeson, G. S., J. P. Grudier, and D. S. Pisetsky. “The antibody response of normal mice to immunization with single-stranded DNA of various species origin.” Clin Immunol Immunopathol 51, no. 3 (June 1989): 362–71. https://doi.org/10.1016/0090-1229(89)90034-2.
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  - Ward, M. M., D. S. Pisetsky, and V. D. Christenson. “Antidouble stranded DNA antibody assays in systemic lupus erythematosus: correlations of longitudinal antibody measurements.” J Rheumatol 16, no. 5 (May 1989): 609–13.
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  - Gilkeson, G. S., J. P. Grudier, D. G. Karounos, and D. S. Pisetsky. “Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.” J Immunol 142, no. 5 (March 1, 1989): 1482–86.
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  - Eisenberg, R. A., S. Y. Craven, C. L. Fisher, S. C. Morris, R. Rapoport, D. S. Pisetsky, and P. L. Cohen. “The genetics of autoantibody production in MRL/lpr lupus mice.” Clin Exp Rheumatol 7 Suppl 3 (1989): S35–40.
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  - St Clair, E. W., D. S. Pisetsky, C. F. Reich, and J. D. Keene. “Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.” J Immunol 141, no. 12 (December 15, 1988): 4173–80.
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  - Shergy, W. J., R. P. Polisson, D. S. Caldwell, J. R. Rice, D. S. Pisetsky, and N. B. Allen. “Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheumatoid arthritis.” Am J Med 85, no. 6 (December 1988): 771–74. https://doi.org/10.1016/s0002-9343(88)80019-6.
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  - Shores, E. W., D. S. Pisetsky, J. Grudier, R. A. Eisenberg, and P. L. Cohen. “Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice.” Immunology 65, no. 3 (November 1988): 473–78.
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  - Pisetsky, D. S. “Mike's treatment.” Am J Med 85, no. 4 (October 1988): 543. https://doi.org/10.1016/0002-9343(88)90645-6.
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  - Shergy, W. J., D. W. Kredich, and D. S. Pisetsky. “The relationship of anticardiolipin antibodies to disease manifestations in pediatric systemic lupus erythematosus.” J Rheumatol 15, no. 9 (September 1988): 1389–94.
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  - St Clair, E. W., D. S. Pisetsky, C. F. Reich, J. C. Chambers, and J. D. Keene. “Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen.” Arthritis Rheum 31, no. 4 (April 1988): 506–14. https://doi.org/10.1002/art.1780310407.
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  - Karounos, D. G., J. P. Grudier, and D. S. Pisetsky. “Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus.” J Immunol 140, no. 2 (January 15, 1988): 451–55.
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  - Pisetsky, D. S. “Inhibition of in vitro NZB antibody responses by cyclosporine.” Clin Exp Immunol 71, no. 1 (January 1988): 155–58.
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  - Pisetsky, D. S. “Mechanisms of anti-DNA production in human and murine SLE.” In Vivo 2, no. 1 (1988): 31–34.
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  - Pisetsky, D. S. “Mechanisms of antinuclear antibody production in the rheumatic diseases.” Rheum Dis Clin North Am 13, no. 3 (December 1987): 569–81.
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  - Shlomchik, M. J., A. H. Aucoin, D. S. Pisetsky, and M. G. Weigert. “Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.” Proc Natl Acad Sci U S A 84, no. 24 (December 1987): 9150–54. https://doi.org/10.1073/pnas.84.24.9150.
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  - Dresser, M., D. Pisetsky, R. Warren, G. McCarty, and M. Moses. “A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei.” J Immunol Methods 104, no. 1–2 (November 23, 1987): 111–21. https://doi.org/10.1016/0022-1759(87)90494-7.
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  - Laster, A. J., D. S. Pisetsky, and B. F. Haynes. “Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens.” Clin Immunol Immunopathol 44, no. 2 (August 1987): 187–205. https://doi.org/10.1016/0090-1229(87)90065-1.
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  - Gorelick, M. H., G. A. Bishop, G. Haughton, and D. S. Pisetsky. “Cyclosporine inhibition of CH series murine B-cell lymphomas.” Cell Immunol 107, no. 1 (June 1987): 219–26. https://doi.org/10.1016/0008-8749(87)90281-4.
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  - Karounos, D. G., and D. S. Pisetsky. “Specificity analysis of monoclonal anti-DNA antibodies.” Immunology 60, no. 4 (April 1987): 497–501.
