Kenneth Daniel Poss
James B. Duke Professor of Cell Biology
Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology
Current Appointments & Affiliations
- James B. Duke Professor of Cell Biology, Cell Biology, Basic Science Departments 2014
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2012
- Professor in Medicine, Medicine, Cardiology, Medicine 2016
- Professor of Biology, Biology, Trinity College of Arts & Sciences 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
- Director of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
- Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2018
Contact Information
- 307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
- Duke Box 3709, Durham, NC 27710
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k.poss@cellbio.duke.edu
(919) 681-8457
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Department of Cell Biology
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Poss Lab
- Background
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Education, Training, & Certifications
- Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003
- Research Fellow, University of Utah 1998 - 2000
- Ph.D., Massachusetts Institute of Technology 1998
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Duke Appointment History
- Acting Chair of Cell Biology, Cell Biology, Basic Science Departments 2015
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2009 - 2012
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2003 - 2009
- Recognition
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In the News
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NOV 3, 2016 -
APR 8, 2016 Daily Mail -
APR 7, 2016 Gizmag -
APR 6, 2016 -
MAR 22, 2016 Nature -
MAR 21, 2016 -
MAY 1, 2015
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Awards & Honors
- Distinguished Achievement Award. Carleton College. 2017
- Merit Award. American Heart Association. 2016
- Ruth and A. Morris Williams Prize in Basic Research. Duke University School of Medicine. 2011
- Early Career Scientist. Howard Hughes Medical Institute. 2009
- Pew Scholars in the Biomedical Sciences. Pew Charitable Trusts, The. 2006
- Research
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Selected Grants
- Advanced Immunobiology Traning Program for Surgeons awarded by National Institutes of Health 2019 - 2024
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation 2019 - 2022
- Regulation of Myocardial Regeneration in Zebrafish awarded by National Institutes of Health 2005 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
- Polyploidy in Cardiac Development and Tissue Repair in Drosophila awarded by National Institutes of Health 2018 - 2020
- Eliciting heart regeneration through cardiomyocyte division awarded by Fondation Leducq 2016 - 2020
- Identification and application of regulatory elements for heart regeneration awarded by National Institutes of Health 2016 - 2020
- Pronobis - 2017: Bioactive peptides as modulators of tissue regeneration awarded by Life Sciences Research Foundation 2017 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Mechanisms protecting cell surface integrity in giant vacuolated cells of the notochord awarded by National Institutes of Health 2017 - 2020
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
- Modulation of heart regeneration by enhancer-delivered factors awarded by American Heart Association 2018 - 2019
- Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
- An integrative cellular blueprint of vertebrate tissue development awarded by University of California - San Diego 2018 - 2019
- Regulatory Mechanisms of Zebrafish Heart Regeneration awarded by American Heart Association 2017 - 2019
- Regulation of Appendage Regeneration in Zebrafish awarded by National Institutes of Health 2006 - 2018
- Regulation of glial bridging during spinal cord regeneration in zebrafish awarded by National Institutes of Health 2016 - 2018
- Duke Research Training Program for Pediatricians awarded by National Institutes of Health 2002 - 2018
- Biomarkers of Heart Regeneration awarded by National Institutes of Health 2013 - 2018
- Identifying a transcription factor collective that specifies cardiomyocyte regeneration awarded by American Heart Association 2017 - 2018
- Dissecting the directional regeneration of ventricular epicardium awarded by American Heart Association 2015 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Center for Molecular & Cellular Studies of Ped Disease awarded by National Institutes of Health 2003 - 2018
- Regulation of cardiomyocyte proliferation dynamics during zebrafish heart development awarded by March of Dimes 2014 - 2017
- Lightsheet Imaging System awarded by National Institutes of Health 2016 - 2017
- Role of Developmental Signaling Pathways in Tuberculosis Pathogenesis awarded by National Institutes of Health 2017
