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Regulatory mechanisms of RIPK1 in cell death and inflammation.

Publication ,  Journal Article
Liu, Z; Chan, FK-M
Published in: Semin Cell Dev Biol
January 2021

Receptor Interacting Protein Kinase 1 (RIPK1) and RIPK3 are key adaptors that play critical roles in inflammatory and cell death signaling. Work in recent years have shown that their activities are tightly regulated by ubiquitination, phosphorylation and proteolysis. In addition to these post-translational modifications, the expression and activities of these kinases can further be tuned by environmental changes in pH and oxygen content. Proper control of these regulatory processes is crucial for the RIP kinases to execute their functions in immune responses and tissue homeostasis. In this review, we discuss recent advance in our understanding of the molecular mechanisms that regulate the activities of the RIP kinases. We will also discuss how the different regulatory mechanisms contribute to the functions of RIPK1 and RIPK3 in different pathophysiological settings.

Duke Scholars

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Published In

Semin Cell Dev Biol

DOI

EISSN

1096-3634

Publication Date

January 2021

Volume

109

Start / End Page

70 / 75

Location

England

Related Subject Headings

  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Inflammation
  • Humans
  • Developmental Biology
  • Cell Death
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 0601 Biochemistry and Cell Biology
 

Citation

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MLA
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Liu, Z., & Chan, F.-M. (2021). Regulatory mechanisms of RIPK1 in cell death and inflammation. Semin Cell Dev Biol, 109, 70–75. https://doi.org/10.1016/j.semcdb.2020.06.013
Liu, Zhijun, and Francis Ka-Ming Chan. “Regulatory mechanisms of RIPK1 in cell death and inflammation.Semin Cell Dev Biol 109 (January 2021): 70–75. https://doi.org/10.1016/j.semcdb.2020.06.013.
Liu Z, Chan FK-M. Regulatory mechanisms of RIPK1 in cell death and inflammation. Semin Cell Dev Biol. 2021 Jan;109:70–5.
Liu, Zhijun, and Francis Ka-Ming Chan. “Regulatory mechanisms of RIPK1 in cell death and inflammation.Semin Cell Dev Biol, vol. 109, Jan. 2021, pp. 70–75. Pubmed, doi:10.1016/j.semcdb.2020.06.013.
Liu Z, Chan FK-M. Regulatory mechanisms of RIPK1 in cell death and inflammation. Semin Cell Dev Biol. 2021 Jan;109:70–75.
Journal cover image

Published In

Semin Cell Dev Biol

DOI

EISSN

1096-3634

Publication Date

January 2021

Volume

109

Start / End Page

70 / 75

Location

England

Related Subject Headings

  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Inflammation
  • Humans
  • Developmental Biology
  • Cell Death
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 0601 Biochemistry and Cell Biology