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  - Pisetsky, D. S., C. Klatt, and S. H. Pincus. “Characterization of monoclonal antibodies with specificity for DNA and the synthetic polypeptide antigen (T,G)-A-L.” Mol Immunol 24, no. 4 (April 1987): 365–69. https://doi.org/10.1016/0161-5890(87)90178-7.
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  - Dang-Vu, A. P., D. S. Pisetsky, and J. B. Weinberg. “Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.” J Immunol 138, no. 6 (March 15, 1987): 1757–61.
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  - Darwin, B. S., J. P. Grudier, C. L. Klatt, and D. S. Pisetsky. “IgG antinuclear antibodies with cross-reactive rheumatoid factor activity.” J Immunol 137, no. 12 (December 15, 1986): 3796–3801.
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  - Emlen, W., D. S. Pisetsky, and R. P. Taylor. “Antibodies to DNA. A perspective.” Arthritis Rheum 29, no. 12 (December 1986): 1417–26. https://doi.org/10.1002/art.1780291201.
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  - Lucas, K. J., D. G. Karounos, G. J. Ellis, M. A. Morris, D. S. Pisetsky, and M. N. Feinglos. “The intravenous insulin tolerance test in type I diabetes.” Res Commun Chem Pathol Pharmacol 53, no. 3 (September 1986): 331–45.
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  - Jones, F. S., D. S. Pisetsky, and R. J. Kurlander. “The clearance of a monoclonal anti-DNA antibody following administration of DNA in normal and autoimmune mice.” Clin Immunol Immunopathol 39, no. 1 (April 1986): 49–60. https://doi.org/10.1016/0090-1229(86)90204-7.
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  - Pisetsky, D. S., and G. Haughton. “Cyclosporine inhibition of a murine B cell lymphoma.” Clin Exp Immunol 63, no. 3 (March 1986): 549–54.
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  - Pisetsky, D. S. “Systemic lupus erythematosus.” Med Clin North Am 70, no. 2 (March 1986): 337–53. https://doi.org/10.1016/s0025-7125(16)30957-9.
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  - Pisetsky, D. S., C. Klatt, D. Dawson, and J. B. Roths. “The influence of Yaa on anti-DNA responses of B6-lpr mice.” Clin Immunol Immunopathol 37, no. 3 (December 1985): 369–76. https://doi.org/10.1016/0090-1229(85)90106-0.
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  - Pisetsky, D. S., S. O. Hoch, C. L. Klatt, M. A. O’Donnell, and J. D. Keene. “Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity.” J Immunol 135, no. 6 (December 1985): 4080–85.
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  - Cohen, P. L., E. W. Shores, R. Rapoport, S. Caster, R. A. Eisenberg, and D. S. Pisetsky. “Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency.” Cell Immunol 96, no. 2 (December 1985): 448–54. https://doi.org/10.1016/0008-8749(85)90376-4.
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  - Mayus, J. L., K. F. Semper, and D. S. Pisetsky. “Inhibition of in vitro anti-DNA B-cell responses by cyclosporine.” Cell Immunol 94, no. 1 (August 1985): 195–204. https://doi.org/10.1016/0008-8749(85)90096-6.
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  - Jones, F. S., D. S. Pisetsky, and R. J. Kurlander. “Defects in mononuclear phagocytic system (MPS) function in autoimmune MRL-lpr/lpr mice.” Clin Immunol Immunopathol 36, no. 1 (July 1985): 30–39. https://doi.org/10.1016/0090-1229(85)90036-4.
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  - Eisenberg, R. A., D. Pisetsky, and P. L. Cohen. “Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids.” Clin Immunol Immunopathol 35, no. 3 (June 1985): 337–45. https://doi.org/10.1016/0090-1229(85)90094-7.
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  - Mayus, J. L., and D. S. Pisetsky. “Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice.” Clin Immunol Immunopathol 34, no. 3 (March 1985): 366–78. https://doi.org/10.1016/0090-1229(85)90185-0.
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  - Monroe, J. G., J. C. Cambier, E. A. Mody, and D. S. Pisetsky. “Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state.” Clin Immunol Immunopathol 34, no. 1 (January 1985): 124–29. https://doi.org/10.1016/0090-1229(85)90015-7.
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  - Warren, R. W., D. M. Sailstad, and D. S. Pisetsky. “Monoclonal rheumatoid factors from B6-lpr/lpr mice.” Clin Exp Immunol 58, no. 3 (December 1984): 731–36.