- CHROMATIN REGULATORY EVENTS UNDERLYING ZEBRAFISH HEART REGENERATION awarded by National Institutes of Health 2014 - 2017
- Vegf Signaling and Cardiac Chamber Morphogenesis in Zebrafish awarded by National Institutes of Health 2015 - 2016
- Regeneration Next Initiative Annual Retreat awarded by North Carolina Biotechnology Center 2016
- Dissecting the directional regeneration of ventricular epicardium awarded by American Heart Association 2015 - 2016
- Mechanisms of Neuregulin 1 in Heart Regeneration awarded by National Institutes of Health 2015 - 2016
- 2016 Weinstein Cardiovascular Development and Regeneration Conference awarded by March of Dimes 2016
- 2016 Weinstein Cardiovascular Development and Regeneration Conference Organizing Committee awarded by The Company of Biologists 2015 - 2016
- Visualizing and dissecting epicardial regeneration in zebrafish awarded by American Heart Association 2014 - 2016
- Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
- Identifying mechanisms of heart regeneration awarded by National Institutes of Health 2011 - 2014
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Han, Yanchao, Anzhi Chen, Kfir-Baruch Umansky, Kelsey A. Oonk, Wen-Yee Choi, Amy L. Dickson, Jianhong Ou, et al. “Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish..” Developmental Cell 48, no. 6 (March 2019): 853-863.e5. https://doi.org/10.1016/j.devcel.2019.01.001.Full Text
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Cox, Ben D., Alessandro De Simone, Valerie A. Tornini, Sumeet P. Singh, Stefano Di Talia, and Kenneth D. Poss. “In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone..” Current Biology : Cb 28, no. 24 (December 2018): 3937-3947.e4. https://doi.org/10.1016/j.cub.2018.10.052.Full Text
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Mokalled, Mayssa H., and Kenneth D. Poss. “A Regeneration Toolkit..” Developmental Cell 47, no. 3 (November 2018): 267–80. https://doi.org/10.1016/j.devcel.2018.10.015.Full Text
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Cao, Jingli, and Kenneth D. Poss. “The epicardium as a hub for heart regeneration..” Nature Reviews. Cardiology 15, no. 10 (October 2018): 631–47. https://doi.org/10.1038/s41569-018-0046-4.Full Text
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Walton, Eric M., Mark R. Cronan, C. J. Cambier, Andrea Rossi, Michele Marass, Matthew D. Foglia, W Jared Brewer, et al. “Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling..” Cell Host & Microbe 24, no. 4 (October 2018): 514-525.e6. https://doi.org/10.1016/j.chom.2018.09.004.Full Text
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Karra, Ravi, Matthew J. Foglia, Wen-Yee Choi, Christine Belliveau, Paige DeBenedittis, and Kenneth D. Poss. “Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish..” Proceedings of the National Academy of Sciences of the United States of America 115, no. 35 (August 13, 2018): 8805–10. https://doi.org/10.1073/pnas.1722594115.Full Text
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Wopat, Susan, Jennifer Bagwell, Kaelyn D. Sumigray, Amy L. Dickson, Leonie F. A. Huitema, Kenneth D. Poss, Stefan Schulte-Merker, and Michel Bagnat. “Spine Patterning Is Guided by Segmentation of the Notochord Sheath..” Cell Reports 22, no. 8 (February 2018): 2026–38. https://doi.org/10.1016/j.celrep.2018.01.084.Full Text
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Yang, Xinan H., Rangarajan D. Nadadur, Catharina Re Hilvering, Valerio Bianchi, Michael Werner, Stefan R. Mazurek, Margaret Gadek, et al. “Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm..” Elife 6 (December 27, 2017). https://doi.org/10.7554/eLife.31683.Full Text
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Chen, Chen-Hui, and Kenneth D. Poss. “Regeneration Genetics..” Annual Review of Genetics 51 (November 2017): 63–82. https://doi.org/10.1146/annurev-genet-120116-024554.Full Text
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Cao, Jingli, Jinhu Wang, Christopher P. Jackman, Amanda H. Cox, Michael A. Trembley, Joseph J. Balowski, Ben D. Cox, et al. “Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue..” Developmental Cell 42, no. 6 (September 2017): 600-615.e4. https://doi.org/10.1016/j.devcel.2017.08.024.Full Text
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Tornini, Valerie A., John D. Thompson, Raymond L. Allen, and Kenneth D. Poss. “Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration..” Development (Cambridge, England) 144, no. 16 (August 2017): 2889–95. https://doi.org/10.1242/dev.155655.Full Text
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Tzahor, Eldad, and Kenneth D. Poss. “Cardiac regeneration strategies: Staying young at heart..” Science (New York, N.Y.) 356, no. 6342 (June 8, 2017): 1035–39. https://doi.org/10.1126/science.aam5894.Full Text
