Kenneth Daniel Poss | Scholars@Duke

Kenneth Daniel Poss
James B. Duke Professor of Cell Biology

Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology

Current Appointments & Affiliations

James B. Duke Professor of Cell Biology, Cell Biology, Basic Science Departments 2014
Professor of Cell Biology, Cell Biology, Basic Science Departments 2012
Professor in Medicine, Medicine, Cardiology, Medicine 2016
Professor of Biology, Biology, Trinity College of Arts & Sciences 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
Director of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2018

Contact Information

307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
Duke Box 3709, Durham, NC 27710
k.poss@cellbio.duke.edu (919) 681-8457
Department of Cell Biology
Poss Lab

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003
- Research Fellow, University of Utah 1998 - 2000
- Ph.D., Massachusetts Institute of Technology 1998
Duke Appointment History
- Acting Chair of Cell Biology, Cell Biology, Basic Science Departments 2015
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2009 - 2012
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2003 - 2009
Recognition
In the News
- NOV 3, 2016
  
  Scientists Find Key Protein For Spinal Cord Repair
- APR 8, 2016 Daily Mail
  
  Study reveals hidden DNA that could be 'reawakened'
- APR 7, 2016 Gizmag
  
  DNA sequence behind muscle regeneration begins to unravel
- APR 6, 2016
  
  Duke Study Uncovers Genetic Elements That Drive Regeneration
- MAR 22, 2016 Nature
  
