Regulation of γδ T Cell Effector Diversification in the Thymus.

Journal Article (Journal Article;Review)

γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a wide variety of tissues where they can provide fast, innate-like sources of effector cytokines for barrier defense. In contrast to conventional αβ T cells that egress the thymus as naïve cells, γδ T cells can be programmed for effector function during development in the thymus. Understanding the molecular mechanisms that determine γδ T cell effector fate is of great interest due to the wide-spread tissue distribution of γδ T cells and their roles in pathogen clearance, immunosurveillance, cancer, and autoimmune diseases. In this review, we will integrate the current understanding of the role of the T cell receptor, environmental signals, and transcription factor networks in controlling mouse innate-like γδ T cell effector commitment.

Full Text

Duke Authors

Cited Authors

  • Parker, ME; Ciofani, M

Published Date

  • 2020

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 42 -

PubMed ID

  • 32038664

Pubmed Central ID

  • PMC6992645

Electronic International Standard Serial Number (EISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2020.00042


  • eng

Conference Location

  • Switzerland