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Goldman, Joseph Aaron, Guray Kuzu, Nutishia Lee, Jaclyn Karasik, Matthew Gemberling, Matthew J. Foglia, Ravi Karra, et al. “Resolving Heart Regeneration by Replacement Histone Profiling..” Developmental Cell 40, no. 4 (February 2017): 392-404.e5. https://doi.org/10.1016/j.devcel.2017.01.013.Full Text
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Karra, Ravi, and Kenneth D. Poss. “Redirecting cardiac growth mechanisms for therapeutic regeneration..” The Journal of Clinical Investigation 127, no. 2 (February 2017): 427–36. https://doi.org/10.1172/JCI89786.Full Text
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Nichols, James T., Bernardo Blanco-Sánchez, Elliott P. Brooks, Raghuveer Parthasarathy, John Dowd, Arul Subramanian, Gregory Nachtrab, Kenneth D. Poss, Thomas F. Schilling, and Charles B. Kimmel. “Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca..” Development (Cambridge, England) 143, no. 23 (December 2016): 4430–40. https://doi.org/10.1242/dev.141036.Full Text
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Tornini, Valerie A., Alberto Puliafito, Leslie A. Slota, John D. Thompson, Gregory Nachtrab, Anna-Lila Kaushik, Marika Kapsimali, Luca Primo, Stefano Di Talia, and Kenneth D. Poss. “Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration..” Current Biology : Cb 26, no. 22 (November 10, 2016): 2981–91. https://doi.org/10.1016/j.cub.2016.08.072.Full Text
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Mokalled, Mayssa H., Chinmoy Patra, Amy L. Dickson, Toyokazu Endo, Didier Y. R. Stainier, and Kenneth D. Poss. “Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish..” Science (New York, N.Y.) 354, no. 6312 (November 2016): 630–34. https://doi.org/10.1126/science.aaf2679.Full Text
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Di Talia, Stefano, and Kenneth D. Poss. “Monitoring Tissue Regeneration at Single-Cell Resolution..” Cell Stem Cell 19, no. 4 (October 2016): 428–31. https://doi.org/10.1016/j.stem.2016.09.007.Full Text
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Cao, Jingli, and Kenneth D. Poss. “Explant culture of adult zebrafish hearts for epicardial regeneration studies..” Nature Protocols 11, no. 5 (May 2016): 872–81. https://doi.org/10.1038/nprot.2016.049.Full Text
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Foglia, Matthew J., Jingli Cao, Valerie A. Tornini, and Kenneth D. Poss. “Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium..” Development (Cambridge, England) 143, no. 10 (May 2016): 1688–96. https://doi.org/10.1242/dev.136606.Full Text
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Han, Yanchao, and Kenneth D. Poss. “Accessories to Limb Regeneration..” Developmental Cell 37, no. 4 (May 2016): 297–98. https://doi.org/10.1016/j.devcel.2016.05.007.Full Text
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Kang, Junsu, Jianxin Hu, Ravi Karra, Amy L. Dickson, Valerie A. Tornini, Gregory Nachtrab, Matthew Gemberling, Joseph A. Goldman, Brian L. Black, and Kenneth D. Poss. “Modulation of tissue repair by regeneration enhancer elements..” Nature 532, no. 7598 (April 6, 2016): 201–6. https://doi.org/10.1038/nature17644.Full Text
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Chen, Chen-Hui, Alberto Puliafito, Ben D. Cox, Luca Primo, Yi Fang, Stefano Di Talia, and Kenneth D. Poss. “Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish..” Dev Cell 36, no. 6 (March 21, 2016): 668–80. https://doi.org/10.1016/j.devcel.2016.02.017.Full Text Link to Item
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Foglia, Matthew J., and Kenneth D. Poss. “Building and re-building the heart by cardiomyocyte proliferation..” Development (Cambridge, England) 143, no. 5 (March 2016): 729–40. https://doi.org/10.1242/dev.132910.Full Text
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Cao, Jingli, Adam Navis, Ben D. Cox, Amy L. Dickson, Matthew Gemberling, Ravi Karra, Michel Bagnat, and Kenneth D. Poss. “Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration..” Development (Cambridge, England) 143, no. 2 (January 2016): 232–43. https://doi.org/10.1242/dev.130534.Full Text
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Wang, Jinhu, and Kenneth D. Poss. “Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish..” Methods in Molecular Biology (Clifton, N.J.) 1451 (January 2016): 225–35. https://doi.org/10.1007/978-1-4939-3771-4_15.Full Text
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Karra, Ravi, Anne K. Knecht, Kazu Kikuchi, and Kenneth D. Poss. “Myocardial NF-κB activation is essential for zebrafish heart regeneration..” Proceedings of the National Academy of Sciences of the United States of America 112, no. 43 (October 15, 2015): 13255–60. https://doi.org/10.1073/pnas.1511209112.Full Text
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Chen, Chen-Hui, Alexander F. Merriman, Jeremiah Savage, Jason Willer, Taylor Wahlig, Nicholas Katsanis, Viravuth P. Yin, and Kenneth D. Poss. “Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration..” Plos Genetics 11, no. 8 (August 25, 2015). https://doi.org/10.1371/journal.pgen.1005437.Full Text