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  - Pisetsky, D. S., and K. F. Semper. “Influence of assay conditions on ELISA determinations of anti-DNA antibodies.” J Immunol Methods 74, no. 2 (November 30, 1984): 217–27. https://doi.org/10.1016/0022-1759(84)90289-8.
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  - Pisetsky, D. S., K. F. Semper, and R. A. Eisenberg. “Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression.” J Immunol 133, no. 4 (October 1984): 2085–89.
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  - Pisetsky, D. S., D. M. Salistad, and J. C. Chambers. “Characterization and idiotypic analysis of an anti-RNP monoclonal antibody.” Clin Exp Immunol 56, no. 3 (June 1984): 593–600.
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  - Warren, R. W., D. M. Sailstad, S. A. Caster, and D. S. Pisetsky. “Specificity analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr mice.” Arthritis Rheum 27, no. 5 (May 1984): 545–51. https://doi.org/10.1002/art.1780270510.
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  - Warren, R. W., S. A. Caster, J. B. Roths, E. D. Murphy, and D. S. Pisetsky. “The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains.” Clin Immunol Immunopathol 31, no. 1 (April 1984): 65–77. https://doi.org/10.1016/0090-1229(84)90190-9.
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  - Pisetsky, D. S., and S. A. Caster. “Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity.” Clin Immunol Immunopathol 30, no. 3 (March 1984): 461–68. https://doi.org/10.1016/0090-1229(84)90031-x.
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  - Pisetsky, D. S., S. A. Caster, M. Piper, D. W. Scott, and A. D. Steinberg. “Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice.” Cell Immunol 84, no. 1 (March 1984): 32–40. https://doi.org/10.1016/0008-8749(84)90074-1.
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  - Warren, R. W., J. B. Roths, E. D. Murphy, and D. S. Pisetsky. “Mechanisms of polyclonal B-cell activation in autoimmune B6-lpr/lpr mice.” Cell Immunol 84, no. 1 (March 1984): 22–31. https://doi.org/10.1016/0008-8749(84)90073-x.
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  - Pisetsky, D. S. “Hybridoma SLE autoantibodies: insights for the pathogenesis of autoimmune disease.” Clin Immunol Rev 3, no. 2 (1984): 169–234.
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  - Pisetsky, D. S., E. A. Lerner, and S. Caster. “Idiotypic cross-reaction between MRL autoantibodies and a BALB/c myeloma.” Mol Immunol 20, no. 6 (June 1983): 615–21. https://doi.org/10.1016/0161-5890(83)90006-8.
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  - Pisetsky, D. “Specificity and idiotype analysis of a monoclonal anti-DNA antibody.” Clin Immunol Immunopathol 27, no. 3 (June 1983): 348–56. https://doi.org/10.1016/0090-1229(83)90087-9.
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  - Pisetsky, D. S., S. A. Caster, and A. D. Steinberg. “Effect os xid on anti-DNA B-cell precursors.” Cell Immunol 78, no. 2 (June 1983): 326–32. https://doi.org/10.1016/0008-8749(83)90287-3.
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  - Pisetsky, D. S., and E. A. Lerner. “Idiotypic analysis of a monoclonal anti-Sm antibody.” J Immunol 129, no. 4 (October 1982): 1489–92.
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  - Pisetsky, D. S., and S. A. Caster. “The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies.” Cell Immunol 72, no. 2 (September 15, 1982): 294–305. https://doi.org/10.1016/0008-8749(82)90477-4.
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  - Pisetsky, D. S., S. A. Caster, J. B. Roths, and E. D. Murphy. “Ipr gene control of the anti-DNA antibody response.” J Immunol 128, no. 5 (May 1982): 2322–25.
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  - Pisetsky, D. S., and S. A. Caster. “Binding specificity of a monoclonal anti-DNA antibody.” Mol Immunol 19, no. 5 (May 1982): 645–50. https://doi.org/10.1016/0161-5890(82)90364-9.
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  - McCarty, G. A., J. R. Rice, B. F. Fetter, and D. S. Pisetsky. “Lymphocytic lymphoma and systemic lupus erythematosus: their coexistence with antibody to the Sm antigen.” Arch Pathol Lab Med 106, no. 4 (April 1982): 196–99.
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  - Pisetsky, D. S., S. A. Caster, J. B. Roths, and E. D. Murphy. “Lpr gene control of the anti-DNA antibody response.” Journal of Immunology 128, no. 5 (January 1, 1982): 2322–25.
  - McCarty, G. A., J. R. Rice, M. L. Bembe, and D. S. Pisetsky. “Independent expression of autoantibodies in systemic lupus erythematosus.” J Rheumatol 9, no. 5 (1982): 691–95.