  Transgenic zebrafish forms technicolor 'skinbow'
- MAR 21, 2016
  
  Technicolor Zebrafish Reveal How Skin Heals
- MAY 1, 2015
  
  Duke Study Uncovers Foundations of Heart Regeneration
Awards & Honors
Research
Selected Grants
- Advanced Immunobiology Traning Program for Surgeons awarded by National Institutes of Health 2019 - 2024
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Regulation of Myocardial Regeneration in Zebrafish awarded by National Institutes of Health 2005 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
- Polyploidy in Cardiac Development and Tissue Repair in Drosophila awarded by National Institutes of Health 2018 - 2020
- Eliciting heart regeneration through cardiomyocyte division awarded by Fondation Leducq 2016 - 2020
- Identification and application of regulatory elements for heart regeneration awarded by National Institutes of Health 2016 - 2020
- Pronobis - 2017: Bioactive peptides as modulators of tissue regeneration awarded by Life Sciences Research Foundation 2017 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Mechanisms protecting cell surface integrity in giant vacuolated cells of the notochord awarded by National Institutes of Health 2017 - 2020
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- Modulation of heart regeneration by enhancer-delivered factors awarded by American Heart Association 2018 - 2019
- Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
- An integrative cellular blueprint of vertebrate tissue development awarded by University of California - San Diego 2018 - 2019
- Regulatory Mechanisms of Zebrafish Heart Regeneration awarded by American Heart Association 2017 - 2019
- Regulation of Appendage Regeneration in Zebrafish awarded by National Institutes of Health 2006 - 2018
- Regulation of glial bridging during spinal cord regeneration in zebrafish awarded by National Institutes of Health 2016 - 2018
- Duke Research Training Program for Pediatricians awarded by National Institutes of Health 2002 - 2018
- Biomarkers of Heart Regeneration awarded by National Institutes of Health 2013 - 2018
- Identifying a transcription factor collective that specifies cardiomyocyte regeneration awarded by American Heart Association 2017 - 2018
- Dissecting the directional regeneration of ventricular epicardium awarded by American Heart Association 2015 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Center for Molecular & Cellular Studies of Ped Disease awarded by National Institutes of Health 2003 - 2018
- Regulation of cardiomyocyte proliferation dynamics during zebrafish heart development awarded by March of Dimes 2014 - 2017
- Lightsheet Imaging System awarded by National Institutes of Health 2016 - 2017
- Role of Developmental Signaling Pathways in Tuberculosis Pathogenesis awarded by National Institutes of Health 2017
- CHROMATIN REGULATORY EVENTS UNDERLYING ZEBRAFISH HEART REGENERATION awarded by National Institutes of Health 2014 - 2017
- Vegf Signaling and Cardiac Chamber Morphogenesis in Zebrafish awarded by National Institutes of Health 2015 - 2016
- Regeneration Next Initiative Annual Retreat awarded by North Carolina Biotechnology Center 2016
- Dissecting the directional regeneration of ventricular epicardium awarded by American Heart Association 2015 - 2016
- Mechanisms of Neuregulin 1 in Heart Regeneration awarded by National Institutes of Health 2015 - 2016
- 2016 Weinstein Cardiovascular Development and Regeneration Conference awarded by March of Dimes 2016
- 2016 Weinstein Cardiovascular Development and Regeneration Conference Organizing Committee awarded by The Company of Biologists 2015 - 2016
- Visualizing and dissecting epicardial regeneration in zebrafish awarded by American Heart Association 2014 - 2016
- Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