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Mahmoud, Ahmed I., Caitlin C. O’Meara, Matthew Gemberling, Long Zhao, Donald M. Bryant, Ruimao Zheng, Joseph B. Gannon, et al. “Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration..” Developmental Cell 34, no. 4 (August 6, 2015): 387–99. https://doi.org/10.1016/j.devcel.2015.06.017.Full Text
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Nagelberg, Danielle, Jinhu Wang, Rina Su, Jesús Torres-Vázquez, Kimara L. Targoff, Kenneth D. Poss, and Holger Knaut. “Origin, Specification, and Plasticity of the Great Vessels of the Heart..” Current Biology : Cb 25, no. 16 (August 6, 2015): 2099–2110. https://doi.org/10.1016/j.cub.2015.06.076.Full Text
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Palencia-Desai, Sharina, Megan S. Rost, Jennifer A. Schumacher, Quynh V. Ton, Michael P. Craig, Kristina Baltrunaite, Andrew L. Koenig, et al. “Myocardium and BMP signaling are required for endocardial differentiation..” Development (Cambridge, England) 142, no. 13 (July 2015): 2304–15. https://doi.org/10.1242/dev.118687.Full Text
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Kang, Junsu, Ravi Karra, and Kenneth D. Poss. “Back in Black..” Developmental Cell 33, no. 6 (June 2015): 623–24. https://doi.org/10.1016/j.devcel.2015.06.001.Full Text
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Wang, Jinhu, Jingli Cao, Amy L. Dickson, and Kenneth D. Poss. “Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling..” Nature 522, no. 7555 (June 2015): 226–30. https://doi.org/10.1038/nature14325.Full Text
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Gemberling, Matthew, Ravi Karra, Amy L. Dickson, and Kenneth D. Poss. “Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish..” Elife 4 (April 2015). https://doi.org/10.7554/eLife.05871.Full Text Open Access Copy
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Schindler, Yocheved L., Kristina M. Garske, Jinhu Wang, Beth A. Firulli, Anthony B. Firulli, Kenneth D. Poss, and Deborah Yelon. “Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration..” Development (Cambridge, England) 141, no. 16 (August 2014): 3112–22. https://doi.org/10.1242/dev.106336.Full Text
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Tornini, Valerie A., and Kenneth D. Poss. “Keeping at arm's length during regeneration..” Developmental Cell 29, no. 2 (April 2014): 139–45. https://doi.org/10.1016/j.devcel.2014.04.007.Full Text
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Chen, Chen-Hui, Ellen Durand, Jinhu Wang, Leonard I. Zon, and Kenneth D. Poss. “zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish..” Development (Cambridge, England) 140, no. 24 (December 2013): 4988–97. https://doi.org/10.1242/dev.102053.Full Text
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Gemberling, M., T. J. Bailey, D. R. Hyde, and K. D. Poss. “The zebrafish as a model for complex tissue regeneration.” Trends in Genetics 29, no. 11 (November 1, 2013): 611–20. https://doi.org/10.1016/j.tig.2013.07.003.Full Text
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Gemberling, Matthew, Travis J. Bailey, David R. Hyde, and Kenneth D. Poss. “The zebrafish as a model for complex tissue regeneration..” Trends in Genetics : Tig 29, no. 11 (November 2013): 611–20. https://doi.org/10.1016/j.tig.2013.07.003.Full Text
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Kang, Junsu, Gregory Nachtrab, and Kenneth D. Poss. “Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins..” Developmental Cell 27, no. 1 (October 2013): 19–31. https://doi.org/10.1016/j.devcel.2013.08.015.Full Text
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Wang, Jinhu, Ravi Karra, Amy L. Dickson, and Kenneth D. Poss. “Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration..” Developmental Biology 382, no. 2 (October 2013): 427–35. https://doi.org/10.1016/j.ydbio.2013.08.012.Full Text
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Johnson, Aaron N., Mayssa H. Mokalled, Juliana M. Valera, Kenneth D. Poss, and Eric N. Olson. “Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi..” Development (Cambridge, England) 140, no. 17 (September 2013): 3645–56. https://doi.org/10.1242/dev.095596.Full Text
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Nachtrab, Gregory, Kazu Kikuchi, Valerie A. Tornini, and Kenneth D. Poss. “Transcriptional components of anteroposterior positional information during zebrafish fin regeneration..” Development (Cambridge, England) 140, no. 18 (September 2013): 3754–64. https://doi.org/10.1242/dev.098798.Full Text
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Fang, Yi, Vikas Gupta, Ravi Karra, Jennifer E. Holdway, Kazu Kikuchi, and Kenneth D. Poss. “Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration..” Proceedings of the National Academy of Sciences of the United States of America 110, no. 33 (August 2013): 13416–21. https://doi.org/10.1073/pnas.1309810110.Full Text