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  - Berzofsky, J. A., D. S. Pisetsky, D. J. Killion, G. Hicks, and D. H. Sachs. “Ir genes of different high responder haplotypes for staphylococcal nuclease are not allelic.” J Immunol 127, no. 6 (December 1981): 2453–55.
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  - Santoro, T. J., D. W. Scott, and D. S. Pisetsky. “The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self.” J Immunol 127, no. 2 (August 1981): 690–93.
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  - Pisetsky, D. S., and D. V. Peters. “A simple enzyme-linked immunosorbent assay for antibodies to native DNA.” J Immunol Methods 41, no. 2 (1981): 187–200. https://doi.org/10.1016/0022-1759(81)90242-8.
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  - Pisetsky, D. S., G. A. McCarty, and D. V. Peters. “Mechanisms of autoantibody production in autoimmune MRL mice.” J Exp Med 152, no. 5 (November 1, 1980): 1302–10. https://doi.org/10.1084/jem.152.5.1302.
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  - Pisetsky, D. S., S. E. Riordan, and D. H. Sachs. “Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus.” J Immunol 122, no. 3 (March 1979): 842–46.
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  - Pisetsky, D. S., and D. H. Sachs. “Genetic control of the immune response to staphylococcal nuclease. VIII. Mapping of genes for antibodies to different antigenic regions of nuclease.” J Exp Med 147, no. 5 (May 1, 1978): 1517–25. https://doi.org/10.1084/jem.147.5.1517.
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  - Pisetsky, D. S., J. A. Berzofsky, and D. H. Sachs. “Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response.” J Exp Med 147, no. 2 (February 1, 1978): 396–408. https://doi.org/10.1084/jem.147.2.396.
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  - Berzofsky, J. A., D. S. Pisetsky, R. H. Schwartz, A. N. Schechter, and D. H. Sachs. “Genetic control of the immune response to staphylococcal nuclease in mice.” Adv Exp Med Biol 98 (1978): 241–57. https://doi.org/10.1007/978-1-4615-8858-0_13.
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  - Sachs, D. H., J. A. Berzofsky, D. S. Pisetsky, and R. H. Schwartz. “Genetic control of the immune response to staphylococcal nuclease.” Springer Seminars in Immunopathology 1, no. 1 (January 1, 1978): 51–83. https://doi.org/10.1007/BF00198646.
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  - Pisetsky, D. S., and D. H. Sachs. “The genetic control of the immune response to staphylococcal nuclease VI. Recombination between genes determining the A/J anti-nuclease idiotypes and the heavy chain allotype locus.” J Exp Med 146, no. 6 (December 1, 1977): 1603–12. https://doi.org/10.1084/jem.146.6.1603.
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  - Fathman, C. G., D. S. Pisetsky, and D. H. Sachs. “Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes.” J Exp Med 145, no. 3 (March 1, 1977): 569–77. https://doi.org/10.1084/jem.145.3.569.
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  - Sachs, D. H., J. A. Berzofsky, C. G. Fathman, D. S. Pisetsky, A. N. Schechter, and R. H. Schwartz. “The immune response to staphylococcal nuclease: a probe of cellular and humoral antigen-specific receptors.” Cold Spring Harb Symp Quant Biol 41 Pt 1 (1977): 295–306. https://doi.org/10.1101/sqb.1977.041.01.035.
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  - Pisetsky, D., I. Berkower, R. Wickner, and J. Hurwitz. “Role of ATP in DNA synthesis in Escherichia coli.” J Mol Biol 71, no. 3 (November 28, 1972): 557–71. https://doi.org/10.1016/s0022-2836(72)80023-8.
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  - Abramson, M. B., and D. Pisetsky. “Thermal-turbidimetric studies of membranes from Acholeplasma laidlawii.” Biochim Biophys Acta 282, no. 1 (September 1, 1972): 80–84. https://doi.org/10.1016/0005-2736(72)90312-4.
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  - Pisetsky, D., and T. M. Terry. “Are mycoplasma membrane proteins affected by variations in membrane fatty acid composition?” Biochim Biophys Acta 274, no. 1 (July 3, 1972): 95–104. https://doi.org/10.1016/0005-2736(72)90284-2.
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- Book Sections
  - Pisetsky, D. S. “Lupus biomarkers.” In Dubois’ Lupus Erythematosus and Related Syndromes, 631–39, 2018. https://doi.org/10.1016/B978-0-323-47927-1.00050-5.
