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Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.

Publication ,  Journal Article
Sun, L; Paschall, AV; Middleton, DR; Ishihara, M; Ozdilek, A; Wantuch, PL; Aceil, J; Duke, JA; LaBranche, CC; Tiemeyer, M; Avci, FY
Published in: Nat Commun
May 21, 2020

The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1 envelope (Env) glycoprotein. Here, we report that a CD4+ T cell repertoire recognizes a glycopeptide epitope on gp120 presented by MHCII pathway. This glycopeptide is strongly immunogenic in eliciting glycan-dependent cellular and humoral immune responses. The glycopeptide specific CD4+ T cells display a prominent feature of Th2 and Th17 differentiation and exert high efficacy and potency to help Env trimer humoral immune responses. Glycopeptide-induced CD4+ T cell response prior to Env trimer immunization elicits neutralizing antibody development and production of antibodies facilitating uptake of immunogens by antigen-presenting cells. Our identification of gp120 glycopeptide-induced, T cell-specific immune responses offers a foundation for developing future knowledge-based vaccines that elicit strong and long-lasting protective immune responses against HIV-1 infection.

Duke Scholars

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

May 21, 2020

Volume

11

Issue

1

Start / End Page

2550

Location

England

Related Subject Headings

  • Th2 Cells
  • Th17 Cells
  • Polysaccharides
  • Mice
  • Immunization
  • Immunity, Humoral
  • Immunity, Cellular
  • Histocompatibility Antigens Class II
  • HIV-1
  • HIV Envelope Protein gp120
 

Citation

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Sun, L., Paschall, A. V., Middleton, D. R., Ishihara, M., Ozdilek, A., Wantuch, P. L., … Avci, F. Y. (2020). Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help. Nat Commun, 11(1), 2550. https://doi.org/10.1038/s41467-020-16319-0
Sun, Lina, Amy V. Paschall, Dustin R. Middleton, Mayumi Ishihara, Ahmet Ozdilek, Paeton L. Wantuch, Javid Aceil, et al. “Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.Nat Commun 11, no. 1 (May 21, 2020): 2550. https://doi.org/10.1038/s41467-020-16319-0.
Sun L, Paschall AV, Middleton DR, Ishihara M, Ozdilek A, Wantuch PL, et al. Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help. Nat Commun. 2020 May 21;11(1):2550.
Sun, Lina, et al. “Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.Nat Commun, vol. 11, no. 1, May 2020, p. 2550. Pubmed, doi:10.1038/s41467-020-16319-0.
Sun L, Paschall AV, Middleton DR, Ishihara M, Ozdilek A, Wantuch PL, Aceil J, Duke JA, LaBranche CC, Tiemeyer M, Avci FY. Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help. Nat Commun. 2020 May 21;11(1):2550.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

May 21, 2020

Volume

11

Issue

1

Start / End Page

2550

Location

England

Related Subject Headings

  • Th2 Cells
  • Th17 Cells
  • Polysaccharides
  • Mice
  • Immunization
  • Immunity, Humoral
  • Immunity, Cellular
  • Histocompatibility Antigens Class II
  • HIV-1
  • HIV Envelope Protein gp120