- Identifying mechanisms of heart regeneration awarded by National Institutes of Health 2011 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Cox, BD, De Simone, A, Tornini, VA, Singh, SP, Di Talia, S, and Poss, KD. "In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone." Current Biology : Cb 28, no. 24 (December 2018): 3937-3947.e4. Full Text
  - Mokalled, MH, and Poss, KD. "A Regeneration Toolkit." Developmental Cell 47, no. 3 (November 2018): 267-280. (Review) Full Text
  - Cao, J, and Poss, KD. "The epicardium as a hub for heart regeneration." Nature Reviews. Cardiology 15, no. 10 (October 2018): 631-647. (Review) Full Text
  - Walton, EM, Cronan, MR, Cambier, CJ, Rossi, A, Marass, M, Foglia, MD, Brewer, WJ, Poss, KD, Stainier, DYR, Bertozzi, CR, and Tobin, DM. "Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling." Cell Host & Microbe 24, no. 4 (October 2018): 514-525.e6. Full Text
  - Karra, R, Foglia, MJ, Choi, W-Y, Belliveau, C, DeBenedittis, P, and Poss, KD. "Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish." Proceedings of the National Academy of Sciences of the United States of America 115, no. 35 (August 13, 2018): 8805-8810. Full Text
  - Wopat, S, Bagwell, J, Sumigray, KD, Dickson, AL, Huitema, LFA, Poss, KD, Schulte-Merker, S, and Bagnat, M. "Spine Patterning Is Guided by Segmentation of the Notochord Sheath." Cell Reports 22, no. 8 (February 2018): 2026-2038. Full Text
  - Yang, XH, Nadadur, RD, Hilvering, CR, Bianchi, V, Werner, M, Mazurek, SR, Gadek, M, Shen, KM, Goldman, JA, Tyan, L, Bekeny, J, Hall, JM, Lee, N, Perez-Cervantes, C, Burnicka-Turek, O, Poss, KD, Weber, CR, de Laat, W, Ruthenburg, AJ, and Moskowitz, IP. "Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm." Elife 6 (December 27, 2017). Full Text
  - Chen, C-H, and Poss, KD. "Regeneration Genetics." Annual Review of Genetics 51 (November 2017): 63-82. (Review) Full Text
  - Cao, J, Wang, J, Jackman, CP, Cox, AH, Trembley, MA, Balowski, JJ, Cox, BD, De Simone, A, Dickson, AL, Di Talia, S, Small, EM, Kiehart, DP, Bursac, N, and Poss, KD. "Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue." Developmental Cell 42, no. 6 (September 2017): 600-615.e4. Full Text
  - Tornini, VA, Thompson, JD, Allen, RL, and Poss, KD. "Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration." Development (Cambridge, England) 144, no. 16 (August 2017): 2889-2895. Full Text
  - Tzahor, E, and Poss, KD. "Cardiac regeneration strategies: Staying young at heart." Science (New York, N.Y.) 356, no. 6342 (June 8, 2017): 1035-1039. (Review) Full Text
  - Goldman, JA, Kuzu, G, Lee, N, Karasik, J, Gemberling, M, Foglia, MJ, Karra, R, Dickson, AL, Sun, F, Tolstorukov, MY, and Poss, KD. "Resolving Heart Regeneration by Replacement Histone Profiling." Developmental Cell 40, no. 4 (February 2017): 392-404.e5. Full Text
  - Karra, R, and Poss, KD. "Redirecting cardiac growth mechanisms for therapeutic regeneration." The Journal of Clinical Investigation 127, no. 2 (February 2017): 427-436. (Review) Full Text
  - Nichols, JT, Blanco-Sánchez, B, Brooks, EP, Parthasarathy, R, Dowd, J, Subramanian, A, Nachtrab, G, Poss, KD, Schilling, TF, and Kimmel, CB. "Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca." Development (Cambridge, England) 143, no. 23 (December 2016): 4430-4440. Full Text
  - Tornini, VA, Puliafito, A, Slota, LA, Thompson, JD, Nachtrab, G, Kaushik, A-L, Kapsimali, M, Primo, L, Di Talia, S, and Poss, KD. "Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration." Current Biology : Cb 26, no. 22 (November 10, 2016): 2981-2991. Full Text
  - Mokalled, MH, Patra, C, Dickson, AL, Endo, T, Stainier, DYR, and Poss, KD. "Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish." Science (New York, N.Y.) 354, no. 6312 (November 2016): 630-634. Full Text