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  - Pisetsky, D. S. “The immunopathogenesis and immunopathology of systemic lupus erythematosus.” In Lupus Erythematosus: Clinical Evaluation and Treatment, 13–26, 2013. https://doi.org/10.1007/978-1-4614-1189-5_2.
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  - Pisetsky, D. S. “Gamow, guppies, and the search for GOD.” In Medicine Science and Dreams: The Making of Physician-Scientists, 15–32, 2011. https://doi.org/10.1007/978-90-481-9538-1_2.
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- Conference Papers
  - Friedman, Daphne Ruth, Tiffany Stewart, Eross Guadalupe, Danielle M. Brander, David S. Pisetsky, and J Brice Weinberg. “Pan-caspase peptide inhibitor to induce primary chronic lymphocytic leukemia (CLL) cell death through a non-apoptotic and non-necroptotic mechanism.” In Journal of Clinical Oncology, 33:e13536–e13536. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.e13536.
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  - Pisetsky, David S., Diane Spencer, Stephen R. Wisniewski, Jason Lyons, Melissa Saul, Mandy J. McGeachy, Yong Gil Hwang, Heather Eng, and Larry W. Moreland. “The Relationship Between Disease Activity and Levels of HMGB1 in Patients with Rheumatoid Arthritis.” In Arthritis & Rheumatology, 66:S172–S172. WILEY-BLACKWELL, 2014.
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  - Kamen, Diane L., Graciela S. Alarcon, Jill P. Buyon, Mary Anne Dooley, Richard A. Furie, David S. Pisetsky, and Tammy O. Utset. “Characteristics Of Lupus Nephritis: Data From a Large Multicenter Registry Of Patients With Systemic Lupus Erythematosus.” In Arthritis and Rheumatism, 65:S261–S261. WILEY-BLACKWELL, 2013.
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  - Bertoncelj, Mojca Frank, Blaz Rozman, Beat A. Michel, Renate E. Gay, David S. Pisetsky, Oliver Distler, Steffen Gay, and Astrid Juengel. “Activation of NF-Kb Via Poly(I:C)-Induced Monocyte-Derived Microparticles Decreases TRAIL-Induced Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts.” In Arthritis and Rheumatism, 64:S392–S392. WILEY-BLACKWELL, 2012.
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  - Ullal, Anirudh, and David S. Pisetsky. “Microparticles as antigenic targets in human and murine SLE.” In Arthritis Research & Therapy, Vol. 14. BIOMED CENTRAL LTD, 2012.
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  - Clowse, Megan E. B., Lisa G. Criscione-Schreiber, and David S. Pisetsky. “Predictors of Preterm Birth and Preeclampsia in Systemic Lupus Erythematosus.” In Arthritis and Rheumatism, 63:S890–91. WILEY-BLACKWELL, 2011.
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  - Dahlhaus, Meike, Joanna Stanczyk, Mojca Frank, Beat A. Michel, Christoph Kolling, David S. Pisetsky, Renate E. Gay, Steffen Gay, Astrid Juengel, and Diego Kyburz. “MiR-451 in Microparticles Derived From Monocytes Influences Gene Expression in Rheumatoid Arthritis Synovial Fibroblasts.” In Arthritis and Rheumatism, 63:S16–S16. WILEY-BLACKWELL, 2011.
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  - Lundberg, Ingrid E., Cecilia Grundtman, Joseph Bruton, Therese Ostberg, David S. Pisetsky, and Helena Erlandsson Harris. “The role of the alarmin HMGB-1 in the pathogenesis of inflammatory myopathies.” In Arthritis and Rheumatism, 58:S922–23. WILEY-BLACKWELL, 2008.
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  - Brice Weinberg, J., Thomas Lang, William E. Wilkinson, David S. Pisetsky, and E William St. Clair. “P132. Serum, urinary, and salivary nitric oxide in rheumatoid arthritis: complexities of interpreting nitric oxide measures.” In Nitric Oxide, 14:61–61. Elsevier BV, 2006. https://doi.org/10.1016/j.niox.2006.04.199.
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- Theses and Dissertations
  - Garza Reyna, Angel. “Analysis of the Mechanisms of Anti-DNA Antibody Binding to DNA.” Edited by David Pisetsky and Diane Spencer, 2020.
    Open Access Copy
  - Garza Reyna, Angel. “Analysis of the Mechanisms of Anti-DNA Antibody Binding to DNA.” Edited by David Pisetsky and Diane Spencer, 2020.
    Open Access Copy
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