Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.
The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1 envelope (Env) glycoprotein. Here, we report that a CD4+ T cell repertoire recognizes a glycopeptide epitope on gp120 presented by MHCII pathway. This glycopeptide is strongly immunogenic in eliciting glycan-dependent cellular and humoral immune responses. The glycopeptide specific CD4+ T cells display a prominent feature of Th2 and Th17 differentiation and exert high efficacy and potency to help Env trimer humoral immune responses. Glycopeptide-induced CD4+ T cell response prior to Env trimer immunization elicits neutralizing antibody development and production of antibodies facilitating uptake of immunogens by antigen-presenting cells. Our identification of gp120 glycopeptide-induced, T cell-specific immune responses offers a foundation for developing future knowledge-based vaccines that elicit strong and long-lasting protective immune responses against HIV-1 infection.
Duke Scholars
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- Th2 Cells
- Th17 Cells
- Polysaccharides
- Mice
- Immunization
- Immunity, Humoral
- Immunity, Cellular
- Histocompatibility Antigens Class II
- HIV-1
- HIV Envelope Protein gp120
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Th2 Cells
- Th17 Cells
- Polysaccharides
- Mice
- Immunization
- Immunity, Humoral
- Immunity, Cellular
- Histocompatibility Antigens Class II
- HIV-1
- HIV Envelope Protein gp120