Metastatic Hormone-Sensitive Prostate Cancer: A Review of the Current Treatment Landscape.
Journal Article (Journal Article;Review)
PURPOSE: In recent years, the treatment options for metastatic hormone-sensitive prostate cancer (mHSPC) have expanded significantly. In addition to androgen deprivation therapy, the systemic treatments now include docetaxel, abiraterone, enzalutamide, and apalutamide. Radiation to the primary is also an option for select low-volume patients. METHODS: We conducted a review of the pivotal trials that have changed the practice of mHSPC. RESULTS: We describe an overview of the trials that investigated docetaxel (CHAARTED and STAMPEDE-Docetaxel), abiraterone (LATTITUDE and STAMPEDE-Abiraterone), enzalutamide (ARCHES, ENZAMET), apalutamide (TITAN), and radiation to the primary (STAMPEDE-Radiation). DISCUSSION: The treatment of mHSPC is a complex topic, and treatment choice should be individualized. Patient preferences, cost, volume of disease, and side effect profiles are important in determining which option is the best for an individual patient.
Full Text
Duke Authors
Cited Authors
- Kinsey, EN; Zhang, T; Armstrong, AJ
Published Date
- 2020
Published In
Volume / Issue
- 26 / 1
Start / End Page
- 64 - 75
PubMed ID
- 31977388
Electronic International Standard Serial Number (EISSN)
- 1540-336X
Digital Object Identifier (DOI)
- 10.1097/PPO.0000000000000418
Language
- eng
Conference Location
- United States