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Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors.

Publication ,  Journal Article
Shi, C; Gonzalez, RS; Zhao, Z; Koyama, T; Cornish, TC; Hande, KR; Walker, R; Sandler, M; Berlin, J; Liu, EH
Published in: Am J Clin Pathol
March 2015

OBJECTIVES: We examined Ki-67 heterogeneity within single and between synchronous liver metastases of small intestine neuroendocrine tumors. METHODS: There were 27 patients (10 men and 17 women) with two or more liver metastases. The Ki-67 index was used to classify the tumors into World Health Organization grade 1, 2, or 3. The association between Ki-67 heterogeneity and tumor size of liver metastases was analyzed. Correlation of tumor grade with patient survival was also evaluated. RESULTS: Primary tumors from 20 patients were graded, including 17 grade 1 and three grade 2. A total of 188 liver metastases were resected, including 122 (65%) grade 1, 47 (25%) grade 2, and 19 (10%) grade 3. The highest tumor grade was grade 1 in 10 (37%), grade 2 in nine (33%), and grade 3 in eight (30%) patients. Patients with one or more grade 3 liver lesions had a shorter progression-free survival compared with those with grade 1/2 tumors (P < .001). A positive association was found between tumor size and Ki-67 index (P = .04), as well as between tumor size and intratumoral Ki-67 heterogeneity (P < .001). CONCLUSIONS: Intratumoral and intertumoral Ki-67 heterogeneity is common and positively correlated with tumor size. The presence of one or more grade 3 liver lesions predicts a worse prognosis.

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Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

March 2015

Volume

143

Issue

3

Start / End Page

398 / 404

Location

England

Related Subject Headings

  • Young Adult
  • World Health Organization
  • Prognosis
  • Pathology
  • Neuroendocrine Tumors
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Liver
 

Citation

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ICMJE
MLA
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Shi, C., Gonzalez, R. S., Zhao, Z., Koyama, T., Cornish, T. C., Hande, K. R., … Liu, E. H. (2015). Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors. Am J Clin Pathol, 143(3), 398–404. https://doi.org/10.1309/AJCPQ55SKOCYFZHN
Shi, Chanjuan, Raul S. Gonzalez, Zhiguo Zhao, Tatsuki Koyama, Toby C. Cornish, Kenneth R. Hande, Ronald Walker, Martin Sandler, Jordan Berlin, and Eric H. Liu. “Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors.Am J Clin Pathol 143, no. 3 (March 2015): 398–404. https://doi.org/10.1309/AJCPQ55SKOCYFZHN.
Shi C, Gonzalez RS, Zhao Z, Koyama T, Cornish TC, Hande KR, et al. Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors. Am J Clin Pathol. 2015 Mar;143(3):398–404.
Shi, Chanjuan, et al. “Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors.Am J Clin Pathol, vol. 143, no. 3, Mar. 2015, pp. 398–404. Pubmed, doi:10.1309/AJCPQ55SKOCYFZHN.
Shi C, Gonzalez RS, Zhao Z, Koyama T, Cornish TC, Hande KR, Walker R, Sandler M, Berlin J, Liu EH. Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors. Am J Clin Pathol. 2015 Mar;143(3):398–404.
Journal cover image

Published In

Am J Clin Pathol

DOI

EISSN

1943-7722

Publication Date

March 2015

Volume

143

Issue

3

Start / End Page

398 / 404

Location

England

Related Subject Headings

  • Young Adult
  • World Health Organization
  • Prognosis
  • Pathology
  • Neuroendocrine Tumors
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Liver