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Gupta, Vikas, Matthew Gemberling, Ravi Karra, Gabriel E. Rosenfeld, Todd Evans, and Kenneth D. Poss. “An injury-responsive gata4 program shapes the zebrafish cardiac ventricle..” Current Biology : Cb 23, no. 13 (July 2013): 1221–27. https://doi.org/10.1016/j.cub.2013.05.028.Full Text
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Le, Xiuning, Emily K. Pugach, Simone Hettmer, Narie Y. Storer, Jianing Liu, Airon A. Wills, Antony DiBiase, et al. “A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development..” Development (Cambridge, England) 140, no. 11 (June 2013): 2354–64. https://doi.org/10.1242/dev.088427.Full Text
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Guner-Ataman, Burcu, Noelle Paffett-Lugassy, Meghan S. Adams, Kathleen R. Nevis, Leila Jahangiri, Pablo Obregon, Kazu Kikuchi, Kenneth D. Poss, Caroline E. Burns, and C Geoffrey Burns. “Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function..” Development (Cambridge, England) 140, no. 6 (March 2013): 1353–63. https://doi.org/10.1242/dev.088351.Full Text
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Choi, Wen-Yee, Matthew Gemberling, Jinhu Wang, Jennifer E. Holdway, Meng-Chieh Shen, Rolf O. Karlstrom, and Kenneth D. Poss. “In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration..” Development (Cambridge, England) 140, no. 3 (February 2013): 660–66. https://doi.org/10.1242/dev.088526.Full Text
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Gupta, V., M. Gemberling, R. Karra, G. E. Rosenfeld, T. Evans, and K. D. Poss. “An injury-responsive gata4 program shapes the zebrafish cardiac ventricle.” Current Biology 23, no. 13 (2013): 1221–27. https://doi.org/10.1016/j.cub.2013.05.028.Full Text
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Nachtrab, Gregory, and Kenneth D. Poss. “Toward a blueprint for regeneration..” Development (Cambridge, England) 139, no. 15 (August 2012): 2639–42. https://doi.org/10.1242/dev.080390.Full Text
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Yin, Viravuth P., Alexandra Lepilina, Ashley Smith, and Kenneth D. Poss. “Regulation of zebrafish heart regeneration by miR-133..” Developmental Biology 365, no. 2 (May 2012): 319–27. https://doi.org/10.1016/j.ydbio.2012.02.018.Full Text
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Gupta, Vikas, and Kenneth D. Poss. “Clonally dominant cardiomyocytes direct heart morphogenesis..” Nature 484, no. 7395 (April 25, 2012): 479–84. https://doi.org/10.1038/nature11045.Full Text
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Singh, Sumeet Pal, Jennifer E. Holdway, and Kenneth D. Poss. “Regeneration of amputated zebrafish fin rays from de novo osteoblasts..” Developmental Cell 22, no. 4 (April 2012): 879–86. https://doi.org/10.1016/j.devcel.2012.03.006.Full Text
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Choi, Wen-Yee, and Kenneth D. Poss. “Cardiac regeneration..” Current Topics in Developmental Biology 100 (January 2012): 319–44. https://doi.org/10.1016/B978-0-12-387786-4.00010-5.Full Text
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Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac regenerative capacity and mechanisms..” Annual Review of Cell and Developmental Biology 28 (January 2012): 719–41. https://doi.org/10.1146/annurev-cellbio-101011-155739.Full Text
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Nachtrab, Gregory, Michael Czerwinski, and Kenneth D. Poss. “Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling..” Current Biology : Cb 21, no. 22 (November 10, 2011): 1912–17. https://doi.org/10.1016/j.cub.2011.09.050.Full Text
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Qin, Zhao, Ambrose R. Kidd, Jennifer L. Thomas, Kenneth D. Poss, David R. Hyde, Pamela A. Raymond, and Ryan Thummel. “FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish..” Experimental Eye Research 93, no. 5 (November 2011): 726–34. https://doi.org/10.1016/j.exer.2011.09.003.Full Text
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Wang, Jinhu, Daniela Panáková, Kazu Kikuchi, Jennifer E. Holdway, Matthew Gemberling, James S. Burris, Sumeet Pal Singh, et al. “The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion..” Development 138, no. 16 (August 2011): 3421–30. https://doi.org/10.1242/dev.068601.Full Text Link to Item
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Kikuchi, Kazu, Vikas Gupta, Jinhu Wang, Jennifer E. Holdway, Airon A. Wills, Yi Fang, and Kenneth D. Poss. “tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration..” Development (Cambridge, England) 138, no. 14 (July 2011): 2895–2902. https://doi.org/10.1242/dev.067041.Full Text
