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ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.

Publication ,  Journal Article
Dasari, A; Morris, VK; Allegra, CJ; Atreya, C; Benson, AB; Boland, P; Chung, K; Copur, MS; Corcoran, RB; Deming, DA; Dwyer, A; Diehn, M ...
Published in: Nat Rev Clin Oncol
December 2020

An increasing number of studies are describing potential uses of circulating tumour DNA (ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area of research, the Colon and Rectal-Anal Task Forces of the United States National Cancer Institute convened a panel of multidisciplinary experts to summarize current data on the utility of ctDNA in the management of colorectal cancer and to provide guidance in promoting the efficient development and integration of this technology into clinical care. The panel focused on four key areas in which ctDNA has the potential to change clinical practice, including the detection of minimal residual disease, the management of patients with rectal cancer, monitoring responses to therapy, and tracking clonal dynamics in response to targeted therapies and other systemic treatments. The panel also provides general guidelines with relevance for ctDNA-related research efforts, irrespective of indication.

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Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

December 2020

Volume

17

Issue

12

Start / End Page

757 / 770

Location

England

Related Subject Headings

  • United States
  • Rectal Neoplasms
  • Neoplasm, Residual
  • National Cancer Institute (U.S.)
  • Liquid Biopsy
  • Humans
  • Colorectal Neoplasms
  • Colon
  • Circulating Tumor DNA
  • Biomarkers, Tumor
 

Citation

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Dasari, A., Morris, V. K., Allegra, C. J., Atreya, C., Benson, A. B., Boland, P., … Kopetz, S. (2020). ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. Nat Rev Clin Oncol, 17(12), 757–770. https://doi.org/10.1038/s41571-020-0392-0
Dasari, Arvind, Van K. Morris, Carmen J. Allegra, Chloe Atreya, Al B. Benson, Patrick Boland, Ki Chung, et al. “ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.Nat Rev Clin Oncol 17, no. 12 (December 2020): 757–70. https://doi.org/10.1038/s41571-020-0392-0.
Dasari A, Morris VK, Allegra CJ, Atreya C, Benson AB, Boland P, et al. ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. Nat Rev Clin Oncol. 2020 Dec;17(12):757–70.
Dasari, Arvind, et al. “ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.Nat Rev Clin Oncol, vol. 17, no. 12, Dec. 2020, pp. 757–70. Pubmed, doi:10.1038/s41571-020-0392-0.
Dasari A, Morris VK, Allegra CJ, Atreya C, Benson AB, Boland P, Chung K, Copur MS, Corcoran RB, Deming DA, Dwyer A, Diehn M, Eng C, George TJ, Gollub MJ, Goodwin RA, Hamilton SR, Hechtman JF, Hochster H, Hong TS, Innocenti F, Iqbal A, Jacobs SA, Kennecke HF, Lee JJ, Lieu CH, Lenz H-J, Lindwasser OW, Montagut C, Odisio B, Ou F-S, Porter L, Raghav K, Schrag D, Scott AJ, Shi Q, Strickler JH, Venook A, Yaeger R, Yothers G, You YN, Zell JA, Kopetz S. ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. Nat Rev Clin Oncol. 2020 Dec;17(12):757–770.

Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

December 2020

Volume

17

Issue

12

Start / End Page

757 / 770

Location

England

Related Subject Headings

  • United States
  • Rectal Neoplasms
  • Neoplasm, Residual
  • National Cancer Institute (U.S.)
  • Liquid Biopsy
  • Humans
  • Colorectal Neoplasms
  • Colon
  • Circulating Tumor DNA
  • Biomarkers, Tumor