  - Di Talia, S, and Poss, KD. "Monitoring Tissue Regeneration at Single-Cell Resolution." Cell stem cell 19, no. 4 (October 2016): 428-431. Full Text
  - Cao, J, and Poss, KD. "Explant culture of adult zebrafish hearts for epicardial regeneration studies." Nature Protocols 11, no. 5 (May 2016): 872-881. Full Text
  - Foglia, MJ, Cao, J, Tornini, VA, and Poss, KD. "Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium." Development (Cambridge, England) 143, no. 10 (May 2016): 1688-1696. Full Text
  - Han, Y, and Poss, KD. "Accessories to Limb Regeneration." Developmental cell 37, no. 4 (May 2016): 297-298. Full Text
  - Kang, J, Hu, J, Karra, R, Dickson, AL, Tornini, VA, Nachtrab, G, Gemberling, M, Goldman, JA, Black, BL, and Poss, KD. "Modulation of tissue repair by regeneration enhancer elements." Nature 532, no. 7598 (April 6, 2016): 201-206. Full Text
  - Chen, C-H, Puliafito, A, Cox, BD, Primo, L, Fang, Y, Di Talia, S, and Poss, KD. "Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish." Developmental Cell 36, no. 6 (March 2016): 668-680. Full Text
  - Foglia, MJ, and Poss, KD. "Building and re-building the heart by cardiomyocyte proliferation." Development (Cambridge, England) 143, no. 5 (March 2016): 729-740. (Review) Full Text
  - Cao, J, Navis, A, Cox, BD, Dickson, AL, Gemberling, M, Karra, R, Bagnat, M, and Poss, KD. "Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration." Development (Cambridge, England) 143, no. 2 (January 2016): 232-243. Full Text
  - Wang, J, and Poss, KD. "Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish." Methods in molecular biology (Clifton, N.J.) 1451 (January 2016): 225-235. Full Text
  - Karra, R, Knecht, AK, Kikuchi, K, and Poss, KD. "Myocardial NF-κB activation is essential for zebrafish heart regeneration." Proceedings of the National Academy of Sciences of the United States of America 112, no. 43 (October 15, 2015): 13255-13260. Full Text
  - Chen, C-H, Merriman, AF, Savage, J, Willer, J, Wahlig, T, Katsanis, N, Yin, VP, and Poss, KD. "Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration." Plos Genetics 11, no. 8 (August 25, 2015): e1005437-null. Full Text
  - Mahmoud, AI, O'Meara, CC, Gemberling, M, Zhao, L, Bryant, DM, Zheng, R, Gannon, JB, Cai, L, Choi, W-Y, Egnaczyk, GF, Burns, CE, Burns, CG, MacRae, CA, Poss, KD, and Lee, RT. "Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration." Developmental Cell 34, no. 4 (August 6, 2015): 387-399. Full Text
  - Nagelberg, D, Wang, J, Su, R, Torres-Vázquez, J, Targoff, KL, Poss, KD, and Knaut, H. "Origin, Specification, and Plasticity of the Great Vessels of the Heart." Current biology : CB 25, no. 16 (August 5, 2015): 2099-2110. Full Text
  - Palencia-Desai, S, Rost, MS, Schumacher, JA, Ton, QV, Craig, MP, Baltrunaite, K, Koenig, AL, Wang, J, Poss, KD, Chi, NC, Stainier, DYR, and Sumanas, S. "Myocardium and BMP signaling are required for endocardial differentiation." Development (Cambridge, England) 142, no. 13 (July 2015): 2304-2315. Full Text
  - Kang, J, Karra, R, and Poss, KD. "Back in Black." Developmental Cell 33, no. 6 (June 2015): 623-624. Full Text
  - Wang, J, Cao, J, Dickson, AL, and Poss, KD. "Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling." Nature 522, no. 7555 (June 2015): 226-230. Full Text
  - Gemberling, M, Karra, R, Dickson, AL, and Poss, KD. "Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish." Elife 4 (April 2015). Full Text Open Access Copy
  - Schindler, YL, Garske, KM, Wang, J, Firulli, BA, Firulli, AB, Poss, KD, and Yelon, D. "Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration." Development (Cambridge, England) 141, no. 16 (August 2014): 3112-3122. Full Text
  - Tornini, VA, and Poss, KD. "Keeping at arm's length during regeneration." Developmental Cell 29, no. 2 (April 2014): 139-145. (Review) Full Text
