Building bridges, not walls: spinal cord regeneration in zebrafish.

Journal Article (Journal Article;Review)

Spinal cord injury is a devastating condition in which massive cell death and disruption of neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals, spinal cord tissue has minimal capacity to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of spinal cord regeneration in zebrafish. We highlight recent progress as well as areas requiring emphasis in a line of study that has great potential to uncover strategies for human spinal cord repair.

Full Text

Duke Authors

Cited Authors

  • Cigliola, V; Becker, CJ; Poss, KD

Published Date

  • May 27, 2020

Published In

Volume / Issue

  • 13 / 5

PubMed ID

  • 32461216

Pubmed Central ID

  • 32461216

Electronic International Standard Serial Number (EISSN)

  • 1754-8411

Digital Object Identifier (DOI)

  • 10.1242/dmm.044131

Language

  • eng

Conference Location

  • England