Treatment of high risk or recurrent meningiomas with hydroxyurea.

Journal Article (Journal Article)

Recurrent, irresectable meningioma constitutes an uncommon but significant problem. Many systemic therapies have been tested without clear evidence of efficacy. More recently, two reports have suggested that hydroxyurea has activity in this context. This study examined the efficacy and toxicity of hydroxyurea in the treatment of 15 patients with high risk meningioma, residual meningioma post resection and progressive meningioma. Hydroxyurea was well tolerated although two patients ceased therapy because of skin rashes. There were no objective responses. Eleven patients achieved stable disease including eight patients who had documented progression prior to commencing hydroxyurea. These results are consistent with previous reports. In conclusion, hydroxyurea may provide some clinical benefit in patients with progressive meningioma by delaying progression of disease.

Full Text

Duke Authors

Cited Authors

  • Rosenthal, MA; Ashley, DL; Cher, L

Published Date

  • March 2002

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 156 - 158

PubMed ID

  • 11922703

International Standard Serial Number (ISSN)

  • 0967-5868

Digital Object Identifier (DOI)

  • 10.1054/jocn.2001.1019


  • eng

Conference Location

  • Scotland