  - Chen, CH, Durand, E, Wang, J, Zon, LI, and Poss, KD. "Zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish." Development (Cambridge) 140, no. 24 (December 15, 2013): 4988-4997. Full Text
  - Gemberling, M, Bailey, TJ, Hyde, DR, and Poss, KD. "The zebrafish as a model for complex tissue regeneration." Trends in Genetics 29, no. 11 (November 1, 2013): 611-620. (Review) Full Text
  - Gemberling, M, Bailey, TJ, Hyde, DR, and Poss, KD. "The zebrafish as a model for complex tissue regeneration." Trends in Genetics : Tig 29, no. 11 (November 2013): 611-620. (Review) Full Text
  - Kang, J, Nachtrab, G, and Poss, KD. "Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins." Developmental Cell 27, no. 1 (October 2013): 19-31. Full Text
  - Wang, J, Karra, R, Dickson, AL, and Poss, KD. "Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration." Developmental Biology 382, no. 2 (October 2013): 427-435. Full Text
  - Johnson, AN, Mokalled, MH, Valera, JM, Poss, KD, and Olson, EN. "Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi." DEVELOPMENT 140, no. 17 (September 1, 2013): 3645-3656. Full Text Link to Item
  - Nachtrab, G, Kikuchi, K, Tornini, VA, and Poss, KD. "Transcriptional components of anteroposterior positional information during zebrafish fin regeneration." Development (Cambridge, England) 140, no. 18 (September 2013): 3754-3764. Full Text
  - Fang, Y, Gupta, V, Karra, R, Holdway, JE, Kikuchi, K, and Poss, KD. "Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration." Proceedings of the National Academy of Sciences of the United States of America 110, no. 33 (August 2013): 13416-13421. Full Text
  - Gupta, V, Gemberling, M, Karra, R, Rosenfeld, GE, Evans, T, and Poss, KD. "An injury-responsive gata4 program shapes the zebrafish cardiac ventricle." Current Biology : Cb 23, no. 13 (July 2013): 1221-1227. Full Text
  - Le, X, Pugach, EK, Hettmer, S, Storer, NY, Liu, J, Wills, AA, DiBiase, A, Chen, EY, Ignatius, MS, Poss, KD, Wagers, AJ, Langenau, DM, and Zon, LI. "A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development." Development (Cambridge, England) 140, no. 11 (June 2013): 2354-2364. Full Text
  - Guner-Ataman, B, Paffett-Lugassy, N, Adams, MS, Nevis, KR, Jahangiri, L, Obregon, P, Kikuchi, K, Poss, KD, Burns, CE, and Burns, CG. "Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function." Development (Cambridge, England) 140, no. 6 (March 2013): 1353-1363. Full Text
  - Choi, W-Y, Gemberling, M, Wang, J, Holdway, JE, Shen, M-C, Karlstrom, RO, and Poss, KD. "In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration." Development (Cambridge, England) 140, no. 3 (February 2013): 660-666. Full Text
  - Gupta, V, Gemberling, M, Karra, R, Rosenfeld, GE, Evans, T, and Poss, KD. "An injury-responsive gata4 program shapes the zebrafish cardiac ventricle." Current Biology 23, no. 13 (2013): 1221-1227. Full Text
  - Nachtrab, G, and Poss, KD. "Toward a blueprint for regeneration." Development (Cambridge, England) 139, no. 15 (August 2012): 2639-2642. Full Text
  - Yin, VP, Lepilina, A, Smith, A, and Poss, KD. "Regulation of zebrafish heart regeneration by miR-133." Developmental Biology 365, no. 2 (May 2012): 319-327. Full Text
  - Gupta, V, and Poss, KD. "Clonally dominant cardiomyocytes direct heart morphogenesis." Nature 484, no. 7395 (April 25, 2012): 479-484. Full Text
  - Singh, SP, Holdway, JE, and Poss, KD. "Regeneration of amputated zebrafish fin rays from de novo osteoblasts." Dev Cell 22, no. 4 (April 17, 2012): 879-886. Full Text Link to Item
  - Choi, W-Y, and Poss, KD. "Cardiac regeneration." Current Topics in Developmental Biology 100 (January 2012): 319-344. (Review) Full Text
  - Kikuchi, K, and Poss, KD. "Cardiac regenerative capacity and mechanisms." Annual Review of Cell and Developmental Biology 28 (January 2012): 719-741. (Review) Full Text
