The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.

Journal Article (Journal Article)

This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage site in p49 was determined, and mutation of the P1 residue of this site abolished the ability of p49 to inhibit caspases, implying that p49 inhibits caspases through an analogous suicide-substrate mechanism to p35. Unlike p35, p49 inhibited the upstream insect caspase DRONC.

Full Text

Duke Authors

Cited Authors

  • Jabbour, AM; Ekert, PG; Coulson, EJ; Knight, MJ; Ashley, DM; Hawkins, CJ

Published Date

  • December 2002

Published In

Volume / Issue

  • 9 / 12

Start / End Page

  • 1311 - 1320

PubMed ID

  • 12478468

International Standard Serial Number (ISSN)

  • 1350-9047

Digital Object Identifier (DOI)

  • 10.1038/sj.cdd.4401135


  • eng

Conference Location

  • England