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Shin, Donghun, Yoonsung Lee, Kenneth D. Poss, and Didier Y. R. Stainier. “Restriction of hepatic competence by Fgf signaling..” Development (Cambridge, England) 138, no. 7 (April 2011): 1339–48. https://doi.org/10.1242/dev.054395.Full Text
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Kikuchi, Kazu, Jennifer E. Holdway, Robert J. Major, Nicola Blum, Randall D. Dahn, Gerrit Begemann, and Kenneth D. Poss. “Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration..” Developmental Cell 20, no. 3 (March 2011): 397–404. https://doi.org/10.1016/j.devcel.2011.01.010.Full Text
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Poss, K. “Cardiac Regeneration in the Zebrafish Model System,” December 1, 2010, 839–53. https://doi.org/10.1016/B978-0-12-381332-9.00040-2.Full Text
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Liu, Jiandong, Michael Bressan, David Hassel, Jan Huisken, David Staudt, Kazu Kikuchi, Kenneth D. Poss, Takashi Mikawa, and Didier Y. R. Stainier. “A dual role for ErbB2 signaling in cardiac trabeculation..” Development (Cambridge, England) 137, no. 22 (November 2010): 3867–75. https://doi.org/10.1242/dev.053736.Full Text Open Access Copy
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Poss, Kenneth D. “Advances in understanding tissue regenerative capacity and mechanisms in animals..” Nature Reviews. Genetics 11, no. 10 (October 2010): 710–22. https://doi.org/10.1038/nrg2879.Full Text
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Lee, Yoonsung, Gregory Nachtrab, Pai W. Klinsawat, Danyal Hami, and Kenneth D. Poss. “Ras controls melanocyte expansion during zebrafish fin stripe regeneration..” Disease Models & Mechanisms 3, no. 7–8 (July 2010): 496–503. https://doi.org/10.1242/dmm.004515.Full Text Open Access Copy
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Yin, Chunyue, Kazu Kikuchi, Tatiana Hochgreb, Kenneth D. Poss, and Didier Y. R. Stainier. “Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish..” Developmental Cell 18, no. 6 (June 2010): 973–84. https://doi.org/10.1016/j.devcel.2010.05.009.Full Text
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Kikuchi, Kazu, Jennifer E. Holdway, Andreas A. Werdich, Ryan M. Anderson, Yi Fang, Gregory F. Egnaczyk, Todd Evans, Calum A. Macrae, Didier Y. R. Stainier, and Kenneth D. Poss. “Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes..” Nature 464, no. 7288 (March 2010): 601–5. https://doi.org/10.1038/nature08804.Full Text
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Gonzalez-Quevedo, Rosa, Yoonsung Lee, Kenneth D. Poss, and David G. Wilkinson. “Neuronal regulation of the spatial patterning of neurogenesis..” Developmental Cell 18, no. 1 (January 2010): 136–47. https://doi.org/10.1016/j.devcel.2009.11.010.Full Text
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Gonzalez-Quevedo, Rosa, Dorothy F. Sobieszczuk, Alexei Poliakov, Yoonsung Lee, Kenneth D. Poss, and David G. Wilkinson. “Feedback regulation of neurogenesis.” Developmental Biology 331, no. 2 (July 2009): 388–89. https://doi.org/10.1016/j.ydbio.2009.05.020.Full Text
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Lee, Yoonsung, Danyal Hami, Sarah De Val, Birgit Kagermeier-Schenk, Airon A. Wills, Brian L. Black, Gilbert Weidinger, and Kenneth D. Poss. “Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins..” Developmental Biology 331, no. 2 (July 2009): 270–80. https://doi.org/10.1016/j.ydbio.2009.05.545.Full Text
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Nachtrab, Gregory, and Kenneth D. Poss. “Genetic DISC-section of regeneration in Drosophila..” Developmental Cell 16, no. 6 (June 2009): 777–78. https://doi.org/10.1016/j.devcel.2009.05.015.Full Text
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Waxman, Joshua S., Brian R. Keegan, Richard W. Roberts, Kenneth D. Poss, and Deborah Yelon. “Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish..” Developmental Cell 15, no. 6 (December 2008): 923–34. https://doi.org/10.1016/j.devcel.2008.09.009.Full Text
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Marques, Sara R., Yoonsung Lee, Kenneth D. Poss, and Deborah Yelon. “Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart..” Developmental Biology 321, no. 2 (September 2008): 397–406. https://doi.org/10.1016/j.ydbio.2008.06.033.Full Text
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Wills, Airon A., Ambrose R. Kidd, Alexandra Lepilina, and Kenneth D. Poss. “Fgfs control homeostatic regeneration in adult zebrafish fins..” Development (Cambridge, England) 135, no. 18 (September 2008): 3063–70. https://doi.org/10.1242/dev.024588.Full Text
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Yin, Viravuth P., and Kenneth D. Poss. “New regulators of vertebrate appendage regeneration..” Current Opinion in Genetics & Development 18, no. 4 (August 11, 2008): 381–86. https://doi.org/10.1016/j.gde.2008.06.008.Full Text
