Overview
John Strickler, MD is a Professor of Medicine in the Division of Medical Oncology, where he is Co-Leader for the Precision Cancer Medicine and Investigational Therapeutics Program at the Duke Cancer Institute, Leader of the Molecular Tumor Board, and Associate Director of Clinical Research – GI Oncology. Dr. Strickler’s clinic specializes on the treatment of gastrointestinal malignancies, with a particular emphasis on gastroesophageal, pancreatic, and colorectal cancers. His research focuses on precision cancer medicine: identification of biomarkers that predict sensitivity or resistance to targeted therapies and immunotherapy. He has designed and executed clinical trials that test novel therapies and innovative therapeutic strategies. He was Principal Investigator on an investigator sponsored trial that led to the first FDA-approved therapy for HER2+ metastatic colorectal cancer. He has first-author publications in several high impact factor medical journals, including the New England Journal of Medicine, Clinical Cancer Research, Cancer Discovery, Journal of Clinical Oncology, and Lancet Oncology. Nationally, he has served as a member of the American Society of Clinical Oncology (ASCO) Treatment Guidelines Committee for Advanced Colon Cancer.
Current Appointments & Affiliations
Professor of Medicine
·
2024 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
2008 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Safety and feasibility of talimogene laherparepvec in peritoneal surface malignancies: Results from the TEMPO trial.
Journal Article Mol Ther Oncol · March 19, 2026 Peritoneal surface malignancies (PSMs) remain a therapeutic challenge, particularly in patients with unresectable disease who cannot benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. The Talimogene Laherparepvec for the Trea ... Full text Link to item CiteTucatinib plus trastuzumab for chemotherapy-refractory, HER2 + , RAS wild-type metastatic colorectal cancer (MOUNTAINEER): final analysis.
Journal Article Nat Commun · January 12, 2026 MOUNTAINEER was a multicenter, open-label, phase 2 trial (NCT03043313) that evaluated the efficacy and safety of tucatinib plus trastuzumab, a dual HER2-targeted chemotherapy-free regimen. Patients were included if they had chemotherapy-refractory, HER2+, ... Full text Link to item CiteFramework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program.
Journal Article Cancer Cell · January 8, 2026 Cancer evolution is a complex and dynamic process, yet most treatment strategies remain static. Infrequent tumor sampling has limited our ability to counteract the transient adaptive states that precede resistance. To address this gap, ARPA-H launched the ... Full text Link to item CiteRecent Grants
First-in-Human, Phase 1 Study of PHN-012, an Antibody Drug Conjugate, in Patients with Advanced Solid Tumors
Clinical TrialPrincipal Investigator · Awarded by Pheon Therapeutics LTD · 2025 - 2030A Global First-in-Human Study in NSCLC, HNSCC, and Solid Tumors with Azirkitug (ABBV¿514) as a Single Agent and in Combination with Budigalimab or Bevacizumab
Clinical TrialPrincipal Investigator · Awarded by AbbVie Inc. · 2025 - 2030A Phase 2 Study to Evaluate the Safety and Efficacy of Telisotuzumab Adizutecan for the Treatment of Subjects with Locally Advanced or Metastatic Solid Tumors that Harbor MET Amplification
Clinical TrialPrincipal Investigator · Awarded by AbbVie Inc. · 2025 - 2030View All Grants
Education, Training & Certifications
The University of Chicago ·
2005
M.D.