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Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells.

Publication ,  Journal Article
Roberts, J; Gonzalez, RS; Revetta, F; Shi, C
Published in: Histopathology
November 2018

AIMS: Mesenteric tumour deposits frequently occur in small-intestine neuroendocrine tumours. In many instances, these mesenteric tumour deposits are surrounded by a dense fibrotic stroma and have associated lymphoplasmacytic inflammation. The aim of this study was to examine whether mesenteric tumour deposits in patients with small-intestine NETs neuroendocrine tumours show histological and immunophenotypic overlap with IgG4-related sclerosing mesenteritis. METHODS AND RESULTS: Sixty-six mesenteric tumour deposits from 66 patients with small-intestine neuroendocrine tumours with blocks available for further studies were identified from our archives. Cases were assessed for clinicopathological features and the presence of IgG4-positive and IgG-positive plasma cells by immunohistochemistry. Ratios of IgG4-positive to IgG-positive plasma cells were calculated. Seventeen mesenteric tumour deposits (26%) showed >40 IgG4-positive plasma cells per high-power field, and the majority of cases (68%) showed at least some staining of IgG4-positive plasma cells. Mesenteric tumour deposits with >20 IgG4-positive plasma cells per high-power field tended to be larger (25.9 ± 13.0 mm versus 18.6 ± 15.8 mm; P = 0.07), and had more IgG-positive plasma cells (88 ± 24 versus 36 ± 37; P < 0.01) and a higher IgG4-positive/IgG-positive plasma cell ratio (0.66 ± 0.18 versus 0.17 ± 0.25; P < 0.01). All but one mesenteric tumour deposit with >20 IgG4-positve plasma cells had a ratio of >40%. CONCLUSIONS: IgG4 expression is frequent in mesenteric tumour deposits from small-intestine neuroendocrine tumours. Undersampling of tumour on biopsies of mesenteric tumour deposits could potentially cause diagnostic confusion with IgG4-related sclerosing mesenteritis.

Duke Scholars

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Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

November 2018

Volume

73

Issue

5

Start / End Page

795 / 800

Location

England

Related Subject Headings

  • Young Adult
  • Plasma Cells
  • Pathology
  • Panniculitis, Peritoneal
  • Neuroendocrine Tumors
  • Neoplasm Metastasis
  • Middle Aged
  • Mesentery
  • Male
  • Intestine, Small
 

Citation

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Chicago
ICMJE
MLA
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Roberts, J., Gonzalez, R. S., Revetta, F., & Shi, C. (2018). Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells. Histopathology, 73(5), 795–800. https://doi.org/10.1111/his.13693
Roberts, Jordan, Raul S. Gonzalez, Frank Revetta, and Chanjuan Shi. “Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells.Histopathology 73, no. 5 (November 2018): 795–800. https://doi.org/10.1111/his.13693.
Roberts, Jordan, et al. “Mesenteric tumour deposits arising from small-intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4-expressing plasma cells.Histopathology, vol. 73, no. 5, Nov. 2018, pp. 795–800. Pubmed, doi:10.1111/his.13693.
Journal cover image

Published In

Histopathology

DOI

EISSN

1365-2559

Publication Date

November 2018

Volume

73

Issue

5

Start / End Page

795 / 800

Location

England

Related Subject Headings

  • Young Adult
  • Plasma Cells
  • Pathology
  • Panniculitis, Peritoneal
  • Neuroendocrine Tumors
  • Neoplasm Metastasis
  • Middle Aged
  • Mesentery
  • Male
  • Intestine, Small