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Yin, Viravuth P., J Michael Thomson, Ryan Thummel, David R. Hyde, Scott M. Hammond, and Kenneth D. Poss. “Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish..” Genes & Development 22, no. 6 (March 2008): 728–33. https://doi.org/10.1101/gad.1641808.Full Text
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Wills, Airon A., Jennifer E. Holdway, Robert J. Major, and Kenneth D. Poss. “Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish..” Development (Cambridge, England) 135, no. 1 (January 2008): 183–92. https://doi.org/10.1242/dev.010363.Full Text
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Shin, Donghun, Chong Hyun Shin, Jennifer Tucker, Elke A. Ober, Fabian Rentzsch, Kenneth D. Poss, Matthias Hammerschmidt, Mary C. Mullins, and Didier Y. R. Stainier. “Bmp and Fgf signaling are essential for liver specification in zebrafish..” Development (Cambridge, England) 134, no. 11 (June 2007): 2041–50. https://doi.org/10.1242/dev.000281.Full Text
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Nechiporuk, Alexei, Tor Linbo, Kenneth D. Poss, and David W. Raible. “Specification of epibranchial placodes in zebrafish..” Development (Cambridge, England) 134, no. 3 (February 2007): 611–23. https://doi.org/10.1242/dev.02749.Full Text
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Poss, Kenneth D. “Getting to the heart of regeneration in zebrafish..” Seminars in Cell & Developmental Biology 18, no. 1 (February 2007): 36–45. https://doi.org/10.1016/j.semcdb.2006.11.009.Full Text
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Major, Robert J., and Kenneth D. Poss. “Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair..” Drug Discovery Today. Disease Models 4, no. 4 (January 2007): 219–25. https://doi.org/10.1016/j.ddmod.2007.09.002.Full Text
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Lepilina, Alexandra, Ashley N. Coon, Kazu Kikuchi, Jennifer E. Holdway, Richard W. Roberts, C Geoffrey Burns, and Kenneth D. Poss. “A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration..” Cell 127, no. 3 (November 2006): 607–19. https://doi.org/10.1016/j.cell.2006.08.052.Full Text
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Lee, Yoonsung, Sara Grill, Angela Sanchez, Maureen Murphy-Ryan, and Kenneth D. Poss. “Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration..” Development (Cambridge, England) 132, no. 23 (December 2005): 5173–83. https://doi.org/10.1242/dev.02101.Full Text
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Poss, Kenneth D. “A zebrafish model of germ cell aneuploidy..” Cell Cycle (Georgetown, Tex.) 3, no. 10 (October 13, 2004): 1225–26. https://doi.org/10.4161/cc.3.10.1170.Full Text
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Poss, Kenneth D., Alex Nechiporuk, Keith F. Stringer, Charles Lee, and Mark T. Keating. “Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1..” Genes & Development 18, no. 13 (July 2004): 1527–32. https://doi.org/10.1101/gad.1182604.Full Text
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Traver, David, Barry H. Paw, Kenneth D. Poss, W Todd Penberthy, Shuo Lin, and Leonard I. Zon. “Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants..” Nature Immunology 4, no. 12 (December 2003): 1238–46. https://doi.org/10.1038/ni1007.Full Text
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Nechiporuk, Alex, Kenneth D. Poss, Stephen L. Johnson, and Mark T. Keating. “Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration..” Developmental Biology 258, no. 2 (June 2003): 291–306. https://doi.org/10.1016/s0012-1606(03)00129-5.Full Text
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Poss, Kenneth D., Mark T. Keating, and Alex Nechiporuk. “Tales of regeneration in zebrafish..” Developmental Dynamics : An Official Publication of the American Association of Anatomists 226, no. 2 (February 2003): 202–10. https://doi.org/10.1002/dvdy.10220.Full Text
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Gillette-Ferguson, I., D. G. Ferguson, K. D. Poss, and S. J. Moorman. “Changes in gravitational force induce alterations in gene expression that can be monitored in the live, developing zebrafish heart..” Advances in Space Research : The Official Journal of the Committee on Space Research (Cospar) 32, no. 8 (January 2003): 1641–46. https://doi.org/10.1016/s0273-1177(03)90405-4.Full Text
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Poss, Kenneth D., Lindsay G. Wilson, and Mark T. Keating. “Heart regeneration in zebrafish..” Science (New York, N.Y.) 298, no. 5601 (December 2002): 2188–90. https://doi.org/10.1126/science.1077857.Full Text
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Poss, Kenneth D., Alex Nechiporuk, Ann M. Hillam, Stephen L. Johnson, and Mark T. Keating. “Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration..” Development (Cambridge, England) 129, no. 22 (November 2002): 5141–49.
