Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells.

Journal Article (Journal Article;Review)

Non-Hodgkin lymphomas (NHLs) are a diverse group of entities, both clinically and molecularly. Here, we review the evolution of classification schemes in B-cell lymphoma, noting the now standard WHO classification system that is based on immune cell-of-origin and molecular phenotypes. We review how lymphomas arise throughout the B-cell development process as well as the molecular and clinical features of prominent B-cell lymphomas. We provide an overview of the major progress that has occurred over the past decade in terms of our molecular understanding of these diseases. We discuss treatment options available and focus on a number of the diverse research tools that have been employed to improve our understanding of these diseases. We discuss the problem of heterogeneity in lymphomas and anticipate that the near future will bring significant advances that provide a measurable impact on NHL outcomes.

Full Text

Duke Authors

Cited Authors

  • Shingleton, J; Wang, J; Baloh, C; Dave, T; Davis, N; Happ, L; Jadi, O; Kositsky, R; Li, X; Love, C; Panea, R; Qin, Q; Reddy, A; Singhi, N; Smith, E; Thakkar, D; Dave, SS

Published Date

  • March 1, 2021

Published In

Volume / Issue

  • 11 / 3

PubMed ID

  • 32152246

Pubmed Central ID

  • PMC7919396

Electronic International Standard Serial Number (EISSN)

  • 2157-1422

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a034843

Language

  • eng

Conference Location

  • United States