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The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.

Publication ,  Journal Article
Jabbour, AM; Ekert, PG; Coulson, EJ; Knight, MJ; Ashley, DM; Hawkins, CJ
Published in: Cell Death Differ
December 2002

This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage site in p49 was determined, and mutation of the P1 residue of this site abolished the ability of p49 to inhibit caspases, implying that p49 inhibits caspases through an analogous suicide-substrate mechanism to p35. Unlike p35, p49 inhibited the upstream insect caspase DRONC.

Duke Scholars

Published In

Cell Death Differ

DOI

ISSN

1350-9047

Publication Date

December 2002

Volume

9

Issue

12

Start / End Page

1311 / 1320

Location

England

Related Subject Headings

  • Viral Proteins
  • Ultraviolet Rays
  • Tumor Necrosis Factor-alpha
  • Trans-Activators
  • TNF-Related Apoptosis-Inducing Ligand
  • Sequence Homology, Nucleic Acid
  • Sequence Homology, Amino Acid
  • Saccharomyces cerevisiae
  • Mutation
  • Molecular Sequence Data
 

Citation

APA
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MLA
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Jabbour, A. M., Ekert, P. G., Coulson, E. J., Knight, M. J., Ashley, D. M., & Hawkins, C. J. (2002). The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death Differ, 9(12), 1311–1320. https://doi.org/10.1038/sj.cdd.4401135
Jabbour, A. M., P. G. Ekert, E. J. Coulson, M. J. Knight, D. M. Ashley, and C. J. Hawkins. “The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.Cell Death Differ 9, no. 12 (December 2002): 1311–20. https://doi.org/10.1038/sj.cdd.4401135.
Jabbour AM, Ekert PG, Coulson EJ, Knight MJ, Ashley DM, Hawkins CJ. The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death Differ. 2002 Dec;9(12):1311–20.
Jabbour, A. M., et al. “The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.Cell Death Differ, vol. 9, no. 12, Dec. 2002, pp. 1311–20. Pubmed, doi:10.1038/sj.cdd.4401135.
Jabbour AM, Ekert PG, Coulson EJ, Knight MJ, Ashley DM, Hawkins CJ. The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death Differ. 2002 Dec;9(12):1311–1320.

Published In

Cell Death Differ

DOI

ISSN

1350-9047

Publication Date

December 2002

Volume

9

Issue

12

Start / End Page

1311 / 1320

Location

England

Related Subject Headings

  • Viral Proteins
  • Ultraviolet Rays
  • Tumor Necrosis Factor-alpha
  • Trans-Activators
  • TNF-Related Apoptosis-Inducing Ligand
  • Sequence Homology, Nucleic Acid
  • Sequence Homology, Amino Acid
  • Saccharomyces cerevisiae
  • Mutation
  • Molecular Sequence Data