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Poss, K. D., J. Shen, and M. T. Keating. “Induction of lef1 during zebrafish fin regeneration..” Developmental Dynamics : An Official Publication of the American Association of Anatomists 219, no. 2 (October 2000): 282–86. https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1045>3.0.co;2-c.Full Text
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Poss, K. D., J. Shen, A. Nechiporuk, G. McMahon, B. Thisse, C. Thisse, and M. T. Keating. “Roles for Fgf signaling during zebrafish fin regeneration..” Developmental Biology 222, no. 2 (June 2000): 347–58. https://doi.org/10.1006/dbio.2000.9722.Full Text
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Nath, K. A., J. J. Haggard, A. J. Croatt, J. P. Grande, K. D. Poss, and J. Alam. “The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo..” The American Journal of Pathology 156, no. 5 (May 2000): 1527–35. https://doi.org/10.1016/s0002-9440(10)65024-9.Full Text
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Shiraishi, F., L. M. Curtis, L. Truong, K. Poss, G. A. Visner, K. Madsen, H. S. Nick, and A. Agarwal. “Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis..” American Journal of Physiology. Renal Physiology 278, no. 5 (May 2000): F726–36. https://doi.org/10.1152/ajprenal.2000.278.5.f726.Full Text
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Poss, K. D., J. Shen, and M. T. Keating. “Induction of lef1 during zebrafish fin regeneration.” Developmental Dynamics 219, no. 2 (January 1, 2000): 282–86. https://doi.org/10.1002/1097-0177(2000)9999:9999<::AID-DVDY1045>3.3.CO;2-3.Full Text
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Ferris, C. D., S. R. Jaffrey, A. Sawa, M. Takahashi, S. D. Brady, R. K. Barrow, S. A. Tysoe, et al. “Haem oxygenase-1 prevents cell death by regulating cellular iron..” Nature Cell Biology 1, no. 3 (July 1999): 152–57. https://doi.org/10.1038/11072.Full Text
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Soares, M. P., Y. Lin, J. Anrather, E. Csizmadia, K. Takigami, K. Sato, S. T. Grey, et al. “Expression of heme oxygenase-1 can determine cardiac xenograft survival..” Nature Medicine 4, no. 9 (September 1998): 1073–77. https://doi.org/10.1038/2063.Full Text
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Dennery, P. A., D. R. Spitz, G. Yang, A. Tatarov, C. S. Lee, M. L. Shegog, and K. D. Poss. “Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2..” The Journal of Clinical Investigation 101, no. 5 (March 1998): 1001–11. https://doi.org/10.1172/jci448.Full Text
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Burnett, A. L., D. G. Johns, L. J. Kriegsfeld, S. L. Klein, D. C. Calvin, G. E. Demas, L. P. Schramm, et al. “Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2..” Nature Medicine 4, no. 1 (January 1998): 84–87. https://doi.org/10.1038/nm0198-084.Full Text
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Zakhary, R., K. D. Poss, S. R. Jaffrey, C. D. Ferris, S. Tonegawa, and S. H. Snyder. “Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide..” Proceedings of the National Academy of Sciences of the United States of America 94, no. 26 (December 1997): 14848–53. https://doi.org/10.1073/pnas.94.26.14848.Full Text
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Poss, K. D., and S. Tonegawa. “Heme oxygenase 1 is required for mammalian iron reutilization..” Proceedings of the National Academy of Sciences of the United States of America 94, no. 20 (September 1997): 10919–24. https://doi.org/10.1073/pnas.94.20.10919.Full Text
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Poss, K. D., and S. Tonegawa. “Reduced stress defense in heme oxygenase 1-deficient cells..” Proceedings of the National Academy of Sciences of the United States of America 94, no. 20 (September 1997): 10925–30. https://doi.org/10.1073/pnas.94.20.10925.Full Text
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Poss, K. D., M. J. Thomas, A. K. Ebralidze, T. J. O’Dell, and S. Tonegawa. “Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice..” Neuron 15, no. 4 (October 1995): 867–73. https://doi.org/10.1016/0896-6273(95)90177-9.Full Text
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Demas, G. E., L. J. Kriegsfeld, K. D. Poss, S. Tonegawa, and R. J. Nelson. “Circadian locomotor rhythms in mice with targeted disruption of the gene for the carbon monoxide synthesizing enzyme, heme oxygenase-2.” Biological Rhythm Research 30, no. 3 (October 27, 1999): 282–89. https://doi.org/10.1076/brhm.30.3.282.3053.Full Text
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Book Sections
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Major, R. J., and K. D. Poss. “III. Does heart regeneration occur?: B. Zebrafish heart regeneration.” In Heart Regeneration: Stem Cells and Beyond, 59–80, 2012. https://doi.org/10.1142/9789814299817_0003.Full Text
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Conference Papers
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Merriman, A. F., C. Chen, and K. D. Poss. “Identification of new regeneration mutants in zebrafish by a forward genetic screen.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.Link to Item
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Waxman, Joshua S., Brian R. Keegan, Richard W. Roberts, Kenneth D. Poss, and Deborah Yelon. “Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.” In Developmental Biology, 319:482–482. Elsevier BV, 2008. https://doi.org/10.1016/j.ydbio.2008.05.060.Full Text
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Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac progenitors during zebrafish heart regeneration.” In Circulation Research, 101:E57–E57. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
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Lee, Y., S. Grill, M. Murphy-Ryan, and K. D. Poss. “A proximodistal gradient of Fgf signaling defines position-dependent rates of zebrafish fin regeneration..” In Developmental Biology, 283:642–642. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.Link to Item
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