  - Nachtrab, G, Czerwinski, M, and Poss, KD. "Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling." Current Biology : Cb 21, no. 22 (November 10, 2011): 1912-1917. Full Text
  - Wang, J, Panáková, D, Kikuchi, K, Holdway, JE, Gemberling, M, Burris, JS, Singh, SP, Dickson, AL, Lin, Y-F, Sabeh, MK, Werdich, AA, Yelon, D, Macrae, CA, and Poss, KD. "The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion." Development (Cambridge, England) 138, no. 16 (August 2011): 3421-3430. Full Text
  - Kikuchi, K, Gupta, V, Wang, J, Holdway, JE, Wills, AA, Fang, Y, and Poss, KD. "tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration." Development (Cambridge, England) 138, no. 14 (July 2011): 2895-2902. Full Text
  - Shin, D, Lee, Y, Poss, KD, and Stainier, DYR. "Restriction of hepatic competence by Fgf signaling." Development (Cambridge, England) 138, no. 7 (April 2011): 1339-1348. Full Text
  - Kikuchi, K, Holdway, JE, Major, RJ, Blum, N, Dahn, RD, Begemann, G, and Poss, KD. "Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration." Developmental Cell 20, no. 3 (March 2011): 397-404. Full Text
  - Qin, Z, Kidd, AR, Thomas, JL, Poss, KD, Hyde, DR, Raymond, PA, and Thummel, R. "FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish." Experimental Eye Research 93, no. 5 (2011): 726-734. Full Text
  - Poss, K. "Cardiac Regeneration in the Zebrafish Model System." (December 1, 2010): 839-853. (Chapter) Full Text
  - Liu, J, Bressan, M, Hassel, D, Huisken, J, Staudt, D, Kikuchi, K, Poss, KD, Mikawa, T, and Stainier, DYR. "A dual role for ErbB2 signaling in cardiac trabeculation." Development (Cambridge, England) 137, no. 22 (November 2010): 3867-3875. Full Text Open Access Copy
  - Poss, KD. "Advances in understanding tissue regenerative capacity and mechanisms in animals." Nature Reviews. Genetics 11, no. 10 (October 2010): 710-722. (Review) Full Text
  - Lee, Y, Nachtrab, G, Klinsawat, PW, Hami, D, and Poss, KD. "Ras controls melanocyte expansion during zebrafish fin stripe regeneration." Dis Model Mech 3, no. 7-8 (July 2010): 496-503. Full Text Open Access Copy Link to Item
  - Yin, C, Kikuchi, K, Hochgreb, T, Poss, KD, and Stainier, DYR. "Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish." Dev Cell 18, no. 6 (June 15, 2010): 973-984. Full Text Link to Item
  - Kikuchi, K, Holdway, JE, Werdich, AA, Anderson, RM, Fang, Y, Egnaczyk, GF, Evans, T, Macrae, CA, Stainier, DYR, and Poss, KD. "Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes." Nature 464, no. 7288 (March 2010): 601-605. Full Text
  - Gonzalez-Quevedo, R, Lee, Y, Poss, KD, and Wilkinson, DG. "Neuronal regulation of the spatial patterning of neurogenesis." Dev Cell 18, no. 1 (January 19, 2010): 136-147. Full Text Link to Item
  - Gonzalez-Quevedo, R, Sobieszczuk, DF, Poliakov, A, Lee, Y, Poss, KD, and Wilkinson, DG. "Feedback regulation of neurogenesis." DEVELOPMENTAL BIOLOGY 331, no. 2 (July 15, 2009): 388-389. Full Text Link to Item
  - Lee, Y, Hami, D, De Val, S, Kagermeier-Schenk, B, Wills, AA, Black, BL, Weidinger, G, and Poss, KD. "Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins." Dev Biol 331, no. 2 (July 15, 2009): 270-280. Full Text Link to Item
  - Nachtrab, G, and Poss, KD. "Genetic DISC-section of regeneration in Drosophila." Developmental Cell 16, no. 6 (June 2009): 777-778. Full Text
  - Waxman, JS, Keegan, BR, Roberts, RW, Poss, KD, and Yelon, D. "Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish." Developmental Cell 15, no. 6 (December 2008): 923-934. Full Text
  - Marques, SR, Lee, Y, Poss, KD, and Yelon, D. "Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart." Developmental Biology 321, no. 2 (September 2008): 397-406. Full Text
  - Wills, AA, Kidd, AR, Lepilina, A, and Poss, KD. "Fgfs control homeostatic regeneration in adult zebrafish fins." Development (Cambridge, England) 135, no. 18 (September 2008): 3063-3070. Full Text
