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Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination.

Publication ,  Journal Article
Van Der Meeren, O; Jongert, E; Seaton, KE; Koutsoukos, M; Aerssens, A; Brackett, C; Debois, M; Janssens, M; Leroux-Roels, G; Mesia Vela, D ...
Published in: Vaccine
February 11, 2020

BACKGROUND: Vaccines eliciting protective and persistent immune responses against multiple human immunodeficiency virus type 1 (HIV-1) clades are needed. This study evaluated the persistence of immune responses induced by an investigational, AS01-adjuvanted HIV-1 vaccine as long as 14 years after vaccination. METHODS: This phase I, open-label, descriptive, mono-centric, extension study with a single group (NCT03368053) was conducted in adults who received ≥3 doses of the clade B gp120-NefTat/AS01B vaccine candidate 14 years earlier in a previous clinical trial (NCT00434512). Binding responses of serum antibodies targeting a panel of envelope glycoproteins, including gp120, gp140 and V1V2-scaffold antigens and representative of the antigenic diversity of HIV-1, were measured by binding antibody multiplex assay (BAMA). The gp120-specific CD4+/CD8+ T-cell responses were assessed by intracellular cytokine staining assay. RESULTS: At Year 14, positive IgG binding antibody responses were detected in 15 out of the 16 antigens from the BAMA V1V2 breadth panel, with positive response rates ranging from 7.1% to 60.7%. The highest response rates were observed for clade B strain V1V2 antigens, with some level of binding antibodies against clade C strains. Anti-V1V2 IgG3 response magnitude breadth, which correlated with decreased risk of infection in a previous efficacy trial, was of limited amplitude. Response rates to the antigens from the gp120 and gp140 breadth panels ranged from 7.7% to 94.1% and from 15.4% to 96.2% at Year 14, respectively. Following stimulation with gp120 peptide pool, highly polyfunctional gp120-specific CD4+ T-cells persisted up to Year 14, with high frequencies of CD40L tumor necrosis factor alpha (TNF-α), CD40L interleukin-2 (IL-2), CD40L TNF-α IL-2 and CD40L interferon gamma (IFN-γ) TNF-α IL-2 CD4+ T-cells, but no CD8+ T-cells detected. CONCLUSIONS: Persistent antibodies binding to HIV-1 envelope glycoproteins, including the V1V2-scaffold, and gp120-specific cellular immunity were observed in volunteers vaccinated 14 years earlier with the gp120-NefTat/AS01B vaccine candidate.

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Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

February 11, 2020

Volume

38

Issue

7

Start / End Page

1678 / 1689

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccination
  • Immunity, Cellular
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • Antibody Formation
  • Adult
 

Citation

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MLA
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Van Der Meeren, O., Jongert, E., Seaton, K. E., Koutsoukos, M., Aerssens, A., Brackett, C., … Roman, F. (2020). Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination. Vaccine, 38(7), 1678–1689. https://doi.org/10.1016/j.vaccine.2019.12.058
Van Der Meeren, Olivier, Erik Jongert, Kelly E. Seaton, Marguerite Koutsoukos, Annelies Aerssens, Caroline Brackett, Muriel Debois, et al. “Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination.Vaccine 38, no. 7 (February 11, 2020): 1678–89. https://doi.org/10.1016/j.vaccine.2019.12.058.
Van Der Meeren O, Jongert E, Seaton KE, Koutsoukos M, Aerssens A, Brackett C, et al. Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination. Vaccine. 2020 Feb 11;38(7):1678–89.
Van Der Meeren, Olivier, et al. “Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination.Vaccine, vol. 38, no. 7, Feb. 2020, pp. 1678–89. Pubmed, doi:10.1016/j.vaccine.2019.12.058.
Van Der Meeren O, Jongert E, Seaton KE, Koutsoukos M, Aerssens A, Brackett C, Debois M, Janssens M, Leroux-Roels G, Mesia Vela D, Sawant S, Yates NL, Tomaras GD, Leroux-Roels I, Roman F. Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01B vaccination. Vaccine. 2020 Feb 11;38(7):1678–1689.
Journal cover image

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

February 11, 2020

Volume

38

Issue

7

Start / End Page

1678 / 1689

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccination
  • Immunity, Cellular
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • Antibody Formation
  • Adult