ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.

Journal Article (Journal Article;Review)

An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area of research, the Colon and Rectal-Anal Task Forces of the United States National Cancer Institute convened a panel of multidisciplinary experts to summarize current data on the utility of ctDNA in the management of colorectal cancer and to provide guidance in promoting the efficient development and integration of this technology into clinical care. The panel focused on four key areas in which ctDNA has the potential to change clinical practice, including the detection of minimal residual disease, the management of patients with rectal cancer, monitoring responses to therapy, and tracking clonal dynamics in response to targeted therapies and other systemic treatments. The panel also provides general guidelines with relevance for ctDNA-related research efforts, irrespective of indication.

Full Text

Duke Authors

Cited Authors

  • Dasari, A; Morris, VK; Allegra, CJ; Atreya, C; Benson, AB; Boland, P; Chung, K; Copur, MS; Corcoran, RB; Deming, DA; Dwyer, A; Diehn, M; Eng, C; George, TJ; Gollub, MJ; Goodwin, RA; Hamilton, SR; Hechtman, JF; Hochster, H; Hong, TS; Innocenti, F; Iqbal, A; Jacobs, SA; Kennecke, HF; Lee, JJ; Lieu, CH; Lenz, H-J; Lindwasser, OW; Montagut, C; Odisio, B; Ou, F-S; Porter, L; Raghav, K; Schrag, D; Scott, AJ; Shi, Q; Strickler, JH; Venook, A; Yaeger, R; Yothers, G; You, YN; Zell, JA; Kopetz, S

Published Date

  • December 2020

Published In

Volume / Issue

  • 17 / 12

Start / End Page

  • 757 - 770

PubMed ID

  • 32632268

Pubmed Central ID

  • PMC7790747

Electronic International Standard Serial Number (EISSN)

  • 1759-4782

Digital Object Identifier (DOI)

  • 10.1038/s41571-020-0392-0


  • eng

Conference Location

  • England