  - Yin, VP, and Poss, KD. "New regulators of vertebrate appendage regeneration." Curr Opin Genet Dev 18, no. 4 (August 2008): 381-386. (Review) Full Text Link to Item
  - Yin, VP, Thomson, JM, Thummel, R, Hyde, DR, Hammond, SM, and Poss, KD. "Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish." Genes & Development 22, no. 6 (March 2008): 728-733. Full Text
  - Wills, AA, Holdway, JE, Major, RJ, and Poss, KD. "Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish." Development (Cambridge, England) 135, no. 1 (January 2008): 183-192. Full Text
  - Shin, D, Shin, CH, Tucker, J, Ober, EA, Rentzsch, F, Poss, KD, Hammerschmidt, M, Mullins, MC, and Stainier, DYR. "Bmp and Fgf signaling are essential for liver specification in zebrafish." Development (Cambridge, England) 134, no. 11 (June 2007): 2041-2050. Full Text
  - Nechiporuk, A, Linbo, T, Poss, KD, and Raible, DW. "Specification of epibranchial placodes in zebrafish." Development 134, no. 3 (February 2007): 611-623. Full Text Link to Item
  - Poss, KD. "Getting to the heart of regeneration in zebrafish." Semin Cell Dev Biol 18, no. 1 (February 2007): 36-45. (Review) Full Text Link to Item
  - Major, RJ, and Poss, KD. "Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair." Drug Discov Today Dis Models 4, no. 4 (2007): 219-225. Full Text Link to Item
  - Lepilina, A, Coon, AN, Kikuchi, K, Holdway, JE, Roberts, RW, Burns, CG, and Poss, KD. "A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration." Cell 127, no. 3 (November 2006): 607-619. Full Text
  - Lee, Y, Grill, S, Sanchez, A, Murphy-Ryan, M, and Poss, KD. "Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration." Development (Cambridge, England) 132, no. 23 (December 2005): 5173-5183. Full Text
  - Poss, KD. "A zebrafish model of germ cell aneuploidy." Cell Cycle 3, no. 10 (October 2004): 1225-1226. Full Text Link to Item
  - Poss, KD, Nechiporuk, A, Stringer, KF, Lee, C, and Keating, MT. "Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1." Genes Dev 18, no. 13 (July 1, 2004): 1527-1532. Full Text Link to Item
  - Traver, D, Paw, BH, Poss, KD, Penberthy, WT, Lin, S, and Zon, LI. "Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants." Nature Immunology 4, no. 12 (December 2003): 1238-1246. Full Text
  - Nechiporuk, A, Poss, KD, Johnson, SL, and Keating, MT. "Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration." Dev Biol 258, no. 2 (June 15, 2003): 291-306. Link to Item
  - Poss, KD, Keating, MT, and Nechiporuk, A. "Tales of regeneration in zebrafish." Developmental Dynamics : an Official Publication of the American Association of Anatomists 226, no. 2 (February 2003): 202-210. (Review) Full Text
  - Gillette-Ferguson, I, Ferguson, DG, Poss, KD, and Moorman, SJ. "Changes in gravitational force induce alterations in gene expression that can be monitored in the live, developing zebrafish heart." Adv Space Res 32, no. 8 (2003): 1641-1646. Link to Item
  - Poss, KD, Wilson, LG, and Keating, MT. "Heart regeneration in zebrafish." Science (New York, N.Y.) 298, no. 5601 (December 2002): 2188-2190. Full Text
  - Poss, KD, Nechiporuk, A, Hillam, AM, Johnson, SL, and Keating, MT. "Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration." Development 129, no. 22 (November 2002): 5141-5149. Link to Item
  - Poss, KD, Shen, J, and Keating, MT. "Induction of lef1 during zebrafish fin regeneration." Developmental Dynamics : an Official Publication of the American Association of Anatomists 219, no. 2 (October 2000): 282-286. Full Text
  - Poss, KD, Shen, J, Nechiporuk, A, McMahon, G, Thisse, B, Thisse, C, and Keating, MT. "Roles for Fgf signaling during zebrafish fin regeneration." Developmental Biology 222, no. 2 (June 2000): 347-358. Full Text
