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Andrew John Armstrong

Professor of Medicine
Medicine, Medical Oncology
Duke Box 103861, Durham, NC 27710
GSRB1 Room 3006, 905 La Salle St, Durham, NC 27710


I am a clinical and translational investigator focused on precision therapies and biomarkers in advanced prostate and other GU cancers.  I oversee a large research team of clinical and lab based investigators focused on improving patient outcomes, preventing metastatic disease, and understanding the biology of aggressive prostate cancer.  Some key themes:
1. Predictors of sensitivity and clinical efficacy of therapies in advanced prostate cancer
2. Novel designs of clinical trials and pharmacodynamic/translational studies in prostate, kidney, bladder cancer
3. Pre-operative models for drug development of novel agents in human testing in prostate cancer
4. Novel therapies and drug development for prostate, renal, bladder, and testicular cancer
5. Design of rational combination therapies in men with metastatic hormone-refractory prostate cancer
6. Developing prognostic and predictive models for progression and survival in metastatic prostate cancer
7. Examining surrogate markers of mortality in metastatic prostate cancer
8. Clear cell and non-clear cell renal cell carcinoma: natural history, sensitivity to novel agents including mTOR and VEGF inhibition

Office Hours

Tuesdays, Wednesdays and Fridays. Contact Peggy Cook, my assistant at for appointments. Or 919-668-4667.

Current Appointments & Affiliations

Professor of Medicine · 2018 - Present Medicine, Medical Oncology, Medicine
Professor in Urology · 2018 - Present Urology, Clinical Science Departments
Professor in Pharmacology and Cancer Biology · 2021 - Present Pharmacology & Cancer Biology, Basic Science Departments
Member of the Duke Cancer Institute · 2006 - Present Duke Cancer Institute, Institutes and Centers

Education, Training & Certifications

Johns Hopkins University · 2008 M.Sc.
University of Virginia, School of Medicine · 2000 M.D.
Duke University · 1996 B.S.E.