Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.

Journal Article (Journal Article)

CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification.

Full Text

Duke Authors

Cited Authors

  • Anderson, MR; Easthausen, I; Gallagher, G; Udupa, J; Tong, Y; Torigian, D; Diamond, JM; Porteous, MK; Palmer, SM; Snyder, LD; Benvenuto, L; Aversa, M; Arcasoy, S; Greenland, JR; Hays, SR; Kukreja, J; Cantu, E; Kim, JS; Gallagher, D; Baldwin, MR; Barr, RG; Lederer, DJ; Christie, JD; Singer, JP

Published Date

  • September 2020

Published In

Volume / Issue

  • 75 / 9

Start / End Page

  • 801 - 804

PubMed ID

  • 32482837

Pubmed Central ID

  • PMC7888552

Electronic International Standard Serial Number (EISSN)

  • 1468-3296

Digital Object Identifier (DOI)

  • 10.1136/thoraxjnl-2019-214461

Language

  • eng

Conference Location

  • England