  - Nath, KA, Haggard, JJ, Croatt, AJ, Grande, JP, Poss, KD, and Alam, J. "The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo." The American Journal of Pathology 156, no. 5 (May 2000): 1527-1535. Full Text
  - Shiraishi, F, Curtis, LM, Truong, L, Poss, K, Visner, GA, Madsen, K, Nick, HS, and Agarwal, A. "Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis." American Journal of Physiology. Renal Physiology 278, no. 5 (May 2000): F726-F736. Full Text
  - Poss, KD, Shen, J, and Keating, MT. "Induction of lef1 during zebrafish fin regeneration." Developmental Dynamics 219, no. 2 (January 1, 2000): 282-286. Full Text
  - Demas, GE, Kriegsfeld, LJ, Poss, KD, Tonegawa, S, and Nelson, RJ. "Circadian Locomotor Rhythms in Mice with Targeted Disruption of the Gene for the Carbon Monoxide Synthesizing Enzyme, Heme Oxygenase-2." Biological Rhythm Research 30, no. 3 (July 1999): 282-289. Full Text
  - Ferris, CD, Jaffrey, SR, Sawa, A, Takahashi, M, Brady, SD, Barrow, RK, Tysoe, SA, Wolosker, H, Barañano, DE, Doré, S, Poss, KD, and Snyder, SH. "Haem oxygenase-1 prevents cell death by regulating cellular iron." Nature Cell Biology 1, no. 3 (July 1999): 152-157. Full Text
  - Soares, MP, Lin, Y, Anrather, J, Csizmadia, E, Takigami, K, Sato, K, Grey, ST, Colvin, RB, Choi, AM, Poss, KD, and Bach, FH. "Expression of heme oxygenase-1 can determine cardiac xenograft survival." Nature Medicine 4, no. 9 (September 1998): 1073-1077. Full Text
  - Dennery, PA, Spitz, DR, Yang, G, Tatarov, A, Lee, CS, Shegog, ML, and Poss, KD. "Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2." The Journal of Clinical Investigation 101, no. 5 (March 1998): 1001-1011. Full Text
  - Burnett, AL, Johns, DG, Kriegsfeld, LJ, Klein, SL, Calvin, DC, Demas, GE, Schramm, LP, Tonegawa, S, Nelson, RJ, Snyder, SH, and Poss, KD. "Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2." Nat Med 4, no. 1 (January 1998): 84-87. Link to Item
  - Zakhary, R, Poss, KD, Jaffrey, SR, Ferris, CD, Tonegawa, S, and Snyder, SH. "Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide." Proc Natl Acad Sci U S A 94, no. 26 (December 23, 1997): 14848-14853. Link to Item
  - Poss, KD, and Tonegawa, S. "Heme oxygenase 1 is required for mammalian iron reutilization." Proceedings of the National Academy of Sciences of the United States of America 94, no. 20 (September 1997): 10919-10924. Full Text
  - Poss, KD, and Tonegawa, S. "Reduced stress defense in heme oxygenase 1-deficient cells." Proceedings of the National Academy of Sciences of the United States of America 94, no. 20 (September 1997): 10925-10930. Full Text
  - Poss, KD, Thomas, MJ, Ebralidze, AK, O'Dell, TJ, and Tonegawa, S. "Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice." Neuron 15, no. 4 (October 1995): 867-873. Link to Item
- Book Sections
  - Major, RJ, and Poss, KD. "III. Does heart regeneration occur?: B. Zebrafish heart regeneration." In Heart Regeneration: Stem Cells and Beyond, 59-80. January 1, 2012. Full Text
- Conference Papers
  - Merriman, AF, Chen, C, and Poss, KD. "Identification of new regeneration mutants in zebrafish by a forward genetic screen." 2015. Link to Item
  - Waxman, JS, Keegan, BR, Roberts, RW, Poss, KD, and Yelon, D. "Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish." July 15, 2008. Full Text Link to Item
  - Kikuchi, K, and Poss, KD. "Cardiac progenitors during zebrafish heart regeneration." August 31, 2007. Link to Item
  - Lee, Y, Grill, S, Murphy-Ryan, M, and Poss, KD. "A proximodistal gradient of Fgf signaling defines position-dependent rates of zebrafish fin regeneration." July 15, 2005. Link to Item
Teaching & Mentoring
Recent Courses
- CELLBIO 493: Research Independent Study 2019
- CMB 710C: Cell & Molecular Biology Module III 2018

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