Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help.

Journal Article (Journal Article)

The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1 envelope (Env) glycoprotein. Here, we report that a CD4+ T cell repertoire recognizes a glycopeptide epitope on gp120 presented by MHCII pathway. This glycopeptide is strongly immunogenic in eliciting glycan-dependent cellular and humoral immune responses. The glycopeptide specific CD4+ T cells display a prominent feature of Th2 and Th17 differentiation and exert high efficacy and potency to help Env trimer humoral immune responses. Glycopeptide-induced CD4+ T cell response prior to Env trimer immunization elicits neutralizing antibody development and production of antibodies facilitating uptake of immunogens by antigen-presenting cells. Our identification of gp120 glycopeptide-induced, T cell-specific immune responses offers a foundation for developing future knowledge-based vaccines that elicit strong and long-lasting protective immune responses against HIV-1 infection.

Full Text

Duke Authors

Cited Authors

  • Sun, L; Paschall, AV; Middleton, DR; Ishihara, M; Ozdilek, A; Wantuch, PL; Aceil, J; Duke, JA; LaBranche, CC; Tiemeyer, M; Avci, FY

Published Date

  • May 21, 2020

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 2550 -

PubMed ID

  • 32439962

Pubmed Central ID

  • PMC7242320

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-020-16319-0

Language

  • eng

Conference Location

  • England